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Near-infrared Emissive 1,2-Dioxetane-based Chemiluminescent Probes

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Chemical Research in Chinese Universities 2024年第5期40卷 806-823页

作者： CHEN Yingqi BUDIANTA richard NING Yingying Spin-X Institute School of Chemistry and Chemical EngineeringSchool of Biomedical Sciences and EngineeringState Key Laboratory of Luminescent Materials and DevicesGuangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsSouth China University of TechnologyGuangzhou510641P.R.China

Chemiluminescence,a phenomenon emitting light from chemical reactions rather than photon absorption,has gained significant interest for applications in bioimaging and biosensing due to its high sensitivity and low background *** there is a growing interest in near-infrared(NIR)chemiluminescent probes for improved tissue penetration and reduced *** review summarizes NIR emissive chemiluminescent probes based on 1,2-dioxetane and discusses their chemical structures and *** modification strategies for red-shifting wavelength and enhancing brightness include incorporating electron-withdrawing groups,designing chemiluminophore-fluorophore cassettes,and exploring alternative chemiluminescent *** review aims to inspire the exploration of NIR chemiluminescent probes in disease detection and treatment.

关键词： Chemiluminescence Near-infrared Dioxetane Bioimaging Biosensing

The good and evil of complement activation in HIV-1 infection

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Cellular & Molecular Immunology 2010年第5期7卷 334-340页

作者： Qigui Yu richard Yu Xuebin Qin Department of Microbiology and Immunology University School of Medicine635 Barnhill DriveIndianapolisINUSA Harvard Medical School Laboratory for Translational ResearchCambridgeMAUSA

The complement system,a key component of innate immunity,is a first-line defender against foreign pathogens such as *** role of the complement system in HIV-1 pathogenesis appears to be *** the complement system plays critical roles in clearing and neutralizing HIV-1 virions,it also represents a critical factor for the spread and maintenance of the virus in the infected *** addition,complement regulators such as human CD59 present in the envelope of HIV-1 prevent complement-mediated lysis of *** novel approaches are proposed to combat HIV-1 infection through the enhancement of antibody-dependent complement activity against *** this paper,we will review these diverse roles of complement in HIV-1 infection.

关键词： antibody complement HIV-1 human CD59

Carboxylesterases in lipid metabolism： From mouse to human

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Protein & Cell 2018年第2期9卷 178-195页

作者： Jihong Lian Randal Nelson richard Lehner Group on Molecular and Cell Biology of Lipids University of Alberta Edmonton Alberta Canada Department of Pediatrics University of Alberta Edmonton Alberta Canada Department of Cell Biology University of Alberta Edmonton Alberta Canada

Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of car- boxylesterases in lipid metabolism and energy home- ostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro through （over）expression, knockdown of expression, and chemical inhibition in a variety of cells. Recent research advances have revealed the relevance of carboxylesterases to metabolic diseases such as obesity and fatty liver disease, suggesting these enzymes might be potential targets for treatment of metabolic disorders. In order to translate pre-clinical studies in cellular and mouse models to humans, dif- ferences and similarities of carboxylesterases between mice and human need to be elucidated. This review presents and discusses the research progress in structure and function of mouse and human car- boxylesterases, and the role of these enzymes in lipid metabolism and metabolic disorders.

关键词： carboxylesterase lipase lipid lipoprotein iver adipose intestine

Preventative medicine and Alzheimer's disease: is Alzheimer's disease risk reduction achievable?

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Neural Regeneration Research 2021年第9期16卷 1772-1773页

作者： Benjamin Sinyor richard Isaacson Christopher Ochner HCA Healthcare NashvilleTNUSA Weil Cornell Medicine New York Presbyterian HospitalNew YorkNYUSA

Alzheimer 's disease(AD) has a multifactorial etiology that has eluded scientists and clinicians for decades. This incomplete understanding of the causal factors likely contributes to the dearth of effective therapeut... 详细信息

关键词： Alzheimer elude likely

THE EARLY INFLUENCE OF PETER LAX ON COMPUTATIONAL HYDRODYNAMICS AND AN APPLICATION OF LAX-FRIEDRICHS AND LAX-WENDROFF ON TRIANGULAR GRIDS IN LAGRANGIAN COORDINATES

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Acta Mathematica Scientia 2011年第6期31卷 2195-2202页

作者： richard Liska Mikhail Shashkov Burton Wendroff Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in Prague Group XCP-4 MS-F644Los Alamos National Laboratry Group T-5 MS-B284Los Alamos National Laboratry

We give a brief discussion of some of the contributions of Peter Lax to Com- putational Fluid Dynamics. These include the Lax-Friedrichs and Lax-Wendroff numerical schemes. We also mention his collaboration in the 1983 HLL Riemann solver. We de- velop two-dimensional Lax-Friedrichs and Lax-Wendroff schemes for the Lagrangian form of the Euler equations on triangular grids. We apply a composite scheme that uses a Lax- Friedrichs time step as a dissipative filter after several Lax-Wendroff time steps. Numerical results for Noh＇s infinite strength shock problem, the Sedov blast wave problem, and the Saltzman piston problem are presented.

关键词： Lax-Friedrichs Lax-Wendroff conservation laws Lagrangian coordinates,triangular grid

Telecentres in Mountain Regions-A Peruvian Case Study of the Impact of Information and Communication Technologies on Remoteness and Exclusion

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Journal of Mountain Science 2009年第4期6卷 320-330页

作者： richard Heeks Laura León Kanashiro Centre for Development Informatics Arthur Lewis BuildingUniversity of Manchester

Communities in developing country mountain areas,in part due to their remoteness,find themselves excluded from social,political and economic systems; and excluded from access to resources. This paper aims to study the impact of information and communication technologies (ICTs) on remoteness and exclusion. It utilises two models - the resource movement framework,and the "information chain" - to analyse a telecentre in one district of mountainous Huancavelica,Peru's poorest region,set in the high Andes. It finds ICTs enabling new and positive resource flows for the two key user groups:teenaged school students and young farmers. These help to maintain social networks. They also support information searches that have improved agricultural practice where other information chain resources have been available. But non-use and ineffective use of the telecentre are found where information chain resources are lacking. ICTs have some impacts on intangible elements of remoteness. In this particular example,they also offer access to some previously-excluded resources. But they have not really addressed the systematic exclusions faced by mountain communities. And they so far appear to be a technology of inequality; favouring those residents who begin with better resource *** paper concludes by offering some recommendations for mountain ICT project practice.

关键词： Exclusion Telecentre Information and communication technologies (ICTs) New technology Andes Peru

Cherishing the Memory of My Father——In Commemoration of 10th Anniversary of Death of richard Frey

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Voice of Friendship 2014年第4期 49-52页

作者： richard Frey

November 16,2014 marked the10th anniversary of the passing of my father richard *** that time,when sorting out books,writings and other materials left by him,I came to know more of family history and many parts of his life previously unfamiliar to *** has made me miss him all the *** father was born into a welloff middle-class Jewish family

关键词： father sorting Death anniversary marked Shanxi Tia

Heading control strategy assessment for coaxial compound helicopters

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Chinese Journal of Aeronautics 2019年第9期32卷 2037-2046页

作者： Ye YUAN Douglas THOMSON Renliang CHEN richard DUNLOP National Key Laboratory of Rotorcraft Aeromechanics Nanjing University of Aeronautics&AstronauticsNanjing 210016China University of Glasgow Glasgow G12 8QQUnited Kingdom

The coaxial compound helicopter has two possible strategies for heading control: collective differential and rudder deflection. A flight dynamics model is developed to assess the effect of different heading control strategies. This includes the trim characteristics, steady flight performance,controllability, and manoeuvrability. The trim study demonstrates that heading control strategies are less influential on trim results, and the steady flight performance is also not significantly affected by the heading control strategy adopted. The controllability analysis shows although heading bandwidth and phase delay results at various speeds with different heading control strategies are all satisfied, the control derivative of the collective differential decreases as speed increases, and its heading aggressive agility is degraded into Level 3 in high-speed flight. In addition, using collective differential would lead to severe heading-rolling coupling as forward speed increases. On the contrary, the control derivative and aggressive agility of the rudder deflection is improved with forward speed, and there is no evidence of heading-rolling coupling. Finally, the transient turn MissionTask-Element(MTE) is utilized to investigate the heading manoeuvre characteristics in different heading control strategies, which indicates that the collective differential would add the amplitude of control input and the power consumption during this MTE.

关键词： Coaxial compound helicopter Control strategy Handling qualities Helicopter flight dynamics Helicopter performance

Investigation of the hydrogen adsorbed density inside the pores of MOF-5 from path integral grand canonical Monte Carlo at supercritical and subcritical temperature

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Science Bulletin 2016年第8期61卷 594-600页

作者： David Durette Pierre Benard Renju Zacharia richard Chahine Hydrogen Research Institute Universite du Quebec a Trois-RivibresTrois-Rivieres G9A 5H7Canada Gas Processing Center College of EngineeringQatar UniversityDohaQatar

We examine the high density limit of the adsorption isotherms of hydrogen on MOF-5. The isotherms are calculated using quantum GCMC simulations over the pressure range： 0-150 atm （1 atm = 1.01325 ~ 105 Pa） in the subcritical and supercritical state at 30, 50, 77, 113, 196 and 296 K. The fluid phase density in the pores for each temper- ature is calculated and shown to reach values higher than normal liquid density. The fluid phase density obtained at 30 K is observed to correspond to a highly compressed liquid. The radial distribution function of the adsorbed phase at 30 and 50 K are calculated. The adsorption isotherms are compared with available experimental data at 30, 50, 77 and 298 K.

关键词： Hydrogen adsorption isotherms MOF-5 Metal-organic frameworks Path integralgrand canonical Monte Carlo Radial distributionfunction . Hydrogen storage Hydrogen energyapplications