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Therapy with bone marrow cells reduces liver alterations in mice chronically infected by Schistosoma mansoni

World Journal of Gastroenterology 2008年第38期14卷 5842-5850页

作者： Sheilla Andrade Oliveira Bruno Solano Freitas Souza Carla Adriana Guimares-Ferreira Elton Sá Barreto Siane campos Souza Luiz Antonio Rodrigues Freitas ricardo Ribeiro-dos-Santos Milena Botelho Pereira Soares Centro de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas 40295-001 Salvador BA Brazil Centro de Pesquisas Aggeu Magalhes Fundao Oswaldo Cruz Recife Av Moraes Rego s/n Cidade Universitária Recife 50670-420 PE Brazil Centro de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas Salvador 40295-001 BA Brazil Centro de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas 40295-001 Salvador BA Brazil Hospital So Rafael Av So Rafael 2152 So Marcos Salvador 41256-900 BA Brazil

AIM： To investigate the potential of bone marrow mononuclear cells （BM-MCs） in the regeneration of hepatic lesions induced by Schistosoma mansoni （***） chronic infection. METHODS： Female mice chronically infected with *** were treated with BM-MCs obtained from male green fluorescent protein （GFP） transgenic mice by intravenous or intralobular injections. Control mice received injections of saline in similar conditions, Enzyme-linked immunosorbent assay （ELISA） assay for transforming growth factor-beta （TGF-β）, polymerase chain reaction （PCR） for GFP DNA, immunofluorescence and morphometric studies were performed. RESULTS： Transplanted GFP^＋ cells migrated to granuloma areas and reduced the percentage of liver fibrosis. The presence of donor-derived cells was confirmed by Fluorescence in situ hybridization （FISH） analysis for detection of cells bearing Y chromosome and by PCR analysis for detection of GFP DNA. The levels of TGF-β, a cytokine associated with fibrosis deposition, in liver fragments of mice submitted to therapy were reduced. The number of oval cells in liver sections of ***-infected mice increased 3-4 fold after transplantation. A partial recovery in albumin expression, which is decreased upon infection with ***, was found in livers of infected mice after cellular therapy. CONCLUSION： In conclusion, transplanted BMCs migrate to and reduce the damage of chronic fibrotic liver lesions caused by ***.

关键词： Schistosoma mansoni Liver injury Fibrosis Bone marrow cells Transplantation Albumin Oval cells

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Nutritional therapy for hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1440-1452页

作者： Astrid Ruiz-Margáin Berenice M Román-Calleja Paulina Moreno-Guillén JoséA González-Regueiro DeyaniraKúsulas-Delint Alejandro campos-Murguía Nayelli C Flores-García ricardo Ulises Macías-Rodríguez Liver Nutrition Clinic Department of GastroenterologyInstituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Liver Fibrosis and Nutrition Lab MICTLÁN-Network(Mechanisms of Liver InjuryCell Death and Translational Nutrition in Liver Diseases-Research Network)Mexico City 14080Mexico Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico

Hepatocellular carcinoma(HCC)is the most frequent primary liver cancer and presents together with cirrhosis in most *** addition to commonly recognized risk factors for HCC development,such as hepatitis B virus/hepatitis C virus infection,age and alcohol/tobacco consumption,there are nutritional risk factors also related to HCC development including high intake of saturated fats derived from red meat,type of cooking(generation of heterocyclic amines)and contamination of foods with *** the contrary,protective nutritional factors include diets rich in fiber,fruits and vegetables,n-3 polyunsaturated fatty acids and *** the patient is being evaluated for staging and treatment of HCC,special attention should be paid to nutritional support,including proper nutritional assessment and therapy by a multidisciplinary *** must be considered that these patients usually develop HCC on top of long-lasting cirrhosis,and therefore they could present with severe *** complications should be properly addressed and considered for nutritional *** addition to traditional methods,functional testing,phase angle and computed tomography scan derived skeletal muscle index-L3 are among the most useful tools for nutritional *** therapy should be centered on providing enough energy and protein to manage the increased requirements of both cirrhosis and *** with branched-chain amino acids is also recommended as it improves response to treatment,nutritional status and survival,and finally physical exercise must be encouraged and adapted to individual needs.

关键词： Sarcopenia Liver Cancer Diet Branched-chain amino acids Nutrition

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Analytical Solutions of the Equations One Mechanical Thermal Model of a Helical Spring NiTi for Use in Heat Engine

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Journal of Mechanics Engineering and Automation 2014年第8期4卷 648-656页

作者： Luciana Lima Monteiro Jose Roberto da Costa campos Tiago Leite Rolim ricardo Artur SanguinettiFerreira Academic Department of Control of lndustrial Process Instituto Federal de Educacao Ciencia e Tecnologia de PernambucoRecife 50740-540 Brazil Department of Mechanical Engineering Polytechnic School of Pernambuco/UPE (University of Pernambuco) Recife 50100-010Brazil Department of Mechanical Engineering Federal University of Pernambuco Recife 50670-90 Brazil

Shape memory effect is capability of certain materials to recover its original shape after an apparently permanent deformation. The NiTi alloy of the composition is approximately equiatomic and it is the materials that exhibit the best characteristics for application of these properties, especially in the biomedical area, because of their excellent biocompatibility as： in the manufacture of medical and dental instruments, orthodontic wires, orthopedic materials, guide wires, stents, filters and components to realize the less invasive surgeries. In other areas, they are used for confections of electronic keys, spectacle frames, application in controllers, junction of pipes and electronic connectors among others. New research topics involving the application of these alloys super-elasticity are also known as pseudo elasticity. This event has an isothermal nature and involves the storage of potential energy in the shape memory effect and super-elasticity. In this context, this work falls within the scope of use of the technologies being an example of the work undertaken, in the course Graduate of Federal University of Pernambuco in skills in these technologies. It will present the results of a heat engine which engine element is a helical spring made of a NiTi alloy equiatomic with memory effect reversibly. The spring is triggered by a hot source （- 373.15 K） and a cold source （273.15 K）. The machine is capable of producing a reciprocating oscillating between the two sources. Heat equations and the equations that describe the dynamic behavior of the spring were developed. Through the development of dynamic equations, it can determine the minimum mass for the motion of the machine, as well as the instantaneous and average power and overall efficiency. You can check the functionality of the machine by way of the inclination angle of the propeller and the coefficient of static friction. Among the main results, it was observed that the overall performance of the machine co

关键词： Experimental mechanics heat engine NiTi.

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Influence of Soil Physical Properties on Grapevine Yield and Maturity Components in an Ultic Palexeralf Soils, Central-Southern, Chile

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Open Journal of Soil Science 2014年第4期4卷 127-135页

作者： Celerino Quezada Maria A. Soriano José Díaz ricardo Merino Alejandro Chandía Jorge campos Marco Sandoval Department of Agronomy University of Cordoba Cordoba Spain Faculty of Agronomy University of Concepcion Chillan Chile

The effects of soil physical properties on yield components, grape quality and grapevine yield cv. Cabernet Sauvignon in Ultic Palexeralf soils located in Central Southern Chile were assessed. The experimental design was completely randomized with three treatments of soil texture: clayey, sandy clay and clayey loam. The higher yield was obtained in the sandy clay and clayey loam soils. The increase of bulk density, penetration resistance and clay content decreased the number of clusters per vine, number of berries per cluster and grapevine yield. Soil texture had not effects on the yield of shoots, berry diameter and total acidity. However, soluble solids were higher in the clayey soil. Shoot orientation only had positive effects on the cluster weight, number of berries per cluster, and grapevine yield, being higher in the upward shoots. This research remarked the importance of soil physical properties on the selection of sites with viticultural aptitude.

关键词： Penetration Resistance Bulk Density Vineyard Upward Shoots

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Detection of antibodies against Toxoplasma gondii in Mirounga leonina Linnaeus,1758(Pinnipedia,Phocidae)from Elephant Island

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Journal of Coastal Life Medicine 2016年第3期4卷 197-199页

作者： Tony Silveira Pedro Quevedo Mariana Remião ricardo Berteaux Robaldo Vinicius Farias campos Adalto Bianchini Graduate Program in Biotechnology Federal University of PelotasBrazil Graduate Program in Parasitology Federal University of PelotasBrazil Graduate Program in Physiological Sciences Federal University of Rio GrandeBrazil

Objective:To investigate the presence of antibodies against Toxoplasma gondii(***)in Mirounga leonina(***)Linnaeus from Elephant Island,***:The animals were anesthetized,restrained,measured,weighed and had their blood collected by venipuncture of intervertebral lumbar epidural *** samples were collected from 102 *** hemagglutination and serum dilution at a proportion of 1:25 was used for specific immunoglobulin G *** ***:Only one(0.98%)specimen,a newly weaned calf,was ***:This study is the highest serological survey for antibody detection against *** in *** results suggest a low level of exposure to ***,probably due to the absence of felids in the study *** seropositivity presented by the elephant seal may be related to the presence of oocysts in water or cysts in their *** being reported the presence of the parasite in fish and molluscs,there are no records of tissue cysts or oocysts in squid or fish of the diet of ***,further parasitological studies focused on preys of elephant seals are needed for a better understanding of infection of *** by ***.

关键词： Antarctic Hemagglutination Marine mammals Parasite Protozoan Zoonosis

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Clinical perspectives,assessment,and mechanisms of metabolicassociated fatty liver disease in patients with COVID-19

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World Journal of Gastroenterology 2021年第33期27卷 5502-5519页

作者： Alejandro campos-Murguía Berenice M Román-Calleja JoséA González-Regueiro Ivonne Hurtado-Díaz-de-León Alberto Adrián Solís-Ortega Nayelli C Flores-García Ignacio García-Juárez Astrid Ruiz-Margáin ricardo Ulises Macías-Rodríguez Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Liver Fibrosis and Nutrition Lab(LFNLab) MICTLÁN-Network(Mechanisms of Liver InjuryCell Death and Translational Nutrition in Liver Diseases-Research Network)Mexico City 14080Mexico

Metabolic diseases are highly prevalent worldwide and have been associated with adverse clinical outcomes,including mortality,in patients developing coronavirus disease(COVID-19).Because of the close relationship between metabolic diseases such as type 2 diabetes mellitus and obesity and the presence of metabolicassociated fatty liver disease(MAFLD),a high number of cases of patients affected by both MAFLD and COVID-19 would be expected,especially in highrisk *** studies have shown an increased risk of adverse clinical outcomes,viral shedding,and deep vein thrombosis,especially in patients with MAFLD-related liver *** predisposition to poor outcomes and severe acute respiratory syndrome coronavirus 2 infection in patients with MAFLD could be secondary to mechanisms common to both,including preexisting systemic chronic inflammation,endothelial dysfunction,and involvement of the renin-angiotensin *** of the increased risk of adverse outcomes,MAFLD should be screened in all patients admitted for *** computed tomography scans could be of help,assessment of liver fibrosis is also recommended,favoring noninvasive methods to limit the exposure of healthcare *** involvement in this population ranges from abnormalities in liver chemistry to hepatic steatosis in postmortem ***,preventive measures should be strongly advocated in patients already known to have MAFLD,including the use of telemedicine and vaccination in addition to general measures.

关键词： Metabolic-associated fatty liver disease COVID-19 Mortality Fibrosis Histology Epidemiology

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Comparison of the systemic action of electroacupuncture and laserpuncture in experimental injuries on the back skin of Wistar rats(Rattus novergicus)

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Journal of Traditional Chinese Medicine 2021年第5期41卷 779-788页

作者： Ivens Takechi Nakagawa Hamilton ricardo Alonso Fabrício campos Kuroda JoséRoberto Passarini Junior Juan Guzman Quispe Cabanillas Fernanda Aparecida Sampaio Mendonça Gláucia Maria Tech dos Santos Andrea Aparecida de Aro Edson Rosa Pimentel Maria Esméria Corezola do Amaral Marcelo Augusto Marretto Esquisatto Graduate Program in Biomedical Sciences University Center of Herminio Ometto Foundation-FHOAvenida Dr.Maximiliano Baruto500-Jardim UniversitarioArarasSao Paulo 13607-339Brazil Department of Structural and Functional Biology Institute of BiologyState University of Campinas-UNICAMPAvenida Bertrand Russels/n.Caixa Postal 6109CampinasSao Paulo 13083-865Brazil

OBJECTIVE:To evaluate the systemic action of electroacupuncture and laserpuncture in the repair of excisional cutaneous injuries on the back of adult female Wistar ***:Ninety animals were divided into three experimental groups:C-control;E-treated with electroacupuncture[acupoints:Feishu(BL13),Geshu(BL17),Zusanli(ST36)];L-treated with laserpuncture(same acupoints)and euthanized on the 7 th,14 th and 21 st days for tissue removal and preparation for histomorphometric and biochemical(dosages,zymography and Western blotting)***:The number of fibroblasts in the E and L groups presented higher values than the C on the14 th and 21 st *** number of granulocytes was lower than C on the 21 st day in groups E and *** total number of newly formed vessels increased on the 21 st day and was higher in both treatments when compared to *** birefringent collagen fibers detected on the 21 st day was lower in groups E and L than group *** glycosaminoglycans and hydroxyproline amount was similar among groups throughout the experimental *** active isoform of matrixmetallo proteinase(MMP)-2 and the latent isoform of MMP-9 did not show any differences among all groups and experimental *** amount of collagenⅠpresented higher values in the L group on the 14 th day and in the E and L groups on the 21 st *** typeⅢcollagen,groups E and L presented values lower than C in all experimental *** amount of transforming growth factor-β1 in the E and L groups showed higher amounts than C on the 7 th day and lower on the 14 th and 21 st *** vascular endothelial growth factor,E and L groups presented similar and lower values than C on the 7 th and 14 th days,respectively,and similar on the 21 st ***:The therapies evaluated in this article stimulated fibroblast proliferation,neoangiogenesis and altered the reorganization of collagen fibers in the repair of excisional injuries in female adult rats.

关键词： wound healing electroacupuncture inflammation morphological and morphometric findings

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Acute pancreatitis complicated with splenic rupture: A case report

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World Journal of Gastrointestinal Surgery 2015年第9期7卷 219-222页

作者： Bruno L Hernani Pedro C Silva ricardo T Nishio Henrique C Mateus José C Assef Tercio De campos Irmandade da Santa Casa de Misericórdia de Sao Paulo Hospital Santa Casa School of Medicine Department of Surgery Emergency UnitIrmandade da Santa Casa de Sao Paulo HospitalSanta Casa School of Medicine

Atraumatic splenic rupture is an uncommon complication of acute pancreatitis. This report describes the case of a 30-year-old man with acute pancreatitis and splenic vein thrombosis complicated by splenic rupture. The patient was admitted to the emergency department with pain in the upper abdomen that had been present for six hours and was associated with vomiting and sweating. He was diagnosed with acute pancreatitis of alcoholic etiology. Upon computed tomography(CT) of the abdomen, the pancreatitis was scored as Balthazar C grade, and a suspicious area of necrosis affecting 30% of the pancreas with splenic vein thrombosis was revealed. Seventytwo hours after admission, the patient had significant improvement in symptoms. However, he showed clinical worsening on the sixth day of hospitalization, with increasing abdominal distension and reduced hemoglobin levels. A CT angiography showed a large amount of free fluid in the abdominal cavity, along with a large splenic hematoma and contrast extravasation along the spleen artery. The patient subsequently underwent laparotomy, which showed hemoperitoneum due to rupture of the splenic parenchyma. A splenectomy was then performed, followed by ultrasound-guided percutaneous drainage.

关键词： Acute pancreatitis Pancreatitis Rupture Splenic rupture Spontaneous

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Restoration-Focused Germination and Development of Five Central Mexican Oak Species

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Open Journal of Forestry 2014年第3期4卷 171-180页

作者： Alfonso-Corrado Cecilia campos Jorge Eduardo Mendoza Ana Aguirre-Hidalgo Victor Valencia-Davalos Susana González-Adame Gabriel Wooden Garvey Fanny Clark-Tapia ricardo Herbario de la Facultad de Ciencias (FCME) Departamento de Biología Comparada UNAM Ciudad Universitaria México D.F. México Instituto de Ecología UNAM Ciudad Universitaria México D.F. México Instituto de Estudios Ambientales Universidad de la Sierra Juárez Oaxaca México Laboratorio de Bioquímica Molecular-Unidad de Biotecnología y Prototipos (UBIPRO) Fes–IZTACALA Tlalnepantla México Nova Universitas Carretera a Puerto ángel Km. 34.5 Ocotlán de Morelos México

In the genus Quercus, regeneration by seed is reduced or absent in many species. The naturally protected area of the Sierra Fria, in Aguascalientes, Mexico contains forests that are fragmented and have been degraded due to human activities. The oak populations in this region demonstrate a very restricted sexual regeneration, with five of the most abundant species of this genus: Quercuseduardii, Q. grisea, Q. potosina, Q. resinosa and Q. sideroxyla presenting low seedling recruitment. In this study we evaluated seed viability and the effect of seed size on the germination, growth and survival of the trees, with the aim of recommending restoration and conservation program management actions for these oak species. In 2005 and 2006, 5000 acorns of each species were collected and viability, germination and growth experiments were performed in the laboratory and greenhouse. We found high seed viability and significant size effect

关键词： Acorns Oak Regeneration Seed Size Seed Viability

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Ecological-Genetic Studies and Conservation of Endemic <i>Quercus sideroxyla</i>(Trel.) in Central Mexico

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Natural Resources 2014年第9期5卷 442-453页

作者： Cecilia Alfonso-Corrado ricardo Clark-Tapia Alejandro Monsalvo-Reyes Carlos Rosas-Osorio Gabriel González-Adame Francisco Naranjo-Luna Crystian-Sadiel Venegas-Barrera Jorge E. campos Instituto de Estudios Ambientales Universidad de la Sierra Juárez Ixtlán de Juárez México InstitutoTecnológico de Ciudad Victoria Ciudad Victoria México Laboratorio de Bioquímica Molecular-Unidad de Biotecnología y Prototipos (UBIPRO) Fes-IZTACALA UNAM Tlalnepantla México

This study examines the distribution, ecology and genetic diversity of Quercus sideroxyla Humb. Bonpl, with an emphasis on its conservation on the Natural Protected Area of Sierra Fría in North Central Mexico. Twenty-nine locations were selected, and in each location, one plot of 1500 m2 was established. At every location, we obtained an abundance of Q. sideroxyla and a basal area for each individual tree, including geographical and climatological data. We used the Outlying Mean Index (OMI) to examine whether environmental conditions had a distributional effect on Q. sideroxyla populations and to obtain the static size population structure of the species. For the genetic analysis, we collected 18 adult individuals from each population, four polymorphic loci were used to estimate genetic diversity. Q. sideroxyla abundance was associated with narrow environmental conditions, especially when considering the topographical and meteorological environmental variables. The allelic richness value was 84 alleles (21 privatealleles), and the expected mean heterozygosity was 0.855 ± 0.009. The high vulnerability of the species to changes in the land use at the local scale and to global climatic changes increases the species’ susceptibility to local disappearance.

关键词： Ecology Genetic Diversity Local Conservation Niche Oaks

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