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Atherogenic Indices and HdL Particle Size as Laboratory Parameters to Evaluate Cardiovascular Risk in the Presence of dyslipidemia

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Journal of Biophysical Chemistry 2014年第2期5卷 24-32页

作者： Ana Paula C.Santos Marcos S.Vieira debora F.deus Rogerio Jorge Bde Oliveira Aleksandra T.Morikawa Roque Aras Ajax M.Atta Fabio d.couto Raul C.Maranhao ricardo d.couto Clinical Biochemistry Laboratory Department of Clinical and Toxicological AnalysisFaculty of PharmacyFederal University of Bahia/UFBASalvadorBrazil Naval Hospital of Salvador Brazilian Marine ForcesSalvadorBrazil Lipid Metabolism Laboratory of the Heart Institute(InCor-Clinical Hospital of Medical School) Faculty of PharmacyUniversity of Sao Paulo/USPSao PauloBrazil Ana Neri Hospital SESAB and Federal University of Bahia/UFBA Faculty of MedicineSalvadorBrazil Laboratory of Research in Immunology(LAPIM) Department of Clinical and Toxicological AnalysisFaculty of PharmacyFederal University of Bahia/UFBASalvadorBrazil Laboratory of Molecular Biology and Genetics at Center of Agricultural Environmental and Biological Sciences(CCAAB-UFRB)Cruz das AlmasBrazil Faculty of Pharmaceutical Sciences Clinical Chemistry DepartmentUniversity of Sao Paulo/USPSao PauloBrazil Central Clinical Laboratory of Professor Edgar Santos University Hospital Federal University of Bahia/UFBASalvadorBrazil

dyslipidemia may influence enzymes and transfer proteins needed to the lipoprotein particle remodeling. Calculated indices and evaluation of lipoprotein particle size have widely been used to predict cardiovascular risk. The aim of this study was to evaluate HdL particle size and LdL particle size estimate based on TG/HdL-C as well as apoB/apoA-I ratio as possible marker and atherogenic indices, respectively, of cardiovascular disease risk in the presence of dyslipidemia. We evaluated 100 individuals of both gender, without treatment with lipid-lowering drugs, 27 normolipidemic and 73 dyslipidemic, such as isolated hypercholesterolemia (n = 16), isolated hypertriglyceridemia (n = 17), low HdL-C (n = 26) and mixed dyslipidemia (n = 14). The HdL particle size did not differ between groups. The TG/HdL-C ratio was higher in groups with isolated hypertriglyceridemia (4.2 ± 1.5), low HdL-C (5.2 ± 3.1) and mixed dyslipidemia (5.3 ± 1.6). The apoB/apoA-I ratio was increased in all groups of dyslipidemia (apoB/apoA-I > 0.5) when compared to normolipidemic (apoB/apoA-I = 0.5, p dL-C ratio and the apoB/apoA-I ratio in low HdL-C group (r = 0.507, p = 0.008, Spearman). The results suggest that the evaluations of lipoproteins particles remodeling markers and the use of calculated indices may contribute to the evaluation of cardiovascular disease risk when dyslipidemia take place.

关键词： dyslipidemia Atherogenic Indices Cardiovascular Risk

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Localized-states quantum confinement induced by roughness in CdMnTe/CdTe heterostructures grown on Si(111) substrates

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Journal of Semiconductors 2024年第9期45卷 28-35页

作者： Leonarde N.Rodrigues Wesley F.Inoch Marcos L.F.Gomes Odilon d.d.couto Jr. Bráulio S.Archanjo Sukarno O.Ferreira Physics department Federal University of ViçosaViçosa36570-900Minas GeraisBrazil Instituto de Física Gleb Wataghin Universidade Estadual de CampinasCampinas13083-859São PauloBrazil National Institute of Metrology Quality and Technology(Inmetro) Materials Metrology Division(DIMAT)Xerém2525-020Rio de JaneiroBrazil

This work shows that despite a lattice mismatch of almost 20%, CdMnTe/CdTe/CdMnTe heterostructures grown directly on Si(111) have surprisingly good optical emission properties. The investigated structures were grown by molecular beam epitaxy and characterized by scanning transmission electron microscopy, macro-and micro-photoluminescence. Low temperature macro-photoluminescence experiments indicate three emission bands which depend on the CdTe layer thickness and have different confinement characteristics. Temperature measurements reveal that the lower energy emission band (at 1.48 eV)is associated to defects and bound exciton states, while the main emission at 1.61 eV has a weak 2d character and the higher energy one at 1.71 eV has a well-defined (zero-dimensional, 0d) 0d nature. Micro-photoluminescence measurements show the existence of sharp and strongly circularly polarized (up to 40%) emission lines which can be related to the presence of Mn in the heterostructure. This result opens the possibility of producing photon sources with the typical spin control of the diluted magnetic semiconductors using the low-cost silicon technology.

关键词： CdMnTe/CdTe/CdMnTe heterostructure CdTe/CdMnTe quantum emitters quantum dot-like emission silicon(111)substrate

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Localized-states quantum confinement induced by roughness in CdMnTe/CdTe heterostructures grown on Si(111) substrates

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Journal of Semiconductors 2024年第9期 34-42页

作者： Leonarde do Nascimento Rodrigues Wesley Fiorio lnoch Marcos L.F.Gomes Odilon d.d.couto Jr. Bráulio S.Archanjo Sukarno Olavo Ferreira Physics department Federal University of Vi?osa Instituto de Física Gleb Wataghin Universidade Estadual de Campinas National Institute of Metrology Quality and Technology (Inmetro) Materials Metrology Division (DIMAT)

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designing for well-Being: Using facial micro-expression analysis and EEG biosensor to evaluate human responses to 2d biophilically-driven geometries

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Frontiers of Architectural Research 2024年第2期13卷 219-234页

作者： Andrea Macruz Ernesto Bueno Gustavo Sol Jaime Vega ricardo Palmieri Bing Zhao College of Architecture and Urban Planning Tongji UniversityShanghaiChina Universidade Presbiteriana Mackenzie Sao PauloBrazil Centro Universitario Belas Artes Sao PauloBrazil Universidade Anhembi Morumbi Sao PauloBrazil Universidade Federal do ABC Santo AndreBrazil

This research explores the capacity of emerging technologies to enhance well-being. It involves the generation of 2d biophilically-driven geometries to represent human-response-oriented built environments and conducts inter and intra-individual analyses to assess human responses using a range of technologies within the realms of facial micro-expression analysis and EEG biosensor use. The outcomes of this analysis allow for the grading of these geometries in terms of emotional valences, meditation levels, and subjective preferences. These graded geometries can subsequently be employed in specific architectural contexts, such as interior decor, wallpapers, furniture surfaces, or other architectural and interior components. It is an interdisciplinary effort that underscores the importance of incorporating emerging technological means with human-response-oriented design approaches to foster built environments that promote well-being.

关键词： Biophilic design Geometrical algorithmicmodeling Facial micro-expressionanalysis EEG biosensor Neuroscience

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Optimizing building retrofit through data analytics:A study of multi-objective optimization and surrogate models derived from energy performance certificates

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Energy and Built Environment 2024年第6期5卷 889-899页

作者： G.R.Araújo ricardo Gomes Paulo Ferrão M.Glória Gomes IN+ DEMTécnico LisboaUniversidade de lisboaAv Rovisco PaisLisboa1049-001Portugal CERIS DECivilTécnico LisboaUniversidade de LisboaAv Rovisco PaisLisboa1049-001Portugal

The building stock is responsible for a large share of global energy consumption and greenhouse gas emissions,therefore,it is critical to promote building retrofit to achieve the proposed carbon and energy neutrality *** of the policies implemented in recent years was the Energy Performance Certificate(EPC)policy,which proposes building stock benchmarking to identify buildings that require ***,research shows that these mechanisms fail to engage stakeholders in the retrofit process because it is widely seen as a mandatory and complex *** study makes use of an EPC database to integrate machine learning techniques with multi-objective optimization and develop an interface capable of(1)predicting a building’s,or household’s,energy needs;and(2)providing the user with optimum retrofit solutions,costs,and return on *** goal is to provide an open-source,easy-to-use interface that guides the user in the building retrofit *** energy and EPC prediction models show a coefficient of determination(R2)of 0.84 and 0.79,and the optimization results for one case study EPC with a 2000€budget limit inÉvora,Portugal,show decreases of up to 60%in energy needs and return on investments of up to 7 in 3 years.

关键词： Building energy performance Building optimization Multi-Objective surrogate models Building retrofitting

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dysregulated microRNAs in type 2 diabetes and breast cancer:Potential associated molecular mechanisms

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World Journal of diabetes 2024年第6期15卷 1187-1198页

作者： Alex Cleber Improta-Caria Filipe Ferrari João Lucas Penteado Gomes Paloma Brasilio Villalta Úrsula Paula RenóSoci ricardo Stein Edilamar M Oliveira Laboratory of Biochemistry and Molecular Biology of the Exercise Physical Education and Sport SchoolUniversity of São PauloSão Paulo 05508-030Brazil Graduate Program in Cardiology and Cardiovascular Sciences Federal University of Rio Grande do SulHospital de Clínicas de Porto AlegrePorto Alegre 90035003Brazil Laboratory of Metabolic disorders(Labdime) School of Applied SciencesUniversity of Campinas-UNICAMPCampinas 13484-350Brazil departments of Internal Medicine Molecular Pharmacology and PhysiologyCenter for Regenerative MedicineUSF Health Heart InstituteMorsani College of MedicineUniversity of South FloridaTampaFL 33602United States

Type 2 diabetes(T2d)is a multifaceted and heterogeneous syndrome associated with complications such as hypertension,coronary artery disease,and notably,breast cancer(BC).The connection between T2d and BC is established through processes that involve insulin resistance,inflammation and other *** this comprehension the specific cellular and molecular mechanisms linking T2d to BC,especially through microRNAs(miRNAs),remain *** are regulators of gene expression at the post-transcriptional level and have the function of regulating target genes by modulating various signaling pathways and biological ***,the signaling pathways and biological processes regulated by miRNAs that are associated with T2d and BC have not yet been *** review aims to identify dysregulated miRNAs in both T2d and BC,exploring potential signaling pathways and biological processes that collectively contribute to the development of BC.

关键词： Type 2 diabetes Breast cancer MicroRNAs Molecular mechanisms

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ITPK1 is an InsP_(6)/AdP phosphotransferase that controls phosphate signaling in Arabidopsis

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Molecular Plant 2024年第7期17卷 1151-1157页

作者： Esther Riemer danye Qiu debabrata Laha Robert K.Harmel Philipp Gaugler Verena Gaugler Michael Frei Mohammad-Reza Hajirezaei Nargis Parvin Laha Lukas Krusenbaum Robin Schneider Adolfo Saiardi dorothea Fiedler Henning J.Jessen Gabriel Schaaf ricardo F.H.Giehi 不详

(Molecular Plant 14,1864-1880;November 12021)We identified a mistake made when calculating the absolute concentrations of inositol(pyro)phosphates derived from CE-ESl-MS measurements reported in the originally published version of our *** to a calculation error when determining concentrations per fresh biomass,the absolute values shown in the manuscript are approximately 30-fold lower than they should *** mistake affects Figures 2d,3C,4C,and 7d and Figures S4,S11B,S13,and *** all conclusions made in the article referred to relative differences between genotypes and treatments,they remained unaffected by these mistakes.

关键词： ipt Arabidopsis absolute

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Modeling of Fluidized Bed Gasification:Assessment of Zero-dimensional and CFd Approaches

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Journal of Thermal Science 2015年第4期24卷 378-385页

作者： Nuno couto Valter Silva Eliseu Monteiro P.S.d.Brito Abel Rouboa University of Tras-os-Montes and Alto douro INEGI/Faculty of Engineering University of Porto C3i-Interdisciplinary Center for Research and Innovation Polytechnic Institute of PortalegreLugar da AbadessaApartado 1487301-901PortalegrePortugal MEAM department University of Pennsylvania

In modeling fluidized bed gasification experiments,equilibrium and CFd models are valuable *** existence of multi-dimensional effects inside the reactor vessel due to the kinetics of the process and the fluid dynamics phenomena could result in deviation from the zero-dimensional *** models integrating kinetics and hydrodynamics are being developed by using a computer fluid dynamics(CFd)*** objective of this investigation is to assess and compare the adequacy of zero-dimensional and CFd approaches in modeling fluidized bed gasification regarding a semi-industrial scale(numerical results are validated under experimental runs).Results show that the zero-dimensional model based on the approach of dual stage equilibrium performs reasonably well in adequately predicting the product gas composition at different operating conditions and for different feedstocks,although with quantitative ***,the discrepancy depends on the oxygen content of the oxidation agent and on the steam-to biomass ratio decreasing when these parameters *** models provide deeper information being able to estimate the syngas composition or other operating parameter at any point of space and *** of some quantitative discrepancy,the zero-dimensional modeling approach is deemed satisfactory from the viewpoint of the determining design conditions simulation.

关键词： Gasification CFd model dual stage equilibrium model

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Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation

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Neural Regeneration Research 2020年第3期15卷 407-415页

作者： Heather R.Lucas ricardo d.Fernández department of Chemistry Virginia Commonwealth University

N-acetylatedα-synuclein(αSyn)has long been established as an intrinsically disordered protein associated with a dysfunctional role in Parkinson’s *** recent years,a physiologically relevant,higher order conformation has been identified as a helical tetramer that is tailored by buried hydrophobic interactions and is distinctively aggregation *** canonical mechanism by which the tetramer assembles remains *** novel biochemical approaches,computational methods,pioneering purification platforms,and powerful imaging techniques continue to develop,puzzling information that once sparked debate as to the veracity of the tetramer has now shed light upon this new counterpart inαSyn *** magnetic resonance and computational studies on multimericαSyn structure have revealed that the protein folding propensity is controlled by small energy barriers that enable large scale ***,familial mutations ablate tetramerization and reconfigure polymorphic *** this review,we will discuss the dynamic landscape ofαSyn quaternary structure with a focus on the tetrameric conformation.

关键词： alpha-synuclein amyloid fibrils intrinsically disordered protein multimer N-acetylation oligomer Parkinson’s disease protein folding protein structure tetramer

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deduction and Validation of an Eulerian-Eulerian Model for Turbulent dilute Two-Phase Flows by Means of the Phase Indicator Function-disperse Elements Probability density Function

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Chinese Journal of Chemical Engineering 2000年第3期8卷 189-202页

作者： Santiago Laín ricardo Aliod MVT-UST Fachbereich Ingenieurwissenschaften Martin-Luther-UniversitatHalle-WittenbergD-06099Halle(Saale)GermanyFluid Mechanica DepartmentE.U.Politecnica de Huesca.University of ZaragozaCarretera Zaragoza km.6722071 HuescaSpain

A statistical formalism overcoming some conceptual and practical difficulties arising in existing two-phase flow (2PHF) mathematical modelling has been applied to propose a model for dilute 2PHF turbulent Hows. Phase interaction terms with a clear physical meaning enter the equations and the formalism provides some guidelines for the avoidance of closure assumptions or the rational approximation of these terms. Continuous phase averaged continuity, momentum, turbulent kinetic energy and turbulence dissipation rate equations have been rigorously and systematically obtained in a single step. These equations display a structure similar to that for single-phase flows. It is also assumed that dispersed phase dynamics is well described by a probability density function (pdf) equation and Eulerian continuity, momentum and fluctuating kinetic energy equations for the dispersed phase are deduced. An extension of the standard k-e turbulence model for the continuous phase is used. A gradient transport model is adopted for the dispersed phase fluctuating fluxes of momentum and kinetic energy at the non-colliding, large inertia limit. This model is then used to predict the behaviour of three axisymmetric turbulent jets of air laden with solid particles varying in size and concentration. Qualitative and quantitative numerical predictions compare reasonably well with the three different sets of experimental results, studying the influence of particle size, loading ratio and flow confinement velocity.

关键词： two-phase flow turbulence phase indicator function pdf ensemble average jet

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