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Designing a locating-routing three-echelon supply chain network under uncertainty

International Journal of Intelligent computing and cybernetics 2022年第4期15卷 562-588页

作者： Leila Hashemi Armin Mahmoodi Milad Jasemi richard c.millar Jeremy Laliberte Department of Industrial Management Islamic Azad University South Tehran BranchTehranIslamic Republic of Iran Department of Industrial Management Islamic Azad University ofMasjid-i-SoliemanMasjid-i-SoliemanIslamic Republic of Iran Stephens college of Business University of MontevalloMontevalloAlabamaUSA Department of Engineering Management and Systems Engineering The George Washington UniversityWashingtonDistrict of ColumbiaUSA Department of Mechanical and Aerospace Engineering Carleton UniversityOttawaCanada

Purpose-In the present research,location and routing problems,as well as the supply chain,which includes manufacturers,distributor candidate sites and retailers,are *** goal of addressing the issue is to reduce delivery times and systemcosts for retailers so that routing and distributor locationmay be ***/methodology/approach-By adding certain unique criteria and limits,the issue becomes more *** expect simultaneous deliveries and pickups,and retail service start times have soft and hard time *** expenses,noncompliance with the soft time window,distributor construction,vehicle purchase or leasing,andmanufacturing costs are all part of the system *** problem’s conceptual model is developed and modeled first,and then General Algebraic Modeling System software(GAMS)and Multiple Objective Particle Swarm Optimization(MOPSO)and non-dominated sorting genetic algorithm II(NSGAII)algorithms are used to solve it in small ***-According to the mathematical model’s solution,the average error of the two suggested methods,in contrast to the exact answer,is less than 0.7%.In addition,the performance of algorithms in terms of deviation from the GAMS exact solution is pretty satisfactory,with a divergence of 0.4%for the biggest problem(N 5100).As a result,NSGAII is shown to be superior to *** limitations/implications-Since this paper deals with two bi-objective models,the priorities of decision-makers in selecting the best solution were not taken into account,and each of the objective functions was given an equal weight based on the weighting *** model has not been compared or studied in both robust and deterministic *** is because,with the exception of the variable that indicates traffic mode uncertainty,all variables are deterministic,and the uncertainty character of demand in each level of the supply chain is *** implications-The suggested model’s conclusions

关键词： Metaheuristic algorithms Time windows Supply chain management Robust optimization Location-routing problems

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Survival outcomes in early-onset oesophageal adenocarcinoma patients:A systematic review and meta-analyses

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World Journal of Gastroenterology 2024年第38期30卷 4221-4231页

作者： Ashleigh Russell Shauna Mitchell richard c Turkington Helen G coleman centre for Public Health Queen's University BelfastBelfast BT126BAUnited Kingdom Patrick G Johnston centre for cancer Research Queen's University BelfastBelfast BT71NNUnited Kingdom

BAcKGROUND The incidence of oesophageal adenocarcinoma(OAc)has been reported to be increasing in many *** this trend,an increase in incidence of early-onset OAc,defined as OAc in adults aged under 50 years,has been *** is unclear whether survival outcomes for early-onset OAc patients differ from older age *** To investigate survival outcomes in early-onset OAc *** Ovid Medline and Embase were searched from inception to January 2022 for relevant studies relating to early-onset OAc and survival *** regarding the overall five-year survival and risk of death of younger and older patients with OAc were extracted and pooled using meta-analyses to produce pooled estimates and 95%cIs where *** Eleven studies which compared survival of early-onset OAc,defined as age at diagnosis ofcluded.A narrative review of median and mean survival demonstrated conflicting results,with studies showing early-onset OAc patients having both better and worse outcomes compared to older age groups.A meta-analysis of five-year survival demonstrated similar outcomes across age groups,with 22%-25%of patients in the young,middle and older age groups alive after five years.A meta-analysis of four studies demon-strated that early-onset OAc patients did not have a significantly increased risk of death compared to middle-aged patients(hazard ratio 1.12,95%cI:0.85-1.47).INTRODUcTION There is concern that the incidence of oesophageal adenocarcinoma(OAc)in patients under 50,described as early-onset OAc,is ***,data regarding survival of younger patients with OAc is ***,while increasing age remains a major non-modifiable risk factor for cancer,the incidence of early-onset cancers,largely accepted to be in adults aged under 50 years,is increasing[1].This includes an observed increase in the incidence of gastrointestinal malignancies such as colorectal,oesophageal,gastric and he

关键词： Early-onset cancer Early-onset oesophageal adenocarcinoma Survival cancer epidemiology Systematic review Meta-analysis

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Is there hybridization between 2 species of the same genus in sympatry?——The genetic relationships between Anoplophora glabripennis,Anoplophora chinensis,and putative hybrids

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Insect Science 2024年第2期31卷 633-645页

作者： Haiwen Qin Huachao Xu Arnaud capron Ilga Porth Mingming cui Melody A.Keena Xiaofang Deng Juan Shi richard c.Hamelin Sino-French Joint Laboratory for Invasive Forest Pests in Eurasia Department of ForestBejing Forestry UniversityBejingChina Department of Forest and conservation Sciences The University of British ColumbiaVancouverCanada college of Forestry and Biotechnology Zhejiang A&F UniversityHangzhouChina Department of Wood and Forest Sciences Laval UniversityQuebecCanada 5 Department of AgricultureNorthern Research StationUSDA Forest ServiceHamdenConnecticutUSA changchun Landscape Plant conservation Station Bureau of Forestry and Landscaping of ChangchunChangchunChina

Anoplophora glabripennis(Asian longhorn beetle,ALB)and Anoplophora chinensis(citrus longhorn beetle,cLB)are native forest pests in china;they have become important international quarantine *** are found using the same Salix aureopendula host tree of cixi,Zhejiang province,*** this host tree,we collected additional beetles that appeared to be morphologically intermediate between ALB and *** using a stereoscope,we observed that there were several bumps on the base of the elytra,which was inconsistent with ALB,which typically has a smooth elytral base,but was more like cLB,which has numerous short tubercles on the elytral *** their sympatry and intermediate morphology,we hypothesized that these may represent ALB×cLB *** studied the genomic profiles for 46 samples(ALB,cLB,and putative hybrids)using genotyping-by-sequencing(GBS)providing a reduced representation of the entire *** principal component analyses on the 163 GBS-derived single nucleotide polymorphism data,we found putative hybrids tightly clustered with ALB,but genetically distinct from the cLB ***,our initial hybrid hypothesis was not supported by genomic ***,while mating experiments between adult ALB and cLB were successful in 4 separate years(2017,2018,2020,and 2021),and oviposition behavior was observed,no progeny was *** employed population genomic analysis and biological hybridization experiments,we conclude that the putative hybrids represent newly discovered morphological variants within *** approach further confirmed the advantage of genome-wide information for Anoplophora species assignment in certain ambiguous classification cases.

关键词： Anoplophora chinensis Anoplophora glabripenni sg enotyping-bysequencing invasive pest mating putative hybrid

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Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos M.Kanczler Stuart Lanham Andrew Rawlings Marta Roldo Gianluca Tozzi Jonathan I.Dawson Gianluca cidonio richard O.c.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK center for Life Nano-and Neuro-Science(cLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-EcM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMScs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-EcM(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMScs viability upon *** composite of human bone-EcM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(cAM)*** inclusion of bone morphogenetic protein-2(BMP-2)with the HBMScs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-EcM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

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The association of physical activity duration and intensity on emotional intelligence in 10-13 year-old children

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Sports Medicine and Health Science 2024年第4期6卷 331-337页

作者： Marie c.Gabour Tongjian You richard Fleming Paul D.McNicholas Philimon N.Gona Department of Health Sciences Regis College235 Wellesley StreetWestonMA02493USA Department of Exercise and Health Sciences University of Massachusetts Boston100 Morrissey BlvdBostonMA02125USA Department of Mathematics&Statistics McMaster UniversityHamiltonOntarioCanada L8S 4L8

Previous studies have shown that Physical Activity(PA)has a positive association with emotional health and intelligence in adolescents but none have focused on the relationship of PA duration and intensity on Emotional Intelligence(EI).The purpose of this study was to cross-sectionally assess the association of PA measures on overall EI and its domains in a cohort of 2029 adolescents aged 10-13 years of age in the National Longitudinal Survey for children and Youth(NLScY)from *** linear regression analysis of EI was adjusted for age,sex,annual household income,and health ***-way analysis of variance(ANOVA)was used to relate PA duration measured in minutes,frequency,and intensity categories with continuous GEI scores and also the corresponding scores for domains of *** mean GEI scores were(28.3±6.6)for 0-30 minute(min)PA duration,(30.0±6.5)for 30 tocally significant linear trend across PA duration categories,p?***-hoc pairwise comparison revealed that compared to the referent category(category)was statistically significantly lower GEI than each of the other two PA categories(30-59 min;and 60-120 min),both p-valuesciated with the higher overall EI and its domains except for Stress Management.

关键词： Physical activity Duration Intensity Emotional Intelligence Adolescents

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cOVID-19 vaccination produces exercise-responsive SARS-coV-2 specific T-cells regardless of infection history

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Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany M.Zúñiga Forrest L.Baker Helena Batatinha charles R.Pedlar Shane c.Burgess Michael P.Gustafson Emmanuel Katsanis richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona cancer center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-coV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(cOVID-19).We sought to determine if cOVID-19 vaccination would elicit exercise-responsive SARS-coV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a cOVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-coV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TcR)-βsequencing,and SARS-coV-2 nAb ***:cOVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of cD4+and cD8+naive T-cells,as well as cD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-coV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-coV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-coV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral cOVID-19 Exercise immunology SARS-coV-2 T-cells Vaccine

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Are there sex-based disparities in cataract surgery?

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 137-143页

作者： Matthew D.Geiger Anne M.Lynch Alan G.Palestine Nathan c.Grove Karen L.christopher richard S.Davidson Michael J.Taravella Naresh Mandava Jennifer L.Patnaik Department of Ophthalmology University of Colorado School of MedicineAuroraCO 80045USA

AIM:To investigate sex-based differences in the occurrence of intra-operative and post-operative complications and associated visual outcomes following cataract ***:This was a retrospective study of patients who had phacoemulsification cataract surgery at the University of colorado School of *** collected included the patient’s health history,ocular comorbidities,operative and post-operative complications,and the post-operative best corrected visual acuity(BcVA).The data were analyzed using univariate and multivariable logistic regression with generalized estimating equations to account for the correlation of some patients having two eyes included in the ***:A total of 11977 eyes from 7253 patients were included in the *** comorbidities differed by sex,with males having significantly higher percentages of traumatic cataracts(males 0.7%vs females 0.1%),prior ocular surgery(6.7%vs 5.5%),and mature cataracts(2.8%vs 1.9%).conversely,females had significantly higher rates of pseudoexfoliation(2.0%vs 3.2%).In unadjusted analysis,males had higher rates of posterior capsular rupture(0.8%vs 0.4%)and vitreous loss(1.0%vs 0.6%),but this difference was not significant after adjustment for *** had a significantly increased risk of post-operative retinal detachment,but in multivariable analysis this was no longer *** were significantly less likely to undergo post-operative neodymium-doped yttrium aluminum garnet(Nd:YAG)laser capsulotomy for posterior capsule opacification(OR=0.8,95%cI=0.7-0.9,P=0.0005).The BcVA was slightly worse for males pre-operatively;but post-operatively,both sexes exhibited similar visual acuity of Snellen equivalent 20/***:The study finds that in a cohort of patients presenting for cataract surgery,sex differences exist in pre-operative comorbidities and surgical characteristics that contribute to higher rates of some complications for ***,observed surgical complicatio

关键词： cataract surgery sex-based disparity phacoemulsification outcomes

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A mutation in TBXT causes congenital vertebral malformations in humans and mice

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Journal of Genetics and Genomics 2024年第4期51卷 433-442页

作者： Shuxia chen Yunping Lei Yajun Yang chennan Liu Lele Kuang Li Jin richard HFinnell Xueyan Yang Hongyan Wang Obstetrics and Gynecology Hospital State Key Laboratory of Genetic Engineering at School of Life SciencesKey Laboratory of Reproduction Regulation of NPFPCInstitute of Reproduction and DevelopmentFudan UniversityShanghai 200438China Shanghai Key Laboratory of Metabolic Remodeling and Health Institute of Metabolism and Integrative BiologyFudan UniversityShanghai 200438China center for Precision Environmental Health Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonTX 77030USA MOE Key Laboratory of contemporary Anthropology School of Life SciencesFudan UniversityShanghai 200438China Department of Assisted Reproduction Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China children’s Hospital Fudan University399 Wanyuan RoadShanghai 201102China

T-box transcription factor T(TBXT;T)is required for mesodermal formation and axial skeletal *** it has been extensively studied in various model organisms,human congenital vertebral malformations(cVMs)involving T are not well ***,we report a family with 15 cVM patients distributed across 4 *** affected individuals carry a heterozygous mutation,T c.596A>G(p.Q199R),which is not found in unaffected family members,indicating co-segregation of the genotype and *** vitro assays show that T p.Q199R increases the nucleocytoplasmic ratio and enhances its DNA-binding affinity,but reduces its transcriptional activity compared to the *** determine the pathogenicity of this mutation in vivo,we generated a Q199R knock-in mouse model that recapitulates the human cVM *** heterozygous Q199R mice show subtle kinked or shortened tails,while homozygous mice exhibit tail filaments and severe vertebral ***,we show that the Q199R mutation in T causes cVM in humans and mice,providing previously unreported evidence supporting the function of T in the genetic etiology of human cVM.

关键词： congenital vertebral malformation TBXT T gene Loss-of-function mutation

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Genomic variation,environmental adaptation,and feralization in ramie,an ancient fiber crop

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Plant communications 2024年第8期5卷 189-207页

作者： Zeng-Yuan Wu Mark A.chapman Jie Liu richard I.Milne Ying Zhao Ya-Huang Luo Guang-Fu Zhu Marc W.cadotte Ming-Bao Luan Peng-Zhen Fan Alex K.Monro Zhi-Peng Li richard T.corlett De-Zhu Li Germplasm Bank of Wild Species&Yunnan Key Laboratory of crop Wild Relatives Omics Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China School of Biological Sciences University of SouthamptonSouthampton SO171BJUK cAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China Institute of Molecular Plant Sciences School of Biological SciencesUniversity of EdinburghEdinburgh EH93JHUK Department of Biological Sciences University of Toronto-ScarboroughTorontoOntarioCanada Institute of Bast Fiber crops Chinese Academy of Agricultural SciencesChangshaHunan 410205China Royal Botanic Gardens Kew RichmondSurrey TW93AEUK center for Integrative conservation and Yunnan Key Laboratory for the conservation of Tropical Rainforests and Asian Elephants Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunYunnan 666303China

Feralization is an important evolutionary process,but the mechanisms behind it remain poorly ***,we use the ancient fiber crop ramie(Boehmeria nivea(L.)Gaudich.)as a model to investigate genomic changes associated with both domestication and *** first produced a chromosome-scale de novo genome assembly of feral ramie and investigated structural variations between feral and domesticated ramie ***,we gathered 915 accessions from 23 countries,comprising cultivars,major landraces,feral populations,and the wild *** on whole-genome resequencing of these accessions,we constructed the most comprehensive ramie genomic variation map to ***,demographic,and admixture signal detection analyses indicated that feral ramie is of exoferal or exo-endo origin,i.e.,descended from hybridization between domesticated ramie and the wild progenitor or ancient *** ramie has higher genetic diversity than wild or domesticated ramie,and genomic regions affected by natural selection during feralization differ from those under selection during *** analyses showed that feral and domesticated ramie have similar ecological niches that differ substantially from the niche of the wild progenitor,and three environmental variables are associated with habitat-specific adaptation in feral *** findings advance our understanding of feralization,providing a scientific basis for the excavation of new crop germplasm resources and offering novel insights into the evolution of feralization in nature.

关键词： ramie fiber offering

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Storylines of family medicine Ⅱ:foundational building blocks—context,community and health

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Family Medicine and community Health 2024年第S3期12卷 12-22页

作者： William B Ventres Leslie A Stone Rupal Shah Tamala carter Geoffrey M Gusoff Winston Liaw Bich-May Nguyen Joanna V Rachelson Mary Alice Scott Teresa L Schiff-Elfalan Seiji Yamada Robert c Like Kathleen Zoppi A Peter catinella richard M Frankel Shailendra Prasad Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Bridge Lane Group Practice LondonUK Penn center for community Health Workers University of PennsylvaniaPhiladelphiaPennsylvaniaUSA National clinician Scholars Program UCLA David Geffen School of MedicineLos AngelesCaliforniaUSA Health Systems and Population Health Sciences University of Houston Tilman J Fertitta Family College of MedicineHoustonTexasUSA Southern New Mexico Family Medicine Residency Program Las CrucesNew MexicoUSA New Mexico Primary care Training Program Silver CityNew MexicoUSA Anthropology New Mexico State UniversityLas CrucesNew MexicoUSA Family Medicine and community Health University of Hawai'i at Manoa John A Burns School of MedicineHonoluluHawaiiUSA Family Medicine and community Health Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNew JerseyUSA Family Medicine Indiana University School of MedicineIndianapolisIndianaUSA Family Medicine–Transmountain Texas Tech University Health Sciences CenterEl PasoTexasUSA Medicine Indiana University School of MedicineIndianapolisIndianaUSA Family Medicine and community Health University of Minnesota Medical School-Twin Cities CampusMinneapolisMinnesotaUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅱ:foundational building blocks—context,community and health’,authors address the following themes:‘context—grounding family medicine in time,place and being’,‘Recentring community’,‘community-oriented primary care’,‘Embeddedness in practice’,‘The meaning of health’,‘Disease,illness and sickness—core concepts’,‘The biopsychosocial model’,‘The biopsychosocial approach’and‘Family medicine as social medicine.’May readers grasp new implications for medical education and practice in these essays.

关键词： thematic illustration dimensions

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