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ALPPS versus portal vein embolization for hepatitis B virus-associated hepatocellular carcinoma: a delicate balance between volume and morbidity

首届中国青年学者微生物遗传学学术研讨会

作者： ricardo carreno-lopez Elmerich Claudine IAAE-CAAS Institut Pasteur

Occurrence of non-pathogenic nitrogen-fixing bacteria living within the plant tissue attracts considerable attention. The A15 strain was isolated from rice paddies in China (You and Zhou 1989, Can. J. Microbiol. 35:403-408). It can fix nitrogen under microaerobic conditions at the free-living state and it colonize rice endophytically. A15 is used as a plant growth promoting inoculant of rice in China.

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 284-286页

作者： Victor lopez-lopez Kohei Miura Asuncion lopez-Conesa Roberto Brusadin Alvaro Navarro ricardo Robles-Campos Department of General Visceral and Transplantation SurgeryClinic and University Hospital Virgen de La ArrixacaIMIB-ARRIXACAEl PalmarMurciaSpain Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental SciencesNiigataJapan

We have read with great interest the recent study published by Li et al.,entitled“Associating liver partition and portal vein ligation for staged hepatectomy versus sequential transarterial chemoembolization and portal vein embolization in staged hepatectomy for HBV-related hepatocellular carcinoma:a randomized comparative study”(1).

关键词： Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) portal vein embolization(PVE) hepatocellular carcinoma(HCC) Hepatitis B

The challenge of hepatic vein reconstruction in surgical oncology

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 473-476页

作者： Víctor lopez-lopez David Ferreras Dilmurodjon Eshmuminov Roberto Brusadin ricardo Robles-Campos Department of General Visceral and Transplantation SurgeryClinic and University Hospital Virgen de La ArrixacaIMIB-ARRIXACAEl PalmarMurciaSpain Department of Surgery and Transplantation Swiss Hepato-Pancreato-Biliary(HPB)CenterUniversity Hospital ZurichZurichSwitzerland

In the liver surgical oncology,a complete resection of the primary or metastatic liver tumors remains the main *** the tumor invades the hepatic vein or the inferior vena cava(IVC)a curative resection becomes ***,recent advances in intraoperative hemodynamic management together with the refinement of the surgical technique acquired by complex liver surgery and transplantation have allowed to perform hepatic vein or vena cava resection for curation with low morbidity and mortality.

关键词： surgical hepatic mortality

Comparison of Control Techniques in a Weight Lifting Exoskeleton

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Journal of Bionic Engineering 2019年第4期16卷 663-673页

作者： Irving Rosales-Diaz Jesus ricardo lopez-Gutierrez Angel Eduardo Zamora Suarez Sergio Rosario Salazar Antonio Osorio-Cordero Hipolito Aguilar-Sierra Rogelio Lozano CINVESTAV Av.Institute Politecnico Nacional 2508Col.San Pedro Zacatenco07360Mexico CityMexico CONACYT-CINVESTAV Av.Institute Politecnico Nacional 2508Col.San Pedro Zacatenco07360Mexico CityMexico Polytechnic University of Tulancingo St.Ingenierias 100Col.Huapalcalco43629TulancingoHidalgoMexico Centre de Recherches de Royalieu UTC-HEUDIASyCCompiegne60205France

The back pain is the most common injury in human activities where heavy objects must be lifted or must be suspended for a long time.A weight lifting exoskeleton also known as force augmentation exoskeleton is designed to reduce the strain on the back and the limbs and reduce the risk to suffer *** the other hand,different kinds of controllers have been implemented to achieve whit this goal,for example,a conventional PD Control,PD Control with Gravity Compensation,PD Control with Adaptive Desired Gravity Compensation and PD Control with Robust *** paper aims to evaluate and compare the performance from the previously cited controllers used to reduce the strain in the back,through the implementation of each controller in a three Degrees Of Freedom(DOF)exoskeleton powered by pneumatic muscle actuators;some numerical simulations as well as experimental trials have been conducted and three different performance indices were used in order to determine the effectiveness of each one with respect to the simple PD controller when the mass to be lifted is unknown.

关键词： augmenting force device exoskeleton robot pneumatic artificial muscles adaptive control robust control

Design and Implementation of a Rehabilitation Upper-limb Exoskeleton Robot Controlled by Cognitive and Physical Interfaces

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Journal of Bionic Engineering 2022年第5期19卷 1374-1391页

作者： Arturo Gonzalez‑Mendoza Ivett Quinones‑Uriostegui Sergio Salazar‑Cruz Alberto‑Isaac Perez‑Sanpablo ricardo lopez‑Gutierrez Rogelio Lozano LAFMIA UMI Center for Research and AdvancedStudies of National Polytechnic InstituteAv.Instituto Politecnico Nacional No.250807360 Mexico CityMexico Motion Analysis Lab National Institute of Rehabilitation Luis Guillermo Ibarra IbarraCalz.Mexico Xochimilco No.28914389 Mexico CityMexico CONACYT-CINVESTAV Av.Instituto Politecnico Nacional 250807360 Mexico CityMexico UTC-CNRS UMR Sorbonne UniversitesUTC-CNRS UMR7253 HeudiasycCompiegneFrance

This paper presents an upper limb exoskeleton that allows cognitive(through electromyography signals)and physical user interaction(through load cells sensors)for passive and active exercises that can activate neuroplasticity in the rehabilitation process of people who suffer from a neurological *** the exoskeleton to be easily accepted by patients who suffer from a neurological injury,we used the ISO9241-210:2010 as a methodology design *** the first steps of the design process,design requirements were collected from previous usability tests and ***,as a second step,a technological solution is proposed,and as a third step,the system was evaluated through performance and user *** part of the technological solution and to allow patient participation during the rehabilitation process,we have proposed a hybrid admittance control whose input is load cell or electromyography *** hybrid admittance control is intended for active therapy exercises,is easily implemented,and does not need musculoskeletal modeling to ***,electromyography signals classification models and features were evaluated to identify the best settings for the cognitive human–robot interaction.

关键词： Human Robot interaction Hybrid admittance control Surface electromyography Upper-limb exoskeletal robot

Engineering Geological Investigations for the Foundations of Large Structures-Examples of a Concrete Dam and a long Bridge in Portugal

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Journal of Mountain Science 2011年第2期8卷 296-306页

作者： ricardo OLIVEIRA COBA and New University of Lisbon Portugal

The safety of large structures requires adequate foundations, which implies a good knowledge of the geological and geotechnical conditions of the respective ground. In general, that is only possible through engineering geological studies which include proper site investigation techniques, adapted to the nature of the ground (rock mass or soil) and to the associated engineering problems. The paper illustrates the studies carried out for the design of the foundations of Ribeiradio 76 m high concrete gravity dam in a difficult rock mass and of Vasco da Gama Bridge, 13 km long, crossing the Tagus River in Lisbon, Portugal, through piles 75 m deep.

关键词： Geological investigation Foundations Concrete dam Bridge

Deduction and Validation of an Eulerian-Eulerian Model for Turbulent Dilute Two-Phase Flows by Means of the Phase Indicator Function-Disperse Elements Probability Density Function

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Chinese Journal of Chemical Engineering 2000年第3期8卷 189-202页

作者： Santiago Laín ricardo Aliod MVT-UST Fachbereich Ingenieurwissenschaften Martin-Luther-UniversitatHalle-WittenbergD-06099Halle(Saale)GermanyFluid Mechanica DepartmentE.U.Politecnica de Huesca.University of ZaragozaCarretera Zaragoza km.6722071 HuescaSpain

A statistical formalism overcoming some conceptual and practical difficulties arising in existing two-phase flow (2PHF) mathematical modelling has been applied to propose a model for dilute 2PHF turbulent Hows. Phase interaction terms with a clear physical meaning enter the equations and the formalism provides some guidelines for the avoidance of closure assumptions or the rational approximation of these terms. Continuous phase averaged continuity, momentum, turbulent kinetic energy and turbulence dissipation rate equations have been rigorously and systematically obtained in a single step. These equations display a structure similar to that for single-phase flows. It is also assumed that dispersed phase dynamics is well described by a probability density function (pdf) equation and Eulerian continuity, momentum and fluctuating kinetic energy equations for the dispersed phase are deduced. An extension of the standard k-e turbulence model for the continuous phase is used. A gradient transport model is adopted for the dispersed phase fluctuating fluxes of momentum and kinetic energy at the non-colliding, large inertia limit. This model is then used to predict the behaviour of three axisymmetric turbulent jets of air laden with solid particles varying in size and concentration. Qualitative and quantitative numerical predictions compare reasonably well with the three different sets of experimental results, studying the influence of particle size, loading ratio and flow confinement velocity.

关键词： two-phase flow turbulence phase indicator function pdf ensemble average jet

Nanoparticle-encapsulated retinoic acid for the modulation of bone marrow hematopoietic stem cell niche

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Bioactive Materials 2024年第4期34卷 311-325页

作者： Emanuel Quartin Susana Rosa Sara Gonzalez-Anton Laura Mosteo lopez Vitor Francisco Delfim Duarte Cristina Lo Celso ricardo Pires das Neves Lino Ferreira CNC-Center for Neuroscience and Cell Biology CIBB-Centre for Innovative Biomedicine and BiotechnologyUniversity of Coimbra3004-517CoimbraPortugal IIIUC-Institute of Interdisciplinary Research University of Coimbra3004-517CoimbraPortugal Faculty of Medicine University of Coimbra3004-517CoimbraPortugal Department of Life Sciences Imperial College LondonSouth Kensington CampusThe Francis Crick InstituteLondonUK Haematopoietic Stem Cell Laboratory The Francis Crick InstituteLondonUK Instituto de Investigação e Inovação em Saúde(i3S) University of PortoPortoPortugal Department of Biomedicine Faculdade de Medicina da Universidade do Porto(FMUP)PortoPortugal Department of Onco-Hematology Instituto Português de Oncologia(IPO)-PortoPortoPortugal

More effective approaches are needed in the treatment of blood cancers,in particular acute myeloid leukemia(AML),that are able to eliminate resistant leukemia stem cells(LSCs)at the bone marrow(BM),after a chemotherapy session,and then enhance hematopoietic stem cell(HSC)engraftment for the re-establishment of the HSC ***,we investigate whether light-activatable nanoparticles(NPs)encapsulating all-trans-retinoic acid(RA^(+)NPs)could solve both *** in vitro results show that mouse AML cells transfected with RA^(+)NPs differentiate towards antitumoral M1 macrophages through RIG.1 and OASL gene *** in vivo results further show that mouse AML cells transfected with RA^(+)NPs home at the BM after transplantation in an AML mouse *** photo-disassembly of the NPs within the grafted cells by a blue laser enables their differentiation towards a macrophage *** macrophage activation seems to have systemic anti-leukemic effect within the BM,with a significant reduction of leukemic cells in all BM compartments,of animals treated with RA^(+)NPs,when compared with animals treated with empty *** a separate group of experiments,we show for the first time that normal HSCs transfected with RA^(+)NPs show superior engraftment at the BM niche than cells without treatment or treated with empty *** is the first time that the activity of RA is tested in terms of long-term hematopoietic reconstitution after transplant using an in situ activation approach without any exogenous priming or genetic conditioning of the transplanted ***,the approach documented here has the potential to improve consolidation therapy in AML since it allows a dual intervention in the BM niche:to tackle resistant leukemia and improve HSC engraftment at the same time.

关键词： Light Nanoparticles Retinoic acid Leukemia M1 macrophages Drug delivery

Synthesis identification analysis for closed loop system

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Journal of Systems Engineering and Electronics 2021年第4期32卷 939-946页

作者： WANG Jianhong ricardo A.Ramirez-Mendoza School of Electronic Engineering and Automation Jiangxi University of Science and TechnologyGanzhou 343100China School of Engineering and Sciences Tecnologico de MonterreyMonterrey 64849Mexico

The existing theories for closed loop identification with the linear feedback controller are very *** apply the existed theories directly in the control field,we propose a new idea about replacing the original unknown and nonlinear feedback controller with one approximated linear controller,while guaranteeing the equivalent property for the obtained closed loop *** on some statistical correlation functions,one condition is derived to show the equivalent property between the approximated linear controller and the original nonlinear *** detailed explicit form,corresponding to the approximated linear controller,is also ***,to give a complete analysis for closed loop identification,the cost function is rewritten as one extended expression,being convenient to *** spectral estimation is introduced to identify the unknown plant in the closed loop ***,the proposed theories are verified by one simulation example.

关键词： synthesis analysis closed loop system simplified function equivalent controller

Comprehensive Euler/Lagrange modelling including particle erosion for confined gas-solid flows

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Particuology 2024年第1期84卷 209-235页

作者： Guiherme A.Novelletto ricardo Martin Sommerfeld Multiphase Flow Systems Institute of Process EngineeringOtto-von-Guericke-University MagdeburgHoher Weg 7b06120Halle(Saale)Germany

The present research aims to assess the capability of a comprehensive Euler/Lagrange approach for predicting gas-solid flows and the associated solid particle *** open-source code OpenFOAM®4.1 was used to carry out the numerical simulations,where the standard Lagrangian libraries were substantially extended to account for all necessary *** are tracked considering both translational and rotational motion as well as all relevant forces,such as gravity/buoyancy,drag and transverse lift due to shear and particle *** tracking time step was dynamically adapted ac-cording to the locally relevant time scales,which drastically reduces computational *** approaches are adopted to model particle turbulent dispersion,particle collisions with rough walls and particle-particle *** solid particle erosion models,available in the literature,were considered to estimate pipe bend *** study cases are provided to validate the adopted nu-merical approach and erosion models *** first case intends to evaluate the ability of the extended CFD code to predict the behaviour of gas-solid flows in pneumatic conveying *** goal is achieved by comparing the numerical results with the experimental data obtained by Huber(1997)and Huber and Sommerfeld(1994,1998)in a pneumatic conveying ***,the importance of considering inter-particle collisions and surface roughness for predicting particle velocity,mass flux and mean diameter distributions in gas-solid flows is *** second and third case intend to evaluate the ability of the erosion models in estimating bend erosion in diluted gas-solid *** erosion data obtained experimentally by Mazumder et al.(2008)and Solnordal et al.(2015)in very dilut pneumatic conveying systems is used for validating the numerical results,neglecting now inter-particle collisions and two-way *** a comprehensive analysis of the different influential properti

关键词： Pneumatic conveying Pipe bend Numerical calculation(CFD) Euler/Lagrange approach Erosion models Wall roughness