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In Vivo Studies and Flow Cytometric Investigation on Anticancer Potential of Selenium Nanoparticles Synthesized via Aqueous Extract of Clerodendron phlomidis

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Proceedings of Anticancer Research 2024年第1期8卷 71-81页

作者： Veeramani Subha Kirubanandan Shanmugam renganathan sahadevan National Centre for Nanoscience and Nanotechnology University of MadrasGuindy CampusChennai 600025Tamil NaduIndia Saveetha School of Engineering SIMATSThandalamChennai 602107Tamil NaduIndia Department of Biotechnology A.C.TechAnna UniversityChennai 600025Tamil NaduIndia

Nowadays,doctors and nutritionists recommend individuals incorporate selenium-rich foods such as nuts,cereals,and mushrooms into their regular diet to maintain fitness and overall *** nanoparticles(SeNPs)exhibit strong chemopreventive *** anticipations for SeNPs with enhanced and tunable bioactive activities have led to a keen interest in *** this study,the aqueous extract of Clerodendron phlomidis plant leaves was utilized for the synthesis of *** traditional Indian medicine,this plant extract is recognized as a significant anti-diabetic *** flavonoids tetrahydroxylflavone,7-hydroxyflavanone,and 6,4’-dimethyl-7-acetoxy-scutellarein present in this plant leaf extract demonstrate excellent anticancer *** secondary metabolites exhibit the ability to reduce sodium selenite into *** a concentration of 13μg/mL,the synthesized SeNPs effectively inhibited the proliferation of the HepG2 cell *** results suggest that the SeNPs possess promising anti-cancer potential against liver cancer and can be considered as a therapeutic agent for liver cancer ***,the cell cycle arrest induced by SeNPs was further confirmed by the fluorescence-activated cell sorting(FACS)method,indicating that SeNPs could efficiently differentiate cancer cells from normal ***,it showed a significant improvement in diethylnitrosamine(DEN)-induced Swiss Wistar rat *** scientific investigation highlights the high anti-cancer potential of SeNPs,positioning them as a promising therapeutic agent for liver cancer treatment.

关键词： Selenium nanoparticles Green synthesis Liver cancer Clerodendron phlomidis Flow cytometry In vivo studies

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Biosynthesis of Silver Nanoparticles with Clerodendron phlomoides Leave Extract:Particle Morphology,Antimicrobial Potential and Application

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Journal of Clinical and Nursing Research 2024年第1期8卷 51-64页

作者： Kirubanandan Shanmugam Subha Veeramani renganathan sahadevan Saveetha School of Engineering SIMATSChennai 602105India National Centre for Nanoscience and Nanotechnology University of MadrasGuindy CampusChennai 600025India Centre for Biotechnology A.C.TechAnna UniversityChennai 600025India

Silver nanoparticles are versatile nanomaterials that have found numerous applications in various *** use of plant extract for the synthesis of silver is a green and sustainable *** phlomoides leaves extract has been found to contain various phytochemicals,such as phenols,flavonoids,tannins,and alkaloids,which possess reducing and stabilizing properties that can aid the production of silver *** this paper,morphological and topographical analyses were performed on silver *** biosynthesized silver nanoparticles showed antimicrobial potential against wound *** and TEM micrographs revealed that the particles were sphere and nanosized,which makes them suitable for various biomedical applications.

关键词： Silver nanoparticles Clerodendron phlomoides Biosynthesis Morphology SEM TEM FTIR Antimicrobial activity and wound pathogens

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