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Effects of aquatic exercise on depression and anxiety in ischemic stroke subjects

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Health 2013年第2期5卷 222-228页

作者： Felipe J.Aidar Nuno D.Garrido Antonio J.Silva Victor M.reis Daniel A.Marinho ricardo Jaco de Oliveira 5^(th) Military State Fireman UberlândiaBrazil University of Tras-os-Montes and Alto Douro—UTAD/CIDESD Vila RealPortugal University of Beira Interior—UBI/CIDESD CovilhaPortugal University of Brasilia—UnB BrasiliaBrazil

Background: Stroke ranks third and is the leading cause of permanent disability in western countries. Furthermore there are no treatments for the psychosocial effects of this pathology. Purpose: Analyse the effect of an aquatic exercise program in depression and trace and state anxiety in subjects who suffered an ischemic stroke. Methods: Two groups were analyzed: experimental group (EG) n = 15, 50.3 ± 9.1 years;control group (CG) n = 13, 52.5 ± 7.7 years. EG underwent a 12-week aquatic exercise program. Both groups were evaluated in pre and post- treatment using Beck Depression Inventory (BDI) and Trace State Anxiety Inventory (IDATE). Wilcoxon signed-rank and Mann-Whitney tests were used to compare moments and groups, respec- tively. Results: The BDI scores of aquatic activities were: pre-treatment, 17.4 ± 7.7 and 16.9 ± 8.6 for the EG and CG, respectively;post-treat- ment, 13.2 + 7.1 and 16.4 + 7.9 for the EG and CG, respectively. The IDATE scores for anxiety trace in strength training were: pre-treatment, 43.2 + 12.5 and 42.9 + 12.2 for the EG and CG, respec- tively;post-treatment, 39.7 + 7.1 and 42.6 + 12.1 for the EG and CG, respectively. The IDATE scores for anxiety state in strength training were: pre-treatment, 46.9 + 7.6 and 47.4 + 8.1 for the EG and CG, respectively;post-treatment, 44.4 + 7.9 and 47.5 + 8.0 for the EG and CG, respectively. Significant differences were found in pre and post-treatment values in the EG and between groups in the depression and trace and state anxiety levels in post-treatment (p Conclusions: Aquatic physical activity contributes to an improvement of the levels of depression and anxiety in people who suffered a stroke.

关键词： Aquatic Physical Activity Beck Depression Inventory Cardiovascular Disease Cerebrovascular Accident Ischemic Stroke Trace State Anxiety Inventory

Antifungal Activity of Oleoresin and Fractions of Pinus elliottii Engelm and Pinus tropicalis against Phytopathogens

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American Journal of Plant Sciences 2014年第26期5卷 3898-3903页

作者： Gessica andrade Fariza Abrao Patrick Silva Sergio ricardo Ambrosio Rodrigo Cassio Sola Veneziani Wilson Roberto Cunha Regina Helena Pires Carlos Henrique G.Martins Laboratory of Research in Applied Microbiology University of FrancaFrancaBrazil Research Group on Natural Products University of FrancaFrancaBrazil

Microorganism resistance to the existing products is yet another difficulty that agriculturalists have to deal with. In this context, the search for new agricultural products that can fight phytopathogens has become increasingly important. Plants have played an important role in this process, because they can serve as a source of new compounds for drug discovery. Plants belonging to the genus Pinus produce an oleoresin that protects the plant against herbivores and pathogens. With a view to developing products that can combat fungal pathogens without harming the environment, this work aimed to evaluate the antifungal activity of the oleoresins and fractions of Pinus elliottii Engelm and Pinus tropicalis against phytopathogens. The methodology based on NCCLS M38-A standards aided antifungal activity assessment. The microdilution method helped to determine the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). The oleoresins of P. elliottii and P. tropicalis afforded the most significant results—they displayed fungicidal activity against all the tested species. MIC values were promising, especially the MIC of the oleoresin of P. elliottii against S. rolfsii (1.95 μg·mL-1). The MIC values of the oleoresins of P. elliottii and P. tropicalis ranged from 1.95 to 1000 μg·mL-1 and from 31.25 to 250 μg·mL-1, respectively. Fraction PT2 of P. tropicalis furnished the best results among all the assayed fractions: MIC values lay between 125 and 500 μg·mL-11. In conclusion, the oleoresin of P. tropicalis is a promising source of new antifungal agents for application in the treatment of phytopathogenic infections.

关键词： Pinus elliottii Pinus tropicalis Phytopathogens Antifungal Activity Oleoresin

腐植酸促进候选细菌丰富植物微生物群以抑制病原体

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腐植酸 2022年第3期 103-115页

作者： Maura Santos reis de andradeda Silva Orlando Carlos Huertas Tavares Thiago Gonçalves Ribeiro Camilla Santos reis de andradeda Silva Carolina Santos reis de andradeda Silva JoséMaria García-Mina Vera Lúcia Divan Baldani Andrés Calderín García ricardo Luiz Louro Berbara Ederson da Conceição Jesus 李子东(译) 熊传教(译) 周欣(译) 余玲玲(译) 刘可星(译) 巴西农业研究公司里约热内卢联邦农村大学弗洛米嫩塞联邦大学西班牙纳瓦拉大学华南农业大学资源环境学院

腐植酸(HA)通过调节植物的激素和氧化还原代谢来刺激几种植物种类的生长,然而,关于HA与植物相关菌群的关系鲜有报道。本文中,我们假设HA效应与植物相关细菌群落的调控同时发生,水稻在施用或不施用HA(80 mg/L)的营养液中生长264 h,每24 ... 详细信息

腐植酸(HA)通过调节植物的激素和氧化还原代谢来刺激几种植物种类的生长,然而,关于HA与植物相关菌群的关系鲜有报道。本文中,我们假设HA效应与植物相关细菌群落的调控同时发生,水稻在施用或不施用HA(80 mg/L)的营养液中生长264 h,每24 h评价1次植株生长,施用240 h后取样品进行16S rRNA基因测序。第1次施用HA后,从100 h到264 h植株净同化率、绝对生长率和相对生长率增加,根系体积和其他生长变量在植物生长周期的不同时间受到刺激。宏基因组分类揭示,使用HA后细菌群落结构和组成受到影响,HA处理的根部,群落成员间的相互作用增强,显示更多关联更密切的细菌群落,鞘氨醇菌属(Chitinophaga)和粘液杆菌属(Mucilaginibacter)是HA处理后根系的优势菌属。据报道,这些细菌能产生酶,降解真菌、卵菌和线虫卵壁中的化合物。铁载体产生者和植物生长促进者——假单胞菌(Pseudomonas)和酸杆菌Gp1(Acidobacteria Gp1)均富集,虽然丰度较低。鉴于这些结果,我们认为植物组建这些微生物是为了应对HA—根互作引起的胁迫。我们的研究结果首次表明,受HA刺激的植物可能采用组建细菌群落成员的生态策略,这些细菌群落成员是抑制病原体的候选者,因而参与植物防御.

关键词：腐殖质宏基因组分类植物微生物群植物生长促进植物-微生物互作植物防御

Prevalence of Low Levels of Vitamin D in Type 2 Diabetes at the City of Mangueirinha, Paraná, Southern Brazil

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Open Journal of Endocrine and Metabolic Diseases 2016年第1期6卷 8-12页

作者： Paulo Sérgio Chiamolera Cristiano Alvariza Amaral Monica Cristina de Oliveira Russo Gilberto de Oliveira Netto ricardo Augusto Fernandes ricardo Teles de andrade José Luiz Gonçalves Buscariolli Denise Rosso Tenório Wanderley Rocha Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School Sao Paulo Brazil Visiting Scholar Harvard T. H. Chan School of Public Health Harvard University Boston USA

Background: Diabetes mellitus is a worldwide epidemic. In 2002 there were 173 million diabetic adults worldwide, and these numbers are expected to reach up to 300 million people by 2030. Meanwhile, vitamin D deficiency has its worldwide prevalence directly influenced by factors as solar radiation, skin color, latitude and seasons, cultural habits of populations such as clothing and food, and these factors are important to explain the different prevalences of vitamin D deficiency in the world. Methods: A prospective cross-sectional cohort study was conducted with patients in the outpatient clinic of the Health Unit of the city of Mangueirinha, Paraná, Southern Brazil. Fifty-four type 2 diabetic patients were evaluated (38 women and 16 men), aged 55.8 ± 12.6 years. The following variables were evaluated: age, ethnicity, presence of type 2 diabetes (DM2), hypertension, dyslipidemia, weight, BMI, WC, blood pressure, blood glucose, glycated hemoglobin, ionized calcium, PTH, 25-OH Vit, total cholesterol, HDL, LDL, urea, creatinine, uric acid and red cell/hematocrit. Results: mean BMI was 30.2 ± 4.4 kg/m2, indicating class 1 obesity in this population. Fasting glucose levels were approximately 169.8 ± 74.5 mg/dL. The 25-OH vitamin D values for this population were 23.4 ± 8.3 ng/mL, and 13% of them showed 25-OH vitamin D levels above 30 mg/dL. Fifty percent of those patients had vitamin D levels lower than 30 mg/dL, and 37% had less than 20 mg/dL. Conclusions: this study suggests that vitamin D is associated with low levels of vitamin D in type 2 diabetic patients. Supplementation of vitamin D should be considered in diabetic patients, when levels under 30 mg/mL are found.

关键词： 25 OH Vitamin D Type 2 Diabetes Mellitus Cardiovascular Risk

Bee venom acupuncture reduces neuroinflammation modulating microglia/macrophage phenotype polarization in spinal cord injury compression model

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Neuroimmunology and Neuroinflammation 2019年第11期6卷 1-13页

作者： Raquel do Nascimento de Souza Júlia Miccolis Azevedo Lopes Lívia da Rocha Natalino Monteiro Raiana andrade Quintanilha Barbosa Gabriela Hollmann Silvana Allodi Luis Carlos reis MagdaAlves de Medeiros Department of Physiological Sciences Institute of Biology and Health SciencesFederal Rural University of Rio de JaneiroSeropedica 23897-000RJBrazil Carlos Chagas Filho Institute of Biophysics Federal University of Rio de JaneiroRio de Janeiro 21941-902RJBrazil.

Aim: The present study aimed to examine whether apipuncture (stimulation of acupuncture points with bee venom)at ST36 and GV3 acupoints promotes neuroprotection and reduces neuroinflammation by modulating M1 and M2 phenotype ***: Wistar rats were treated with bee venom (BV) (0.08 mg/kg) injection at acupoints ST36 and GV3 [BV (ST36 + GV3)-spinal cord injury (SCI)] or BV injection at non-acupoints [BV (NP)-SCI] or no treatment (CTL-SCI)after SCI by compression. The spinal cord mRNA expression of iNOS, Arg-1 and TGF-β was measured by real time PCR and the levels of IBA-1;BCL-2;NeuN e CNPase was measured by western blotting. Locomotor performance was measured by Basso, Beattie, and Bresnahan (BBB) and grid-walking ***: Apipuncture treatment was able to (1) ameliorate locomotor performance;(2) reduce inflammatory markers (Cox-2 levels) and activation of microglia and macrophages;(3) reduce the polarization of the M1 phenotype marker (iNOS) and increase M2 (Arg-1 and TGF-β) phenotypic markers;(4) promote neuroprotection by reducing the death of neurons and oligodendrocytes;and (5) increase the expression of the anti-apoptotic factor ***: Apipuncture treatment induces locomotor recovery and neuroprotection after the compression model of spinal cord injury. Further, it reduces neuroinflammation by decreasing M1 polarization and increasing M2 phenotype.

关键词： Acupuncture bee venom spinal cord injury compression microglia macrophage neuroinflammation

Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease

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World Journal of Gastroenterology 2007年第7期13卷 1067-1073页

作者： Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson andrade de Carvalho Bernd Genser ricardo Ribeiro dos Santos luiz Guilherme Costa lyra Hos-pital Sao Rafael Salvador Bahia Brazil Centro de Pesquisas Goncalo Moniz Fundacao Oswaldo Cruz Salvador Bahia Brazil BGStats Consulting Graz Austria

AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease.

关键词：可行性分析安全性能自体骨髓干细胞细胞移植慢性肝疾病

SCS123 Pérola: A Brazilian Rice Variety for Risotto

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Agricultural Sciences 2018年第12期9卷 1589-1600页

作者： Ester Wickert Adriana Pereira Alexander de andrade Fabiana Schmidt Klaus Konrad Scheuermann Rubens Marschalek José Alberto Noldin Gabriela Neves Martins Eduardo Hickel Marcos Lima Campos do Vale Laerte reis Terres Agricultural Research and Rural Extension Company of Santa Catarina (EPAGRI) Itajaí Experimental Station Itajaí Brazil

Specialty rices can present differences in some aspects related to grain pericarp color, shape, size, amylose content or aroma. Most of these rice types are related to cultural traditions and ceremonies, and some of them have also different nutritional value. As a specific market, the economic values of these grains are also higher than common milled rice. Santa Catarina State has the ideal conditions to produce specialty rices. The objective of this work was to develop a rice cultivar with special attributes for the well-appreciated risotto. Two rice lines were combined, evaluated and selected during ten years for characteristics related to Italian food. One line was selected and becomes the new rice variety SCS123 Pérola, developed to attend the economically important specialty rices market of Italian food, specifically the risotto. Experimental tests performed with this variety showed that it can be recommended to all rice-producing regions of Santa Catarina State, Brazil. Cooking tests showed that the grains are appropriated for risotto.

关键词： Agriculture Rice Production Oryza sativa Rice Breeding Specialty Rices

Therapy with bone marrow cells reduces liver alterations in mice chronically infected by Schistosoma mansoni

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World Journal of Gastroenterology 2008年第38期14卷 5842-5850页

作者： Sheilla andrade Oliveira Bruno Solano Freitas Souza Carla Adriana Guimares-Ferreira Elton Sá Barreto Siane Campos Souza Luiz Antonio Rodrigues Freitas ricardo Ribeiro-dos-Santos Milena Botelho Pereira Soares Centro de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas 40295-001 Salvador BA Brazil Centro de Pesquisas Aggeu Magalhes Fundao Oswaldo Cruz Recife Av Moraes Rego s/n Cidade Universitária Recife 50670-420 PE Brazil Centro de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas Salvador 40295-001 BA Brazil Centro de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas 40295-001 Salvador BA Brazil Hospital So Rafael Av So Rafael 2152 So Marcos Salvador 41256-900 BA Brazil

AIM: To investigate the potential of bone marrow mononuclear cells (BM-MCs) in the regeneration of hepatic lesions induced by Schistosoma mansoni (***) chronic infection. METHODS: Female mice chronically infected with *** were treated with BM-MCs obtained from male green fluorescent protein (GFP) transgenic mice by intravenous or intralobular injections. Control mice received injections of saline in similar conditions. Enzyme-linked immunosorbent assay (ELISA) assay fortransforming growth factor-beta (TGF-β), polymerase chain reaction (PCR) for GFP DNA, immunofluorescence and morphometric studies were performed. RESULTS: Transplanted GFP+ cells migrated to granuloma areas and reduced the percentage of liver fibrosis. The presence of donor-derived cells was confirmed by Fluorescence in situ hybridization (FISH) analysis for detection of cells bearing Y chromosome and by PCR analysis for detection of GFP DNA. The levels of TGF-β, a cytokine associated with fibrosis deposition, in liver fragments of mice submitted to therapy were reduced. The number of oval cells in liver sections of ***-infected mice increased 3-4 fold after transplantation. A partial recovery in albumin expression, which is decreased upon infection with ***, was found in livers of infected mice after cellular therapy. CONCLUSION: In conclusion, transplanted BMCs migrate to and reduce the damage of chronic fibrotic liver lesions caused by ***.

关键词：肝损害肝纤维化骨髓细胞慢性感染动物模型治疗

COVID-19:It's still time for health professionals,physical activity enthusiasts and sportive leagues not to let guard down

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Sports Medicine and Health Science 2021年第1期3卷 49-53页

作者： Rodrigo L.Vancini Marília S.andrade Pantelis T.Nikolaidis Beat Knechtle Thomas Rosemann ricardo B.Viana Claudio A.B.de Lira Centro de Educaçao Física e Desportos(CEFD) Universidade Federal do Espírito Santo(UFES)Espírito Santo(ES)Brazil Departamento de Fisiologia Universidade Federal de Sao Paulo(UNIFESP)Sao Paulo(SP)Brazil Exercise Physiology Laboratory NikaiaGreece Medbase St.Gallen Am Vadianplatz St.Gallen and Institute of Primary CareUniversity of ZurichZurichSwitzerland Institute of Primary Care University of ZurichSwitzerland Setor de Fisiologia Humana e do Exercício Faculdade de Educaçao Física e DançaUniversidade Federal de Goias(UFG)GoianiaGois(GO)Brazil Setor de Fisiologia Humana e do Exercício Faculdade de Educaçao Física e DançaUniversidade Federal de Goias(UFG)Goi^aniaGoias(GO)Brazil

Emerging viral diseases represent a serious issue to public and global healthcare systems and have a high potential for disease dissemination in sport/physical activity and exercise *** Coronavirus disease 2019(COVID-19)pandemic has frightened the sports and physical activity community and enthusiasts for potential trans-mission,dissemination,and lethality in vulnerable populations;those with chronic diseases,co-morbidities,the elderly people,and in young and healthy *** pandemic has caused a chain reaction with cancellations of sports competitions and gymnasiums closing around the ***,some sporting events are gradually resuming in certain regions of the world and also the return of competitions and *** general,without fans and public,the sports media can only report the infection of athletes and coaching staff ***,this situation is dynamic-the world is currently experiencing the second wave of the disease;with the safety and containment measures for the disease is changing *** purpose of this article is to present information concerning the COVID-19 pandemic,to clarify health issues for professionals and people connected to sport and physical activity venues,presenting information to assist in educations and the health promotion and *** time is now for making changes,reviewing the actions and conducts necessary for prevention,and most importantly not letting our guard down,even as vaccines become available for all people in the *** that even after getting vaccinated,it is necessary to continue with safety measures,for example,the use of facial masks and social distance and hygiene,that is,washing your hands frequently and/or sanitizing with 70%*** can't let our guard down for COVID-19.

关键词： Viral disease Covid-19 Coronavirus Sport Physical activity