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In vivo evaluation of additively manufacturedmulti-layered scaffold for the repair of large osteochondral defects

Bio-Design and Manufacturing 2022年第3期5卷 481-496页

作者： Maryam Tamaddon Gordon Blunn Rongwei Tan Pan Yang Xiaodan Sun Shen-Mao Chen Jiajun Luo Ziyu Liu Ling Wang Dichen Li ricardo donate Mario Monzón Chaozong Liu Institute of Orthopaedic and Musculoskeletal Science Royal National Orthopaedic HospitalUniversity College LondonStanmore HA74LPUK School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO12DTUK Guangdong Engineering Research Center of Implantable Medical Polymer Shenzhen Lando Biomaterials Co.Ltd.Shenzhen 518107China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China State Key Laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710054China Departamento de Ingeniería Mecánica Grupo de Investigación en Fabricación Integrada y AvanzadaUniversidad de Las Palmas de Gran CanariaCampus Universitario de Tafira s/n35017 Las PalmasSpain

The repair of osteochondral defects is one of the major clinical challenges in ***-established osteochondral tissue engineering methods have shown promising results for the early treatment of small ***,less success has been achieved for the regeneration of large defects,which is mainly due to the mechanical environment of the joint and the heterogeneous nature of the *** this study,we developed a multi-layered osteochondral scaffold to match the heterogeneous nature of osteochondral tissue by harnessing additive manufacturing technologies and combining the established art laser sintering and material extrusion *** developed scaffold is based on a titanium and polylactic acid matrix-reinforced collagen“sandwich”composite *** microstructure and mechanical properties of the scaffold were examined,and its safety and efficacy in the repair of large osteochondral defects were tested in an ovine condyle *** 12-week in vivo evaluation period revealed extensive and significantly higher bone in-growth in the multi-layered scaffold compared with the collagen–HAp scaffold,and the achieved stable mechanical fixation provided strong support to the healing of the overlying cartilage,as demonstrated by hyaline-like cartilage *** histological examination showed that the regenerated cartilage in the multi-layer scaffold group was superior to that formed in the control *** genes such as aggrecan and collagen-II were upregulated in the scaffold and were higher than those in the control *** findings showed the safety and efficacy of the cell-free“translation-ready”osteochondral scaffold,which has the potential to be used in a one-step surgical procedure for the treatment of large osteochondral defects.

关键词： Osteochondral scaffold Large animal Additive manufacturing Porous titanium

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Translation through collaboration:practice applied in BAMOS project in in vivo testing of innovative osteochondral scaffolds

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Biomaterials Translational 2022年第2期3卷 102-104页

作者： ricardo donate Maryam Tamaddon Viviana Ribeiro Mario Monzón J.Miguel Oliveira Chaozong Liu Departamento de Ingeniería Mecánica Grupo de Investigación en Fabricación Integrada y AvanzadaUniversidad de Las Palmas de Gran CanariaLas PalmasSpain Division of Surgery&Interventional Science University College LondonRoyal National Orthopaedic HospitalStanmoreUK B’s Research Group I3B’s-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoBarcoGuimarãesPortugal ICVS/3B’s-PT Government Associated Laboratory BragaGuimarãesPortugal.

Osteoarthritis is the most common chronic degenerative joint disease,recognized by the World Health Organization as a public health problem that affects millions of people *** project Biomaterials and Additive Manufacturing:Osteochondral Scaffold(BAMOS)innovation applied to osteoarthritis,funded under the frame of the Horizon 2020 Research and Innovation Staff Exchanges(RISE)program,aims to delay or avoid the use of joint replacements by developing novel cost-effective osteochondral scaffold technology for early intervention of *** multidisciplinary consortium of BAMOS,formed by international leading research centres,collaborates through research and innovation staff *** project covers all the stages of the development before the clinical trials:design of scaffolds,biomaterials development,processability under additive manufacturing,in vitro test,and in vivo *** paper reports the translational practice adopted in the project in in vivo assessment of the osteochondral scaffolds developed.

关键词： bone cartilage in vivo evaluation regenerative medicine tissue engineering

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Functionally graded additive manufacturing to achieve functionality specifications of osteochondral scaffolds

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Bio-Design and Manufacturing 2018年第1期1卷 69-75页

作者： Mario Monzon Chaozong Liu Sara Ajami Miguel Oliveira ricardo donate Viviana Ribeiro Rui L. Reis Departamento de Ingenieria Mecanica Universidad de Las Palmas de Gran Canaria Edificio de fabricacion integrada 35017 Las Palmas de GC Spain Division of Surgery and Interventional Science University College London Stanmore London HA7 4LP UK 3Bs Biomaterials Biodegradables and Biomimetics Universidade Do Minho Parque de Ciencia e Tecnologia Zona Industrial da Gandra 4805-17 Barco GMR Portugal Integrated and Advanced Manufacturing Processes Research Group Universidad de Las PaJmas de Gran Canaria Edificio de fabricacion integrada 35017 Las Palmas de GC Spain

IntroductionOsteoarthritis (OA) is a degenerative joint disease,characterized by cartilage loss and changes in bone at the interface of a joint resulting in pain,stiffness and reduced *** is one of the most prevalent chronic conditions as identified in Bone and Joint *** to the World Health Organization,40％ of people over the age of 70 have *** joint disease affects around 0.4 billion people with patients in Europe accounting for up to 30％.The figure is set to increase with the ageing problem.

关键词：骨性关节炎疾病治疗方法生物技术

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Influence of the Type of Circulatory/Ventricular Assistance in the Primary Graft Failure and Heart Transplantation Mortality

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World Journal of Cardiovascular Diseases 2019年第8期9卷 545-552页

作者： Raquel López-Vilella Ignacio J.Sánchez-Lázaro María Paz Fuset Cabanes Azucena Pajares Moncho Lucía donate Bertolín ricardo Gimeno Costa Ignacio Moreno Puigdollers Luis Martínez Dolz Iratxe Zarragoikoetxea Jauregui Salvador Torregrosa Puerta Luis Almenar Bonet Heart Failure and Transplant Unit Hospital Universitario y Politécnico La FeValenciaSpain Intensive Care Department Hospital Universitario y Politécnico La FeValenciaSpain Anesthesiology Department Hospital Universitario y Politécnico La FeValenciaSpain Cardiovascular Surgery Department Hospital Universitario y Politécnico La FeValenciaSpain

OBJECTIVES: In recent years, the percentage of heart transplantation (HT) with short/medium-term assistance devices has increased. This study aims at analyzing primary graft failure and in-hospital mortality according to the type of care. MATERIAL AND METHODS: From January 2013 to December?2017 all patients undergoing urgent HT with circulatory/ventricular assistance?were retrospectively and consecutively recruited. Combined transplants, retransplantations and pediatric transplants were excluded. The sample was divided in 10 groups according to the type of shot/medium term assistance devices. RESULTS: A total of 53 patients were recruited, 79% men, average age 49 ± 13 years. 26 patients (51%) had mechanical ventilation at the time of the HT. Primary graft failure occurred in 20 patients (38.5%), whilst it was more frequent in patients assisted with ECMO (8 patients in group 1 (45%) and 7 in group 2 (54%), p 0.5). 14 deaths (27%) were registered, whereas a higher mortality was observed in the group assisted with ECMO (6 patients in group 1 (34%) and 4 in group 2 (31%), p 0.6). Mortality was 17% in the group of non-urgent Levitronix. CONCLUSIONS: Despite not showing statistical significance due to the low number of patients in some subgroups, hospital?mortality was high in HT patients with circulatory assistance. A trend towards a higher incidence of primary graft failure and mortality in patients assisted with ECMO was observed. The direct implantation of a centrifugal pump as a bridge to urgent transplantation could identify a subgroup with a better prognosis.

关键词： Urgent Heart Transplantation Short-Medium Term Circulatory/Ventricular Assistance Primary Graft Failure

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