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Amniotic membrane as a potent source of stem cells and a matrix for engineering heart tissue

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Journal of Biomedical Science and Engineering 2013年第12期6卷 1178-1185页

作者： Julio Cesar Francisco ricardo correa cunha Rossana Baggio Simeoni Luiz Cesar Guarita-Souza Reginaldo Justino Ferreira Ana Carolina Irioda Carolina Maria C.Oliveira Souza Garikipati Venkata Naga Srikanth Soniya Nityanand Juan Carlos Chachques Katherine Athayde Teixeira de Carvalho Bioprocess Engineering and Biotechnology Department Federal University of ParanáCuritibaBrazil Cell Therapy and Biotechnology in Regenerative Medicine Research Group Pele Pequeno Príncipe InstituteCuritibaBrazil Experimental Laboratory of Institute of Biological and Health Sciences Pontificial Catholic University of Paraná(PUCPR)Rua Imaculada ConceicaoCuritibaBrazil Federal University of Technology CuritibaBrazil Department of Hematology Stem Cell Research FacultySanjay Gandhi Post-Graduate Institute of Medical SciencesLucknowIndia Laboratory of Biosurgical Research Pompidou HospitalUniversity of Paris DescartesParisFrance

Existing therapies for the treatment of chronic heart failure still have some limitations and there is a pressing need for the development of new therapeutic modalities. The amniotic membrane has been used for the treatment of various diseases, such as conjunctive defects;however, the mechanisms behind its repair functions are still unclear. Regenerative medicine is seeking newer alternatives and among them, biomaterials have emerged in recent years for developing and manipulating molecules, cells, tissues or organs grown in laboratories in order to replace human body parts. Many such materials have been used for this purpose, either synthetically or biologically, in order to provide new medical devices. This review provides a wider view of the regeneration potential of the use of amniotic membrane as a potential biomaterial to facilitate the implementation of new research in surgical procedures. Amniotic membrane appears to be an alternative source of stem cells as well as an excellent biomaterial for cell-based therapeutic applications in engineering heart tissue.

关键词： Amniotic Membrane Heart Tissue Engineering Stem Cells

Extrahepatic cholestasis associated with paracoccidioidomycosis:Challenges in the differential diagnosis of biliopancreatic neoplasia

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2531-2540页

作者： Jose Sebastiao dos Santos Vitor de Moura Arrais William Jose Rosseto Ferreira ricardo Ribeiro correa Filho Mariangela Ottoboni Brunaldi Rafael Kemp Ajith Kumar Sankanrakutty Jorge Elias Junior Fernando Bellissimo-Rodrigues Roberto Martinez Edson Zangiacomi Martinez Jose Celso Ardengh Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP) Departamento de Cirurgia e AnatomiaRibeirao Preto 14049-900Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de PatologiaRibeirao Preto 14048900Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Imagens MédicasHematologia e Oncologia ClínicaRibeirao Preto 14048900Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Medicina SocialRibeirao Preto 14015-010Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Clínica MédicaRibeirao Preto 14015-010Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Cirurgia e AnatomiaRibeirao Preto 14049-900Sao PauloBrazil and Hospital MoriahServico de Endoscopia DigestivaSao Paulo 04084-002Sao PauloBrazil

BACKGROUND Paracoccidioidomycosis(PCM)may involve the hepatic pedicle and peripan creatic lymph nodes,cause damage to the bile duct and manifest,exceptionally,in combination with extrahepatic cholestasis(EHC),making investigation and treatment *** To investigate the management of patients with visceral PCM admitted with *** All patients diagnosed with PCM treated in a public,tertiary teaching hospital between 1982 and 2020 were retrospectively *** also identified with EHC were allocated to two groups according to the treatment approach for the purpose of comparing clinical,laboratory,and imaging findings,resources used for etiological diagnosis,treatment results,and *** analyses were performed using the linear mixed-effects model(random and fixed effects),which was adjusted using the PROC MIXED procedure of the SAS®9.0 software,and Fisher’s exact *** Of 1645 patients diagnosed with PCM,40(2.4%)had *** these,20(50.0%)lived in the rural area and 29(72.5%)were men,with a mean age of 27.1 years(3-65 years).Jaundice as first symptom and weight loss of at least 10 kg were observed in 16 patients(40.0%),and a mass in the head of the pancreas was observed in 8(20.0%).The etiological diagnosis was made by tissue collection during surgery in 4 cases(10.0%)and by endoscopic methods in 3 cases(7.5%).Twenty-seven patients(67.5%)received drug treatment alone(Group 1),whereas 13(32.5%)underwent endoscopic and/or surgical procedures in combination with drug treatment(Group 2).EHC was significantly reduced in both groups(40.7% in Group 1,with a mean time of 3 months;and 38.4% in Group 2,with a mean time of 7.5 months),with no statistically significant difference between *** recurrence rates,associated mainly with treatment nonadherence,were similar in both groups:37% in Group 1 and 15.4% in Group *** mortality rate was 18.5% in Group 1 and 23% in Group 2,with survival estimates of 71.3% and 72.5%,respectively,with

关键词： Cholestasis Jaundice Obstructive Blastomycosis Paracoccidioides Diagnosis Treatment

Quadruple therapy with furazolidone for retreatment in patients with peptic ulcer disease

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World Journal of Gastroenterology 2008年第40期14卷 6224-6227页

作者： Guilherme Eduardo Gonalves Felga Fernando Marcuz Silva ricardo correa Barbuti Tomás Navarro-Rodriguez Schlioma Zaterka Jaime Natan Eisig Department of Gastroenterology University of So PauloSchool of Medicine

AIM: To establish the efficacy and safety of a 7-d therapeutic regimen using omeprazole,bismuth subcitrate,furazolidone and amoxicillin in patients with peptic ulcer disease who had been previously treated with other therapeutic regimens without ***: Open cohort study which included patients with peptic ulcer who had previously been treated unsuccessfully with one or more eradication *** therapeutic regimen consisted of 20 mg omeprazole,240 mg colloidal bismuth subcitrate,1000 mg amoxicillin,and 200 mg furazolidone,taken twice a day for 7 *** were considered as eradicated when samples taken from the gastric antrum and corpus 12 wk after the end of treatment were negative for Helicobacter pylori (H pylori) (rapid urease test and histology).Safety was determined by the presence of adverse ***: Fifty-one patients were *** eradication rate was 68.8% (31/45).Adverse effects were reported by 31.4% of the patients,and these were usually considered to be slight or moderate in the majority of the *** patients had to withdraw from the treatment due to the presence of severe adverse ***: The association of bismuth,furazolidone,amoxicillin and a proton-pump inhibitor is a valuable alternative for patients who failed to respond to other eradication *** is an effective,cheap and safe option for salvage therapy of positive patients.

关键词： Gastric ulcer Duodenal ulcer Helicobacter pylori Retreatment Furazolidone

Health production and risk of obesity among Chilean adolescents: Understanding health related behaviors in youth

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Health 2012年第12期4卷 1413-1419页

作者： Paulina correa-Burrows Raquel Burrows ricardo Uauy Cecilia Albala Department of Applied Economics II Rey Juan Carlos University Madrid Spain Institute of Nutrition and Food Technology University of Chile Santiago de Chile Chile

Background: Adolescent obesity is associated with high cardiovascular and metabolic risk. Western diet and reduced physical activity are strong environmental determinants. The “Health Production” model posits that individuals born with a certain amount of health stock, which depreciates over life, but can be augmented by individual behaviors, including exercise and dieting. Objective: To study the association between health production and obesity in a random sample of 1692 Chilean adolescents (14.8 ± 0.7 years old), and to study the effect of gender and socioeconomic characteristics on health production. Method: We used an indicator that considered the quality of food intake and physical activity, establishing three categories: good (GHP), intermediate (IHP) and poor health producers (PHP). Multivariate analysis was used to study the odds of obesity and good health production. Results: There was 31% of GHP, 32% of IHP and 38% of PHP. Obesity (Adj. OR: 1.59;95%CI: 1.04 - 2.42) and abdominal obesity (Adj. OR: 2.24;95%CI: 1.35 - 3.40) were significantly higher in the PHP group, compared to the GHP and IHP group. Health production was significantly associated with socioeconomic factors and gender. Female sex and coming from a less wealthy household significantly reduced the odds of good health production. Conclusions: Poor health production in adolescence, as defined by food intake and physical activity, depreciates individuals’ “health stock”, increasing the risk of obesity. In our sample, health production was strongly associated with socio-economic factors and gender.

关键词： Adolescent Health Adolescent Obesity Health Behavior Health Promotion Non-Communicable Diseases Chile

Changes in Mangrove Epifaunal Assemblages Caused by Forest Logging during Hunting of the Neotropical Cormorant (<i>Phalacrocorax brasilianus</i>) on the Colombian Pacific Coast

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Open Journal of Marine Science 2012年第4期2卷 150-156页

作者： Carlos Andrés Satizabal R. Jaime ricardo Cantera Kintz Paula Cristina Sierra-correa Marine and Coastal Research Institute (INVEMAR) Cerro Punta Betín Santa Marta Colombia Universidad del Valle Ecology of Estuaries and Mangroves Research Group (ECOMANGLARES) Cali Colombia

Although the importance of mangroves is clearly recognized around the world, these ecosystems are being strongly altered by the logging of their forests for multiple purposes. The Colombian Pacific coast is not an exception to this situation, and apart from the traditional logging of wood, the hunting of the Neotropical Cormorant or Pato-cuervo (Phalacrocorax brasilianus), an activity largely unknown but widespread in the region, is also causing the logging of great extensions of mangroves. The aim of this research was to determine if the assemblages of mollusks and crustaceans of these mangroves are being affected by the hunting of the cormorant. To answer this question, quantitative samplings were realized in four transects in logged and unlogged mangrove areas on the southwestern coast of the Colombian Pacific and diversity, equitability and dominance of macrofaunal assemblages of mangroves were calculated. The data show that although significant differences between diversity indices were not found, there were important differences in equitability (total J’: 0.55 in T1, 0.77 in T2, 0.46 in T3 and 0.65 in T4), specific dominance, and composition of species (T1: 11 species, T2: 13, T3: 9 and T4: 11) between logged and unlogged areas. Based on these results, although forest structure and interstitial salinity were different among transects, we conclude that the present practice of exploitation of the Neotropical Cormorant is affecting the epifaunal populations of mangroves, causing changes in the composition and dominance of species.

关键词： Mangrove Mollusks Crustaceans Neotropical Cormorant Colombian Pacific

Antifungal Activity against <i>Aspergillus parasiticus</i>of Supernatants from Whey Permeates Fermented with Kefir Grains

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Advances in Microbiology 2015年第6期5卷 479-492页

作者： Raúl ricardo Gamba Carolina Ni Colo Mariana correa Andrea Astoreca Teresa Alconada Graciela De Antoni Angela León Peláez Cátedra de Microbiología Facultad de Ciencias Exactas Universidad Nacional de La Plata La Plata Argentine CIDCA (Centro de Investigación y Desarrollo en Criotecnología de los Alimentos) La Plata Argentine CONICET (Consejo Nacional de Investigaciones Científicas y Tecnológicas) CCT-La Plata La Plata Argentine CINDEFI (Centro de Investigación y Desarrollo en Fermentaciones Industriales) Universidad Nacional de La Plata La Plata Argentine CIC-PBA (Comisión de Investigaciones Científicas-Provincia de Buenas Aires) Buenas Aires Argentine

Aspergillus parasiticus, a common fungal contaminant in food, produces aflatoxin B1, which is classified as human carcinogen. Kefir is an ancient fermented beverage obtained by the fermentation of different substrates with kefir grains. A very important waste produced by the dairy cheese industry is the whey permeate, which nowadays is a strong ambient contaminant. The aim of this work was to assess the effect of whey permeates fermented with kefir grains against A. parasiticus growth, aflatoxin B1 biosynthesis, and the kefir microorganisms protection against the cell damage produced by aflatoxin B1. It was observed that kefir-cell-free-supernatants (CFS) produced fungal inhibition. A fungicidal effect was observed with 65% v/v of CFS in the culture medium (final pH 4.55 and total undissociated lactic and acetic acid concentration 34.08 mM). Under these conditions, aflatoxin production was not detected. Finally, it was found that non-viable kefir microorganisms protected HepG2 cells from the damage produced by aflatoxin B1.

关键词： Aspergillus parasiticus Whey Permeate Aflatoxin B1 Kefir Supernatants Lactic Acid Acetic Acid Cytotoxicity HepG2 Cells

Visible Losses in Mechanized Harvesting of Sugarcane Using the Case IH A4000 Harvester

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American Journal of Plant Sciences 2014年第18期5卷 2734-2740页

作者： Carmen Maria Coimbra Manhaes ricardo Ferreira Garcia Francisco Maurício Alves Francelino Delorme correa Junior Cristobal Soto Solano Helenilson de Oliveira Francelino Laboratory of Agricultural Engineering State University of North Fluminense Darcy RibeiroCampos dos GoytacazesBrazil

Sugarcane is a major Brazilian agricultural product. The area cultivated in the state of Rio de Janeiro for the 2011-12 crop was of 41.31 thousand hectares. The process of mechanized harvesting of the crop still has many visible losses of raw materials caused by several factors. This study aimed at evaluating the visible losses of sugarcane and ratoon damage using the Case A4000 harvester and was conducted in the municipality of Campos dos Goytacazes, in the state of Rio de Janeiro, Brazil. The materials left on the field by the harvester were collected in six ratoon cane rows, with a length of 350 m, setting the frame sampling to every 50 m. The sampling area consisted of 20 m2, with eight repetitions. The losses were calculated in t·ha-1 and in %. The comparison of averages was performed by using the confidence interval, constructed by statistical “t” at 5% probability to compare the types of losses. The estimated productivity of the area was of 54 t·ha-1. The differences between the types of losses were significant. The billets and splinters were found in greater quantity.

关键词： Saccharum spp. Green Cane Mechanized Harvesting

Evaluation of Visible Losses and Damage to the Ratoon Cane in the Mechanized Harvesting of Sugarcane for Different Displacement Speeds

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American Journal of Plant Sciences 2014年第20期5卷 2956-2964页

作者： Carmen Maria Coimbra Manhaes ricardo Ferreira Garcia Delorme correa Junior Francisco Mauricio Alves Francelino Helenilson de Oliveira Francelino Carlos Mair Franca Goncalves dos Santos Laboratory of Agricultural Engineering State University of North Fluminense Darcy RibeiroCampos dos GoytacazesBrazil

This study aimed at quantitatively evaluating the sugarcane losses and the damage caused to the ratoon cane while using the Case IH A8800 harvester in different displacement speeds;it was conducted in the municipality of Campos dos Goytacazes, in Rio de Janeiro, Brazil. Three speeds were used as treatment (2 km·h-1, 3 km·h-1, and 4.5 km·h-1), and each treatment was composed of six rows of harvested ratoon, each with a length of 290 m. In order to evaluate the quantitative losses in t·ha-1 and the percentage of losses, the remaining sugarcane, left on the field after harvesting, was collected. The sampling frame was set to every 50 m, dividing the borders by 40 m;the measurement for each sampling area was of 20 m2, with five repetitions. In order to evaluate the damage caused to the ratoon canes, we chose a visual methodology to classify the damage degrees, ranging from one to four. There was no significant difference in losses when comparing different speeds. Therefore, it is more advantageous and economically viable to use the speed of 4.5 km·h-1, which collects more in less time.

关键词： Harvesting Mechanization Displacement Speed Sugarcane

Neuromuscular Electrical Stimulation in Intensive Care Unit Patients:Integrative Review

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Modern Research in Inflammation 2019年第2期8卷 11-27页

作者： Miriam Viviane Baron Marcus Vinicius de Mello Pinto Janine Koepp Cristine Brandenburg Paulo ricardo Martins Amanda correa dos Santos Daniela Moraes Carolina Goncalves Pinheiro Nathália Ken Pereira Iketani Bartira Ercilia Pinheiro da Costa Nephrology Laboratory Department of Postgraduate of Medicine and Health SciencesSchool of MedicinePontifical Catholic University of Rio Grande do SulPorto AlegreBrazil Celulare Institute Rio de JaneiroBrazil Nursing Course Department of Nursing and DentistryUniversity of Santa Cruz do SulSanta Cruz do SulBrazil Postgraduate Program in Brazilian Education Department of Fundamentals of EducationFederal University of CearáFortalezaBrazil School of Medicine Pontifical Catholic University of Rio Grande do SulPorto AlegreBrazil Physiotherapy Course Department of PhysiotherapyVale do Salgado FacultyIcóBrazil Department of Physiotherapy Dom Luiz I Hospital-Portuguese Beneficent of BelemParaBrazil

Intensive care units’ acquired muscle weakness is present in approximately 50% of the patients. Although active muscle training can attenuate weakness, a large proportion of critical patients cannot participate in any active mobilization. Neuromuscular electrical stimulation may be an alternative strategy to reverse muscle weakness. The objective of the study was to review the scientific publications on the use of neuromuscular electrical stimulation and its parameters and the main results in patients hospitalized in intensive care units. This is an integrative review surveying studies in online databases. The studies were selected from the following descriptors: neuromuscular electrical stimulation AND parameters AND intensive care units AND muscle weakness. The inclusion criteria included articles that addressed the topic of neuromuscular electrical stimulation and the parameters used in patients admitted to intensive care units, aged 18 years or older. Exclusion criteria were studies involving animals, case reports, letters to the editor and book chapters. The search comprised articles in the Portuguese, English and Spanish languages from January 2013 to March 2019. Of the 185 articles identified, nine met the eligibility criteria. The studies were evaluated assessing the level of evidence, and the relevant information was presented in the table and discussed. The parameters of the neuromuscular electrical stimulation employed in the studies showed positive results for the maintenance of strength and muscle mass. There was evidence of benefits in the local and systemic microcirculation, potentially mobilizing endothelial stem cells, to prevent atrophy, to reduce mechanical ventilation time and stay in intensive care unit;and when incorporated into the usual physiotherapy care, proved to be more effective than usual care. Its use is safe and viable in critically ill patients.

关键词： Muscle Weakness Critical Illness Polyneuropathy Sepsis Electric Stimulation Therapy Physical Therapy Modalities