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中国高等医学教育 2024年第6期 102-103,112页

作者：方泽斌翁宇翔俞建波詹仁雅肖峰浙江大学医学院附属第一医院浙江杭州310000

目的:探讨带教老师担任SP的改良CBD教学法在神经外科见习教学中的应用效果。方法:选择2022年7月至2022年12月在浙江大学医学院附属第一医院神经外科见习的五年制本科生40名为研究对象。试验组(n=20)采用带教老师担任SP的改良CBD教学法,... 详细信息

目的:探讨带教老师担任SP的改良CBD教学法在神经外科见习教学中的应用效果。方法:选择2022年7月至2022年12月在浙江大学医学院附属第一医院神经外科见习的五年制本科生40名为研究对象。试验组(n=20)采用带教老师担任SP的改良CBD教学法,对照组(n=20)采用传统CBD教学法,见习轮转出科时进行量化考核。结果:试验组体格检查和临床思维得分显著高于对照组(P0.05)。结论:带教老师担任SP的改良CBD教学法在神经外科见习教学中是一种值得推荐的方法。

关键词： SP 改良CBD 神经外科见习带教

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Clinical and radiological outcome after treatment of unrupturedparaophthalmic internal carotid artery aneurysms:A comparative and pooled analysis of single-center experiences

Clinical and radiological outcome after treatment of unruptu...

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浙江省神经科学学会-神经外科分会成立大会&2015钱江神经外科高峰论坛暨高血压脑出血诊治新进展学习班

作者： Yu Zhu renya zhan The Department of Neurosurgery 1~(st) Affiliated HospitalCollege of MedicineZhejiang University

Objective Unrupturedparaophthalmic aneurysms present unique challenges and the ideal management remains *** We performed a pooled analysis of single-center experiences to compare the risks and effectiveness involving patients with unrupturedparaophthalmic aneurysm treated with clipping,coiling alone,stent-assisted coiling and *** MEDLINE database was searched and thirty-three series(including our institutional experience)were included.

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The occurrence of diffuse axonal injury in the brain:associated with the accumulation and clearance of myelin debris

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Neural Regeneration Research 2014年第21期9卷 1902-1906页

作者： Liang Wen Jun Xu Tianxiang zhan Hao Wang Xin Huang Wenchao Liu Xiaofeng Yang renya zhan Department of Neurosurgery First Affiliated HospitalCollege of MedicineZhejiang University

The accumulation of myelin debris may be a major contributor to the inlfammatory response after diffuse axonal injury. In this study, we examined the accumulation and clearance of myelin debris in a rat model of diffuse axonal injury. Oil Red O staining was performed on sections from the cerebral cortex, hippocampus and brain stem to identify the myelin debris. Seven days after diffuse axonal injury, many Oil Red O-stained particles were observed in the cerebral cortex, hippocampus and brain stem. In the cerebral cortex and hippocampus, the amount of myelin debris peaked at 14 days after injury, and decreased signiifcantly at 28 days. In the brain stem, the amount of myelin debris peaked at 7 days after injury, and decreased signiifcantly at 14 and 28 days. In the cortex and hippocampus, some myelin debris could still be observed at 28 days after diffuse axonal injury. Our ifndings suggest that myelin debris may persist in the rat central ner-vous system after diffuse axonal injury, which would hinder recovery.

关键词： nerve regeneration neurodegeneration diffuse axonal injury myelin debris neuroin-flammation traumatic brain injury head trauma central nervous system inflammation axon prognosis NSFC grants neural regeneration

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Successful Treatment of Multifoci Nocardial Brain Abscesses A Case Report Literature Review

Successful Treatment of Multifoci Nocardial Brain Abscesses ...

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浙江省神经科学学会-神经外科分会成立大会&2015钱江神经外科高峰论坛暨高血压脑出血诊治新进展学习班

作者： Qingsheng Xu renya zhan Yiping Feng Jiajia Chen

Brain nocardiosis is a serious opportunistic infection with high *** exists more common in the immunocompromised hosts than the immunocompetent ***-sulfamethoxazole(TMP-SMZ) has been mostly considered as the choice of the medical *** is also newly found to be effective to avoid the invasive *** authors reported a case of patient with multifoci nocardial brain abscesseswho failed with the combination of linezolid and TMP-SMZ alone but recovered with the surgery intervention and sequential antibiotics for 2 *** patient lived a high quality life without recurrence and complications during the 30 months *** the literature review,we recommend earlier stereotactic aspiration for diagnosis,combination with surgery intervention and prolonged anti-infection therapy would improve the prognosis.

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Serum alkaline phosphatase level is associated with angiographic vasospasm,delayed cerebral ischemia-caused clinical deterioration and functional outcome after aneurysmal subarachnoid hemorrhage

Serum alkaline phosphatase level is associated with angiogra...

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2019年浙江省神经外科学学术大会

作者： Yu Zhu Hao Jiang Yongda Li renya zhan The First Affiliated Hospital Zhejiang University School of Medicine

Background Alkaline Phosphatase (ALP) has been implicated to be associated with poor outcome in ischemic stroke patients,yet its role in aneurysmal subarachnoid hemorrhage (aSAH) patients is *** current study aimed to investigate the on-admission and short-term variation trend of ALP levels in aSAH patients as well as its associations with vasospasm,delayed cerebral ischemia (DCI) and outcome after aSAH.

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胚胎发育不良性胶质神经上皮肿瘤病理和影像分析(附7例报告)

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中国神经精神疾病杂志 2012年第9期38卷 517-521页

作者：吴晔詹仁雅浙江省立同德医院杭州310003 浙江大学医学院附属第一医院神经外科

目的探讨罕见中枢神经系统肿瘤——胚胎发育不良性胶质神经上皮肿瘤的临床病理及影像学特征,以提高诊断的准确性。方法回顾性分析2001年1月至2011年12月7例外科手术后病理证实的胚胎发育不良性胶质神经上皮肿瘤的临床表现、影像学特点... 详细信息

目的探讨罕见中枢神经系统肿瘤——胚胎发育不良性胶质神经上皮肿瘤的临床病理及影像学特征,以提高诊断的准确性。方法回顾性分析2001年1月至2011年12月7例外科手术后病理证实的胚胎发育不良性胶质神经上皮肿瘤的临床表现、影像学特点、手术方法、组织学特点及免疫组化结果。结果肿瘤4例位于颞叶,2例位于额叶,1例位于侧脑室及三脑室。具有特征性的"三角征"、"脑回征"等影像学表现和"特异性胶质神经元成分"的病理学表现。全部病例经显微手术治疗,随访1至10年,癫痫控制良好,肿瘤未见复发及转移,效果满意。结论胚胎发育不良性胶质神经上皮肿瘤具有特征性的影像学和病理学表现,病理组织学"特异性胶质神经元成分"对其诊断和鉴别诊断具有重要价值。

关键词：胚胎发育不良性胶质神经上皮肿瘤病理影像

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Effects of molecular targeted therapy on meningeal carcinomatosis after diagnosis of solid carcinoma :A single-center experience

Effects of molecular targeted therapy on meningeal carcinoma...

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2018年浙江省神经外科学学术年会

作者： Xinfa Pan Jie Shen renya zhan Yuehui Ma Department of Neurosurgery The First Affiliated Hospital College of Medicine Zhejiang University

Background Meningeal carcinomatosis(MC) is a severe complication in the natural history of malignancies that occurs in 4-15 % of patients with solid tumors. Recently, molecular targeted therapy have shown promising results in subsets of solid tumors. In this retrospective study, we compared the prognosis of meningeal carcinomatosis in patients who received molecular targeted therapy on solid tumors, or no molecular targeted therapy before diagnosis of *** and Methods Thirty-two patients with solid tumors were diagnosed MC by cerebrospinal fluid(CSF) cytology in our institution between January 2010 and January 2018. Among these, 18 received molecular targeted therapy on solid tumors and 14 did not. Time to death from leptomeningeal carcinomatosis diagnosis was compared between the molecular targeted therapy and no molecular targeted therapy *** Duration between meningeal carcinomatosis and death or the end of follow-up was longer in the molecular targeted therapy group than in the no molecular targeted therapy group(10.67 vs 3.64 months, P=0.014). Conclusion Molecular targeted therapy on solid tumors improved MC-free survival(MC-FS) time and had a better prognosis after diagnosis of MC compared to no molecular targeted therapy.

关键词： Meningeal carcinomatosis Molecular targeted therapy Prognosis

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Supratentorial arteriovenous malformation treatment with Onyx-18:Possibility and predictors of curative embolization

Supratentorial arteriovenous malformation treatment with Ony...

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2014浙江省神经外科学学术年会

作者： Jianwei Pan Ming Yan Weijian Fan Feng Xiao renya zhan

BACKGROUD AND PURPOSE:Onyx is increasingly used in endovascular therapy of brain arteriovenous malformations(AVMs).However,the curative effect and post-embolic complication are still *** study aims to assess the outcomes,complications and angiographic predictors of curative effect after Onyx-18 embolization for supratentorial brain AVMs(sbAVMs).MATERIALS AND METHODS:The clinical and angiographic characteristics of130 consecutive patients with sbAVMs embolization in our institutions from 2005-2008were retrospectively *** these patients were embolized by Onyx-18 for the first *** and multivariate analyses were conducted to assess the angiographic features in patients with and without total occlusion of ***:In 130 patients with sbAVMs were embolized by Onyx-18,there were28 complete(21.54%),and 102 non-complete embolization(78.46%).Non-technical peri-procedural hemorrhage occurs in 5 cases,transient neurological deficit in 13 cases,persistent neurological deficit in 9 cases,and 1 *** is no significant difference on complications between patients with and without complete *** univariate analyses,small size(≤3cm),single feeding artery,double feeding artery,terminal feeders,single drainage vein,superficial venous drainage and Spetzler-Matin I-II were associated with cure by embolization(p<0.05).Single drainage vein(p=0.003)and 1-2feeding arteries(p=0.009)were correlated with AVM volume reduction in multivariate ***:Onyx-18 embolization for sbAVMs could achieve excellent *** embolization can be achieved by low morbidity,and not correlated with *** draining vein and 1-2 arterial feeders could be predictive for curative embolization.

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Bronchogenic cyst in left anterior cranial fossa

Bronchogenic cyst in left anterior cranial fossa

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浙江省神经科学学会-神经外科分会成立大会&2015钱江神经外科高峰论坛暨高血压脑出血诊治新进展学习班

作者： Qingsheng Xu Yiping Feng Ke Ye Yongqing Zhou renya zhan From the First Affiliated Hospital College of MedicineZhejiang University

A 33-year-old man had dizziness for 3 days without provoking *** CT demonstrated a mass in the left lateral anterior cranial fossa with calcification and cystic degeneration(figure 1,A-C).MRI showed an irregularly shaped mass with mixed signal and slight marginal enhancement(figure 1,D-F).He underwent mass resection with no recurrent dizziness during 12 months’*** pathologic examination,the cyst inner lining consisted of ciliated pseudostratified columnar epithelium 1,2(figure 2).The diagnosis was bronchogenic cyst,a rare congenital malformation of ventral foregut *** excision is the elective treatment.

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Overexpression of midkine contributes to anti-apoptotic effects in human meningiomas

Overexpression of midkine contributes to anti-apoptotic effe...

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2006年浙江省神经外科学术会议

作者： Department of Neurosurgery, the First Affiliated Hospital, School of Medicine, Zhejiang University Ying Tong, renya zhan

Meningiomas are the second most common tumors of the central nervous system. Most of meningiomas grow slowly whereas atypical and anaplastic meningiomas show an aggressive biological behavior and a high risk of recurrence. Overexpression of growth factors is often considered to be a cause of carcinogenesis. Midkine and pleiotrophin are heparin-binding growth factors that promote growth, survival, migration and differentiation of various target cells. They are expressed during embryogenesis or

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