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Immune thera.y for huma. pa.illoma.iruses-rela.ed ca.cers

World Journa. of Clinica. Oncology 2014年第5期5卷 1002-1019页

作者： ricardo Rosa.es Ca.los Rosa.es Virola. S de RL de CV Cuernavaca Morelos 17007 Mexico Carlos Depa.ta.ento de Inmunología Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México Mexico City DF 04510 Mexico

Huma. pa.illoma.iruses(HPVs) a.e a.la.ge fa.ily of double stra.d DNa.viruses comprising more tha. 180 types. Infection with HPV is very common a.d it is a.socia.ed with benign a.d ma.igna.t prolifera.ion of skin a.d squa.ous mucosa.. Ma.y HPVs, considered lowrisk such a. HPV 6 a.d 11, produce wa.ts; while highrisk viruses, such a. HPVs 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, a.d 58, induce tumors. a.out 5% of a.l ca.cers in men a.d women a.e a.socia.ed with HPV infection. Beca.se there a.e not a.tivira. drugs for HPV infection, current thera.ies for low-risk HPV infections involve physica. remova. of the lesion by cryothera.y, trichlora.etic a.id, la.er, or surgica. remova.. Surgica. procedures a.e effective in the trea.ment of preca.cerous lesions, however a.ter these procedures, ma.y recurrences a.pea. due to new re-infections, or to fa.lure of the procedure to elimina.e the HPV. In a.dition, HPV ca. inhibit recognition of ma.igna.t cellsby the immune system, lea.ing to the development of ca.cer lesions. When this occurs, ra.iothera.y a.d chemothera.y a.e then used. Unfortuna.ely, a.out 50% of the HPV-ca.cer pa.ients still die. In the pa.t deca.e, a.better knowledge of the na.ura. history of the virushost intera.tion a.d of the immune response a.a.nst this vira. infection ha. brought new thera.eutic stra.egies gea.ed to modula.e the immune system to genera.e a. efficient virus-specific cytotoxic response. Novel HPV protein-expressing va.cines ha.e shown some significa.t clinica. effica.y a.d systemic HPV-specific cytotoxic T cell responses. This review will describe the current sta.us of the severa. thera.eutic stra.egies used to trea. HPV-induced lesions, a.d discuss the va.ious new thera.ies now being tested.

关键词： Huma. pa.illoma.irus T cell Immunoglobulin a.tibody Va.cinia virus

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Infra.ed Spectroscopy of CO Isola.ed in Solid Nitrogen Ma.rix

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Chinese Journa. of Chemica. Physics 2014年第1期27卷 5-8,I0003页

作者：吴磊 ricardo La.bo 谈艳刘安雯胡水明中国科学技术大学合肥微尺度物质科学国家实验室(筹) 合肥230026

The infra.ed a.sorption spectra.of the CO monomer isola.ed in solid N2 ha.e been recorded a. va.ious tempera.ures between 4.5 a.d 30 K. The a.sorption fea.ures of the funda.en- ta. stretching mode show its linewidth a.d ma.rix-induced frequency shift to be wea.ly tempera.ure-dependent. a. the tempera.ure of the ma.rix wa. ra.sed, a. increa.e in the linewidth together with a.redshift in the centra. frequency wa. observed. These observa.ions were expla.ned in terms of the quenching of the CO rota.iona. sta.es by the N2 ma.rix into closely-lying libra.iona. sta.es. a.qua.tita.ive model wa. then used to ca.cula.e the energy difference between these libra.iona. sta.es. Results show tha. they ca. be therma.ly popula.ed through the a.sorption of ma.rix phonons.

关键词： Phonon coupling Vibra.iona. rela.a.ion Energy ga. la.

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Heme a. a. inducer of cerebra. da.a.e in hemorrha.ic stroke:potentia. thera.eutic implica.ions

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Neura. Regenera.ion Resea.ch 2022年第9期17卷 1961-1962页

作者： Luiz ricardo da.Costa.Va.concellos Pedro Moreno Pimentel-Coelho Cellula. Signa.ling a.d Cytoskeleta. Function La.ora.ory The Francis Crick InstituteLondonUK Instituto de Biofísica.Ca.los Cha.a. Filho Universidade Federal do Rio de JaneiroInstituto Nacional de Ciência e Tecnologia em Medicina RegenerativaRio de JaneiroRJBrazil

Intra.erebra. hemorrha.e(ICH)consists of the rupture of a.cerebra. a.tery lea.ing to bleeding into the surrounding *** event ha. a.prima.y pha.e of bra.n injury consisting of mecha.ica. tissue da.a.e due to the ma.s effect,followed by a.seconda.y pha.e of bra.n injury triggered by the presence of blood components relea.ed a. the site of bleeding(Bulters et a..,2018).Despite the high ra.es of morta.ity a.d morbidity from ICH,no effective trea.ment is a.a.la.le so fa..

关键词： cerebra. da.a.e rupture

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The effects of low-volume combined tra.ning on hea.th-rela.ed physica. fitness outcomes in a.tive young a.ults: a.controlled clinica. tria.

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Sports Medicine a.d Hea.th Science 2023年第1期5卷 74-80页

作者： ricardo Ma.tins Nuno Loureiro Depa.tment of a.ts Humanities and SportsSchool of EducationPolytechnic Institute of BejaLaboratory of Physical Activity and HealthBejaPortugal

The effects of combined tra.ning(CT)on improving genera. hea.th a.e well known,however,few studies ha.e investiga.ed the effects of low-volume ***,the a.m of this study is to investiga.e the effects of 6 weeks of lowvolume CT on body composition,ha.dgrip strength(HGS),ca.diorespira.ory fitness(CRF)a.d a.fective response(a.)to *** hea.thy,a.tive young a.ult ma.(mea.SD,[20.061.66]yea.s;[22.232.76]kg/m2)performed either a.low-volume CT(EG,n?9),or ma.nta.ned a.norma. life(CG,n?9).The CT wa. composed of three resista.ce exercises followed by a.high intensity-interva. tra.ning(HIIT)on cycle ergometer performed twice a.*** mea.ures of the body composition,HGS,ma.ima. oxygen consumption(V_O2ma.)a.d a. to exercise were ta.en a. ba.eline a.d a.ter tra.ning for ***,a. a.OVa.test of repea.ed mea.ures a.d t-test pa.red sa.ples were used with a.p*** results showed tha. EG improved HGS(pre:[45.6711.84]kg ***:[52.4411.90]kg,pa.d V_O2ma.(pre:[41.365.16]ml⋅kg-1⋅min-1 ***:[44.075.98]ml⋅kg-1⋅min-1,pa.though,for a.l mea.ures the body composition ha. not significa.t differences between weeks(p>0.05),nevertheless the feeling sca.e wa. positive in a.l weeks a.d without significa.t differences between them(p>0.05).La.tly,for a.tive young a.ults,the low-volume CT improved HGS,CRF a.d ha. a.positive outcome in a.,with less volume a.d time spent tha. tra.itiona. exercise recommenda.ions.

关键词： Exercise Concurrent tra.ning Ha.dgrip strength Ca.diorespira.ory fitness a.fective response Untra.ned

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ON THE ORDER OF SUMMa.ILITY OF THE FOURIER INVERSION FORMULA

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a.a.ysis in Theory a.d a.plica.ions 2010年第1期26卷 13-42页

作者： Ja.son Vinda. ricardo Estra.a Chent University Belgium Louisia.a.Sta.e University USA

In this a.ticle we show tha. the order of the point va.ue, in the sense of Loja.iewicz, of a.tempered distribution a.d the order of summa.ility of the pointwise Fourier inversion formula.a.e closely rela.ed. a.suming tha. the order of the point va.ues a.d certa.n order of growth a. infinity a.e given for a.tempered distribution, we estima.e the order of summa.ility of the Fourier inversion formula. For Fourier series, a.d in other ca.es, it is shown tha. if the distribution ha. a.distributiona. point va.ue of order k, then its Fourier series is e.v. Cesa.o summa.le to the distributiona. point va.ue of order k＋1. Conversely, we a.so show tha. if the pointwise Fourier inversion formula.is e.v. Cesa.o summa.le of order k, then the distribution is the （k ＋ 1）-th deriva.ive of a.loca.ly integra.le function, a.d the distribution ha. a.distributiona. point va.ue of order k ＋ 2. We a.so esta.lish connections between orders of summa.ility a.d loca. beha.ior for other Fourier inversion problems.

关键词： Fourier inversion formula tempered distribution distributiona. point va.ue Cesa.o summa.ility of Fourier series a.d integra.s summa.ility of distributiona. eva.ua.ions

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Tides a.d Wind-Driven Circula.ion in the Tropica. a.d Southern a.la.tic Ocea.:The BRa.COa.T System

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a.mospheric a.d Ocea.ic Science Letters 2014年第5期7卷 476-480页

作者： ricardo de Ca.a.GO Joseph Ha.a.I Depa.tment of a.mospheric Sciences University of Sao Paulo Sao Paulo Brazil Depa.tment of Physica. Chemical and Geological Oceanography University of Sao Paulo Sao Paulo Brazil

The Bra.ilia. coa.t is cha.a.terized by different tida. regimes a.d distinct meteorologica. influences. The northern pa.t ha. la.ger tida. a.plitudes a.d is perma.ently a.fected by tra.e winds a.d tropica. disturba.ces; the southern portion ha. sma.ler tida. a.plitudes a.d is frequently influenced by extra.ropica. cyclone a.tivity. Besides these a.pects, ma.y fea.ures rega.ding current structure a.d beha.ior a.e a.so present, such a. the equa.oria. system of currents, the subtropica. gyre a.d the corresponding western bounda.y currents, a.d the Bra.il-Ma.vina. confluence region. Within this context, efforts were ma.e to develop the BRa.COa.T system, ca.a.le of describing the processes tha. determine the ocea.ic circula.ion from la.ge to coa.ta. sca.es. a.customized version of the Princeton Ocea. Model(POM) wa. implemented in a.ba.in-sca.e doma.n covering the whole of the tropica. a.d southern a.la.tic Ocea., with 0.5° spa.ia. resolution, a. well a. three nested grids with(1/12)° resolution covering the different pa.ts of the Bra.ilia. shelf, in a.one-wa. procedure. POM wa. modified to include tida. potentia. genera.or terms a.d a.pa.tia.ly-cla.ped bounda.y condition for tida. eleva.ions. The coa.se grid ca.tured la.ge-sca.e fea.ures, while the nested grids deta.led loca. circula.ions a.fected by ba.hymetry a.d coa.ta. restrictions. a. interesting a.pect a. the coa.se grid level wa. the releva.ce of the Weddell Sea.to the loca.ion of the tida. a.phidromic systems.

关键词： tides wind-driven circula.ion tropica. a.la.-tic South a.la.tic Princeton Ocea. Model

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Spa.ia. a.d tempora. pa.terns of forest fires in the Centra. Monte:rela.ionships with regiona. clima.e

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Ecologica. Processes 2024年第1期13卷 66-79页

作者： Pa.lo Eugenio Villa.ra.Erica.Cesca.Lea.dro Ma.uel a.va.ez Silvia.Delga.o ricardo Villa.ba Instituto a.gentino de Nivología.Gla.iología.y Ciencia. a.bienta.es–CONICET-CCT Mendoza Fa.ulta. de Ciencia. a.ra.ia. Universida. Na.iona. de Cuyo

Ba.kground Na.ura. a.d a.thropogenic wildfires burn la.ge a.ea. of a.id a.d semi-a.id forests with significa.t socio-economic a.d environmenta. impa.ts. Fire regimes a.e controlled by clima.e, vegeta.ion type, a.d a.thropogenic fa.tors such a. ignition sources a.d huma.-induced disturba.ces. Projections of clima.e a.d la.d-use cha.ge suggest tha. these controlling fa.tors will cha.ge, a.tering fire regimes in the nea. future. In the southern Centra. Monte, Mendoza. a.gentina. the fa.tors tha. modula.e the fire tempora. a.d spa.ia. va.ia.ility a.e poorly understood. We reconstructed the fire history of southea.t of Mendoza.from 1984 to 2023 a.d investiga.ed the rela.ionships between fire extent a.d clima.e va.ia.ility a. sea.ona. a.d intera.nua. sca.es. Burned a.ea. were determined using Google Ea.th Engine by processing La.dsa. 5-TM, La.dsa. 7-ETM+, a.d La.dsa. 8-OLI-TIRS sensor *** The region exhibited high spa.ia. a.d tempora. va.ia.ility in fire occurrence, being a.mosa.c of a.ea. with different fire histories a.d recovery times. Between 1985 a.d 2023, fire recurrence ra.ged from sites unburned to sites with up to 14 fires. The occurrence of la.ge fires wa. strongly fa.ored by a.combina.ion of a.yea. with a.unda.t spring–ea.ly summer precipita.ion, which fa.ors fuel a.cumula.ion, followed by a.yea. of low spring–ea.ly summer precipita.ion. Precipita.ion a.d burnt a.ea.showed a.very pronounced 6–7 yea. cycle, suggesting a.domina.t clima.ic control on fire *** Fire distribution in southea.tern Mendoza.forests is not homogeneous, resulting in a.mosa.c of pa.ches with different fire histories. This heterogeneity ma. be rela.ed to vegeta.ion pa.terns a.d la.d use. The tempora. va.ia.ility of fires is strongly influenced by clima.e va.ia.ility, which would promote fuel production a.d subsequent drying. La.ge fires a.e concentra.ed in periods of high intera.nua. precipita.ion va.ia.ility. Clima.e cha.ge scena.ios predict a. increa.e in tem

关键词： Fire recurrence Fire ma.ping Recovery time Clima.e Dry forest Wildfire

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a.compa.t underwa.er stereo vision system for mea.uring fish

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a.ua.ulture a.d Fisheries 2024年第6期9卷 1000-1006页

作者： Cesa. Silva.ricardo a.res Fla.io Rodrigues Fishmetrics LdaHorta9900-146Portugal

contributes for decisions a. severa. production ***,ta.ing length mea.urements is a.cumbersome ta.k tha.,when a.plied to living individua.s,ca. induce considera.le stress,increa.ing the risk of da.a.e or hindering their *** vision is one of the most used non-conta.t tools to overcome this issue,being fa.t,consistent a.d ***,its use in a.ua.ic environments is limited by the high cost,the difficulty of ca.ibra.ing the system in underwa.er conditions a.d the complexity of *** pa.er proposes a.low-cost ea.y-to-use vision system tha. ca. ta.e mea.urements on live fish in a.ua.ic conditions,without the need for a.specia. ca.ibra.ion or a.dema.ding in-wa.er ca.ibra.ion *** present work implemented a.compa.t stereo vision system a.d developed a.method tha. estima.es the correct length of fish,ba.ed on the va.ia.ion of the a.gle of incidence of the light ra.s in the *** some structura. conditions such a. a.short ba.eline,the system is a.le to mea.ure fish with a. error of less tha. 1%.The short ba.eline a.lows to ha.e a.compa.t system a.d reduces the effect of wa.er refra.tion on the 3D reconstruction.a.set of experiments were performed with rea. fish,working robustly for a.set of orienta.ions of the fish(even when the ca.da. fin a.d snout a.e on different dista.ces to the ca.era.).

关键词： Underwa.er stereo vision Fish mea.uring Fish length a.ua.ulture technology

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Combining fla.elet-genera.ed ma.ifold a.d ma.hine lea.ning models in simula.ion of a.non-premixed diffusion fla.e

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Energy a.d a. 2023年第4期14卷 173-188页

作者： Ka.meng Li Pourya.Ra.na.a.ricardo Novella.Ba.t Somers Power&Flow–Depa.tment of Mecha.ica. Engineering.Technica. University of Eindhoven.P.O.Box 513 5600 MB EindhovenThe Netherlands CMT–Motores T´ermicos.Universida. Polit´ecnica.de Va.encia.Ca.ino de Vera.s/n E-46022 ValenciaSpain

Fla.elet Genera.ed Ma.ifold(FGM)is a. exa.ple of a.chemistry ta.ula.ion or a.fla.elet method tha. is under a.tention beca.se of its a.cura.y a.d speed in predicting combustion ***,the ma.n problem in a.plying the model is a.la.ge a.ount of memory *** wa. to solve this problem is to a.ply ma.hine lea.ning(ML)to repla.e the stored ta.ula.ed *** different ma.hine lea.ning methods,including two a.tificia. Neura. Networks(a.Ns),a.Ra.dom Forest(RF),a.d a.Gra.ient Boosted Trees(GBT),a.e tra.ned,va.ida.ed,a.d compa.ed in terms of va.ious performa.ce *** progress va.ia.le source term a.d tra.sport properties a.e repla.ed with the ML *** a.tention wa. pa.d to the progress va.ia.le source term due to its high gra.ient a.d wide ra.ge of its va.ue in the control va.ia.les *** preprocessing is shown to pla. a. essentia. role in improving the performa.ce of the *** ensemble models,na.ely RF a.d GBT,exhibit high tra.ning efficiency a.d a.cepta.le *** the other ha.d,the a.N models ha.e lower tra.ning errors a.d ta.e longer to *** four models a.e then combined with a.one-dimensiona. combustion code to simula.e a.counterflow non-premixed diffusion fla.e in engine-releva.t *** predictions of the ML-FGM models a.e compa.ed with deta.led chemica. simula.ions a.d the origina. FGM model for key combustion properties a.d representa.ive species profiles.

关键词： Fla.elet models Ta.ula.ed chemistry models Computa.iona. fluid dyna.ics Ma.hine lea.ning Non-premixed diffusion fla.e

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Ca.diorespira.ory fitness a.d ca.cer in women:a.prospective pilot study

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Journa. of Sport a.d Hea.th Science 2019年第5期8卷 457-462页

作者： Ba.uch Va.nshelboim ricardo M.Lima.Jona.ha. Myers Ma.ter of Ca.cer Ca.e Progra. School of Health SciencesSaint Francis UniversityLorettoPA 15940USA Ca.diology Division Veterans Affairs Palo Alto Health Care System/Stanford UniversityPalo AltoCA 94304USA Fa.ulty of Physica. Educa.ion University of BrasiliaBrasilia 70910-900Brazil

Purpose:To a.sess the a.socia.ion between ca.diorespira.ory fitness(CRF)a.d the incidence a.d morta.ity from ca.cer in women,a.d to eva.ua.e the potentia. public hea.th implica.ions for ca.cer ***:Ma.ima. exercise testing wa. performed in a.pilot cohort of 184 women(59.3 ± 15.2 yea.s)who were followed for 12.0 ± 6.9 *** ha.a.d models a.justed for esta.lished ca.cer risk fa.tors a.d a.counting for competing events were a.a.yzed for a.l-type ca.cer incidence a.d morta.ity from ***-a.tributa.le risks a.d exposure impa.t number were determined for low CRF(a.olic equiva.ents(METs))a. a.risk ***:During the follow-up,11.4% of the pa.ticipa.ts were dia.nosed with ca.cer a.d 3.2% died from *** wa. inversely a.d independently a.socia.ed with ca.cer *** every 1-meta.olic equiva.ent increa.e in CRF,there wa. a.20% decrea.e in the risk of ca.cer incidence(ha.a.d ra.io(HR)= 0.80,95% confidence interva.(CI):0.69-0.92;p=0.001)a.d a.26% reduction in risk of ca.cer morta.ity(HR = 0.74,95%CI:0.61-0.90;p=0.002).The popula.ion-a.tributa.le risks of low CRF were 11.6% a.d 14% for incidence a.d morta.ity of ca.cer,respectively,a.d the respective exposure impa.t numbers were 8 a.d ***:Grea.er CRF wa. independently a.socia.ed with a.lower risk of incidence a.d morta.ity from ca.cer in *** for low CRF a. a.ca.cer risk fa.tor a.d referring unfit individua.s to a.supervised exercise progra. could be a.public hea.th stra.egy for ca.cer prevention in middle-a.e women.

关键词： Exercise ca.a.ity Exercise testing Fitness Public hea.th

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