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Targeting epidermal growth factor receptor signaling to facilitate cortical injury repair?

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Neural Regeneration Research 2024年第5期19卷 935-936页

作者： ricardo Gómez-Oliva Pedro Nunez-Abades Carmen Castro Área de Fisiología Facultad de Medicina Universidad de CádizCadizSpain Instituto de Investigación e Innovación en Biomedicina de Cádiz CadizSpain Departamento de Fisiología Facultad de FarmaciaUniversidad de SevillaSevilleSpain

The existence of neural stem cells(NSC)in specific areas of the adult mammalian brain leads to the generation of new neurons involved in homeostatic *** is the case of the NSC of the subventricular zone(SVZ)that produces olfactory bulb(OB)*** neurons integrate into circuits to modulate sensory information and participate in olfactory processing(Bragado Alonso et al.,2019).A series of hierarchical events need to take place to produce OB neurons from NSC of the ***,the activation of quiescent NSC is necessary to produce intermediate transit amplifying progenitors(TAP),which will generate *** latter are cells that maintain a proliferative phenotype while in an immature ***,once they initiate migration toward the OB,they progressively undergo their differentiation into neurons(Kjell et al.,2020).

关键词： ventricular maintain

Immune therapy for human papillomaviruses-related cancers

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World Journal of Clinical Oncology 2014年第5期5卷 1002-1019页

作者： ricardo Rosales Carlos Rosales Virolab S de RL de CV Cuernavaca Morelos 17007 Mexico Carlos Departamento de Inmunología Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México Mexico City DF 04510 Mexico

Human papillomaviruses(HPVs) are a large family of double strand DNA viruses comprising more than 180 types. Infection with HPV is very common and it is associated with benign and malignant proliferation of skin and squamous mucosae. Many HPVs, considered lowrisk such as HPV 6 and 11, produce warts; while highrisk viruses, such as HPVs 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, and 58, induce tumors. About 5% of all cancers in men and women are associated with HPV infection. Because there are not antiviral drugs for HPV infection, current therapies for low-risk HPV infections involve physical removal of the lesion by cryotherapy, trichloracetic acid, laser, or surgical removal. Surgical procedures are effective in the treatment of precancerous lesions, however after these procedures, many recurrences appear due to new re-infections, or to failure of the procedure to eliminate the HPV. In addition, HPV can inhibit recognition of malignant cellsby the immune system, leading to the development of cancer lesions. When this occurs, radiotherapy and chemotherapy are then used. Unfortunately, about 50% of the HPV-cancer patients still die. In the past decade, a better knowledge of the natural history of the virushost interaction and of the immune response against this viral infection has brought new therapeutic strategies geared to modulate the immune system to generate an efficient virus-specific cytotoxic response. Novel HPV protein-expressing vaccines have shown some significant clinical efficacy and systemic HPV-specific cytotoxic T cell responses. This review will describe the current status of the several therapeutic strategies used to treat HPV-induced lesions, and discuss the various new therapies now being tested.

关键词： Human papillomavirus T cell Immunoglobulin Antibody Vaccinia virus

Infrared Spectroscopy of CO Isolated in Solid Nitrogen Matrix

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Chinese Journal of Chemical Physics 2014年第1期27卷 5-8,I0003页

作者：吴磊 ricardo Lambo 谈艳刘安雯胡水明中国科学技术大学合肥微尺度物质科学国家实验室(筹) 合肥230026

The infrared absorption spectra of the CO monomer isolated in solid N2 have been recorded at various temperatures between 4.5 and 30 K. The absorption features of the fundamen- tal stretching mode show its linewidth and matrix-induced frequency shift to be weakly temperature-dependent. As the temperature of the matrix was raised, an increase in the linewidth together with a redshift in the central frequency was observed. These observations were explained in terms of the quenching of the CO rotational states by the N2 matrix into closely-lying librational states. A quantitative model was then used to calculate the energy difference between these librational states. Results show that they can be thermally populated through the absorption of matrix phonons.

关键词： Phonon coupling Vibrational relaxation Energy gap law

ON THE ORDER OF SUMMABILITY OF THE FOURIER INVERSION FORMULA

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Analysis in Theory and Applications 2010年第1期26卷 13-42页

作者： Jasson Vindas ricardo Estrada Chent University Belgium Louisiana State University USA

In this article we show that the order of the point value, in the sense of Lojasiewicz, of a tempered distribution and the order of summability of the pointwise Fourier inversion formula are closely related. Assuming that the order of the point values and certain order of growth at infinity are given for a tempered distribution, we estimate the order of summability of the Fourier inversion formula. For Fourier series, and in other cases, it is shown that if the distribution has a distributional point value of order k, then its Fourier series is e.v. Cesaro summable to the distributional point value of order k＋1. Conversely, we also show that if the pointwise Fourier inversion formula is e.v. Cesaro summable of order k, then the distribution is the （k ＋ 1）-th derivative of a locally integrable function, and the distribution has a distributional point value of order k ＋ 2. We also establish connections between orders of summability and local behavior for other Fourier inversion problems.

关键词： Fourier inversion formula tempered distribution distributional point value Cesaro summability of Fourier series and integrals summability of distributional evaluations

The effects of low-volume combined training on health-related physical fitness outcomes in active young adults: A controlled clinical trial

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Sports Medicine and Health Science 2023年第1期5卷 74-80页

作者： ricardo Martins Nuno Loureiro Department of Arts Humanities and SportsSchool of EducationPolytechnic Institute of BejaLaboratory of Physical Activity and HealthBejaPortugal

The effects of combined training(CT)on improving general health are well known,however,few studies have investigated the effects of low-volume ***,the aim of this study is to investigate the effects of 6 weeks of lowvolume CT on body composition,handgrip strength(HGS),cardiorespiratory fitness(CRF)and affective response(AR)to *** healthy,active young adult man(meanSD,[20.061.66]years;[22.232.76]kg/m2)performed either a low-volume CT(EG,n?9),or maintained a normal life(CG,n?9).The CT was composed of three resistance exercises followed by a high intensity-interval training(HIIT)on cycle ergometer performed twice a *** measures of the body composition,HGS,maximal oxygen consumption(V_O2max)and AR to exercise were taken at baseline and after training for ***,an ANOVA test of repeated measures and t-test paired samples were used with a p*** results showed that EG improved HGS(pre:[45.6711.84]kg ***:[52.4411.90]kg,p0.05),nevertheless the feeling scale was positive in all weeks and without significant differences between them(p>0.05).Lastly,for active young adults,the low-volume CT improved HGS,CRF and had a positive outcome in AR,with less volume and time spent than traditional exercise recommendations.

关键词： Exercise Concurrent training Handgrip strength Cardiorespiratory fitness Affective response Untrained

Tides and Wind-Driven Circulation in the Tropical and Southern Atlantic Ocean:The BRAZCOAST System

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Atmospheric and Oceanic Science Letters 2014年第5期7卷 476-480页

作者： ricardo de CAMARGO Joseph HARARI Department of Atmospheric Sciences University of Sao Paulo Sao Paulo Brazil Department of Physical Chemical and Geological Oceanography University of Sao Paulo Sao Paulo Brazil

The Brazilian coast is characterized by different tidal regimes and distinct meteorological influences. The northern part has larger tidal amplitudes and is permanently affected by trade winds and tropical disturbances; the southern portion has smaller tidal amplitudes and is frequently influenced by extratropical cyclone activity. Besides these aspects, many features regarding current structure and behavior are also present, such as the equatorial system of currents, the subtropical gyre and the corresponding western boundary currents, and the Brazil-Malvinas confluence region. Within this context, efforts were made to develop the BRAZCOAST system, capable of describing the processes that determine the oceanic circulation from large to coastal scales. A customized version of the Princeton Ocean Model(POM) was implemented in a basin-scale domain covering the whole of the tropical and southern Atlantic Ocean, with 0.5° spatial resolution, as well as three nested grids with(1/12)° resolution covering the different parts of the Brazilian shelf, in a one-way procedure. POM was modified to include tidal potential generator terms and a partially-clamped boundary condition for tidal elevations. The coarse grid captured large-scale features, while the nested grids detailed local circulations affected by bathymetry and coastal restrictions. An interesting aspect at the coarse grid level was the relevance of the Weddell Sea to the location of the tidal amphidromic systems.

关键词： tides wind-driven circulation tropical Atlan-tic South Atlantic Princeton Ocean Model

Spatial and temporal patterns of forest fires in the Central Monte:relationships with regional climate

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Ecological Processes 2024年第1期13卷 66-79页

作者： Pablo Eugenio Villagra Erica Cesca Leandro Manuel Alvarez Silvia Delgado ricardo Villalba Instituto Argentino de Nivología Glaciología y Ciencias Ambientales–CONICET-CCT Mendoza Facultad de Ciencias Agrarias Universidad Nacional de Cuyo

Background Natural and anthropogenic wildfires burn large areas of arid and semi-arid forests with significant socio-economic and environmental impacts. Fire regimes are controlled by climate, vegetation type, and anthropogenic factors such as ignition sources and human-induced disturbances. Projections of climate and land-use change suggest that these controlling factors will change, altering fire regimes in the near future. In the southern Central Monte, Mendoza, Argentina, the factors that modulate the fire temporal and spatial variability are poorly understood. We reconstructed the fire history of southeast of Mendoza from 1984 to 2023 and investigated the relationships between fire extent and climate variability at seasonal and interannual scales. Burned areas were determined using Google Earth Engine by processing Landsat 5-TM, Landsat 7-ETM+, and Landsat 8-OLI-TIRS sensor *** The region exhibited high spatial and temporal variability in fire occurrence, being a mosaic of areas with different fire histories and recovery times. Between 1985 and 2023, fire recurrence ranged from sites unburned to sites with up to 14 fires. The occurrence of large fires was strongly favored by a combination of a year with abundant spring–early summer precipitation, which favors fuel accumulation, followed by a year of low spring–early summer precipitation. Precipitation and burnt area showed a very pronounced 6–7 year cycle, suggesting a dominant climatic control on fire *** Fire distribution in southeastern Mendoza forests is not homogeneous, resulting in a mosaic of patches with different fire histories. This heterogeneity may be related to vegetation patterns and land use. The temporal variability of fires is strongly influenced by climate variability, which would promote fuel production and subsequent drying. Large fires are concentrated in periods of high interannual precipitation variability. Climate change scenarios predict an increase in tem

关键词： Fire recurrence Fire mapping Recovery time Climate Dry forest Wildfire

A compact underwater stereo vision system for measuring fish

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Aquaculture and Fisheries 2024年第6期9卷 1000-1006页

作者： Cesar Silva ricardo Aires Flavio Rodrigues Fishmetrics LdaHorta9900-146Portugal

contributes for decisions at several production ***,taking length measurements is a cumbersome task that,when applied to living individuals,can induce considerable stress,increasing the risk of damage or hindering their *** vision is one of the most used non-contact tools to overcome this issue,being fast,consistent and ***,its use in aquatic environments is limited by the high cost,the difficulty of calibrating the system in underwater conditions and the complexity of *** paper proposes a low-cost easy-to-use vision system that can take measurements on live fish in aquatic conditions,without the need for a special calibration or a demanding in-water calibration *** present work implemented a compact stereo vision system and developed a method that estimates the correct length of fish,based on the variation of the angle of incidence of the light rays in the *** some structural conditions such as a short baseline,the system is able to measure fish with an error of less than 1%.The short baseline allows to have a compact system and reduces the effect of water refraction on the 3D reconstruction.A set of experiments were performed with real fish,working robustly for a set of orientations of the fish(even when the caudal fin and snout are on different distances to the cameras).

关键词： Underwater stereo vision Fish measuring Fish length Aquaculture technology

Combining flamelet-generated manifold and machine learning models in simulation of a non-premixed diffusion flame

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Energy and AI 2023年第4期14卷 173-188页

作者： Kaimeng Li Pourya Rahnama ricardo Novella Bart Somers Power&Flow–Department of Mechanical Engineering.Technical University of Eindhoven.P.O.Box 513 5600 MB EindhovenThe Netherlands CMT–Motores T´ermicos.Universidad Polit´ecnica de Valencia.Camino de Vera s/n E-46022 ValenciaSpain

Flamelet Generated Manifold(FGM)is an example of a chemistry tabulation or a flamelet method that is under attention because of its accuracy and speed in predicting combustion ***,the main problem in applying the model is a large amount of memory *** way to solve this problem is to apply machine learning(ML)to replace the stored tabulated *** different machine learning methods,including two Artificial Neural Networks(ANNs),a Random Forest(RF),and a Gradient Boosted Trees(GBT),are trained,validated,and compared in terms of various performance *** progress variable source term and transport properties are replaced with the ML *** attention was paid to the progress variable source term due to its high gradient and wide range of its value in the control variables *** preprocessing is shown to play an essential role in improving the performance of the *** ensemble models,namely RF and GBT,exhibit high training efficiency and acceptable *** the other hand,the ANN models have lower training errors and take longer to *** four models are then combined with a one-dimensional combustion code to simulate a counterflow non-premixed diffusion flame in engine-relevant *** predictions of the ML-FGM models are compared with detailed chemical simulations and the original FGM model for key combustion properties and representative species profiles.

关键词： Flamelet models Tabulated chemistry models Computational fluid dynamics Machine learning Non-premixed diffusion flame