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International Conference:Technology Transfer in Biological Control:From Research to Practice

作者： richard j.milner Lisa MILLER CSIRO Division of EntomologyGPO Box 1700ACT 2601Australia

The black field cricket,Teleogryllus commodus,is a serious pest of pastures in western Victoria,*** insect has an annual life cycle with the eggs hatching in *** nymphs live in cracks in the gound and emerge,mainly at night,to feed on pasture foliage and *** are particularly damaging in autumn(March/April) and they reduce the ability

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绿僵菌对小菜蛾的感染反应分析

中国生物防治 2000年第1期16卷 15-18页

作者：马骏 richardj.milner 湖南农业大学植保系长沙410128 CSIRO Division of Entomology

用绿僵菌孢子悬浮液中浸渍过的甘蓝叶喂饲小菜蛾的方法 ,测定小菜蛾对 FI1 2 48菌株的感染反应。运用时间 -剂量 -死亡率模型 ,对死亡率随时间和剂量的变化作了拟合。接种后第9天的 L C5 0 为 4.1 7× 1 0 5～ 6 .33× 1 0 5孢子 / ml,... 详细信息

用绿僵菌孢子悬浮液中浸渍过的甘蓝叶喂饲小菜蛾的方法 ,测定小菜蛾对 FI1 2 48菌株的感染反应。运用时间 -剂量 -死亡率模型 ,对死亡率随时间和剂量的变化作了拟合。接种后第9天的 L C5 0 为 4.1 7× 1 0 5～ 6 .33× 1 0 5孢子 / ml,在 1 0 7孢子 / ml浓度下的 L T5 0 为 4.7天。结果表明 FI1 2 48菌株对小菜蛾具有较强的致死作用。

关键词：绿僵菌小菜蛾生物测定感染反应时间剂量

Identification of a novel pathway involving a GATA transcription factor in yeast and possibly in plant Zn uptake and homeostasis

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journal of Integrative Plant Biology 2014年第3期56卷 271-280页

作者： Matthew j.milner Nicole S.Pence jiping Liu Leon V.Kochian Robert W.Holley Center for Agriculture and Health USDA‐ARS Cornell University Department of Plant Biology Cornell University

To gain a better understanding of the regulation of Zn homeostasis in plants and the degree of conservation of Zn homeostasis between plants and yeast, a cDNA library from the Zn/Cd hyperaccumulating plant species, Noccaea caerulescens, was screened for its ability to restore growth under Zn limiting conditions in the yeast mutant zaplA. ZAP1 is a transcription factor that activates the Zn dependent transcription of yeast genes involved in Zn uptake, including ZRT1, the yeast high affinity Zn transporter. From this screen two members of the E2F family of transcription factors were found to activate ZRT1 expression in a Zn independent manner. The activation of ZRTI by the plant E2F proteins involves E2F- mediated activation of a yeast GATA transcription factor which in turn activates ZRT1 expression. A ZRT1 promoter region necessary for activation by E2F and GATA proteins is upstream of two zinc responsive elements previously shown to bind ZAP1 in ZRT1. This activation may not involve direct binding of E2F to the ZRT1 promoter. The expression of E2F genes in yeast does not replace function of ZAP1; instead it appears to activate a novel GATA regulatory pathway involved in Zn uptake and homeostasis that is not Zn responsive.

关键词： E2F transcription factor GATA transcription factor ZRT1 Znhomeostasis

Mineralized collagen scaffolds fabricated with amniotic membrane matrix increase osteogenesis under inflammatory conditions

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Regenerative Biomaterials 2020年第3期7卷 247-258页

作者： Marley j.Dewey Eileen M.johnson Simona T.Slater Derek j.milner Matthew B.Wheeler Brendan A.C.Harley Department of Materials Science and Engineering University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Department of Bioengineering University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Department of Chemical and Biomolecular Engineering University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Carl R.Woese Institute for Genomic Biology University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA Department of Animal Sciences University of Illinois at Urbana-Champaign110 Roger Adams Laboratory600 S.Mathews Ave.UrbanaIL 61801USA

Defects in craniofacial bones occur congenitally,after high-energy impacts,and during the course of treatment for stroke and *** injuries are difficult to heal due to the overwhelming size of the injury area and the inflammatory environment surrounding the *** inflammatory response after injury may greatly inhibit regenerative *** have developed mineralized collagen scaffolds that can induce osteogenic differentiation and matrix biosynthesis in the absence of osteogenic media or supplemental *** amniotic membrane is derived from placentas and has been recently investigated as an extracellular matrix to prevent chronic ***,we hypothesized that a mineralized collagen-amnion composite scaffold could increase osteogenic activity in the presence of inflammatory *** report mechanical properties of a mineralized collagen-amnion scaffold and investigated osteogenic differentiation and mineral deposition of porcine adipose-derived stem cells within these scaffolds as a function of inflammatory *** of amniotic membrane matrix promotes osteogenesis similarly to un-modified mineralized collagen scaffolds,and increases in mineralized collagen-amnion scaffolds under inflammatory ***,these findings suggest that a mineralized collagen-amnion scaffold may provide a beneficial environment to aid craniomaxillofacial bone repair,especially in the course of defects presenting significant inflammatory complications.

关键词： mineralized collagen scaffolds amniotic membrane inflammation stem cell osteogenesis

Superchiral near fields detect virus structure

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Light(Science & Applications) 2020年第1期9卷 103-112页

作者： Tarun Kakkar Chantal Keijzer Marion Rodier Tatyana Bukharova Michael Taliansky Andrew j.Love joel j.milner Affar S.Karimullah Laurence D.Barron Nikolaj Gadegaard Adrian j.Lapthorn Malcolm Kadodwala School of Chemistry Joseph Black BuildingUniversity of GlasgowGlasgow G128QQUK Institute of Molecular Cell and Systems Biology and School of Life SciencesUniversity of GlasgowG128QQ GlasgowUK james Hutton Inst Cell&Mol SciDundee DD25DAUK Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS Moscow 117997Russia School of Engineering Rankine BuildingUniversity of GlasgowGlasgow G128LTUK

Optical spectroscopy can be used to quickly characterise the structural properties of individual ***,it cannot be applied to biological assemblies because light is generally blind to the spatial distribution of the component *** insensitivity arises from the mismatch in length scales between the assemblies(a few tens of nm)and the wavelength of light required to excite chromophores(≥150 nm).Consequently,with conventional spectroscopy,ordered assemblies,such as the icosahedral capsids of viruses,appear to be indistinguishable isotropic spherical *** limits potential routes to rapid high-throughput portable detection appropriate for point-of-care ***,we demonstrate that chiral electromagnetic(EM)near fields,which have both enhanced chiral asymmetry(referred to as superchirality)and subwavelength spatial localisation(∼10 nm),can detect the icosahedral structure of virus ***,they can detect both the presence and relative orientation of a bound virus *** illustrate the potential uses of the exquisite structural sensitivity of subwavelength superchiral fields,we have used them to successfully detect virus particles in the complex milieu of blood serum.

关键词： chiral detect fields

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p53在肿瘤中的抑制和促进功能

自然杂志 1991年第7期14卷 520-523,537页

作者： j.milner 吴炯英国剑桥大学

什么是p53?现在认为p53基因在人类肿瘤发生过程中起着重要作用。野生型p53基因的功能是抑制异常细胞生长及向恶性状态发展。然而,一个点突变就可以使p53变成为细胞增殖和肿瘤发生的促进剂。本文将重点阐述有关p53基因对细胞增殖发挥功... 详细信息

什么是p53?现在认为p53基因在人类肿瘤发生过程中起着重要作用。野生型p53基因的功能是抑制异常细胞生长及向恶性状态发展。然而,一个点突变就可以使p53变成为细胞增殖和肿瘤发生的促进剂。本文将重点阐述有关p53基因对细胞增殖发挥功能效应的两个问题。首先,在正常细胞对生长刺激产生应答过程中野生型p53基因的抑制效应是如何被解除的?其次,野生型和突变型p53等位基因是如何发挥对细胞增殖抑制和促进这两个相对立的效应的?

关键词：细胞增殖细胞生长 p53 抑制效应野生型应答过程基因对构像细胞周期成纤维细胞

Social media growth of orthopaedic surgery residency programs in response to the COVID-19 pandemic

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World journal of Orthopedics 2022年第8期13卷 693-702页

作者： joseph S Geller Dustin H Massel Michael G Rizzo Ean Schwartz jacob Eric milner Chester j Donnally III Department of Orthopaedic Surgery University of Miami Miller School of MedicineMiamiFL 33136United States Department of Orthopedics University of Miami Miller School of MedicineMiamiFL 33136United States University of Miami Leonard M.Miller School of Medicine University of Miami Miller School of MedicineMiamiFL 33136United States Miller School of Medicine University of MiamiMiamiFL 33136United States Texas Spine Consultants Texas Spine ConsultantsAddisonTX 75001United States

BACKGROUND In the Spring of 2020,residency programs across the country experienced rapid and drastic changes to their application process as a result of the coronavirus disease 2019(COVID-19)*** response,residency programs shifted to virtual events and began harnessing social media to communicate with *** To analyze the changes in social media usage by orthopaedic surgery programs in response to the COVID-19 *** Based on the 2019 residency and fellowship electronic database,accredited US orthopaedic surgery programs were reviewed for social media presence on Instagram and *** 47000 tweets from 2011-2021 were extracted through the Twitter application programming *** extracted:Total number of followers,accounts following,tweets,likes,date of account creation,hashtags,and *** language processing was utilized for tweet sentiment analysis and classified as positive,neutral,or *** data was collected and deemed current as of August 11,*** account foundation date analysis was based on the date recognized as the start of the COVID-19 outbreak in the United States,before or after March 1,*** A total of 85(42.3%)orthopaedic surgery residency program Twitter handles were ***-five(41.2%)programs joined Twitter in the nine months after the 2020 covid *** 2020,there was a 126.6%increase in volume of tweets by orthopaedic surgery residency accounts as compared to *** median number of followers was 474.5(interquartile range 205.0-796.5).The account with the highest number of tweets was Hospital for Special Surgery(@HSpecialSurgery)with 13776 tweets followed by University of Virginia(@UVA_Ortho)with 5063 and Yale(@OrthoAtYale)with *** analysis before 2020 revealed 30.4%positive,60.8%neutral,and 8.8%negative sentiments across ***,the positive sentiment percentage increased in 2020 from 30.4%to 34.5%.Of the 201 ACGME-accredited ortho

关键词： Social media COVID-19 Orthopaedic surgery Residency

Acute kidney injury following spinal instrumentation surgery in children

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World journal of Nephrology 2017年第2期6卷 79-85页

作者： jasper j jobsis Abdullah Alabbas Ruth milner Christopher Reilly Kishore Mulpuri Cherry Mammen Department of Paediatrics Tergooi Hospital1261 AN BlaricumThe Netherlands Stollery Children's Hospital EdmontonAB T6G 2L9Canada BC Children's Hospital VancouverBC V6H 3V4Canada

AIM To determine acute kidney in jury （AKI） incidence and potential risk factors of AKI in children undergoing spinal instrumentation surgery. METHODS AKI incidence in children undergoing spinal instru-mentation surgery at British Columbia Children’s Hospital between january 2006 and December 2008 was determined by the Acute Kidney Injury Networ classification using serum creatinine and urine output criteria. During this specific time period, all patients following spinal surgery were monitored in the pediatric intensive care unit and had an indwelling Foley catheter permitting hourly urine output recording. Cases of AKI were identifed from our database. From the remaining cohort, we selected group-matched controls that did not satisfy criteria for AKI. The controls were matched for sex, age and underlying diagnosis （idiopathic vs non-idiopathic scoliosis）. RESULTS Thirty five of 208 patients met criteria for AKI with an incidence of 17% （95%CI： 12%-23%）. Of all children who developed AKI, 17 （49%） developed mild AKI （AKI Stage 1）, 17 （49%） developed moderate AKI （Stage 2） and 1 patient （3%） met criteria for severe AKI （Stage 3）. An inverse relationship was observed with AKI incidence and the amount of fluids received intra-operatively. An inverse relationship was observed with AKI incidence and the amount of fuids received intra-operatively classifed by fluid tertiles： 70% incidence in those that received the least amount of fluids vs 29% that received the most fluids （〉 7.9, P = 0.02）. Patients who developed AKI were more frequently exposed to nephrotoxins （non steroidal anti inflammatory drugs or aminoglycosides） than control patients during their peri-operative course （60% vs 22%, P 〈 0.001）. CONCLUSION We observed a high incidence of AKI following spinal instrumentation surgery in children that is potentially related to the frequent use of nephrotoxins and the amount of fuid administered peri-operatively.

关键词： Acute kidney injury Epidemiology Acute Kidney Injury Network Spinal surgery Children

Development of Fuel Economy Gear Oil Technology

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润滑油 2010年第3期25卷 11-19页

作者： Tze-Chi jao Chip Hewette Dave DeGonia jeff milner Timothy M.Cameron Anthony j.Rollin Afton Chemical Corporation Richmond Kettering University Flint

Vehicle fuel economy will continue to increase in importance as world vehicle production grows and fuel supplies become more limited year by *** OEMs strive to produce cars and trucks with greater fuel efficiency and extended durability,additive technology developers are increasingly being asked to contribute to these goals from the lubricant *** inefficiency can account for as much as 10% of the overall losses in an automotive driveline so improvements in axle efficiency can contribute greatly to improving vehicle fuel *** good durability,low axle oil operating temperatures are also needed to minimize oxidative and thermal degradation of the oil,reduce deposits and sludge formation,and extend oil drain *** develop gear oils that can increase axle efficiency significantly while maintaining stable operating temperatures requires rig tests that are fast,precise and *** paper documents the development of a new axle test rig and test procedures and presents test results on several gear *** test results show the contributions of base oil viscosity,base oil chemistry,and additive chemistry on the fuel economy and temperature of the various *** a dependable tool is enabling the development of new fuel-efficient and durable gear oil technology.

关键词： axle efficiency fuel economy gear oil durability axle operating temperature EHD

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快速且恒温的皮氏规

国外计量 1985年第2期 33-35页

作者： C、j.milner 张淞荃

一、前言过去的皮氏规均存在热时间常数大且需用薄的材料制造 TDR~* 的缺点。对此,本文作了改进,采用一个简单而新型的双运算放大器电路,将皮氏规的惠斯登电桥做成自动平衡的,并将压力计做成恒温的。改进后的系统不仅保持了原先装置的... 详细信息

一、前言过去的皮氏规均存在热时间常数大且需用薄的材料制造 TDR~* 的缺点。对此,本文作了改进,采用一个简单而新型的双运算放大器电路,将皮氏规的惠斯登电桥做成自动平衡的,并将压力计做成恒温的。改进后的系统不仅保持了原先装置的耐久性和量程宽的特点,而且依赖于温度的电阻不须用超薄材料制造,在真空中达到了小于30ms 的响应时间常数。在小于

关键词：惠斯登电桥程宽时间常数运算放大器自动平衡电源端真空灯平衡电桥电桥平衡热测量