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The bone marrow niche landscape:a journey through aging,extrinsic and intrinsic stressors in the haemopoietic milieu

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 526-537页

作者： Antonio Giovanni Solimando Assunta Melaccio Angelo Vacca Roberto ria Department of Biomedical Sciences and Human Oncology Section of Internal Medicine and Clinical OncologyUniversity of Bari Medical SchoolBari 70124 Italy

Inflammation and its effects in the bone marrow microenvironment represent a paradigmatic condition in which the hematopoietic niche and the immune systems,thought to properly sustain blood cell production and distinguish between friend and foe,can actively sustain a corrupted neighborhood within a chronic aberrant inflamed *** bone marrow niche hijacks the physiologic *** interactions between the hematopoietic stem cells and the niche in the bone marrow are critical determinants of *** examined several approaches to confront the available evidence;three key points emerged,pointing to the chronic inflammation process,especially the chronic infection and systemic inflammatory states,as leading causes of hematopoietic stem cell *** hematopoiesis,defined as a relative expansion of individual clones,is caused by somatic alterations in essential hematopoietic genes,which increase stem cell ***,terminal differentiation plays a significant role in progenitor loss and inflammatory signaling,promoting clonal selection and clonal hematopoiesis *** myeloid malignancies as paradigmatic examples are discussed as a condition associated with inflammation,including the 5q-syndrome,Philadelphia negative myeloproliferative neoplasms,and chronic myeloid *** with increased fitness and hematopoietic stem cell attrition,extrinsic stress,enhanced stressor-specific fitness,and intrinsic defect across the hematopoietic process represent the route for novel insights in defective *** discussion in this review also points out that the hematopoietic niches’inflammatory stimulation may affect differentiation patterns and the function of downstream cells.

关键词： Hematopoietic niche immune system inflammation tumor microenvironment

Evaluation of Terra/MODIS atmospheric profiles product(MOD07)over the Iberian Peninsula:a comparison with radiosonde stations

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International Journal of Digital Earth 2015年第10期8卷 771-783页

作者： JoséA.Sobrino Juan C.Jiménez-Muñoz Cristian Mattar Guillem Sòria Global Change Unit–Image Processing Laboratory University of ValenciaValenciaSpain Laboratory for Analysis of the Biosphere Universidad de ChileSantiagoChile

Remote sensing techniques are a useful tool for continuous observation of the Earth at global ***,products derived from remote sensing data require a rigorous validation using in situ *** Resolution Imaging Spectroradiometer(MODIS)is not really a sounding instrument,but it does have 16 infrared bands(bands 20-36 covering the spectral range from 3μm to 14μm)that allow the retrieval of temperature and moisture profiles as well as total column integrated *** this paper we show the results obtained in the evaluation of MOD07 daytime and nighttime products over the Iberian Peninsula during the decade from 2000 to 2010 using nine radiosonde *** MODIS limitations in comparison with other sounding instruments,the validation provided satisfactory results,with bias(MOD07 minus radiosonde)<0.3 cm and a standard deviation of 0.5 cm for the total column water vapor,and bias around 1 K on average with standard deviations between 2 K and 3 K for air temperature at different pressure *** average,bias was positive and below 2 K with standard deviations around 5 K for the dew point temperature *** errors were found in this case for pressure levels higher than 50 hPa.

关键词： MODIS MOD07 atmospheric profiles water vapor air temperature dew point temperature

How does the brown mussel Perna perna respond to environmental pollution?A review on pollution biomarkers

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Journal of Environmental Sciences 2022年第1期34卷 412-428页

作者： Fernanda Silva dos Santos Raquel A.F.Neves Mirian Araújo Carlos Crapez Valéria Laneuville Teixeira Natascha Krepsky Fluminense Federal University(UFF) Institute of BiologyGraduate Program in Science and BiotechnologyMario Santos Braga Streets/n.CentroNiteróiRJ CEP 24.020-141Brazil Federal University of the State of Rio de Janeiro(UNIRIO) Institute of Biosciences(IBIO)Graduate Program in Neotropical Biodiversity(PPGBIO)Pasteur Avenue458.UrcaRio de JaneiroRJ CEP 22.290-255Brazil Fluminense Federal University(UFF) Institute of BiologyGraduate Program in Marine Biology and Coastal EnvironmentsMario Santos Braga Streets/n.CentroNiteróiRJ CEP 24.020-141Brazil Federal University of the State of Rio de Janeiro(UNIRIO) Institute of Biosciences(IBIO)Graduate Program in Ecotourism and ConservationPasteur Avenue458.UrcaRio de JaneiroRJ CEP 22.290-255Brazil

The brown mussel Perna perna(Linnaeus,1758)is a valuable resource for aquaculture in tropical and subtropical coastal *** presents desirable characteristics for biomonitoring,including being sessile,widely distributed and abundant,and is a filter-feeder able to accumulate several classes of pollutants(e.g.,metals,hydrocarbons,among others).Mussels’biological responses to pollution exposure can be measured as biomarkers,which include alterations ranging from molecular to physiological levels,to estimate the degree of environmental contamination and its effects on *** full review compiles two decades(2000–2020)of literature concerning biological effects on *** mussel caused by environmental pollutants(i.e.,metals,hydrocarbons,and emerging pollutants),considering environmental and farm-based *** markers related to mussels’oxidative status were efficient for the biomonitoring of metals(i.e.,antioxidant enzymes associated with oxidative damage in biomolecules).Genotoxicity and cytotoxicity indicators(i.e.,comet,micronucleus,and neutral red assays)provided a depiction of hydrocarbon *** neutral red assay gave a time-concentration cytotoxic response to a wide range of pollutants,including emerging pollutants(e.g.,pharmaceuticals and biocides)and *** perna hemocyte parameters provided a useful approach for biocide *** paper summarizes useful biomarkers from molecular to physiological levels in this mussel species used to identify and quantify the degree of coastal *** integrated biomarker analysis may provide a way to overcome possible biomarker variations and assess multi-polluted ***,it is necessary to investigate biomarker variations according to natural factors(e.g.,season and gonad maturation stage)to standardize them for trustworthy biomonitoring.

关键词： Biological indexes Biomonitoring Emerging pollutants Hydrocarbons Metals Sentinel species

Advantageous mechanochemical synthesis of copper(Ⅰ)selenide semiconductor,characterization,and properties

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Frontiers of Chemical Science and Engineering 2022年第3期16卷 433-442页

作者： Katarína Gáborová Marcela Achimovičová Michal Hegedüs Vladimír Girman Mária Kaňuchová Erika Dutková Institute of Geotechnics Slovak Academy of SciencesKošice04001Slovakia Institute of Metallurgy Faculty of MaterialsMetallurgy and RecyclingTechnical UniversityKošice04201Slovakia Synthon s.r.o.Blansko67801Czech Republic Faculty of Science Pavol JozefŠafárik UniversityKošice04154Slovakia Institute of Earth Resources Faculty of MiningEcologyProcess Control and GeotechnologiesTechnical UniversityKošice04200Slovakia

Copper(I)selenide-nanocrystalline semiconductor was synthesized via one-step mechanochemical synthesis after 5 min milling in a planetary ball *** kinetics of synthesis was followed by X-ray powder diffraction analysis and specific surface area measurements of milled 2Cu/Se *** X-ray diffraction confirmed the orthorhombic crystal structure of Cu_(2)Se with the crystallite size∼25 *** surface chemical structure was studied by X-ray photoelectron spectroscopy,whereby the binding energy of the Cu 2p and Se 3d signals corresponded to Cu^(+)and Se^(2−)oxidation *** electron microscopy revealed agglomerated nanocrystals and confirmed their orthorhombic structure,as *** optical properties were studied utilizing ultraviolet-visible spectroscopy and photoluminescence *** direct bandgap energy 3.7 eV indicated a blue-shift phenomenon due to the quantum size *** type of Cu_(2)Se synthesis can be easily adapted to production dimensions using an industrial vibratory *** advantages of mechanochemical synthesis represent the potential for inexpensive,environmentally-friendly,and waste-free manufacturing of Cu_(2)Se.

关键词： Cu_(2)Se berzelianite nanocrystalline semiconductor mechanochemical synthesis planetary ball mill

Identification of Lynch syndrome: How should we proceed in the 21^(st) century?

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World Journal of Gastroenterology 2007年第33期13卷 4413-4416页

作者： Antoni Castells Francesc Balaguer Sergi Castellví-Bel Victòria Gonzalo Teresa Ocaa Gastroenterology Department Institut de Malalties Digestives i Metabòliques Hospital ClínicCIBERehd IDIBAPS University of Barcelona BarcelonaCatalonia Spain

Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC), is the most common form of hereditary colorectal cancer. Although great advances in the understanding of its molecular basis have taken place in the last decade, optimal selection of individuals for HNPCC genetic testing remains controversial. This is especially relevant since colonoscopy has been proven effective for reducing colorectal cancer incidence and mortality in individuals at-risk for this disorder. In this manuscript, we summarize the most significant contributions to this important issue that have appearedin the last few years.

关键词： Hereditary non-polyposis colorectal cancer Screening Prevention Microsatellite instability Genetics

Analysis of Compression Resistance and Oil Adsorption Capacity of Cellulose/NaOH Cryogels

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Journal of Renewable Materials 2019年第3期7卷 227-234页

作者： Lídia K.Lazzari Vitória B.Zampieri Ademir J.Zattera Camila Baldasso Center for Exact Sciences and Technologies-University of Caxias do Sul.1130 Francisco Getúlio Vargas Street Caxias do Sul95070-560Brazil

This work aimed at analyzing the petroleum adsorption capacity and the compressive strength of cellulose cryogels produced with the addition of 4 and 8%(w/w)sodium hydroxide(NaOH).Cryogels were produced from a 1.5%(m/m)suspension of cellulose microfibers,which originated from Pinus elliotti,in distilled *** addition of NaOH increased the compression strength of cryogel by 30% when compared to cryogel without the *** to the 50% decrease in volume,the cryogel FLNB-8h(8%NaOH)has its petroleum adsorption capacity decreased in average by 58%,whereas the FLNB-4(4%NaOH)cryogel had it only by 14%.The cellulose suspension which provided the best results for the properties of the cryogels tested had a 4%concentration of NaOH.

关键词： Cryogel cellulose NaOH adsorption compression resistance

The potential application of red mud and soil mixture as additive to the surface layer of a landfill cover system

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Journal of Environmental Sciences 2016年第6期28卷 189-196页

作者： Eva Ujaczki Viktória Feigl Mónika Molnár Emese Vaszita Nikolett Uzinger Attila Erdélyi Katalin Gruiz Department of Applied Biotechnology and Food Science Faculty of Chemical Technology and Biotechnology Budapest University of Technology and Economics H-1111 Budapest Muegyetem rkp. 3 Hungar Institute for Soil Sciences and Agricultural Chemistry Centre for Agricultural Research Hungarian Academy of Sciences H-1022 Budapest Herman Otto Street 15 Hungary A.S.A. Hungary Ltd. H-2360 Gydl Karosi Street 53 Hungary

Red mud, the by-product of aluminum production, has been regarded as a problematic residue all over the world. Its storage involves risks as evidenced by the Ajka red mud spill,an accident in Hungary where the slurry broke free, flooding the surrounding areas. As an immediate remediation measure more than 5 cm thick red mud layer was removed from the flooded soil surface. The removed red mud and soil mixture（RMSM） was transferred into the reservoirs for storage. In this paper the application of RMSM is evaluated in a field study aiming at re-utilizing waste, decreasing cost of waste disposal and providing a value-added product. The purpose was to investigate the applicability of RMSM as surface layer component of landfill cover systems. The field study was carried out in two steps： in lysimeters and in field plots. The RMSM was mixed at ratios ranging between 0 and 50% w/w with low quality subsoil（LQS） originally used as surface layer of an interim landfill cover. The characteristics of the LQS ＋ RMSM mixtures compared to the subsoil（LQS） and the RMSM were determined by physical–chemical, biological and ecotoxicological methods. The addition of RMSM to the subsoil（LQS） at up to 20% did not result any ecotoxic effect, but it increased the water holding capacity. In addition, the microbial substrate utilization became about triple of subsoil（LQS） after 10 months. According to our results the RMSM mixed into subsoil（LQS） at20% w/w dose may be applied as surface layer of landfill cover systems.

关键词： Red mud Soil amelioration Environmental toxicology Landfill cover constituent Field-study Lysimeter

Preparation and Compaction Behaviour of Poly(methyl methacrylate) Coated Iron Microparticles

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Journal of Materials Science & Technology 2010年第5期26卷 454-460页

作者： Daniela Kladeková Renáta Orináková Annamária Krajníková Miriam Kupková Margita Kabátová Kveta Markuová Institute of Chemistry Faculty of ScienceP.J.afárik University in Koice Institute of Materials Research of the Slovak Academy of Sciences in Koice

The poly（methyl methacrylate）（PMMA） coatings onto surface of iron particles were electrochemically prepared and the effect on both surface structure and internal structure of the resulted material after compaction was carried *** electrochemical polymerization treatment was performed in a fluidized bed electrolyzer using sulphuric acid solution containing potassium persulphate and methyl methacrylate（MMA）.The surface topography and the microstructure of the samples were observed by scanning electron microscopy（SEM） and optical microscopy（OM）.It was found that the PMMA layer coated onto iron particles results in improvement of their compressibility compared with uncoated powders,and classical lubricants are not necessary for compacting particles coated.

关键词： Cathodic electropolymerization Poly(methyl methacrylate) coating Surface appearance Microstructure Compaction process

Climate Change Impacts on Environmental Hazards on the Great Hungarian Plain, Carpathian Basin

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International Journal of Disaster Risk Science 2014年第2期5卷 136-146页

作者： Gábor Mezosi Teodóra Bata Burghard C.Meyer Viktória Blanka Zsuzsanna Ladányi Department of Physical Geography and Geoinformatics University of SzegedEgyetem u.2-6Szeged 6722Hungary

The potential impacts of climate change on the Great Hungarian Plain based on two regional climate models,REMO and ALADIN,were analyzed using indicators for environmental *** the climate parameters(temperature,precipitation,and wind)will change in the two investigated periods(2021–2050 and 2071–2100),their influences on drought,wind erosion,and inland excess water hazards are modeled by simple predictive *** hazards on arable lands will increasingly affect the productivity of agriculture compared to the reference period(1961–1990).The models predict an increase between 12.3%(REMO)and 20%(ALADIN)in the first period,and between 35.6%(REMO)and 45.2%(ALADIN)in the second *** increase of wind erosion hazards is not as obvious(+15%for the first period in the REMO model).Inland excess water hazards are expected to be slightly reduced(-4 to 0%)by both model predictions in the two periods without showing a clear tendency on *** three indicators together give a first regional picture of potential hazards of climate *** predictive model and data combinations of the regional climate change models and the hazard assessment models provide insights into regional and subregional impacts of climate change and will be useful in planning and land management activities.

关键词： Great inland drought