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Aut.somal dominant.polycyst.c liver disease in a family wit.out.polycyst.c kidney disease associat.d wit. a novel missense prot.in kinase C subst.at. 80K-H mut.t.on

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World Journal of Gast.oent.rology 2005年第48期11卷 7690-7693页

作者： Ramón Peces Joost.PH Drent. rene hm t. morsche Pedro González Carlos Peces Sect.on of Nephrology Depart.ent.of Medicine Sect.on of Digest.ve Hospit.l General La Mancha-Cent.o Comput.r Science Superior School

Polycyst.c liver disease (PLD) is charact.rized by t.e presence of mult.ple bile duct.derived epit.elial cyst. scat.ered in t.e liver parenchyma. PLD can manifest.it.elf in pat.ent. wit. severe aut.somal dominant.polycyst.c kidney disease (ADPKD). Isolat.d aut.somal dominant.polycyst.c liver disease (ADPLD) is genet.cally dist.nct.from PLD associat.d wit. ADPKD, alt.ough it.may have similar pat.ogenesis and clinical ***, mut.t.ons in t.o causat.ve genes for ADPLD,independent.y from ADPKD, have been ident.fied. We report.here a family (a mot.er and her daught.r) wit. a severe form of ADPLD not.associat.d wit. ADPKD produced by a novel missense prot.in kinase C subst.at. 80K-H (PRKCSH) mut.t.on (R281W). t.is mut.t.on causes a severe phenot.pe, since t.e t.o affect.d subject. manifest.d signs of port.l hypert.nsion. Doppler sonography, comput.d t.mography (Ct. and magnet.c resonance (MR) imaging are effect.ve in document.ng t.e underlying lesions in a non-invasive way.

关键词： ADPLD Hepat.c cyst. Hepat.cyst.n Inferior vena cava compression Polycyst.c liver disease Port.l hypert.nsion

Cyclooxygenase-2 polymorphisms and t.e risk of esophageal adeno-or squamous cell carcinoma

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World Journal of Gast.oent.rology 2009年第28期15卷 3493-3497页

作者： Jón O Krist.nsson Paul van West.rveld rene hm t. morsche Hennie MJ Roelofs t.Wobbes Ben JM Wit.eman Adriaan CIt. t.n Mart.jn GH van Oijen Jan BMJ Jansen Wilbert.hm Pet.rs Depart.ent.of Gast.oent.rolog Radboud Universit. Nijmegen Medical Cent.r PO Box 9106500 HB Nijmegen The Netherlands Depart.ent.of Surgery Radboud UniversityNijmegen Medical Center PO Box 9101 6500 HB NijmegenThe Netherlands Depart.ent.of Gast.oent.rology Hospital Gelderse Vallei PO Box 9025 6710 HN Ede The Netherlands Depart.ent.of Gast.oent.rology Canisius Wilhelmina Hospital Weg door Jonkerbos 100 6532 SZ Nijmegen The Netherlands

AIM： t. det.rmine whet.er -1195 A→G and/or -765 G→C polymorphisms in Cyclooxygenase-2 CCOX-2） may have a risk modifying effect.on t.e development.of esophageal carcinoma in a Dut.h Caucasian populat.on. MEt.ODS： t.o st.dy groups were recruit.d, 252 pat.ent. wit. esophageal carcinoma and 240 healt.y cont.ols, mat.hed for race, age, gender and recruit.ng area. DNA was isolat.d from whole blood and used for genot.ping. PCR product. were digest.d wit. rest.ict.on enzymes and product. were analyzed by agarose gel elect.ophoresis. Odds rat.os （OR） and 95% confidence int.rvals （CI） were est.mat.d. RESULt.： t.e dist.ibut.on of t.e -1195A→G polymorphism was significant.y different.in esophageal cancer pat.ent. compared t. cont.ols. t.e -1195 GG genot.pe result.d in a higher risk of developing esophageal adenocarcinoma （OR = 3.85, 95% CI： 1.45-10.3） compared wit. t.e -1195AA genot.pe as a reference. t.e -765 G→C genot.pe dist.ibut.on was not.different.bet.een t.e t.o groups. t.e GG/ GG haplot.pe was present.more oft.n in esophageal adenocarcinoma pat.ent. t.an in cont.ols （OR = 3.45, 95% CI： 1.24-9.58; wit. AG/AG as a reference）. t.e same t.ends were observed in pat.ent. wit. squamous cell carcinomas, however, t.e result. did not.reach st.t.st.cal significance. CONCLUSION： Presence of t.e COX-2 -1195 GG genot.pe and of t.e GG/GG haplot.pe may result.in a higher risk of developing esophageal carcinoma.

关键词： Adenocarcinoma Cyclooxygenase-2 Esophagus Genet.c polymorphism Squamous cellcarcinoma

Ident.ficat.on of Rhizobia Isolat.d from Nodules of Mexican Commercial Soybean Variet.es

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American Journal of Plant.Sciences 2024年第1期15卷 29-45页

作者： Cecilia Vázquez Rodríguez Lourdes Vit.l López Jesús Gerardo García Olivares Homar rene Gill Langarica Laborat.rio de Biot.cnología Veget.l Centro de Biotecnología Genómica Instituto Politécnico Nacional Reynosa México Carrera de Mant.nimient. Indust.ial Universidad Tecnológica de Tamaulipas Norte Universidad Tecnológica Reynosa México

Rhizobia, crucial for nit.ogen fixat.on in leguminous plant., play a vit.l role in soybean cult.vat.on. t.is st.dy, conduct.d in Mexico, a major soybean import.r, aimed t. ident.fy bact.ria from nodules of five soybean variet.es in high-product.on regions. Mult.locus sequence analysis (MLSA) was employed for enhanced species resolut.on. t.e st.dy ident.fied six Bradyrhizobium species: Bradyrhizobium japonicum USDA 110, Bradyrhizobium japonicum USDA 6, Bradyrhizobium elkanii USDA 76, Bradyrhizobium neot.opicale, Bradyrhizobium lablabi, and Bradyrhizobium icense. Bradyrhizobium japonicum USDA 110 predominat.d in t.e soils, displaying symbiot.c preference for t.e Huast.ca 400 variet.. However, phylogenet.c analysis didn't.reveal a clear associat.on bet.een st.ains, soil, and soybean variet.. t.is research sheds light.on t.e diversit. of rhizobia in Mexican soybean cult.vat.on, cont.ibut.ng t. t.e underst.nding of symbiot.c relat.onships in soybean product.on syst.ms.

关键词： Nodules Soybean Housekeeping Genes MLSA Rhizobia Bradyrhizobium Nit.ogen Fixat.on Symbiosis Phylogenet.c Analysis

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盗版泰勒经济

商业周刊（中文版） 2024年第6期 8-10页

作者： Ella Ceron St.cey rene 晴川(译) 不详

泰勒·斯威夫特(t.ylor Swift.的歌迷们若想购买t.、紧身衣、友谊手环或各种其他纪念品来表达他们对这位流行巨星的热爱,他们或许会考虑去官网。但最近试过的人都不太走运。这家店在新专辑《t.e t.rt.red Poet. Depart.ent.发布之前,... 详细信息

泰勒·斯威夫特(t.ylor Swift.的歌迷们若想购买t.、紧身衣、友谊手环或各种其他纪念品来表达他们对这位流行巨星的热爱,他们或许会考虑去官网。但最近试过的人都不太走运。这家店在新专辑《t.e t.rt.red Poet. Depart.ent.发布之前,只提供珍藏版CD、磁带和黑胶唱片的预订。不过,这并没有妨碍“泰勒迷经济”的蓬勃发展,因为在Et.y、亚马逊(***)和Redbubble等按需印制网站上已涌现了无数的零售店铺,提供大量带有泰勒照片或歌词的商品。

关键词：斯威夫特黑胶唱片珍藏版紧身衣泰勒亚马逊

Expression and regulat.on of plasminogen act.vat.r and plasminogen act.vat.r inhibit.r t.pe-1 in rat.epididymis

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Chinese Science Bullet.n 1997年第9期42卷 779-783页

作者： Zhou, hm Zhang, t.Liu, YX CHINESE ACAD SCI INST ZOOLSTATE KEY LAB REPROD BIOLBEIJING 100080PEOPLES R CHINA

EPIDIDYMIS is t.e sit. where spermat.zoa released from t.st.s undergo mat.rat.on and become capable of fert.lizing *** epididymal secret.ons including enzymes,nut.ient. and hor-mones are believed t. be essent.al for sperm *** prot.olysis cont.ibut.s t.loss or modificat.on of surface molecules of spermat.zoa,which is an import.nt.aspect.of

关键词： plasminogen act.vat.r plasminogen act.vat.r inhibit.r human chorionic gonadot.opin/lut.inizing hormone epi-didymis.

Dysfunct.on of t.e adhesion G prot.in-coupled recept.r lat.ophilin 1(ADGRL1/LPHN1)increases t.e risk of obesit.

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Signal t.ansduct.on and t.rget.d t.erapy 2024年第5期9卷 2298-2311页

作者： Heba Zabrit.rst.n Schöneberg AndréNguyen Diet.sch Hadi Al-Hasani Joachim Alt.chmied Kat.arina Bot.ermann Jana Brendler Judit. Haendeler Susanne Horn Isabell Kaczmarek Ant.e Körner Kerst.n Krause Kat.rin Landgraf Diana Le Duc Laura Lehmann St.fan Lehr St.phanie Pick Albert.Ricken rene Schnorr Angela Schulz Mart.na St.nadová Akhil Velluva Heba Zabri t.rst.n Schöneberg Doreen t.or Simone Prömel Rudolf Schönheimer Inst.t.t. of Biochemist.y Medical FacultyLeipzig UniversityLeipzigGermany Inst.t.t. for Clinical Biochemist.y and Pat.obiochemist.y Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Cent.r for Diabet.s Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degenerat.on Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Inst.t.t.(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Inst.t.t. of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Inst.t.t. of Anat.my Medical FacultyLeipzig UniversityLeipzigGermany Cent.r for Pediat.ic Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholt. Inst.t.t. for Met.bolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Depart.ent.of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Inst.t.t. of Human Genet.cs Leipzig University Medical CenterLeipzigGermany Inst.t.t. of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesit. is one of t.e diseases wit. severe healt. consequences and rapidly increasing worldwide *** t.e complex net.ork of food int.ke and energy balance regulat.on is an essent.al prerequisit. for pharmacological int.rvent.on wit. obesit..G prot.in-coupled recept.rs(GPCRs)are among t.e main modulat.rs of met.bolism and energy ***,for inst.nce,regulat. appet.t. and sat.et. in cert.in hypot.alamic neurons,as well as glucose and lipid met.bolism and hormone secret.on from *** in some GPCRs,such as t.e melanocort.n recept.r t.pe 4(MC4R),have been associat.d wit. early-onset.***,we ident.fied t.e adhesion GPCR lat.ophilin 1(ADGRL1/LPHN1)as a member of t.e regulat.ng net.ork governing food int.ke and t.e maint.nance of energy *** of t.e highly conserved recept.r in mice result. in increased food consumpt.on and severe obesit.,accompanied by dysregulat.on of glucose ***,we ident.fied a part.ally inact.vat.ng mut.t.on in human ADGRL1/LPHN1 in a pat.ent.suffering from ***,we propose t.at.LPHN1 dysfunct.on is a risk fact.r for obesit. development.

关键词： obesit. met.bolism int.ke

Dose-dependent.effect.of hist.mine on ant.body generat.on in vivo

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Asian Pacific Journal of t.opical Medicine 2010年第2期3卷 112-116页

作者： t.ipat.i t.Shahid M Khan hm Khan RA Siddiqui MU DePart.ent.of Biochemist.y Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Depart.ent.of Microbiology Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Depart.ent.of Pharmacology Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University Depart.ent.of Biochemist.y Faculty of MedicineJawaharlal Nehru Medical College and HospitalAligarh Muslim University

Object.ve:t. delineat. immunomodulat.ry role of hist.mine on ant.body generat.on pr of ile in rabbit.in t.e present.dose-dependent.hist.mine ***:t.e cohort.comprised of t.ree groups(Ⅲ,ⅣandⅤ),cont.ining six rabbit. each,and received subcut.neous hist.mine 50μg/kg×bis in die(b.i.d.),100μg/kg×*** 200μg/kg X b.i.d.,respect.vely for 10 days (st.rt.ng from t.e 1st.day).t.ey were subsequent.y immunized on t.e 3rd day wit. int.avenous inject.on of sheep blood cell(SRBC)(1×10 cells/mL).GroupⅡ(posit.ve cont.ol)(n=6) received vehicle(st.rile dist.lled wat.r) and immunized at.day 3 similarly while groupⅠ(negat.ve cont.ol) (n=6) remained non-immunized and received only *** experiment.t.ons were performed in *** samples were collect.d on pre-immunizat.on(pre-I)(day 0),as well as on days 7-,14-,21-,28- and 58- post.immunizat.on(post.I).Immunological paramet.rs[t.t.l immunoglobulins(Igs),IgM and IgG]were analyzed by enzyme linked immunosorbent.assay (ELISA) ***:Hist.mine could influence a det.ct.ble ant.body response t. SRBC as early as day 7-post.I,which last.d unt.l day 58- *** result. were found st.t.st.cally significant.P<. 0.05).Conclusions:Our result. provide evidence t.at.hist.mine has a short.t.rm effect.on ant.body generat.on(unt.l it. presence in t.e body),and t.e ant.body generat.on t.t.r in vivo were affect.d by t.e concent.at.on of hist.mine.

关键词： Hist.mine Immumomodulat.on t.cell dependent ant.body response Humoral immune response SRBC

Hemat.logy and Some Biochemical Paramet.rs of Wild Rodent. in Pist.chio Gardens of Kerman Province, Sout.east.Iran

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应用与环境生物学报 2011年第6期17卷 907-909页

作者： MADJDZADEH SM ABBASNEJAD M t.KALLOOZADEH hm Mammalian Biodiversit. Research Unit Department of Biology Faculty of Sciences Shahid Bahonar University of Kerman 76169-14111 Kerman Iran Depart.ent.of Plant.Pat.ology Faculty of Agriculture Shahid Bahonar University of Kerman 76169-14111 Kerman Iran

Wild rodent. were collect.d using live snap t.aps in pist.chio gardens of Kerman Province, Sout.east.Iran from 2007 t. 2009, t.en some physiological paramet.rs of t.em were measured. t.e samples were ident.fied as follow: Nesokia indica, Meriones persicus, Meriones lybicus and t.t.ra indica. Blood samples were obt.ined from t.e heart. t.en t.e blood paramet.rs (glucose, cholest.rol, t.iglyceride, t.t.l prot.in, HDL, red and whit. blood cell number) in wild species of rodent. and laborat.ry rat.were compared. t.e result. showed t.at.t.ere were no significant.differences in serum glucose, t.iglyceride, HDL and t.t.l prot.in levels among different.experiment.l groups. t.e concent.at.on of cholest.rol in t. indica was more t.an t.at.in N. indica (P t.e t.t.l numbers of red blood cells also showed significant.difference bet.een wild garden rodent.species and laborat.ry rat.(P t.e numbers of whit. blood cells showed no significant.difference.

关键词： rodent. hemat.logical paramet.r biochemical paramet.r pist.chio gardens Kerman Province, Iran

Assessing Growt. Paramet.rs from Culm Cut.ings of Bambusa vulgaris at.t.e Universit. of Dschang Bot.nic Garden, West.Region of Cameroon: Implicat.ons for t.e Bamboo Resource Base and Rural Livelihoods

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Open Journal of Forest.y 2022年第1期12卷 88-106页

作者： Gilles Ananfack Baurel At.hombou Herman t. Zanguim Nyong Princely Awazi St.ve N. t.ssiamba Loic t. t.ent.heu Barnabas Neba Nfornkah rene Kaam Mart.n N. t.hamba Laborat.ry of Environment.l Geomat.cs Department of Forestry Faculty of Agronomy and Agricultural Sciences The University of Dschang Dschang Cameroon Depart.ent.of Forest.y and Wildlife t.chnology College of Technology The University of Bamenda Bambili Cameroon t.e Int.rnat.onal Bamboo and Rat.an Organizat.on (INBAR) Yaoundé Cameroon

Dwindling supplies of bamboo resources and t.e increase in t.e demand for bamboo have led t. t.e need for bet.er propagat.on t.chniques. t.is is t.e only way t. ensure t.e sust.inabilit. of t.e bamboo resource base an... 详细信息

Dwindling supplies of bamboo resources and t.e increase in t.e demand for bamboo havet.le="font.family:""> led t. t.e need for bet.er propagat.on t.chniques. t.is is t.e only way t. ensure t.e sust.inabilit. of t.e bamboo resource base and improve livelihoods. t.us, t.is st.dy was carried out.t. examine t.e different.growt. paramet.rs of culm cut.ings of Bambusa vulgaris in propagat.on beds wit. a subst.at. consist.ng of dark soil, manure (compost. and sand in a rat.o of 1:1:1. Dat. on different.growt. paramet.rs was collect.d on a daily basis over a t.ree week period and analyzed using appropriat. descript.ve and inferent.al st.t.st.cs. It.was found t.at.t.e different.growt. paramet.rs (diamet.r, height. leaves and sheat.s) of culm cut.ings of B. vulgaris evolved in like manner in t.ree propagat.on beds. Descript.ve st.t.st.cs for growt. paramet.rs of culm cut.ings of B. vulgaris showed lit.le or no differences across t.ree shelt.r/propagat.on beds (shelt.r bed 1, shelt.r bed 2 and shelt.r bed 3) wit. 1.4675 ± 1.6172 cm, 93 ± 112 cm, 22 ± 30 leaves, and 4 ± 6 sheat.s being t.e mean diamet.r, height. number of leaves and number of sheat.s for all t.ree propagat.on beds, respect.vely. ANOVA t.st.showed no st.t.st.cally significant.variat.on (p > 0.05) bet.een growt. paramet.rs of culm cut.ings of B. vulgaris across t.e t.ree propagat.on beds, implying t.at.t.e different.growt. paramet.rs were relat.vely similar. Pearson correlat.on showed t.e exist.nce of direct.and inverse relat.onships bet.een t.e different.growt. paramet.rs of culm cut.ings of bamboo. t.e exist.nce of t.ese direct.and inverse relat.onships could be at.ribut.d t. t.e rapid growt. rat. of bamboo, t.e subst.at. used, and t.e species of bamboo used (B. vulgaris). t.e st.dy recommends more large-scale propagat.on project. of t.is bamboo species in order t. ensure t.e s

关键词： Bamboo Bambusa vulgaris Growt. Paramet.rs Culm Cut.ings Universit. of Dschang Bot.nic Garden Cameroon