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Prospective study of transsphenoidal pituitary surgery： is tumor volume a predictor for the residual tumor？

Chinese Medical Journal 2012年第14期125卷 2444-2448页

作者： resha shrestha qi lei bao gang wang mao-de department of Neurosurgery First Affiliated Hospital of MedicalSchool Xi'an Jiaotong University Xi'an Shaanxi 710061 China

Background The presence of residual tumor after surgery for pituitary adenoma may necessitate further treatment. The suprasellar and parasellar extension of the tumor have been widely considered as the predictors for residual tumor. However there is scarcity of studies regarding the preoperative tumor volume and residual tumor. This study was conducted to evaluate if tumor volume could predict the outcome of transsphenoidal pituitary surgery. Methods A prospective study was designed and 48 patients who underwent transsphenoidal pituitary surgery within 1 year in the First Affiliated Hospital of Xi＇an Jiaotong University were included in this study. The preoperative tumor volume and immediate postoperative tumor volume （within 4-7 days） were calculated in the contrast magnetic resonance imaging by using the formula of ellipsoid. All these volumes were divided into three subgroups, i.e. group 1, group 2 and group 3 with preoperative volume of less than 4 cm3, 4-8 cm3, and more than 8 cm3 respectively. The parasellar and suprasellar extension of the tumor were also classified by Knosp and modified Hardy＇s classifications. Results Baseline characteristics were comparable. The preoperative tumor volume of more than 8 cm3 （group 3, （12.1±1.1） cm3） had increased risk on postoperative tumor residue （P 〈0.01） than the other two groups （（2.1±0.3） cm3 and （6.1±0.3） cm3 in groups 1 and 2）. The mean postoperative volume in group 3 patients （（2.2±0.1） cm3） was significantly higher than the other two groups （P 〈0.01）. Conclusion Preoperative volume of more than 8 cm3 can be considered as a predictor for postoperative residual volume.

关键词： pituitary neoplasms, transsphenoidal approach, tumor volume, residual volume predictor

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Exploration of pathogenic microorganism within the small intestine of necrotizing enterocolitis

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World Journal of Pediatrics 2024年第2期20卷 165-172页

作者： Yan wang Kun Jiang qiao Xia Xia Kang Shan wang Ji-Hong Yu Wen-Feng Ni Xiao-qin qi Ying-Na Zhang Jin-bao Han gang Liu lei Hou Zhi-Chun Feng Liu-Ming Huang Clinical Biobank Center Medical Innovation Research Division of ChinesePLA General HospitalBeijingChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Senior department of Pediatrics The Seventh Medical Center of PLA General HospitalBeijing 100700China department of Neurology The First Medical CenterChinese PLA General HospitalBeijing 100853China department of Emergency Center National Center for Children's HealthBeijing Children's HospitalCapital Medical UniversityBeijing 100045China

Background Necrotizing enterocolitis(NEC)is the most common severe gastrointestinal emergency in *** designed this study to identify the pathogenic microorganisms of NEC in the microbiota of the small intestine of *** Using the 16S ribosomal DNA(rDNA)sequencing method,we compared and analyzed the structure and diversity of microbiotas in the intestinal feces of different groups of neonates:patients undergoing jejunostomy to treat NEC(NP group),neonates undergoing jejunostomy to treat other conditions(NN group),and neonates with NEC undergoing conservative treatment(NC group).We took intestinal feces and saliva samples from patients at different time *** The beta diversities of the NP,NN,and NC groups were all *** comparing the beta diversities between different time points in the NP group,we found similar beta diversities at time points El to E3 but significant differences between the E2-E3 and E4 time points:the abundances of Klebsiella and Enterococcus(Proteobacteria)were higher at the E1-E3 time points;the abundance of Escherichia-Shigella(Proteobacteria)increased at the E2 time point,and the abundance of Klebsiella decreased significantly,whereas that of Streptococcus increased significantly at the E4 time *** Our results suggest that the pathological changes of intestinal necrosis in the small intestine of infants with NEC are not directly caused by excessive proliferation of pathogenic bacteria in the small *** sources of microbiota in the small intestine of neonates,especially in premature infants,may be affected by multiple factors.

关键词： Microbiota Necrotizing enterocolitis-Small intestine 16S rDNA

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Study of tree shrew biology and models: A booming and prosperous field for biomedical research

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Zoological Research 2024年第4期45卷 877-909页

作者： Yong-gang Yao Li Lu Rong-Jun Ni Rui Bi Ceshi Chen Jia-qi Chen Eberhard Fuchs Marina Gorbatyuk Hao lei Hongli Li Chunyu Liu Long-bao Lv Kyoko Tsukiyama-Kohara Michinori Kohara Claudia Perez-Cruz Gregor Rainer bao-Ci Shan Fang Shen An-Zhou Tang Jing wang Wei Xia Xueshan Xia Ling Xu Dandan Yu Feng Zhang Ping Zheng Yong-Tang Zheng Jumin Zhou Jiang-Ning Zhou Key Laboratory of Genetic Evolution and Animal Models Yunnan Key Laboratory of Animal Models and Human Disease MechanismsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility) and National Resource Center for Non-Human PrimatesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650204China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Mental Health Center and Psychiatric Laboratory West China HospitalSichuan UniversityChengduSichuan 610041China Sichuan Clinical Medical Research Center for Mental Disorders ChengduSichuan 610044China German Primate Center Leibniz Institute of Primate ResearchGöttingen 37077Germany department of Optometry and Vision Science School of OptometryUniversity of Alabama at BirminghamBirminghamAL 35294USA State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Soong Ching Ling Institute of Maternity and Child Health International Peace Maternity and Child Health HospitalShanghai Jiao Tong University School of MedicineShanghai 200030China Transboundary Animal Diseases Center Joint Faculty of Veterinary MedicineKagoshima UniversityKagoshima-cityKagoshima 890-8580Japan department of Microbiology and Cell Biology Tokyo Metropolitan Institute of Medical ScienceTokyo 156-8506Japan Pharmacology department CinvestavMexico City 07360Mexico department of Medicine University of FribourgFribourg CH-1700Switzerland Beijing Engineering Research Center of Radiog

The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with *** recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain ***,the limited availability of tree shrews globally remains a substantial challenge in the ***,determining the key questions best answered using tree shrews constitutes another *** shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative *** these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical *** review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this *** emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew *** use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.

关键词： Tree shrew Animal model Neurodegenerative diseases Infectious diseases Neuroscience Phenome

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OsMas1,a novel maspardin protein gene,confers tolerance to salt and drought stresses by regulating ABA signaling in rice

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Journal of Integrative Agriculture 2023年第2期22卷 341-359页

作者： wang Fei-bing WAN Chen-zhong NIU Hao-fei qi Ming-yang LI gang ZHANG Fan HU Lai-bao YE Yu-xiu wang Zun-xin PEI bao-lei CHEN Xin-hong YUAN Cai-yong School of Life Science and Food Engineering Huaiyin Institute of TechnologyHuai'an 223003P.R.China Huaiyin Institute of Agricultural Sciences of Xuhuai Region Huai'an 223001P.R.China Institute of Botany Jiangsu Province and Chinese Academy of SciencesNanjing 210014P.R.China

Drought and salt stresses,the major environmental abiotic stresses in agriculture worldwide,affect plant growth,crop productivity,and ***,developing crops with higher drought and salt tolerance is highly *** study reported the isolation,biological function,and molecular characterization of a novel maspardin gene,OsMas1,from *** OsMas1 protein was localized to the *** expression levels of OsMas1 were up-regulated under mannitol,PEG6000,NaCl,and abscisic acid(ABA) treatments in *** OsMas1 gene was introduced into the rice cultivar Zhonghua 11(wild type,WT).OsMas1-overexpression(OsMas1-OE) plants exhibited significantly enhanced salt and drought tolerance;in contrast,OsMas1-interference(OsMas1-RNAi) plants exhibited decreased tolerance to salt and drought stresses,compared with ***1-OE plants exhibited enhanced hypersensitivity,while OsMas1-RNAi plants showed less sensitivity to exogenous ABA treatment at both germination and post-germination ***,proline and K+ contents and superoxide dismutase(SOD),catalase(CAT),peroxidase(POD),and photosynthesis activities were significantly *** contrast,malonaldehyde(MDA),hydrogen peroxide(H2O2),superoxide anion radical(O2-··),and Na+ contents were significantly decreased in OsMas1-OE plants compared with OsMas1-RNAi and WT *** of OsMas1 up-regulated the genes involved in ABA signaling,proline biosynthesis,reactive oxygen species(ROS)-scavenging system,photosynthesis,and ion transport under salt and drought *** results indicate that the OsMas1 gene improves salt and drought tolerance in rice,which may serve as a candidate gene for enhancing crop resistance to abiotic stresses.

关键词： ABA signaling OsMas1 gene rice salt and drought tolerance

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非贯通节理花岗岩剪切断裂力学特性及声发射特征研究

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岩土力学 2022年第6期43卷 1533-1545页

作者：王刚宋磊博刘夕奇包春燕吝曼卿刘广建绍兴文理学院土木工程学院浙江绍兴312000 武汉大学土木建筑工程学院湖北武汉430070 绍兴文理学院浙江省岩石力学与地质灾害重点实验室浙江绍兴312000 武汉工程大学资源与安全工程学院湖北武汉430070

为探究节理岩体在压剪复合作用下的断裂力学行为与破坏机制,采用完整及非贯通节理花岗岩开展了剪切试验,从宏观力学特性、声发射信号特征、颗粒流细观演化规律等多角度进行解析,并提出了一种利用声发射信号特征及其关键信息点预判花岗... 详细信息

为探究节理岩体在压剪复合作用下的断裂力学行为与破坏机制,采用完整及非贯通节理花岗岩开展了剪切试验,从宏观力学特性、声发射信号特征、颗粒流细观演化规律等多角度进行解析,并提出了一种利用声发射信号特征及其关键信息点预判花岗岩剪切破坏的方法。研究结果表明:节理破坏了岩石完整性,降低了岩石的剪切刚度和峰值剪切强度;此外,节理的存在会影响裂纹的扩展路径和破坏模式,且这种影响会随着法向应力的增加而削弱。法向应力和节理对声发射特征点影响显著,声发射信号的缓慢增长及b值的持续下降可作为岩石剪切破坏的前兆特征;利用声发射信号特征及其关键信息点可以有效预判花岗岩的剪切失稳破坏过程。该研究成果为节理岩体剪切破坏机制分析及其稳定性预测提供了一定参考。

关键词：岩石力学非贯通性节理花岗岩声发射特征破坏机制

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钌多吡啶配合物的合成及插入配体的位阻效应对键合DNA的影响

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高等学校化学学报 1999年第11期20卷 1661-1666页

作者：甄启雄叶保辉刘劲刚计亮年王雷中山大学化学系广州510275 广州师范大学化学系广州510400

合成了２，３－二甲基－１，４，８，９－四氮三联苯（ｄｍｔａｔｐ）和２，３－二苯基－１，４，８，９－四氮三联苯（ｄｐｔａｔｐ）两种新配体及它们与２，２′－联吡啶和钌（Ⅱ）的混配物［Ｒｕ（ｂｐｙ）２ｄｍｔａｔｐ］２＋ ... 详细信息

合成了２，３－二甲基－１，４，８，９－四氮三联苯（ｄｍｔａｔｐ）和２，３－二苯基－１，４，８，９－四氮三联苯（ｄｐｔａｔｐ）两种新配体及它们与２，２′－联吡啶和钌（Ⅱ）的混配物［Ｒｕ（ｂｐｙ）２ｄｍｔａｔｐ］２＋（１）和［Ｒｕ（ｂｐｙ）２ｄｐｔａｔｐ］２＋（２），用电子吸收光谱、稳态荧光、粘度测定和圆二色谱研究了配合物与小牛胸腺ＤＮＡ的相互作用．结合我们以前对配合物［Ｒｕ（ｂｐｙ）２ｔａｔｐ］２＋（３）（ｔａｔｐ为１，４，８，９－四氮三联苯）与小牛胸腺ＤＮＡ的作用研究，得出配合物与ＤＮＡ的键合强度顺序为：［Ｒｕ（ｂｐｙ）２ｔａｔｐ］２＋＞［Ｒｕ（ｂｐｙ）２ｄｐｔａｔｐ］２＋＞［Ｒｕ（ｂｐｙ）２ｄｍｔａｔｐ］２＋，这与插入配体的位阻效应的减少趋势相一致．同时，还测定了配合物与ＤＮＡ的键合常数．

关键词：多吡啶钌 DNA 插入作用位阻效应探针结构

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First proof-of-principle experiment with the post-accelerated isotope separator on-line beam at BRIF:measurement of the angular distribution of ^(23)Na+^(40)Ca elastic scattering

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Nuclear Science and Techniques 2021年第5期32卷 101-106页

作者： Wei Nan Bing Guo Cheng-Jian Lin lei Yang Dong-Xi wang Yang-Ping Shen Bing Tang bao-Qun Cui Tao Ge Yin-Long Lyu Hui-Ming Jia Yun-Ju Li Chen Chen Li-Hua Chen qi-Wen Fan Xin-Yue Li gang Lian Jian-Cheng Liu Tian-Peng Luo Nan-Ru Ma Rui-gang Ma Xie Ma Ying-Jun Ma Wei-Ke Nan Dan-Yang Pang You-bao wang Pei-Wei Wen Feng Yang Yong-Jin Yao Sheng Zeng Hao Zhang Fu-Peng Zhong Shan-Hao Zhong Zhi-Hong Li Tian-Jue Zhang Wei-Ping Liu BRIF Collaboration China Institute of Atomic Energy(CIAE) P.O.Box 275(10)Beijing 102413China department of Physics Guangxi Normal UniversityGuilin 541004China College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China School of Physics Beihang UniversityBeijing 100191China Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 100191China

The reaction dynamics of exotic nuclei near the drip line is one of the main research topics of current *** scattering is a useful probe for investigating the size and surface diffuseness of exotic *** development of rare isotope accelerators offers opportunities for such *** date,many relevant measurements have been performed at accelerators using the projectile fragmentation technique,while the measurements at accelerators using isotope separator on-line(ISOL)systems are still quite *** this work,we present the first proof-of-principle experiment with a post-accelerated ISOL beam at the Beijing Radioactive Ion Beam Facility(BRIF)by measuring the angular distribution of elastic scattering for the stable nucleus^(23)Na from the doubly magic nucleus^(40)Ca at energies above the Coulomb *** angular distribution measured by a silicon strip detector array in a scattering chamber using the ISOL beam at BRIF is in good agreement with that measured by the high-precision Q3 D magnetic spectrograph using the nonISOL beam at nearly the same *** work provides useful background for making BRIF a powerful tool for the investigation of the reaction dynamics of exotic nuclei.

关键词： BRIF Exotic nuclei Elastic scattering Angular distribution

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遗传性耳聋基因治疗临床指南

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实用医院临床杂志 2024年第2期21卷 39-44页

作者：齐洁玉谈方志张李燕陆玲王洪阳李文妍刘闻闻付小龙贺祖宏丁小琼孙珊方巧军董耀东朱学伟童步升曹现宝郭敏范欣淼汪芹马璐张天虹于亚峰李永新樊建刚崔勇吴佩娜张宏征唐杰郭维维查定军叶放蕾何双八曹卫杨见明钱晓云赵宇孙敬武陈晓巍孙宇夏明王秋菊袁慧军冯永孔维佳杨仕明王海波高下李华伟徐磊柴人杰东南大学数字医学工程全国重点实验室附属中大医院耳鼻咽喉头颈外科生命科学与技术学院生命与健康高等研究院江苏省生物医学高新技术研究重点实验室江苏南京210096 南通大学神经再生联合创新中心江苏南通226001 北京理工大学航天中心医院神经内科生命学院北京10081 南京大学医学院附属鼓楼医院耳鼻喉头颈外科江苏省医学重点学科(实验室)江苏南京210008 中国人民解放军总医院耳鼻咽喉头颈外科医学部北京100853 听觉与平衡觉全国重点实验室北京100853 国家耳鼻咽喉疾病临床医学研究中心北京100853 聋病教育部重点实验室北京100853 聋病防治北京市重点实验室北京100853 复旦大学附属眼耳鼻喉科医院医学神经生物学国家重点实验室教育部脑科学前沿研究中心上海200031 复旦大学生物医学研究所上海200032 国家卫健委听觉医学重点实验室上海200031 复旦大学脑科学研究院和脑科学协同创新中心上海200032 山东大学山东省耳鼻喉医院耳鼻咽喉头颈外科山东济南250022 山东省耳鼻喉研究所山东济南250022 山东第一医科大学/山东省医学科学院医学科技创新中心山东济南250000 武汉大学中南医院耳鼻咽喉头颈外科湖北武汉430071 东南大学附属中大医院耳鼻咽喉头颈外科江苏南京210009 复旦大学附属眼耳鼻喉科医院耳鼻喉科上海200032 安徽医科大学第二附属医院耳鼻咽喉头颈外科安徽合肥230601 中国医科大学附属盛京医院耳鼻咽喉头颈外科辽宁沈阳110004 吉林大学中日联谊医院耳鼻咽喉头颈外科吉林长春130033 安徽医科大学第一附属医院耳鼻咽喉头颈外科安徽合肥230022 云南省第一人民医院耳鼻喉科云南昆明650032 昆明医科大学第一附属医院耳鼻喉科云南昆明650032 中国医学科学院北京协和医学院北京协和医院耳鼻咽喉科北京100730 中南大学湘雅二医院耳鼻咽喉头颈外科湖南长沙410008 南华大学衡阳医学院基础医学院细胞生物学与遗传学教研室细胞应激生物学衡阳市重点实验室湖南衡阳421001 哈尔滨医科大学附属第一医院黑龙江哈尔滨150001 苏州大学附属第一医院耳鼻咽喉科江苏苏州215006 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科北京100730 四川省医学科学院·四川省人民医院/电子科技大学附属医院耳鼻咽喉头颈外科四川成都610072 广东省人民医院耳鼻咽喉头颈外科/广东省医学科学院/南方医科大学广东广州510080 南方医科大学珠江医院耳鼻咽喉头颈外科广东广州510282 空军军医大学西京医院耳鼻咽喉-头颈外科陕西西安710032 郑州大学第一附属医院耳科河南郑州450000 东南大学医学院附属南京同仁医院耳鼻咽喉头颈外科江苏南京211102 四川大学华西医院耳鼻咽喉头颈外科四川成都610041 中国科学技术大学附属第一医院耳鼻咽喉头颈外科安徽合肥230001 华中科技大学同济医学院附属协和医院耳鼻咽喉头颈外科湖北武汉430022 山东第一医科大学附属山东省立医院耳鼻咽喉科山东济南250021 山东省医学科学院医学科技创新中心山东济南250021 山东大学附属山东省立医院耳鼻咽喉科山东济南250021 国家卫生健康委耳鼻咽喉重点实验室山东济南250021 四川大学华西医院罕见病研究院四川成都6010041 南华大学衡阳医学院南华大学附属妇幼保健院湖南长沙410008 中南大学湘雅医院耳鼻咽喉头颈外科湖南长沙410008 上海人工耳蜗工程技术研究中心上海200031 东南大学深圳研究院广东深圳518063

遗传性耳聋是一种常见的遗传性疾病,新生儿的发病率为1‰~3‰。患者终身携带致病突变,导致不可逆性耳聋,至今尚无临床可用的治疗药物。在部分遗传性耳聋动物模型中,基因治疗已被证实为潜在有效的治疗方法。国内外已开展了多项遗传性耳... 详细信息

遗传性耳聋是一种常见的遗传性疾病,新生儿的发病率为1‰~3‰。患者终身携带致病突变,导致不可逆性耳聋,至今尚无临床可用的治疗药物。在部分遗传性耳聋动物模型中,基因治疗已被证实为潜在有效的治疗方法。国内外已开展了多项遗传性耳聋基因治疗的临床试验。其中,由东南大学附属中大医院牵头,联合国内多家医院成功开展的遗传性耳聋基因治疗临床试验,取得了显著的疗效,并积累了丰富的经验。为规范遗传性耳聋基因治疗并提供临床研究指导,全国多家医院的耳科专家讨论制定了遗传性耳聋基因治疗临床指南,内容涵盖了伦理审查、遗传性耳聋的诊断和入组标准、临床前准备、药物、疗效与安全性评估标准、术后言语康复等。本指南将为耳聋基因治疗的临床诊疗提供规范的理论和技术指导。

关键词：遗传性耳聋基因治疗临床指南

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地基大口径拼接镜面主动控制技术综述

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中国光学 2020年第6期13卷 1194-1208页

作者：范文强王志臣陈宝刚李洪文陈涛安其昌范磊中国科学院长春光学精密机械与物理研究所吉林长春130033

拼接镜面技术是光学合成孔径望远镜的三种实现方式之一,是未来大口径望远镜的重要研究方向。由于拼接镜面主动控制系统直接影响拼接镜面等效大口径镜面的光学性能,本文着眼于地基大口径望远镜的拼接镜面主动控制技术,由地基拼接镜面望... 详细信息

拼接镜面技术是光学合成孔径望远镜的三种实现方式之一,是未来大口径望远镜的重要研究方向。由于拼接镜面主动控制系统直接影响拼接镜面等效大口径镜面的光学性能,本文着眼于地基大口径望远镜的拼接镜面主动控制技术,由地基拼接镜面望远镜的发展过程展开,阐述拼接镜面主动控制系统的主要结构,对国内外拼接镜面主动控制系统发展概况进行分析和总结。归纳了拼接镜面主动控制系统实现主动调整和主动保持的关键技术,明确了深度学习理论在闭环控制,共相检测与校正和系统级仿真建模技术中的逐步应用和未来发展方向,为国内下一代地基大口径望远镜拼接镜面的控制方案设计提供相应的指导。

关键词：地基望远镜拼接镜面主动控制系统主动调整主动保持

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PUREX流程中铀/钚分离用四价铀还原剂的制备

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当代化工 2023年第3期52卷 559-564页

作者：宋淼王博张宝钢胡彦涛张晓腾蔡梦琦纪雷鸣侯宝林中国核电工程有限公司北京100840 中国科学院大连化学物理研究所辽宁大连116023

源于不向系统引入新的固体无机盐杂质,四价铀作为铀/钚分离的最佳还原剂得到了广泛的应用。目前,从硝酸铀酰还原制备四价铀的生产工艺有电解法、硝酸肼催化还原法和氢催化还原法。首先从热力学的角度论证了各工艺过程中所涉及的主反应... 详细信息

源于不向系统引入新的固体无机盐杂质,四价铀作为铀/钚分离的最佳还原剂得到了广泛的应用。目前,从硝酸铀酰还原制备四价铀的生产工艺有电解法、硝酸肼催化还原法和氢催化还原法。首先从热力学的角度论证了各工艺过程中所涉及的主反应与副反应,并结合工艺操作参数对比了各工艺过程。对比结果显示:电解法技术成熟、廉价可靠,但是转化率相对较低,需要后续开发新的电极材料及长寿命离子膜;硝酸肼催化还原法制备四价铀的工艺具有操作条件温和、产量大的优点,但是要求的原料纯度高,副反应严重且复杂;氢催化还原法已经在法国实现工程应用多年,具有成本低、产量高、反应速度快、副反应少的优点。因此,建议通过借鉴一般化工工业中氢气安全使用经验,在我国后处理厂中使用氢催化还原法制备四价铀工艺,并使用滴流床反应器,提高气液固接触效率,突破四价铀产能和产物浓度的瓶颈,满足使用需求。

关键词：四价铀铀钚分离电解还原催化肼还原催化氢还原

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