检索结果-南通市图书馆

Journal of Environmental Sciences 2024年第3期137卷 370-381页

作者： Shuxian Zhang Miaomiao Zhao Shichang Li renjun yang Nuoya Yin Francesco Faiola State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

In recent years,neonicotinoids(NEOs)and organophosphate esters(OPEs)have been widely used as substitutes for traditional pesticides and brominated fame-retardants,respectively.Previous studies have shown that those compounds can be frequently detected in environmental and human samples,are able to penetrate the placental barrier,and are toxic to animals.Thus,it is reasonable to speculate that NEOs and OPEs may have potential adverse effects in humans,especially during development.We employed a human embryonic stem cell differentiation-and liver S9 fraction metabolism-based fast screening model to assess the potential embryonic toxicity of those two types of chemicals.We show that four NEO and five OPE prototypes targeted mostly ectoderm specification,as neural ectoderm and neural crest genes were down-regulated,and surface ectoderm and placode markers up-regulated.Human liver S9 fraction's treatment could generally reduce the effects of the chemicals,except in a few specific instances,indicating the liver may detoxify NEOs and OPEs.Our findings suggest that NEOs and OPEs interfere with human early embryonic development.

关键词： Neonicotinoids Organophosphate esters Human embryonic stem cells Fast screening model Developmental toxicity

Real-time Operation Optimization in Active Distribution Networks Based on Multi-agent Deep Reinforcement Learning

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 886-899页

作者： Jie Xu Hongjun Gao renjun Wang Junyong Liu the College of Electrical Engineering Sichuan University

The increasing integration of intermittent renewable energy sources(RESs) poses great challenges to active distribution networks(ADNs), such as frequent voltage fluctuations. This paper proposes a novel ADN strategy based on multiagent deep reinforcement learning(MADRL), which harnesses the regulating function of switch state transitions for the realtime voltage regulation and loss minimization. After deploying the calculated optimal switch topologies, the distribution network operator will dynamically adjust the distributed energy resources(DERs) to enhance the operation performance of ADNs based on the policies trained by the MADRL algorithm. Owing to the model-free characteristics and the generalization of deep reinforcement learning, the proposed strategy can still achieve optimization objectives even when applied to similar but unseen environments. Additionally, integrating parameter sharing(PS) and prioritized experience replay(PER) mechanisms substantially improves the strategic performance and scalability. This framework has been tested on modified IEEE 33-bus, IEEE 118-bus, and three-phase unbalanced 123-bus systems. The results demonstrate the significant real-time regulation capabilities of the proposed strategy.

关键词： Real-time systems Switches Scalability Reinforcement learning Deep learning Topology Mathematical models

Flexible bidirectional self-powered photodetector with significantly reduced volume and accelerated response speed based on hydrogel and lift-off GaN-based nanowires

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Fundamental Research 2024年第2期4卷 369-378页

作者： Min Jiang Yukun Zhao Penghui Zheng Jianya Zhang Wenxian yang Min Zhou Yuanyuan Wu renjun Pei Shulong Lu Key Lab of Nanodevices and Applications Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)Suzhou 215123China School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China CAS Key Laboratory of Nano-Bio Interface Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Nanchang Research Institute Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesNanchang 330200China

Due to the wide range of potential applications for next-generation multi-functional devices,the flexible selfpowered photodetector(PD)with polarity-switchable behavior is essential but very challenging to be realized.Herein,a wearable bidirectional self-powered PD based on detached(Al,Ga)N and(In,Ga)N nanowires has been proposed and demonstrated successfully.Arising from the photovoltage-competing dynamics across(Al,Ga)N and(In,Ga)N nanowire photoelectrodes,such PD can generate the positive(33.3 mA W−1)and negative(-0.019 mA W−1)photo-responsivity under ultraviolet(UV)and visible illumination,respectively,leading to the bidirectional photocurrent behavior.Thanks to the introduction of quasi solid-state hydrogel,the PD can work without the liquid-electrolyte,thus remarkably reducing the volume from about 482 cm3 to only 0.18 cm3.Furthermore,the use of hydrogel is found to enhance response speed in the UV range by reducing the response time for more than 95%,which is mainly attributed to the increased open circuit potential and reduced ion transport distance.As the GaN connecting segment is pretty thin,the piezoelectric charges generated by stress are proposed to have only a limited effect on the photocurrent density.Therefore,both the stable on-off switching characteristics and photocurrent densities can still be achieved after being bent 400 times.With an excellent flexibility,this work creates opportunities for technological applications of bidirectional photocurrent PDs in flexible optoelectronic devices,e.g.,wearable intelligent sensors.

关键词： Flexible photodetector Bidirectional photocurrent Lift-off GaN-based nanowires Hydrogel Self-powered device

Comparison of the Minimum Bounding Rectangle and Minimum Circumscribed Ellipse of Rain Cells from TRMM

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2024年第3期41卷 391-406页

作者： Hongke CAI Yaqin MAO Xuanhao ZHU Yunfei FU renjun ZHOU Plateau Atmospheric and Environment Laboratory of Sichuan Province School of Atmospheric SciencesChengdu University of Information TechnologyChengdu 610225China School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Center for Atmospheric Optics Anhui Institute of Optics and Fine MechanicsChinese Academy of SciencesHefei 230031China

Based on the TRMM dataset, this paper compares the applicability of the improved MCE(minimum circumscribed ellipse), MBR(minimum bounding rectangle), and DIA(direct indexing area) methods for rain cell fitting. These three methods can reflect the geometric characteristics of clouds and apply geometric parameters to estimate the real dimensions of rain cells. The MCE method shows a major advantage in identifying the circumference of rain cells. The circumference of rain cells identified by MCE in most samples is smaller than that identified by DIA and MBR, and more similar to the observed rain cells. The area of rain cells identified by MBR is relatively robust. For rain cells composed of many pixels(N> 20), the overall performance is better than that of MCE, but the contribution of MBR to the best identification results,which have the shortest circumference and the smallest area, is less than that of MCE. The DIA method is best suited to small rain cells with a circumference of less than 100 km and an area of less than 120 km^(2), but the overall performance is mediocre. The MCE method tends to achieve the highest success at any angle, whereas there are fewer “best identification”results from DIA or MBR and more of the worst ones in the along-track direction and cross-track direction. Through this comprehensive comparison, we conclude that MCE can obtain the best fitting results with the shortest circumference and the smallest area on behalf of the high filling effect for all sizes of rain cells.

关键词： TRMM minimum bounding rectangle minimum circumscribed ellipse

The short-chain perfluorinated compounds PFBS,PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self-renewal and adipogenic differentiation

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2020年第2期32卷 187-199页

作者： Shuyu Liu renjun yang Nuoya Yin Francesco Faiola State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Wellcome Trust/CRUK Gurdon Institute Department of PathologyUniversity of CambridgeCambridge CB21QNUK

Per-and polyfluorinated alkyl substances(PFASs) are commonly used in industrial processes and daily life products.Because they are persistent, they accumulate in the environment, wildlife and humans.Although many studies have focused on two of the most representative PFASs, PFOS and PFOA, the potential toxicity of short-chain PFASs has not yet been given sufficient attention.We used a battery of assays to evaluate the toxicity of several four-carbon and six-carbon perfluorinated sulfonates and carboxyl acids(PFBS,PFHxS, PFBA and PFHxA), with a human mesenchymal stem cell(hMSC) system.Our results demonstrate significant cyto-and potential developmental toxicity for all the compounds analyzed, with shared but also distinct mechanisms of toxicity.Moreover, the effects of PFBS and PFHxS were stronger than those of PFBA and PFHxA, but occurred at higher doses compared to PFOS or PFOA.

关键词： Short-chain perfluorinated compounds Human mesenchymal stem cells(hMSCs) Adipogenesis/osteogenesis Developmental toxicity PFBS/PFBA/PFHxS/PFHxA

提高损害赔偿数额能否威慑专利侵权?——基于19596份裁判文书的实证分析

在线全文

学校读者我要写书评

暂无评论

环球法律评论 2024年第2期46卷 91-108页

作者：边仁君北京大学法学院

在公共政策的制定、立法和司法活动中,“提高损害赔偿可以威慑专利侵权”往往被当作不证自明的真理而广泛应用。然而,损害赔偿客观属性的变化如何作用于潜在侵权人的主观行为,其理论路径和实践效果皆不清晰。参照对威慑理论研究较为深... 详细信息

在公共政策的制定、立法和司法活动中,“提高损害赔偿可以威慑专利侵权”往往被当作不证自明的真理而广泛应用。然而,损害赔偿客观属性的变化如何作用于潜在侵权人的主观行为,其理论路径和实践效果皆不清晰。参照对威慑理论研究较为深入的犯罪学成果,可以构建兼具立体维度和中介条件的专利侵权损害赔偿威慑机制理论模型。对上述理论进行实证检验可以发现,“高赔偿”作为当下威慑侵权的主要制度工具,威慑效力十分有限,反而是常常被忽略的赔偿确定性和及时性呈现出显著而稳定的威慑效力。而且,仅就损害赔偿数额高低而言,其主观属性比客观属性更具威慑效力。因此,应当重新思考单纯追求高赔偿的若干法律规则的合理性问题,构建兼具确定性和及时性的立体威慑机制,用“疏而不漏”代替“小惩大诫”,以期达到最优的威慑侵权效果。

关键词：专利侵权损害赔偿威慑效果实证研究

Oscillating Cellulase Adsorption and Enhanced Lignocellulose Hydrolysis upon Ultrasound Treatment

在线全文

学校读者我要写书评

暂无评论

Transactions of Tianjin University 2017年第1期23卷 11-19页

作者： Rongxin Su renjun yang yang Jifeng Ruoyu Du Renliang Huang Wei Qi Zhimin He State Key Laboratory of Chemical Engineering School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072 China Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin 300072 China Chongqing Key Laboratory of Catalysis and Functional Organic Molecules College of Environment and ResourceChongqing Technology and Business UniversityChongqing 400067 China School of Environmental Science and Engineering Tianjin University Tianjin 300072 China

We investigated the effects of ultrasound treatment on cellulase adsorption and lignocellulose hydrolysis.The activity of cellulase remained constant upon lowpower ultrasound treatment(280 W).Oscillating cellulase adsorption occurred upon ultrasound treatment with any intensity.The maxima for desorption and adsorption were41.9 and 83.1%,respectively,during 1 h of 90 W ultrasound treatment at 50 °C.A comparison between the shorttime with long-time ultrasound experiments indicated that ultrasound treatment tended to desorb cellulase from substrate.However,ultrasound treatment also led to further surface erosion of biomass,which increased cellulase accessibility.These joint actions of ultrasound treatment induced the oscillating adsorption of cellulase.The increase in cellulase accessibility caused by ultrasound treatment led to a significant enhancement in lignocellulose hydrolysis.

关键词： Lignocellulose Cellulase Ultrasound Adsorption Desorption Hydrolysis

在线全文

学校读者我要写书评

暂无评论

中国民族学知识生产的演进脉络与内在逻辑

民族研究 2024年第1期 44-57,M0003页

作者：何明谭任均云南大学西南边疆少数民族研究中心昆明市650091

中国传统民族思想是中国民族学知识生产的重要来源,是中国民族学自主知识体系建构的根脉。作为现代学科意义上的中国民族学之知识生产,主要经历了现代民族学知识体系的建构、马克思主义民族理论中国化的初步形成、民族学知识生产全球化... 详细信息

中国传统民族思想是中国民族学知识生产的重要来源,是中国民族学自主知识体系建构的根脉。作为现代学科意义上的中国民族学之知识生产,主要经历了现代民族学知识体系的建构、马克思主义民族理论中国化的初步形成、民族学知识生产全球化、民族学自主知识体系的自觉建构等不同历史发展阶段,形成了独特的演进脉络与内在逻辑。对中国民族学知识生产的历史过程进行反思和梳理,是建构中国自主的民族学知识体系不可或缺的基础工作,对于推动中国哲学社会科学学科体系、学术体系与话语体系的建构也有着积极的探索价值。

关键词：中国民族学知识生产知识体系演进脉络

结构化思维视域下中考复习阶段的深度备课——以“物理探究题的复习”为例

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

物理教学 2024年第6期46卷 39-42,38页

作者：程仁军嘉兴一实学校浙江314050

深度备课能解决中考复习阶段出现的“忙”“盲”“茫”现象。它需要备课教师以结构化思维为指导,率先跳入题海去梳理出复习的方向,研究出试题的组成并形成试题的破解策略。新课程非常注重学生科学探究能力的培养和评价,近年来出现了各... 详细信息

深度备课能解决中考复习阶段出现的“忙”“盲”“茫”现象。它需要备课教师以结构化思维为指导,率先跳入题海去梳理出复习的方向,研究出试题的组成并形成试题的破解策略。新课程非常注重学生科学探究能力的培养和评价,近年来出现了各式各样的中考物理探究题,成为很多师生共同的教学难题,更是初三师生在中考复习阶段绕不开的教学话题。文章以“物理探究题的复习”为例,阐述了结构化思维视域下的深度备课的教学实施和效果。

关键词：科学探究中考复习深度备课结构化思维

右归丸治疗腰椎间盘突出症:网络药理学分析活性成分及潜在治疗靶点

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究 2024年第27期28卷 4346-4352页

作者：杨敬言马涉黄仁俊杨骁侠汤笑尘于栋北京中医药大学第三临床医学院北京市100029 北京中医药大学第三附属医院北京市100029

背景:右归丸具有温肾助阳、益精填髓的作用,临床多用于治疗肾阳虚证的腰椎间盘突出症且具有较好的疗效。目的:采用网络药理学、分子对接技术并结合动物实验探讨右归丸治疗腰椎间盘突出症的潜在靶点及作用机制。方法:①网络药理学分析:通... 详细信息

背景:右归丸具有温肾助阳、益精填髓的作用,临床多用于治疗肾阳虚证的腰椎间盘突出症且具有较好的疗效。目的:采用网络药理学、分子对接技术并结合动物实验探讨右归丸治疗腰椎间盘突出症的潜在靶点及作用机制。方法:①网络药理学分析:通过TCMSP等数据库获取经过筛选后的右归丸有效成分与作用基因靶点,在GeneCards等数据库中收集与腰椎间盘突出症相关的基因,取二者交集进行拓扑结构分析,得到主要活性成分及核心治疗靶点。使用R软件对核心治疗靶点进行GO功能及KEGG通路富集分析。②分子对接:运用Autodock和Pymol软件进行中药活性成分与核心治疗靶点分子结合能预测。③动物实验:将18只SD大鼠随机分为对照组、退变组与退变+右归丸组,每组6只。取退变组与退变+右归丸组大鼠,采用纤维穿刺法制备椎间盘退行性变模型,造模后2周,退变+右归丸组大鼠给予右归丸汤剂(1次/d)灌胃,连续给药2周。给药结束后,采用ELISA法检测血清中肿瘤坏死因子α质量浓度,苏木精-伊红染色后观察椎间盘纤维环及髓核细胞的形态学改变。结果与结论:①筛选出右归丸有90种活性成分和64种靶点,且主要活性成分为槲皮素、山奈酚、β-胡萝卜素、大豆黄素,4′-O-甲基尼亚萨酚。右归丸治疗腰椎间盘突出症的核心靶点为白细胞介素6、肿瘤坏死因子α、AKT1、白细胞介素1B、血管内皮生长因子A。富集分析发现,交集基因可能通过白细胞介素17、肿瘤坏死因子、MAPK、PI3K-AKT等信号通路改善椎间盘退变。②分子对接实验验证了右归丸中的槲皮素、山奈酚、β-胡萝卜素等与核心靶点有较强的结合能力。③动物实验结果显示,退变组大鼠血清肿瘤坏死因子α质量浓度高于对照组(P<0.05),退变+右归丸组大鼠血清肿瘤坏死因子α质量浓度低于退变组(P<0.05);苏木精-伊红染色显示,退变组大鼠椎间盘纤维环、髓核结构遭到破坏,髓核细胞数量减少;退变+右归丸组大鼠椎间盘纤维环可见重建趋势,髓核细胞数量较退变组增加。④结果表明,右归丸可能通过槲皮素、山奈酚、β-胡萝卜素等主要活性成分作用于肿瘤坏死因子α等核心靶点改善椎间盘退变,进而治疗腰椎间盘突出症。

关键词：右归丸腰椎间盘突出症网络药理学分子对接信号通路炎症因子潜在靶点纤维环穿刺