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Influence of cardiorespiratory fitness and body composition on resting and post-exercise indices of vascular health in young adults

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Sports Medicine and Health Science 2024年第1期6卷 54-62页

作者： rian q.landers-ramos Kathleen Dondero Ian Imery Nicholas Reveille Hannah A.Zabriskie Devon A.Dobrosielski Towson University Department of KinesiologyTowsonMDUSA University of Maryland School of Medicine Department of Physical Therapy and Rehabilitation SciencesBaltimoreMDUSA Johns Hopkins University Department of Cell BiologyBaltimoreMDUSA University of Florida Department of Applied Physiology and KinesiologyGainesvilleFLUSA

Poor cardiorespiratory fitness may mediate vascular impairments at rest and following an acute bout of exercise in young healthy *** study aimed to compare flow mediated dilation(FMD)and vascular augmentation index(AIx75)between young adults with low,moderate,and high levels of cardiorespiratory fitness before and after an acute bout of aerobic ***-three participants(22 men;21 women)between 18 and 29 years of age completed the *** were classified into low,moderate,and high health-related cardiorespiratory fitness groups according to age-and sex-based relative maximal oxygen consumption(V_O2 max)percentile *** was performed using Doppler ultrasound and AIx75 was performed using pulse wave analysis at baseline and 60-min after a 30-min bout of treadmill running at 70%V_O2 max.A significant interaction(p=0.047;ηp 2=0.142)was observed,with the moderate fitness group exhibiting a higher FMD post-exercise compared with baseline([6.7%3.1%]vs.[8.5%2.8%],p=0.028;d=0.598).We found a significant main effect of group for AIx75(p=0.023;ηp 2=0.168),with the high fitness group exhibiting lower AIx75 compared to low fitness group([10%10%]vs.[2%10%],respectively,p=0.019;g=1.07).This was eliminated after covarying for body fat percentage(p=0.489).Our findings suggest that resting FMD and AIx75 responses are not significantly influenced by cardiorespiratory fitness,but FMD recovery responses to exercise may be enhanced in individuals with moderate cardiorespiratory fitness levels.

关键词： Cardiorespiratory fitness Flow mediated dilation Augmentation index Vascular Acute exercise Body composition

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Peripheral Vascular and Neuromuscular Responses to Ultramarathon Running

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Journal of Science in Sport and Exercise 2022年第2期4卷 99-108页

作者： rian q.landers-ramos Kathleen R.Dondero Robert W.Rowland Derrick Larkins Odessa Addison Department of Kinesiology Towson University8000 York RdTowsonMD 21252USA Department of Physical Therapy and Rehabilitation Sciences University of Maryland School of MedicineBaltimoreMDUSA Veterans Affairs Geriatric Research Education and Clinical CenterBaltimoreMDUSA

Participation in ultramarathon events has grown substantially in the past ***,poor understanding of the physiological outcomes associated with participation in this sport prevents athletes and clinicians from adequately addressing performance and recovery *** purpose of this review was to summarize developments in the literature in the last 10 years regarding acute and chronic responses to ultramarathon running with a focus on the peripheral vascular system,neuromuscular outcomes,and running *** suggests that there are acute impairments in large artery compliance especially following the longer ultramarathon ***,most literature indicates that chronic vascular impairments are not evident in ultramarathon *** central and peripheral fatigue mechanisms contribute to declines in muscle force production that may last up to several weeks in some muscles following an *** in gait kinematics and skeletal muscle oxidative capacity increase the metabolic cost of running over prolonged running distances(>4 h).Several factors such as elevation changes and nutritional practices make interpretation of findings *** studies are needed to better understand the interplay among systems and how external factors contribute to these outcomes to optimize performance and inform recovery strategies in this increasingly popular sport.

关键词： Aerobic exercise Vascular stiffness Muscle fatigue Kinematics Ultramarathon running Running mechanics

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Drug repurposing for COVID-19 using machine learning and mechanistic models of signal transduction circuits related to SARS-CoV-2 infection

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Signal Transduction and Targeted Therapy 2021年第1期6卷 11-13页

作者： Carlos Loucera Marina Esteban-Medina Kinza rian Matias MFalco Joaquin Dopazo Maria Pena-Chilet Clinical Bioinformatics Area.Fundacion Progreso y Salud(FPS).CDCA Hospital Virgen del Rocio41013 SevillaSpain Computational Systems Medicine Institute of Biomedicine of Seville(IBIS)Hospital Virgen del Rocio41013 SevillaSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigacion Biomedica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del Rocio41013 SevillaSpain FPS/ELIXIR-es Hospital Virgen del RocioSevilla 42013Spain

Dear Editor,Drug repurposing is a convenient alternative when the need for new drugs in an unexpected medical scenario is urgent,as is the case of emerging *** recent years,approaches based on network biology have demonstrated to be superior to genecentric ones.1 Here,we use an innovative methodology that combines mechanistic modeling of the signal transduction circuits related to SARS-CoV-2 infection(the COVID-19 disease map)with a machine-learning algorithm that learns potential causal interactions between proteins,already targets of drugs,and specific signaling circuits in the COVID-19 disease map,to suggest potentially repurposable drugs.

关键词： signal network drugs

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