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Inhibitory Effect of the Essential Oil from Hyptis suaveolens （L.） Poit on the Growth and Aflatoxins Synthesis of Aspergillus flavus

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Journal of Life Sciences 2013年第3期7卷 276-281页

作者： Ana Carolina Pessoa Moreira Egberto Santos Carmo Paulo Alves Wanderley Evandro leite de souza Edeltrudes de Oliveira Lima department of Pharmaceutical Sciences Federal University of Paraiba Joao Pessoa 58051-900 Brazil Academic Unit of Health Federal University of Campina Grande Cuitd 58175-000 Brazil department of Agriculture Federal University of Paraiba Bananeiras 58220-000 Brazil Laboratory of Food Microbiology Department of Nutrition Federal University of Paraiba Joao Pessoa 58051-900 Brazil

H. suaveolens （L.） Poit has been used in folk medicine revealing a wide pharmacological potential. This study aimed to evaluate the efficacy of the essential oil from 11. suaveolens leaves in inhibiting the growth of A. flavus LM257 and synthesis of aflatoxins Bl and B2. The essential oil at 20, 40 and 80 laL/mL strongly reduced the biomass and spore germination ofA. flavus. A 100% inhibition was found at 40 μL/mL and 80μL/mL, while at 20 μL/mL the growth depressed over 50% for both tested parameters. The essential oil at all assayed concentrations totally inhibited the production of aflatoxin B1 and B2. From these results, the essential oil from 11. suaveolens leaves may be considered as an alternative and effective inhibitor ofA. flavus, in addition to offer some protective effect to the production of aflatoxins.

关键词： Hyptis suaveolens essential oil Aspergillusflavus mycotoxins inhibitory effect.

The Behavior of Recycled Concrete through the Application of an Isotropic Damage Model

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Open Journal of Civil Engineering 2015年第3期5卷 339-351页

作者： Marcelo Pedreira da Silva Magno Teixeira Mota Anderson de souza Matos Gadea Monica Batista leite Koji de Jesus Nagahama Civil and Environmental Engineering Post-Graduate Program State University of Feira de SantanaFeira de SantanaBrazil

The main goal of this paper is to describe the mechanical behavior of the CDW recycled concrete in compression, using an isotropic damage model adapted to the variation of the replacement rate of natural aggregates by recycled ones. The isotropic model by Mazars was used as a constitutive equation for the CDW concrete and its adjustment parameters, A and B, were written as quadratic polynomials according to the aggregates replacement rate. The model was evaluated for conventional and recycled concretes. For the latter ones, the aggregates replacement ratios evaluated were 50% and 100%. The results show good approximation between the analytical and numerical values obtained with the adapted isotropic damage model and experimental concrete results for both compressive and flexural strength.

关键词： Recycled Concrete Construction and demolition Waste Isotropic Damage Mazars Isotropic Model

Arctic Sea Ice: decadal Simulations and Future Scenarios Using BESM-OA

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Atmospheric and Climate Sciences 2016年第2期6卷 351-366页

作者： Fernanda Casagrande Paulo Nobre Ronald Buss de souza Andre Lanfer Marquez Etienne Tourigny Vinicius Capistrano Raquel leite Mello National Institute for Space Research Earth System Science Centre S&#227o José dos Campos Brazil National Institute for Space Research Centre for Weather Forecasting and Climate Research Cachoeira Paulista Brazil National Institute for Space Research Southern Center for Space Research Santa Maria Brazil

Important international reports and a significant number of scientific publications have reported on the abrupt decline of Arctic sea ice and its impact on the Global Climate System. In this paper, we evaluated the ability of the newly implemented Brazilian Earth System Model (BESM-OA) to represent Arctic sea ice and sensitivity to CO2 forcing, using decadal simulations (1980-2012) and future scenarios (2006-2100). We validated our results with satellite observations and compared them to Coupled Model Intercomparison Project, Phase 5 (CMIP5) for the same numerical experiment. BESM results for the seasonal cycle are consistent with CMIP5 models and observations. However, almost all models tend to overestimate sea ice extent in March compared to observations. The correct evaluation of minimum record of sea ice, in terms of time, spatial and area remains a limitation in Coupled Global Climate Models. Looking to spatial patterns, we found a systematic model error in September sea ice cover between the Beaufort Sea and East Siberia for most models. Future scenarios show a decrease in sea ice extent in response to an increase in radiative forcing for all models. From the year 2045 onwards, all models show a dramatic shrinking in sea ice and ice free conditions at the end of the melting season. The projected future sea ice loss is explained by the combined effects of the amplified warming in northern hemisphere high latitudes and feedbacks processes.

关键词： Arctic Sea Ice Climate Models Brazilian Earth System Model

High Levels Production of Recombinant Human Activin A—Effect upon <i>in Vivo</i>Follicle Stimulation

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Advances in Bioscience and Biotechnology 2015年第2期6卷 96-104页

作者： Nélia Ferreira de souza Meire Coelho de Almeida Geralda Walkiria de Araujo Raquel Mariana de Melo leite Ivan Carlos dos Santos Mercia de Paula Lima Jorge Luiz Pesquero Universidade de Mogi das Cruzes Mogi das Cruzes Brazil Faculdade Pitágoras Belo Horizonte Brazil departamento de Fisiologia e Biofísica Instituto de Ciências Biológicas Universidade Federal de Minas Gerais Belo Horizonte Brazil departamento de Engenharia de Biossistemas Universidade Federal de S&atildeo Jo&atildeo del Rei S&atildeo Jo&atildeo del Rei Brazil departamento de Enfermagem Básica Escola de Enfermagem Universidade Federal de Minas Gerais Belo Horizonte Brazil

Activin plays an important role in numerous physiological processes such as cell differentiation and remodeling, regeneration and repair of tissues from various organs, angiogenesis, morphogenesis of glandular organs, pluripotency and differentiation of stem cells, cell adhesion and apoptosis. It participates in reproductive processes like embryogenesis, in the expression of Follicle Stimulating Hormone and Luteinizing Hormone and maturation of ovarian follicles and therefore has application in the area of reproduction of vertebrates. Given the economic importance of activin, we develop an efficient and economical method for the production of recombinant human activin A (rACT), using as expression system the yeast Pichia pastoris. rACT showed biological activity as it induced, on submicromolar dose, the increase of ovarian mass and the ovulation process in a mammal model.

关键词： Recombinant Human Activin Yeast Superovulation

development and implementation of an automated system to aid laboratory diagnosis using image processing

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Journal of Biomedical Science and Engineering 2013年第5期6卷 579-585页

作者： Alvaro Manoel de souza Soares Marco Rogério da Silva Richetto Joao Bosco Goncalves Pedro Paulo leite do Prado department of Mechanical Engineering University of TaubateTaubateBrasil department of Electrical Engineering University of TaubateTaubateBrasil

The objective of this work is to provide an automatic system to count white blood cells in a blood smear. To do so an experiment was assembled, composed by a standard microscope with two step motors coupled to its knobs in order to move the microscope in x and y directions and a web cam which was mounted in the top of the microscope responsible for to acquire images from the smear. The step motors and the web cam are controlled by a microcomputer PC standard via software developed indelphi. The motors use the parallel port to communicate with the PC and the camera use the USB port. The main idea is to set an initial point into the smear and the automated system will carry over the smear acquiring images (frames with 640 × 480 pixels) and counting the white blood cells encountered. The double histogram threshold technique is implemented to initially exclude the red cells from the image leaving only the white ones. Preliminaries results are obtained and show that the system is quite fast and has a good capacity of selection, even when different kinds of smear are used.

关键词： Image Processing Robotics Automation Pattern Recognition

Environmental Exposure Associated with Oxidative Stress Biomarkers in Children and Adolescents Residents in Brazilian Western Amazon

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Journal of Environmental Protection 2018年第4期9卷 347-367页

作者： Beatriz Fatima Alves de Oliveira Leandro Vargas Barreto de Carvalho dennys de souza Mourao Rita de Cassia Oliveira da Costa Mattos Hermano Albuquerque de Castro Paulo Artaxo Washington leite Junger Sandra Hacon National School of Public Health Oswaldo Cruz FoundationRio de JaneiroBrazil Center for Studies of Worker’s Health and Human Ecology Oswaldo Cruz FoundationRio de JaneiroBrazil Institute of Physics University of Sao PauloSao PauloBrazil departament of Epidemiology/Social Medicine Institute State University of Rio de JaneiroRio de JaneiroBrazil

Oxidative stress is a biological process that occurs in response to an imbalance between prooxidant and antioxidant substances and has been described in the pathophysiology of more than 200 clinical disorders. In this study, we evaluate the relationship between genetic, demographic, social, environmental, and health factors and redox imbalance biomarkers in a group of children and adolescents environmentally exposed to atmospheric pollutants and mercury in the Brazilian Western Amazon. This is a cross-sectional study of the relationship between demographic, genetic, and socioenvironmental factors and serum concentrations of redox imbalance biomarkers (thiol groups, malondialdehyde, and glutathione S-transferase [GST]) in children and adolescents living in the municipality of Porto Velho, Rond?nia. The investigated factors were hierarchically organized into groups of variables and their relationship with redox imbalance biomarkers was estimated by a multiple linear regression model. Children and adolescents with asthma, with C-reactive protein values, with the polymorphic variant GSTP1, and exposed to indoor air pollution presented lower thiol serum concentrations when compared to those categorized in their respective reference groups. GST activity and malondialdehyde serum concentrations were positively related to weekly fish consumption and exposure to PM2.5. This study showed that enzymatic GST activity and malondialdehyde serum concentrations are positively associated with environmental factors, especially air pollution (β = 8.64 U/L for GST and β = 0.244 μmol/L for MDA in high exposure group;p-value < 0.01);while serum thiol concentrations presented an inversely proportional relationship with markers of general health status, such asthma (median: 0.45 mmol/L vs. 0.48 mmol/L;p-value < 0.05), acute inflammation (β = -0.25 mmol/L;p-value < 0.01), and positively with genetic factor (β = 0.12 mmol/L for Val/Val;p-value < 0.05).

关键词： Redox Imbalance Glutathione S-Transferase Thiol Groups Malondialdehyde Brazilian Amazon

Can gadoxetic acid–enhanced magnetic resonance imaging be used to avoid liver biopsy in patients with nonalcoholic fatty liver disease?

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World Journal of Hepatology 2020年第9期12卷 661-671页

作者： Viviane Brandão Amorim Daniella Braz Parente Fernando Fernandes Paiva Jaime Araújo Oliveira Neto Amanda Almeida Miranda Cláudia Cravo Moreira Flávia Ferreira Fernandes Carlos Frederico FerreiraCampos Nathalie Carvalho leite Renata de Mello Perez Rosana souza Rodrigues Research department D’Or Institute for Research and EducationRio de Janeiro 22281Brazil Radiology department Brazilian National Cancer InstituteRio de Janeiro 20230-130Brazil Radiology department Fleury Group S.A.Rio de Janeiro 20765-000Brazil Radiology department Hospital Universitário Clementino Fraga FilhoFederal University of Rio de JaneiroRio de Janeiro 21941-590Brazil São Carlos Institute of Physics University of São PauloSão Carlos 13560-970Brazil Radiology department Quinta D'Or HospitalRio de Janeiro 20941-150Brazil Radiology department Centro de Diagnóstico Médico do MaranhãoMaranhão 65074-441Brazil department of Clinical Medicine Hospital Universitário Clementino Fraga FilhoFederal University of Rio de JaneiroRio de Janeiro 21941-590Brazil Gastroenterology and Hepatology department Hospital Federal de BonsucessoRio de Janeiro 21041-030Brazil department of Pathology and Laboratories University of the State of Rio de JaneiroRio de Janeiro 20551-030Brazil Internal Medicine department Hospital Universitário Clementino Fraga FilhoFederal University of Rio de JaneiroRio de Janeiro 21941-590Brazil Gastroenterology department Hospital Universitário Pedro ErnestoUniversity of the State of Rio de JaneiroRio de Janeiro 20551-030Brazil

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a major cause of liver disease *** diagnosis of nonalcoholic steatohepatitis(NASH),the most severe form of NAFLD,is crucial and has prognostic and therapeutic ***,currently this diagnosis is based on liver biopsy and has several *** To evaluate the performance of gadoxetic acid–enhanced magnetic resonance imaging(GA-MRI)in differentiating isolated steatosis from NASH in patients with *** In this prospective study,56 patients with NAFLD(18 with isolated steatosis and 38 with NASH)underwent *** contrast enhancement index(CEI)was calculated as the rate of increase of the liver-to-muscle signal intensity ratio from before and 20 min after intravenous GA ***-group differences in mean CEI were examined using Student's t *** area under the receiver operator characteristic curve and the diagnostic performance of gadoxetic acid–enhanced magnetic resonance imaging were *** The mean CEI for all subjects was 1.82±*** mean CEI was significantly lower in patients with NASH than in those with isolated steatosis(P=0.008).Two CEI cut-off points were used:2.00(89%sensitivity)to characterize isolated *** values between 1.66 and 2.00 indicated liver biopsy,and the procedure could be avoided in 40%of patients with *** GA-MRI is an effective noninvasive method that may be useful for the differentiation of NASH from isolated steatosis,and could help to avoid liver biopsy in patients with NAFLD.

关键词： Fatty liver Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Gadoxetic

determinant Factors in Maintaining the Exclusive Breastfeeding and Premature Weaning in Postpartum Mothers in the Brazilian Semiarid

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Health 2015年第3期7卷 355-364页

作者： Hellen Lívia Oliveira Catunda Elizian Braga Rodrigues Bernardo Lara leite de Oliveira Mirna Fontenele de Oliveira Régia Christina Moura Barbosa Castro Priscila de souza Aquino Ana Karina Bezerra Pinheiro department of Nursing Federal University of Ceará Fortaleza Brazil department of Nursing Federal University of Cariri Juazeiro do Norte Brazil

This is a cross-sectional, correlational and quantitative study conducted on 210 postpartum women from January to July 2013 at the breastfeeding outpatient clinic of a public maternity. The study was carried out in order to assess the determining factors in maintaining an exclusive breastfeeding in the first month of the newborn’s life, the participation of the nurse in encouraging this process, and the reasons leading to a premature weaning. Prior births proved to be a positive factor for exclusive breastfeeding (Odds Ratio (OR) 0.359;CI 95% 0.137 - 0.941;p = 0.031). The absence of a nurse in the medical appointments resulted in a threefold risk to have no prenatal exclusive breastfeeding guidance whatsoever (OR 3.025;CI 95% 1.567 - 5.840;p = 0.001). The reported reasons for a premature weaning were difficulty latching-on, cracked nipples, poor milk that does not satiate the baby’s hunger, and production of little or no milk at all. The results provide information for the adoption of strategies during pregnancy and the postpartum period aimed to promote an exclusive breastfeeding, checking for the possible influence of the woman’s personal circumstances in her choosing exclusive breastfeeding, as well as the participation of the nurse in the mother’s decision.

关键词： Breastfeeding Weaning Health Promotion Nursing

Culture Circle as a Teaching Approach in the Education of Teenager Health Multipliers on Leprosy Awareness

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Health 2015年第14期7卷 1813-1823页

作者： Estela Maria leite Meirelles Monteiro Amanda Araújo das Merces Amanda Carla Borba de souza Cavalcanti Ana Márcia Tenorio de souza Cavalcanti Ana Catarina Torres de Lacerda Rosália Daniela Medeiros da Silva Andrea Rosane Sousa Silva Waldemar Brandao Neto Graduate Program in Nursing Federal University of Pernambuco (UFPE) Recife Brazil Graduate Program in Child and Adolescent Health Centre of Health Sciences Federal University of Pernambuco Recife Brazil Nursing department at the Federal University of Pernambuco Recife Brazil

Objective: The study aims to evaluate the use of a teaching method proposed by Paulo Freire, Culture Circles, in the education of teenagers multipliers on leprosy awareness. Methods: It is an action-research study with a qualitative approach developed in a public school in Pernambuco, Brazil. Five Culture Circles were conducted involving the participation of 26 teenagers. The followings were used as data collection tools: observation, field notes, photography and filming. Results: The educational intervention on health addressed the following topics: 1) definition and transmission of leprosy;2) Characteristics and diagnosis of leprosy;3) Treatment of leprosy;4) Aesthetics, prejudice and mental health related to leprosy;and 5) Planning of educational activities for teenagers as health multipliers on leprosy awareness. The educational action on health provided this age group to perceive themselves, act as political subjects in the development of Culture Circles, and act as protagonists in the dissemination of knowledge on leprosy. Conclusions: This study highlights that the application of active methodologies, such as Culture Circles, is able to encourage the engagement of young people in community empowerment and bring together health professionals and the school community in an intersectoral work in order to develop action strategies involving the promotion of health in the context of neglected diseases such as leprosy.

关键词： Adolescents School Health Leprosy Awareness Culture Circles Health Promotion