检索结果-南通市图书馆

Refnement of the supercontinent cycle with Hf, Nd and Sr isotopes

Geoscience Frontiers 2013年第6期4卷 667-680页

作者： Kent c.condie richard c.Aster Department of Earth and Environmental Science New Mexico Institute of Mining and Technology Geosciences Department Colorado State University

The combined use of Hf,Nd and Sr isotopes is more useful in understanding the supercontinent cycle than the use of only Hf isotopic data from detrital *** and Nd seawater isotopes,although not as precise as εNd and εHf distributions,also record input from ocean ridge *** detrital zircons where sources cannot be precisely located because of crustal recycling,both the location and tectonic setting often can be constrained for whole-rock Nd isotopic ***,primary zircon sources may not reside on the same continent as derivative detrital zircons due to supercontinent breakup and *** to all of the isotopic studies are geographic sampling biases reflecting outcrop distributions,river system sampling,or geologists,and these may be responsible for most of the decorrelation observed between isotopic *** between 3.5 and 2 Ga based on εHf median values of four detrital zircon databases as well as our compiled εNd database are noisy but uniformly distributed in time,whereas data between 2 and 1 Ga data are more tightly clustered with smaller *** age peaks suggest that both isotopic systems are sampling similar types of *** after 1 Ga and before 3.5 Ga do we see wide variations and significant disagreement between databases,which may partially reflect variations in both the number of sample locations and the number of samples per *** and internal orogens show similar patterns in εNd and εHfwith age suggesting that both juvenile and reworked crustal components are produced in both types of orogens with similar ***,both types of orogens clearly produce more juvenile isotopic signatures in retreating mode than in advancing *** secular changes in εHf and εNd distributions correlate with the supercontinent *** supercontinent breakup is correlated with short-lived decreasing εHf and εNd （≤ 100 Myr） for most supercontinents,there is no isotopic evidence for

关键词： Supercontinent cycle Hf isotopes Nd isotopes collisional orogens Accretionary orogens

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Smart cutting Tools and Smart Machining: Development Approaches, and Their Implementation and Application Perspectives

引用

chinese Journal of Mechanical Engineering 2017年第5期30卷 1162-1176页

作者： Kai cheng Zhi-chao Niu Robin c.Wang richard Rakowski richard Bateman college of Engineering Design and Physical SciencesBrunel University London

Smart machining has tremendous potential and is becoming one of new generation high value precision manufacturing technologies in line with the advance of Industry 4.0 concepts. This paper presents some innovative design concepts and, in particular, the development of four types of smart cutting tools, including a force-based smart cutting tool, a temperature-based internally-cooled cutting tool, a fast tool servo （FTS） and smart collets for ultra- precision and micro manufacturing purposes. Implemen- tation and application perspectives of these smart cutting tools are explored and discussed particularly for smart machining against a number of industrial application requirements. They are contamination-free machining, machining of tool-wear-prone Si-based infra-red devices and medical applications, high speed micro milling and micro drilling, etc. Furthermore, implementation tech- niques are presented focusing on：（a） plug-and-produce design principle and the associated smart control algo- rithms, （b） piezoelectric film and surface acoustic wave transducers to measure cutting forces in process, （c） critical cutting temperature control in real-time machining, （d） in- process calibration through machining trials, （e） FE-based design and analysis of smart cutting tools, and （f） applica- tion exemplars on adaptive smart machining.

关键词： Smart cutting tool Smart machining Fast toolservo (FFS) Precision machining Micro manufacturing Smart tooling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Random signals for engineers using MATLAB and Mathcad richard c. Jaffe.

引用

丛书名： AIP series in modern acoustics and signal processing

2000年

作者： richard c. Jaffe.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Epidemiological, Diagnostic, Therapeutic and Progressive Aspects of Arterial Hypertension in children at the University Hospital center of Bouaké (côte d’Ivoire)

引用

Open Journal of Pediatrics 2024年第2期14卷 379-390页

作者： richard Azagoh-Kouadio Yao Kossonou Roland Yeboua Kouassi christian Yao John Patrick Yenan Iburaima Alamun Akanji Kouadio Vincent Assé Pediatric Department of Angré University Hospital Abidjan Ivory Coast Pediatric Department of Bouaké University Hospital Bouaké Ivory Coast

Introduction: Arterial hypertension (AH) in children is under-diagnosed and often has a poor prognosis. The aim of this study was to describe the epidemiological, diagnostic, therapeutic and evolutionary aspects of hypertension in children at the University Hospital of Bouaké, with a view to improving the prognosis. Methods: This was a cross-sectional, analytical study carried out in the paediatrics department of Bouaké University Hospital. It concerned the medical records of children aged 4 to 15 hospitalised from 1 January 2017 to 31 December 2020 for hypertension. Diagnosis was based on the simplified blood pressure guidelines of the Expert consensus of the French Society of Hypertension. The variables studied were epidemiological, diagnostic, therapeutic and evolutionary. Quantitative variables were compared at the significance level p ≤ 0.05. Results: The hospital incidence of hypertension was 0.32% (69/21,642). The sex ratio was 0.72. 97.1% of the children were over five years of age. Oedema (49.3%) and breathing difficulties (20.2%) were the main reasons for consultation. Hypertension was classified as threatening (56.5%), confirmed (31.9%) and borderline (11.6%). The cause was renal in 66.7%, dominated by impure nephrotic syndrome (24.6%). Treatment for hypertension consisted mainly of a diuretic (79.7%) and a calcium channel blocker (47.8%). Outcome was favourable in 50.7% of cases. Mortality was 20.3%. No factor was significantly associated with death. conclusion: Hypertension in children at Bouaké University Hospital is serious. The aetiology is mainly renal. Early diagnosis and management are key to improving prognosis.

关键词： Hypertension children Renal Pathologies Prognosis côte d’Ivoire

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

cDc7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYc degradation

引用

Signal Transduction and Targeted Therapy 2024年第8期9卷 3519-3532页

作者： Alvaro Quintanal-Villalonga Kenta Kawasaki Esther Redin Fathema Uddin Swanand Rakhade Vidushi Durani Amin Sabet Moniquetta Shafer Wouter R.Karthaus Samir Zaidi Yingqian A.Zhan Parvathy Manoj Harsha Sridhar Dennis Kinyua Hong Zhong Barbara P.Mello Metamia ciampricotti Umesh K.Bhanot Irina Linkov Juan Qiu Radhika A.Patel colm Morrsey Sanjoy Mehta Jesse Barnes Michael c.Haffner Nichlas D.Socci richard P.Koche Elisa de Stanchina Sonia Molina-Pinelo Sohrab Salehi Helena A.Yu Joseph M.chan charles M.Rudin Department of Medicine Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNYUSA cancer Biology and Genetics Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Vagelos college of Physicians and Surgeons Columbia UniversityNew YorkNYUSA Weill cornell Graduate School of Medical Sciences Weill Cornell MedicineNew YorkNYUA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNYUSA center for Epigenetics Research Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Pathology core Facilty Department of Pathology and Laboratory MedicineMSKCCNew YorkNYUSA Antitumor Assessment core Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Divisionsof Human Biology and clinical Research Fred Hutchinon Cancer CenterSeattleWAUSA Deparmentof Urology University of WashingtonSeattleWAUSA Gene Editing&Screening core Facility Memorial Sloan Kettering cancer center New YorkNYUSA Department of Laboratory Medicine and Pathology University of WashingtonSeattleWAUSA Bioinfomatics coreFacility Memorial Soan Kettering Cancer CenterNew YorkNYUSA Institute of Biomedicine of Seille(Bis) HURCSCUniversidad de SevillaSevilleSpain computational Oncology Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Well cornell Medical college New York NYUSA Present address:Swiss Institute for Experimental cancer Research(ISREc) School of Life SciencesEPFLLausanneSwitzerland

Neuroendocrine(NE)transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor *** to date,even if patients at high risk of transformation can be identified by the occurrence of Tumor Protein P53(TP53)and Retinoblastoma Transcriptional corepressor 1(RB1)mutations in their tumors,no therapeutic strategies are available to prevent or delay histological *** of the cell cycle kinase cell Division cycle 7(cDc7)occurred in tumors during the initial steps of NE transformation,already after TP53/RB1 co-inactivation,leading to induced sensitivity to the cDc7 inhibitor ***7 inhibition suppressed NE transdifferentiation and extended response to targeted therapy in in vivo models of NE transformation by inducing the proteasome-mediated degradation of the MYc Proto-Oncogen(MYc),implicated in stemness and histological *** overexpression of a degradation-resistant MYc isoform reestablished the NE transformation phenotype observed on targeted therapy,even in the presence of ***7 inhibition also markedly extended response to standard cytotoxics(cisplatin,irinotecan)in lung and prostate small cell carcinoma *** results nominate cDc7 inhibition as a therapeutic strategy to constrain lineage plasticity,as well as to effectively treat NE tumors de novo or after *** simurosertib clinical efficacy trials are ongoing,this concept could be readily translated for patients at risk oftransformation.

关键词： tumors markedly transformation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transcriptomic biomarkers for predicting response to neoadjuvant treatment in oesophageal cancer

引用

Gastroenterology Report 2020年第6期8卷 411-424,I0001页

作者： Anita Lavery richard c.Turkington Patrick G Johnston centre for cancer Research Queen’s University BelfastBelfastUK

Oesophageal cancer is a devastating disease with poor outcomes and is the sixth leading cause of cancer death *** the setting of resectable disease,there is clear evidence that neoadjuvant chemotherapy and chemoradiotherapy result in improved ***,only 15%-30%of patients obtain a histopathological response to neoadjuvant therapy,often at the expense of significant *** are no predictive biomarkers in routine clinical use in this setting and the ability to stratify patients for treatment could dramatically improve *** this review,we aim to outline current progress in evaluating predictive transcriptomic biomarkers for neoadjuvant therapy in oesophageal cancer and discuss the challenges facing biomarker development in this *** place these issues in the wider context of recommendations for biomarker development and *** majority of studies focus on messenger RNA(mRNA)and microRNA(miRNA)*** studies report a range of different genes involved in a wide variety of pathways and biological processes,and this is explained to a large extent by the different platforms and analysis methods *** studies are also vastly underpowered so are not suitable for identifying a candidate *** molecular subtypes of oesophageal cancer have been proposed,although little is known about how these relate to clinical *** anticipate that the accumulating wealth of genomic and transcriptomic data and clinical trial collaborations in the coming years will provide unique opportunities to stratify patients in this poor-prognosis disease and recommend that future biomarker development incorporates well-designed retrospective and prospective analyses.

关键词： oesophageal cancer predictive biomarkers chemotherapy radiotherapy gene expression pathological response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A great thermal divergence in the mantle beginning 2.5 Ga:Geochemical constraints from greenstone basalts and komatiites

引用

Geoscience Frontiers 2016年第4期7卷 543-553页

作者： Kent c.condie richard c.Aster Jeroen van Hunen Department of Earth and Environmental Science New Mexico Tech Geosciences Department Colorado State University Department of Earth Sciences University of Durham

Greenstone basalts and komatiites provide a means to track both mantle composition and magma generation temperature with time. Four types of mantle are characterized from incompatible element distributions in basalts and komatiites： depleted, hydrated, enriched and mantle from which komatiites are derived. Our most important observation is the recognition for the first time of what we refer to as a Great Thermal Divergence within the mantle beginning near the end of the Archean, which we ascribe to thermal and convective evolution. Prior to 2.5 Ga, depleted and enriched mantle have indistinguishable thermal histories, whereas at 2.5-2.0 Ga a divergence in mantle magma generation temperature begins between these two types of mantle. Major and incompatible element distributions and calculated magma generation temperatures suggest that Archean enriched mantle did not come from mantle plumes, but was part of an undifferentiated or well-mixed mantle similar in composition to calculated primitive mantle. During this time, however, high-temperature mantle plumes from dominantly depleted sources gave rise to komatiites and associated basalts. Recycling of oceanic crust into the deep mantle after the Archean may have contributed to enrichment ofTi, A1, ca and Na in basalts derived from enriched mantle sources. After 2.5 Ga, increases in Mg# in basalts from depleted mantle and decreases in Fe and Mn reflect some combination of growing depletion and cooling of depleted mantle with time. A delay in cooling of depleted mantle until after the Archean probably reflects a combination of greater radiogenic heat sources in the Archean mantle and the propagation of plate tectonics after 3 Ga.

关键词： Archean greenstones Mantle thermal evolution Basalts Mantle geochemistry Komatiites

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Design of a Biomimetic Skin for an Octopus-Inspired Robot - Part I： characterising Octopus Skin

引用

Journal of Bionic Engineering 2011年第3期8卷 288-296页

作者： Jinping Hou richard H. c. Bonser George Jeronimidis centre for Biomimetics School of Construction Management and Engineering University of Reading Reading RG6 6AY UK

Octopus skin samples were tested under quasi-static and scissor cutting conditions to measure the in-plane material prop- erties and fracture toughness. Samples from all eight arms of one octopus were tested statically to investigate how properties vary from arm to arm. Another nine octopus skins were measured to study the influence of body mass on skin properties. In- fluence of specimen location on skin mechanical properties was also studied. Material properties of skin, i.e. the Young＇s modulus, ultimate stress, failure strain and fracture toughness have been plotted against the position of skin along the length of arm or body. Statistical studies were carried out to help analyzing experimental data obtained. Results of this work will be used as guidelines for the design and development of artificial skins for an octopus-inspired robot.

关键词： octopus skin uniaxial tension scissor cutting Young's modulus failure strain fracture toughness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Developing Skin Analogues for a Robotic Octopus

引用

Journal of Bionic Engineering 2012年第3期9卷 385-390页

作者： Jinping Hou richard H. c. Bonser George Jeronimidis centre for Biomimetics School of Construction Management and Engineering University of Reading Reading RG6 6AY UK School of Engineering and Design Brunel University Uxbridge Middlesex UB8 3PH UK

In order to fabricate a biomimetic skin for an octopus inspired robot, a new process was developed based on mechanical properties measured from real octopus skin. Various knitted nylon textiles were tested and the one of 10-denier nylon was chosen as reinforcement. A combination of Ecoflex 0030 and 0010 silicone rubbers was used as matrix of the composite to obtain the right stiffness for the skin-analogue system. The open mould fabrication process developed allows air bubble to escape easily and the artificial skin produced was thin and waterproof. Material properties of the biomimetic skin were char- acterised using static tensile and instrumented scissors cutting tests. The Young＇s moduli of the artificial skin are 0.08 MPa and 0.13 MPa in the longitudinal and transverse directions, which are much lower than those of the octopus skin. The strength and fracture toughness of the artificial skin, on the other hand are higher than those of real octopus skins. conically-shaped skin prototypes to be used to cover the robotic arm unit were manufactured and tested. The biomimetic skin prototype was stiff enough to maintain it conical shape when filled with water. The driving force for elongation was reduced significantly compared with previous prototypes.

关键词： biomimetic skin artefact octopus robot textile composite

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design of a Biomimetic Skin for an Octopus-Inspired Robot - Part Ⅱ： Development of the Skin Artefact

引用

Journal of Bionic Engineering 2011年第3期8卷 297-304页

作者： Jinping Hou richard H. c. Bonser George Jeronimidis centre for Biomimetics School of Construction Management and Engineering UniversiO~ of Reading Reading RG6 6A Y UK

In order to develop skin artefact for an octopus-inspired robot arm, which is designed to be able to elongate 60% of its original length, silicone nlbber and knitted nylon sheet were selected to manufacture an artificial skin, due to their higher elastic strain and high flexibility. Tensile and scissors cutting tests were conducted to characterise the matrix and reinforcing materials and the skin artefact. Material properties of the individual and the composite materials were compared with the measured properties of real octopus skin presented ill Part I. The Young＇s modulus of the skin should be below 20 MPa and the elastic strain range should be over 60%. The fracture toughness should be at least 0.9 kJ.m 2. Tubes made of the skin artefact filled with liquid were tested to study volume change under deformation. Finite element analysis model was developed to simulate the material and arm structure under tensile loading. Results show that the skin artefact developed has similar mechanical properties as the real octopus skin and satisfies all the design specifications of the OcTOPUS robot.

关键词： octopus skin static tensile test toughness skin artefact nylon/silicone composite

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：