The occurrence of diffuse axonal injury in the brain:associated with the accumulation and clearance of myelin debris

作     者：Liang Wen Jun Xu Tianxiang Zhan Hao Wang Xin Huang Wenchao Liu Xiaofeng Yang Renya Zhan 

作者机构：Department of NeurosurgeryFirst Affiliated HospitalCollege of MedicineZhejiang University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2014年第9卷第21期

页      面：1902-1906页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China No.81200955 81271357 

主　　题：nerve regeneration neurodegeneration diffuse axonal injury myelin debris neuroin-flammation traumatic brain injury head trauma central nervous system inflammation axon prognosis NSFC grants neural regeneration 

摘      要：The accumulation of myelin debris may be a major contributor to the inlfammatory response after diffuse axonal injury. In this study, we examined the accumulation and clearance of myelin debris in a rat model of diffuse axonal injury. Oil Red O staining was performed on sections from the cerebral cortex, hippocampus and brain stem to identify the myelin debris. Seven days after diffuse axonal injury, many Oil Red O-stained particles were observed in the cerebral cortex, hippocampus and brain stem. In the cerebral cortex and hippocampus, the amount of myelin debris peaked at 14 days after injury, and decreased signiifcantly at 28 days. In the brain stem, the amount of myelin debris peaked at 7 days after injury, and decreased signiifcantly at 14 and 28 days. In the cortex and hippocampus, some myelin debris could still be observed at 28 days after diffuse axonal injury. Our ifndings suggest that myelin debris may persist in the rat central ner-vous system after diffuse axonal injury, which would hinder recovery.