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Current perspectives on neuroendocrine tumors

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hLife 2024年第11期2卷 563-575页

作者： Sunil Kumar Verma Renu khare Devendra Singh Faculty of Biotechnology Institute of Biosciences and TechnologyShri Ramswaroop Memorial UniversityLucknow-Deva RoadBarabankiUttar Pradesh 225001India Faculty of Biosciences Institute of Biosciences and TechnologyShri Ramswaroop Memorial UniversityLucknow-Deva RoadBarabankiUttar Pradesh 225001India

Neoplasms arising from neuroendocrine cells form a heterogeneous group known as neuroendocrine tumors(NETs),which possess both endocrine and neural *** tumors can occur in various organs throughout the body,with the most prominent sites being the gastrointestinal tract,pancreas,and *** their relatively low incidence,NETs have gained significant attention due to their unique biology and clinical *** review intends to provide a widespread gestalt of the present perception of NETs,including their epidemiology,etiology,pathogenesis,classification,clinical presentation,diagnostic modalities,treatment options,and *** strategies for NETs depend on tumor grade,stage,location,and functional *** resection remains the pillar of curative treatment for localized disease;on the other hand,systemic therapies take account of targeted therapies like tyrosine kinase inhibitors(TKIs),peptide receptor radionuclide therapy(PRRT),somatostatin analogs,and immunotherapy have shown promising results in advanced *** conclusion,this review provides an up-to-date summary of our current knowledge regarding neuroendocrine *** research is needed to better understand the underlying molecular mechanisms driving tumor development and *** will aid in developing novel therapeutic strategies targeting specific pathways involved in NET pathogenesis to improve patient outcomes.

关键词： cancer clinical therapy metastasis endocrine

Physico-chemical and elemental investigation of aqueous leaching of high sulfur coal and mine overburden from Ledo coalfield of Northeast India

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International Journal of Coal Science & Technology 2018年第3期5卷 265-281页

作者： Madhulika Dutta Puja khare Sanchita Chakravarty Durlov Saikia Binoy K. Saikia Polymer Petroleum and Coal Chemistry Group Materials Sciences and Technology Division CSIR-North East Institute of Science and Technology Jorhat 785006 India School of Applied Sciences Department of Chemistry University of Science and TechnologyRibhoi 793101 Meghalaya India Department of Chemistry CNB College Bokakhat 785612India Agrotechnology Division CSIR- Central Institute of Medicinal and Aromatic Plants Lucknow 226015 India Analytical Chemistry Division CSIR- National Metallurgical Laboratory Jamshedpur 831007 India

Acid mine drainage （AMD） is one of the major problems in high sulfur coal mining areas generating acidic water. The acidic mine water generated contain hazardous elements in varying concentrations. The Northeastern Indian coalfield produces considerable amounts of AMD. The AMD and metal leaching from coal and mine over burden （OB） are the two important naturally occurring processes. In order to know the AMD potential, the aqueous leaching experiment of a few coal and OB samples from the Ledo colliery of the Northeastern coalfield, Mergherita （India）, at different time periods （1, 3, 5, and 8 h） and at different temperatures （25, 45, 65, and 90℃） were performed in the laboratory. The physico- chemical analysis of the aqueous leachates shows the pH, electrical conductivity （EC）, and total dissolved solid （TDS） in the range of 1.62-3.52, 106-2006 μs/cm, and 106-1003 ppm for the raw coal samples respectively. The OB samples produced pH, EC, and TDS in the range of 3.68-6.92, 48.6-480 μs/cm, and 69.5-240 ppm respectively. From the study, it was revealed that the concentrations of major （Si, A1, K, Na, Fe, Ca, Mg）, minor （Mn） and trace/hazardous elements （As, Ba, Cd, Co, Cr, Cu, Hg, Ni, Pb, Se, Zn） considerably change with leaching time as well as with leaching temperature. Out of these elements As, Cd, Hg, Pb, Cr, and Se are of greater environmental importance. Alteration of the physico-chemical structure of the coal and OB samples resulting from leaching was also studied by field emission scanning electron microscope- energy-dispersive X-ray spectroscopy method. The release of the potentially hazardous elements from the raw coal and OB during leaching time periods to the leachates was detected by inductively coupled plasma-atomic emission spectroscopy and ion-chromatographic analyses. The major minerals found in coal and OB are quartz （SiO2）, pyrite （FeS2）, hematite, marcasite, and kaolinite. The association of different functional groups in minerals and their mode of a

关键词： AMD High sulfur coal Coal mine overburden Aqueous leaching Elements in coal and OB Coal qualityassessment

The Direction of Slant and Horizontal Stroke as Potential Suggestive Markers for the Determination of Handedness

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Journal of Forensic Science and Medicine 2024年第3期10卷 165-170页

作者： Pawan Gupta Anu Singla Baljeet Yadav Vartika khare Dr.APJ Abdul Kalam Institute of Forensic Science and Criminology Bundelkhand UniversityJhansiUttar PradeshIndia Department of Forensic Science Medi-Cap UniversityIndoreMadhya PradeshIndia

Background:The task of document examiners is very challenging,as they need to gather all the relevant facts to make an informed decision regarding the questioned *** the present study,a total of 300 handwriting samples from 100 different writers(involving 50 right-handed and 50 left-handed)were collected at Bundelkhand University,*** and stroke,as characteristic features of handwriting,were visually examined under a stereomicroscope to ascertain the ***:Slants and Strokes as characteristic features were analyzed in a total of 300 handwriting samples collected from 50 left-handed and 50 right-handed writers of age 17–22 years.A reference text comprising three pangram sentences printed on A4 paper and a blue ball point pen was used for ***:The data collected during the study were analyzed using a statistical method(Chi-square test)and revealed that the left-handed writers(LHWs)had a significantly(P<0.05)different writing style than the right-handed *** indicated that LHWs are more likely to make strokes in the right-to-left direction and slant of letters in the backward direction,while right-handed writers make strokes in the left-to-right direction and slant of letters in the forward ***:The findings of the study showed valuable insight and highlighted the significance of the direction of slant and horizontal stroke as potential indicators for the determination of handedness.

关键词： Forensic science handedness handwriting stroke questioned document slant

Performance of Non-invasive Blood Parameters for Ruling Out Significant Liver Fibrosis in Patients with Chronic Hepatitis B

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Journal of Clinical and Translational Hepatology 2020年第2期8卷 143-149页

作者： Shivam khare Anil Arora Praveen Sharma Shashi Dhawan Naresh Bansal Vikas Singla Ashish Kumar Institute of Liver Gastroenterology&Pancreatico-Biliary SciencesSir Ganga Ram HospitalNew DelhiIndia Department of Histopathology Sir Ganga Ram HospitalNew DelhiIndia

Background and Aims:Evaluation of significant liver fibro-sis is important for treatment decision and treatment re-sponse evaluation in patients with chronic hepatitis B. Since liver biopsy is invasive and transient elastography (TE) has limited availability, various non-invasive blood parameters need evaluation for their capabilities for detection of signifi-cant fibrosis. Methods:In this retrospective study, records of patients who had undergone liver biopsy for treatment-na?ve chronic hepatitis B were evaluated to obtain various non-in-vasive blood parameters (aspartate aminotransferase-to-pla-telet ratio index [referred to as APRI], Fibrosis-4 score [referred to as FIB-4], gamma-glutamyl transpeptidase-to-platelet ratio [referred to as GPR], and gamma-glutamyl transpeptidase-to-albumin ratio [referred to as GAR]), in ad-dition to TE, to assess significant liver fibrosis and compare these to fibrosis stage in liver biopsy. Results:A total of 113 patients were included in the study (median age 33 [inter-quartile range: 11-82 years], 74% males). Most (75%) pa-tients were HBeAg-negative. The liver biopsy revealed significant fibrosis (Ishak ≥3) in 13% of the patients and nil or mild fibrosis (Ishak<3) in 87%of the patients. TE findings were available for 85 patients, APRI and FIB-4 for 95 patients, GPR for 79 patients, and GAR for 78 patients. The median values of all the parameters were significantly higher in pa-tients with significant fibrosis, as compared to patients with non-significant fibrosis, and all the blood parameters as well as TE were able to identify patients with significant fibrosis significantly well (p<0.05). All non-invasive parameters had low positive predictive value but negative predictive value above 92%. Compared to TE, all the non-invasive blood pa-rameters had similar area under the curve for detecting sig-nificant fibrosis, with excellent negative predictive value (≥93%). Conclusions: Non-invasive blood parameters (APRI, FIB-4, GPR, and G

关键词： Hepatitis B Liver fibrosis Cirrhosis Transient elastography APRI FIB-4 GPR GAR

Multi-gradient-direction based deep learning model for arecanut disease identification

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CAAI Transactions on Intelligence Technology 2022年第2期7卷 156-166页

作者： S.B.Mallikarjuna Palaiahnakote Shivakumara Vijeta khare M.Basavanna Umapada Pal B.Poornima Department of Computer Science and Engineering Bapuji Institute of Engineering and TechnologyDavanagereAffiliated to Visvesvaraya Theological UniversityBelagaviKarnatakaIndia Faculty of Computer Science and Information Technology University of MalayaKuala LumpurMalaysia Adani Institute of Infrastructure Engineering AhmedabadIndia Department of Computer Science Davanagere UniversityDavanagereKarnatakaIndia Computer Vision and Pattern Recognition Unit Indian Statistical InstituteKolkataWest BengalIndia

Arecanut disease identification is a challenging problem in the field of image *** this work,we present a new combination of multi-gradient-direction and deep con-volutional neural networks for arecanut disease identification,namely,rot,split and *** to the effect of the disease,there are chances of losing vital details in the *** enhance the fine details in the images affected by diseases,we explore multi-Sobel directional masks for convolving with the input image,which results in enhanced *** proposed method extracts arecanut as foreground from the enhanced images using Otsu ***,the features are extracted for foreground information for disease identification by exploring the ResNet *** advantage of the proposed approach is that it identifies the diseased images from the healthy arecanut *** results on the dataset of four classes(healthy,rot,split and rot-split)show that the proposed model is superior in terms of classification rate.

关键词： deep learning image analysis pattern recognition

Foliar spraying of chlorpyrifos induces morphometric changes in Glycine max(L.)and shifts native soil microbiome

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Emerging Contaminants 2024年第3期10卷 86-102页

作者： Aman Raj Muneer Ahmad Malla Ashwani Kumar Pramod Kumar khare Sheena Kumari Metagenomics and Secretomics Research Laboratory Department of BotanyDr.Harisingh Gour University(A Central University)Sagar470003M.P.India Institute for Water and Wastewater Technology Durban University of TechnologyDurban4001South Africa Metagenomics and Secretomics Research Laboratory Department of BotanyUniversity of Allahabad(A Central University)Prayagraj211002U.P.India Department of Botany Ecology laboratoryDr.Harisingh Gour Vishwavidyalaya(A Central University)SagarMadhya Pradesh470003India

Pesticide usage alters plant growth,and development and disturbs native soil *** present study was carried out to evaluate the effect of Chlorpyrifos(CP-20%EC)on the growth and development of soybean(Glycine max),soil fertility,and soil *** conducted a pot experiment to assess the impact of different concentrations of chlorpyrifos;recommended dose(RD)and higher dose rates(2×and 4×RD).Chlorpyrifos application significantly altered the growth parameters in soybean(p<0.05).At higher concentrations(2×and 4×RD)shoot length(17.16±1.04;14.33±1.15,p<0.05),root length(3.40±0.36;2.66±0.28,p<0.050),leaf count(6.33±0.57;2.66±0.57;p<0.05)reduced significantly compared to RD and Control *** at these concentrations(2×and 4×RD),significant reduction in fresh shoot weight(0.86±0.008;0.66±0.002,p<0.05),dry shoot weight(0.14±0.001;0.13±0.003,p<0.05)and root fresh weight(0.13±0.001;0.09±0.003,p<0.05)and root dry weight(0.030±0.0005,0.037±0.003,p<0.05)was observed compared to the RD and control ***,a significant increase in root and shoot morphometric parameters was observed in RD compared to control(p<0.05).All the physio-chemical properties such as pH(8.51±0.82),moisture content(33.73±0.04),and electrical conductivity(3.44±0.03)were higher in CP-treated soils compared to ***,nutrient content such as nitrogen,carbon,and hydrogen were significantly reduced in treated soils compared to *** analysis showed higher concentrations of As,Cd,and Pb in CP-treated soil(8.7 mg/g,0.254 mg/g,and 16.477 mg/g,respectively)compared to untreated soil(8.09 mg/g,0.228 mg/g,and 15.25 mg/g,respectively).We also assessed soil metabolic activity and diversity using Community-level Physiological Profiling(CLPP).CP-treated soil exhibited significantly lesser microbial diversity,with lesser metabolic *** analysis revealed a shift in bacterial community composition,with Pseudomonadota and Bacteroidota dominating CP-treated s

关键词： Chlorpyrifos Glycine max Proline Metabolic activity CLPP Metagenomics Bacterial microbiome

Exploring the benefits of biochar over other organic amendments for reducing of metal toxicity in Withania somnifera

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Biochar 2019年第3期1卷 293-307页

作者： Nidhi Nigam Vineet Yadav Puja khare Raghuvendra Pratap Singh Paurabi Das Karuna Shanker Ram Suresh Sharma Agronomy and Soil Science Division CSIR-Central Institute of Medicinal and Aromatic PlantsP.O.-CIMAPNear Kukrail Picnic SpotLucknow 226015India Analytical Chemistry Division CSIR-Central Institute of Medicinal and Aromatic PlantsLucknow 226015India Technology and Business Development Division CSIR-Central Institute of Medicinal and Aromatic PlantsLucknow 226015India

Biochar is considered as a good metal sequester and ameliorates the metal toxicity and uptake in ***,its effec-tiveness over other organic amendments is not well *** aim of this study is to compare the biochar amendments alleviating the levels of Pb and Cd in Withania somnifera *** with other organic *** manure,vermicom-post,and biochar were applied in the field spiked with highly available Pb and *** bioavailability and accumulation,plant growth and plant physiology,antioxidant enzymes and metabolite content of *** along with soil properties were evaluated in all *** indicates that the application of organic manures significantly alleviated the metal levels(33-72%)in the plant in comparison with *** herbage yield was significantly higher(33-69%)under different organic manures as compared to the metal *** metabolite contents and antioxidant enzymes were higher in metal treatments in comparison with *** manures were not only able to restrain the Pb and Cd in soil but also enhanced the soil microbial *** indicate that biochar amendments were more promising than farmyard manure and vermicompost due to the presence of more stable carbon in biochar and more alleviation in metal *** addition,net profit in the cultivation of *** was higher for biochar amendments(50%higher)compared to *** study recommended that biochar could be a better option for commercial and safer production of ***.

关键词： Toxic metals Withania somnifera Biochar Phytotoxicity

Comparative assessment for removal of anionic dye from water by different waste-derived biochar vis a vis reusability of generated sludge

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Biochar 2022年第1期4卷 986-1002页

作者： Mayank Singh MohdAhsan Versha Pandey Anupama Singh Disha Mishra Neerja Tiwari Pooja Singh Tanmoy Karak Puja khare Crop Production and Protection DivisionCSIR-Central Institute of Medicinal and Aromatic PlantsLucknow 226015India Phytochemistry Division CSIR-Central Institute of Medicinal and Aromatic PlantsLucknow 226015India Upper Assam Advisory Centre Tea Research AssociationDikomDibrugarh 786101AssamIndia Academy of Scientific and Innovative Research(AcSIR) GaziabadIndia Biotechnology Division Central Institute of Medicinal and Aromatic PlantsLucknow 226015India

In this study,four biochars prepared from different crop residue waste *** bagasse(SBB),coconut shell(CNB),paddy straw(PDB),and distilled waste of lemongrass(LGB)were evaluated for removal of Remazol Brilliant Blue R from the aqueous *** RBBR adsorption capacities of biochar were 97-79%for SBB,99.9-99.47%for CNB,66.1-48%for PDB,and 78-68%for LGB,dominantly controlled by their aromaticity and mineral *** Langmuir and Freundlich isotherms and pseudo-second-order kinetic models have described the chemisorption of RBBR on biochar *** thermodynamic data suggested that adsorption was spontaneous and *** biochars demonstrated excellent reusability(till four cycles with 50-61%regeneration).The purified water and biochar dye sludge demonstrated no *** findings obtained in this study may provide supports for the potential of biochars for anionic dye removal from water and utilization of generated sludge for zero waste-producing technologies in the future.

关键词： Biochar Remazol Brilliant Blue R Dye Adsorption Biochar dye sludge

Tracking of Non-Rigid Object in Complex Wavelet Domain

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Journal of Signal and Information Processing 2011年第2期2卷 105-111页

作者： Om Prakash Ashish khare 不详

In this paper we have proposed an object tracking method using Dual Tree Complex Wavelet Transform (DTCxWT). The proposed method is capable of tracking the moving object in video sequences. The object is assumed to be deform-able under limit i.e. it may change its shape from one frame to another. The basic idea in the proposed method is to decompose the image into two components: a two dimensional motion and a two dimensional shape change. The motion component is factored out while the shape is explicitly represented by storing a sequence of two dimensional models. Each model corresponds to each image frame. The proposed method performs well when the change in the shape in the consecutive frames is small however the 2-D motion in consecutive frames may be large. The proposed algorithm is capable of handling the partial as well as full occlusion of the object.

关键词： Object Tracking Dual Tree Complex Wavelet Transform Model Based Tracking Biorthogonal Filters