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Compartmentalized necroptosis activation in excitotoxicityinduced axonal degeneration: a novel mechanism implicated in neurodegenerative disease pathology

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Neural Regeneration Research 2019年第8期14卷 1385-1386页

作者： Macarena S. Arrazola Felipe A. court Center for Integrative Biology Faculty of Sciences Universidad Mayor de Chile Santiago CnileFONDAP Center for Geroscience Brain Health and Metabolism Santiago Chile Buck Institute for Research on Ageing Novato San Francisco CA USA

Excitotoxicity and neuronal cell death: Glutamate is the main excitatory neurotransmitter of the central nervous system and functionally involved in most brain activities, including brain development, synaptic plasticity, learning and memory. Exc让atory synaptic transmission is primarily mediated by ligana-gated ion channels, including a-amino-3-hydroxy-5-methylisoxazoIe-4-propionic acid (AMPA), N-methyl-d-aspartate (NMdA) and kainate receptors. Activation of glutamate receptors, particularly NMdA receptors, usually leads to calcium influx, whicn can act as a second messenger for several processes to mediate synaptic activity and brain function. Nevertheless, excessive release of glutamate neurotransmitter may produce intracellular calcium overload, leading to a cascade of events mediating cytoskeleton damage accompanied w让h reactive oxygen species (ROS) generation, mitochondrial dysfunction and ultimately neuronal cell death. These toxic effects of glutamate are known as excitotoxicity. Neuronal excitotoxicity has been linked to several acute and chronic brain diseases, such as stroke/ischemia, epilepsy and a range of neurodegenerative disorders, including Alzheimer's disease (Ad), Huntingtons disease, amyotrophic lateral sclerosis (ALS) and Parkinsons disease (Pd), contributing to the neuronal lost in different brain regions. Unfortunately, treating nervous system disorders with general glutamate receptor blockers has been associated with undesirable side effects, becoming increasingly necessary to unravel downstream effectors in the excitotoxicity-dependent cell death pathway in order to develop novel therapeutic strategies.

关键词： Compartmentalized necroptosis activation excitotoxicityinduced axonal neurodegenerative disease

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Extraction of physical Schottky parameters using the Lambert function in Ni/AIGaN/GaN HEMT devices with defined conduction phenomena

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Journal of Semiconductors 2017年第1期38卷 95-99页

作者： O.Latry A.divay d.Fadil P.dherbécourt Normandie Université URGPM CNRS UMR 663476801 St-Etienne-du-RouvrayFrance

Electrical characterization analyses are proposed in this work using the Lambert function on Schottky junctions in GaN wide band gap semiconductor devices for extraction of physical *** Lambert function is used to give an explicit expression of the current in the Schottky *** function is applied with defined conduction phenomena,whereas other work presented arbitrary（or undefined）conduction mechanisms in such parameters＇ *** upon AlGaN/GaN HEMT structures,extractions of parameters are undergone in order to provide physical *** work highlights a new expression of current with defined conduction phenomena in order to quantify the physical properties of Schottky contacts in AlGaN/GaN HEMT transistors.

关键词： GaN Schottky junction conduction mechanisms Lambert function parameters extraction

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Perspectives on atmospheric mercury and its fate in aquatic ecosystems

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Journal of Environmental Sciences 2000年第S1期12卷 85-91页

作者： d.B. Porcella (1034 Lindsey court, Lafayette CA 94549 USA E mail: dporcell@***)

Mercury (Hg) is a neurotoxin to humans and wildlife that has a quantitatively important gas phase that makes its atmospheric cycle an important part of exposure pathways to these organisms. The important atmospheric forms are elemental Hg (Hg(0)), inorganic gas phase Hg (HgH gs ), and inorganic particulate Hg(HgIIp). Each form has different behavior depending on its chemical and physical properties. Generally, scientists have found with trace metal clean sampling and analytical techniques, that background Hg levels are 1—2 ng/m\+3 in air, 0.1—2 ng/L in surface waters, 5—25 ng/L in rainwater, and less than 0.1 μg/g in sediments remote from natural Hg minerals and wastewater sources. Values in excess of these concentrations generally indicate local anthropogenic influences or contaminated samples. Broad scale estimates of Hg inputs to the atmosphere suggest that annual anthropogenic fluxes to the atmosphere as Hg(0) are about 40 percent of the total global cycle, oceanic evasion is about 40 percent, and (by difference) the remaining input to the global cycle (20 percent) is evasion from terrestrial sources, largely via soils and vegetation. This paper summarizes recent data that will constrain estimates from these sources. For example, terrestrial sources could approach 40 percent and annual anthropogenic inputs be correspondingly less. Furthermore, a historic perspective is needed because Hg has cycled atmospherically over geologic time. In addition to the uncertainty in source quantification, methylation must be a focus of risk analysis, because this process is responsible for risks to human and ecosystem health for almost all modern day Hg exposures.

关键词： Perspectives on atmospheric mercury and its fate in aquatic ecosystems

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rnc基因的高表达及核糖核酸酶Ⅲ的纯化

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生物工程学报 1992年第2期8卷 116-122页

作者：陈苏民 court d.L. 第四军医大学生物化学教研室美国NIH/NCI-FCRF-BRI染色体生物学实验室

根据大肠杆菌中核糖核酸酶Ⅲ(RNaseⅢ)含量很低的原因是RNaseⅢ能作用于自身基因(rnc)转录物5'端、负反馈调控其自身合成,设计RNaseⅢ高表达的方案。去除rnc基因5'侧能转录生成可被RNaseⅢ降解的RNA结构的序列,保留整个rnc基因及其5'侧... 详细信息

根据大肠杆菌中核糖核酸酶Ⅲ(RNaseⅢ)含量很低的原因是RNaseⅢ能作用于自身基因(rnc)转录物5'端、负反馈调控其自身合成,设计RNaseⅢ高表达的方案。去除rnc基因5'侧能转录生成可被RNaseⅢ降解的RNA结构的序列,保留整个rnc基因及其5'侧的天然翻译起始序列,将之置于λP_L启动子控制下,所构建的质粒在大肠杆菌中经诱导后高表达出RNase Ⅲ,其含量达细胞总蛋白质量的65%以上,并在菌体内形成包涵体。利用RNaseⅢ溶解度变化的特点,在低温、低盐条件中裂菌,并洗涤沉淀,在室温、高盐条件下溶解、过Q-Sepharose FF柱,获得具有良好活性、电泳纯的RNase Ⅲ,收获量为10—12mg/100ml培养液。同时还发现RNase Ⅲ具有特异性结合ATP的活性。

关键词：核糖核酸酶Ⅲ rnc基因基因表达

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Sonoluminescence and cold fusion

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Nuclear Science and Techniques 1996年第1期7卷 1-5页

作者： T V Prevenslik(2E Greenery court, discovery Bay, Hong Kong)

Ｓｏｎｏｌｕｍｉｎｅｓｃｅｎｃｅａｎｄｃｏｌｄｆｕｓｉｏｎ￥ＴＶＰｒｅｖｅｎｓｌｉｋ（２ＥＧｒｅｅｎｅｒｙＣｏｕｒｔ，ＤｉｓｃｏｖｅｒｙＢａｙ，ＨｏｎｇＫｏｎｇ）Ａｂｓｔｒａｃｔ：Ａｔｈｅｏｒｙｏｆｓｏｎｏｌｕｍｉｎ... 详细信息

Ｓｏｎｏｌｕｍｉｎｅｓｃｅｎｃｅａｎｄｃｏｌｄｆｕｓｉｏｎ￥ＴＶＰｒｅｖｅｎｓｌｉｋ（２ＥＧｒｅｅｎｅｒｙＣｏｕｒｔ，ＤｉｓｃｏｖｅｒｙＢａｙ，ＨｏｎｇＫｏｎｇ）Ａｂｓｔｒａｃｔ：Ａｔｈｅｏｒｙｏｆｓｏｎｏｌｕｍｉｎｅｓｃｅｎｃｅ（ＳＬ）ｐｒｏｐｏｓ...

关键词：冷聚变声致发光 X射线红外线

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Prison Term Reduction and Release on Parole in Wuxi

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人权 2008年第2期 35-37页

作者： LI QIN a reporter of the People’s court News

In China,there is a system known as"legal award,"which is applied to people serving prison terms.A prison- er who gets such award may have his or her prison terms reduced or even have himself or herself released on *** legal award has to be passed by the people’s court according to a strict judicial procedure after receiving the application from penalty execution organ or the prison *** principle for such award is that there must be good performance in repent and there is no longer threat to the society.

关键词： In Prison Term Reduction and Release on Parole in Wuxi

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Rosuvastatin‑Eluting Gold‑Nanoparticle‑Loaded Perivascular Wrap for Enhanced Arteriovenous Fistula Maturation in a Murine Model

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Advanced Fiber Materials 2023年第6期5卷 1986-2001页

作者： Carleigh Klusman Benjamin Martin Joy Vanessa d.Perez Allan John R.Barcena Marvin R.Bernardino Erin Marie d.San Valentin Jossana A.damasco Huckie C.del Mundo Karem A.court Biana Godin Gino Martin Canlas Natalie Fowlkes richa.d Bouchard Jizhong Cheng Steven Y.Huang Marites P.Melancon department of Interventional Radiology The University of Texas MD Anderson Cancer CenterHouston 77030USA Baylor College of Medicine Houston 77030USA College of Medicine University of the Philippines Manila1000 ManilaPhilippines department of Nanomedicine Houston Methodist Research InstituteHouston 77030USA department of Chemistry Lamar UniversityBeaumont 77710USA department of Veterinary Medicine and Surgery The University of Texas MD Anderson Cancer CenterHouston 77030USA department of Imaging Physics The University of Texas MD Anderson Cancer CenterHouston 77030USA Section of Nephrology Department of MedicineSelzman Institute for Kidney HealthBaylor College of MedicineHouston 77030USA The University of Texas Md Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences Houston 77030USA

Arteriovenous fistulas(AVFs)are a vital form of AV access for patients requiring hemodialysis,but they link to overall morbidity and mortality when they fail to *** most common cause of AVF non-maturation is neointimal hyperplasia(NIH).To minimize the deleterious effects of NIH,a perivascular wrap composed of polycaprolactone(PCL),rosuvastatin(ROSU),and gold nanoparticles(AUNPs)was *** study assessed the impact of ROSU-eluting,radiopaque resorbable perivascular wraps on pathologic NIH in a chronic kidney disease(CKd)rodent model of *** PCL wraps containing AuNPs and/or ROSU were monitored for in vitro tensile strength,AuNP release,ROSU elution,and effect on cellular *** wraps were then implanted around an AVF in a CKd rodent model for in vivo ultrasound(US)and micro-computed tomography(mCT)*** specimens were collected for histological *** viability was preserved in the presence of both AuNP-and ROSU-containing *** vitro release of ROSU and AuNPs correlated with in vivo findings of decreasing radiopacity on mCT over ***-loaded wraps had higher radiopacity(1270.0-1412.0 HU at week 2)compared with other wraps(103.5-456.0 HU),which decreased over *** addition of ROSU decreased US and histologic measurements of *** reduced NIH seen with ROSU-loaded perivascular wraps suggests a synergistic effect between mechanical support and anti-hyperplasia ***,AuNP loading increased wrap ***,our results show that AuNP-and ROSU-loaded PCL wraps induce AVF maturation and suppress NIH while facilitating optimal implanted device visualization.

关键词： Arteriovenous fistula Chronic kidney disease Nanoparticles Polycaprolactone Radiopacity Rosuvastatin

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双报道基因系统的构建以及在N蛋白生物功能研究中的应用

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中国生物化学与分子生物学报 1999年第4期15卷 568-571页

作者：周建光 donaldL.court 军事医学科学院生物工程研究所北京100850 美国国家肿瘤研究所Frederick肿瘤研究和发展中心

为研究 λ噬菌体调控因子Ｎ蛋白的生物功能，应用 λ噬菌体感染、Ｐ１噬菌体转导、体内、体外重组方法，通过对遗传标记的筛选，将ｌａｃＺ和ｇａｌＫ报道基因、λ噬菌体ｐＬ操纵子负责调控转录、翻译的ＤＮＡ序列... 详细信息

为研究 λ噬菌体调控因子Ｎ蛋白的生物功能，应用 λ噬菌体感染、Ｐ１噬菌体转导、体内、体外重组方法，通过对遗传标记的筛选，将ｌａｃＺ和ｇａｌＫ报道基因、λ噬菌体ｐＬ操纵子负责调控转录、翻译的ＤＮＡ序列以及转录终止子装配到大肠杆菌染色体上，构建成菌株ＺＨ１０４１、ＺＨ１０４２和ＺＨ１１４２．应用ＺＨ１１４２菌株模拟 λ噬菌体的自然状态对其调控蛋白Ｎ的生物功能进行了研究．研究证明，Ｎ蛋白不仅在转录水平上正向调控基因表达，还具有一种新的在翻译水平上负向调节自身基因表达的生物功能．

关键词：报道基因 N蛋白 λ噬菌体生物功能

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大体积负氢离子源的研究

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国外核聚变与等离子体应用 1996年第4期 58-65页

作者： court.,C 卢大伦

本文报导了一个大体积混合多多会切点负离子源的电子和负离子的密度和温度。基于定标律做了等离子的形成和损失过程的分析。分析表明，正离子到壁上的损失是主要的，尽管注意到定标律是ｎ＋∞Ｉ＾０．５７ｄ。然而，总的等离子体的损... 详细信息

本文报导了一个大体积混合多多会切点负离子源的电子和负离子的密度和温度。基于定标律做了等离子的形成和损失过程的分析。分析表明，正离子到壁上的损失是主要的，尽管注意到定标律是ｎ＋∞Ｉ＾０．５７ｄ。然而，总的等离子体的损失与放电电流成线性关系，同理论模型吻合。

关键词：大体积负氢离子源光致分离技术

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Comprehensive Analysis of Pan-African Mitochondrial dNA Variation Provides New Insights into Continental Variation and demography

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Journal of Genetics and Genomics 2016年第3期43卷 133-143页

作者： Maria Cerezo Leonor Gusmao Viktor Cerny Nabeel Uddin denise Syndercombe-court Alberto Gdmez-Carballa Tanja Gobel Peter M. Schneider Antonio Salas Unidade de Xenetica Departamento de Anatomia Patoloxica e Ciencias Forenses Instituto de Medicina Legal Facultade de Medicina Universidade de Santiago de Compostela Galicia 15782 Spain The Wellcome Trust Sanger Institute Hinxton CBIO 1SA UK dNA diagnostic Laboratory Institute of Biology State University of Rio de Janeiro Rio de Janeiro 20550-900 Brazil IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto Porto 4200-465 Portugal Archaeogenetics Laboratory Institute of Archaeology of the Academy of Sciences of the Czech Republic Prague 118-01 Czech Republic Faculty of Life Sciences and Medicine King's College London London SE1 9NH UK Barts and The London School of Medicine and dentistry Blizard Institute London E1 2AT UK Institute of Legal Medicine Medical Faculty University of Cologne Cologne D-50823 Germany

Africa is the cradle of all human beings, and although it has been the focus of a number of genetic studies, there are many questions that remain unresolved. We have performed one of the largest and most comprehensive meta-analyses of mitochondrial dNA （mtdNA） lineages carried out in the African continent to date. We generated high-throughput mtdNA single nucleotide polymorphism （SNP） data （230 SNPs） from 2024 Africans, where more than 500 of them were additionally genotyped for the control region. These data were analyzed together with over 12,700 control region profiles collected from the literature, representing more than 300 population samples from Africa. Insights into the African homeland of humans are discussed. Phylogeographic patterns for the African continent are shown at a high phylogeographic resolution as well as at the population and regional levels. The deepest branch of the mtdNA tree, haplogroup L0, shows the highest sub-haplogroup diversity in Southeast and East Africa, suggesting this region as the homeland for modem humans. Several demographic estimates point to the coast as a facilitator of human migration in Africa, but the data indicate complex patterns, perhaps mirroring the effect of recent continental-scaled demographic events in re-shaping African mtdNA variability.

关键词： mtdNA Haplotype Haplogroup SNP MALdI-TOF

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