The good and evil of complement activation in HIV-1 infection

作     者：Qigui Yu Richard Yu Xuebin Qin 

作者机构：Department of Microbiology and ImmunologyUniversity School of Medicine635 Barnhill DriveIndianapolisINUSA Harvard Medical SchoolLaboratory for Translational ResearchCambridgeMAUSA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2010年第7卷第5期

页      面：334-340页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：National Institute of Allergy and Infectious Diseases  NIAID  (R01AI061174) 

主　　题：antibody complement HIV-1 human CD59 

摘      要：The complement system,a key component of innate immunity,is a first-line defender against foreign pathogens such as *** role of the complement system in HIV-1 pathogenesis appears to be *** the complement system plays critical roles in clearing and neutralizing HIV-1 virions,it also represents a critical factor for the spread and maintenance of the virus in the infected *** addition,complement regulators such as human CD59 present in the envelope of HIV-1 prevent complement-mediated lysis of *** novel approaches are proposed to combat HIV-1 infection through the enhancement of antibody-dependent complement activity against *** this paper,we will review these diverse roles of complement in HIV-1 infection.