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Use of Ultrasound and Microwave Irradiation for Clean and Efficient Synthesis of 3,3’-(Arylmethylene)bis (2-hydroxynaphthalene-1,4-dione) Derivatives

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Green and Sustainable Chemistry 2014年第4期4卷 177-184页

作者： Aldo S. de oliveira Luana C. Llanes Ricardo J. Nunes Rosendo A. Yunes Inês M. C. Brighente Departamento de Química Universidade Federal de Santa Catarina Campus Universitário Trindade Florianópolis Brazil

Nine 3,3’-(arylmethylene)bis(2-hydroxynaphthalene-1,4-dione) derivatives were synthesized through the reaction between 2-hydroxy-1,4-naphthalen-1,4-dione and different aromatic alde-hydes in water applying ultrasonic irradiation for 5 min at room temperature and microwave irradiation for 15 min at 70°;C. Two of the nine derivatives, compounds 3-e and 3-i, obtained from 3-bromo-hydroxybenzaldehyde and 5-methylfuran-2-carbaldehyde, respectively, are previously unpublished. The structures of all compounds were established on the basis of their spectral data and mass analysis. The attractive features of this synthesis protocol include mild conditions, high atom-economy and excellent yields with the elimination of water as the only by-product.

关键词： 2-Hydroxy-1 4-naphthoquinone 3 3’-(Arylmethylene)bis(2-hydroxynaphthalene-1 4-dione) Derivatives Green Chemistry

Diabetic gastroenteropathy:An underdiagnosed complication

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World Journal of Diabetes 2021年第6期12卷 794-809页

作者： Marcio joséConcepción Zavaleta Jhean Gabriel Gonzáles Yovera Diego Martín Moreno Marreros Luciana del Pilar Rafael Robles Kely Roxana Palomino Taype Karen Nohelly Soto Gálvez Luis Fernando Arriola Torres Julia Cristina Coronado Arroyo Luis Alberto Concepción Urteaga Division of Endocrinology Hospital Nacional Guillermo Almenara IrigoyenLima 12590Peru Division of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyenLima 12590Peru Division of Medicine Universidad Nacional de TrujilloTrujillo 13011Peru Division of Endocrinology Hospital Nacional Dos de MayoLima 150101Peru Division of Endocrinology Instituto de Neurología y Endocrinología AvanzadaAndahuaylas 03700Peru Clinical Management Unit Hospital Nacional Guillermo Almenara IrigoyenLima 12590Peru Division of Neurology Instituto de Neurología y Endocrinología AvanzadaAndahuaylas 03700Peru Division of Obstetrics and Gynaecology Clínica VesalioLima 15036Peru Division of Neumology Hospital Regional Docente de TrujilloTrujillo 13011Peru

This article is an extensive review that provides an update on the pathophysiology,symptoms,diagnosis,and treatment of diabetic *** is no reported prevalence,but it has been described that patients with type 1 diabetes have a cumulative incidence at 10 years of 5.2%,and type 2 patients,1%.Also,in the group of type 1 diabetes,it has been observed that women are more likely to present this condition(5.8%vs 3.5%).Many factors are associate with its development(e.g.,hyperglycemia,vagal dysfunction,loss of expression of neural nitric oxide synthase in the myenteric plexus,alterations in the Cajal interstitial cell network,and oxidative stress).Gastrointestinal discomfort could be perceived 70% higher in diabetic patients,describing that 25%of diabetic patients experience gastrointestinal *** enteropathy could affect any portion of the gastrointestinal tract,but esophageal alterations were described in more than 60% of diabetic patients,also 60% of them present constipation,and 20%,*** emptying scintigraphy is useful to evaluate gastroparesis,therefore,gastric retention of more than 60%at 2 h has a sensitivity of 100% and specificity of 20% for diagnosis;however,other studies such as breath tests,with a sensitivity of 89% and a specificity of 80%,or the endoscopic capsule contribute to the *** is no cure;however,management must be multidisciplinary,focused on slowing the progression of diabetic gastroenteropathy,reducing symptoms,and restoring function;that includes nutritional recommendation,maintain glucose levels kept below 180 mg/dL,use of prokinetics,anti-emetics;nowadays,it has been special interest in surgical treatment,such as pyloroplasty,also gastric electrical stimulation appears to be another alternative.

关键词： Gastroenteropathy Gastroparesis Diabetes mellitus Complication Gastrointestinal disease Treatment

游戏是哲学的真正官能——游戏本体论与谢林、赫伊津哈、博尔赫斯及其他

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社会科学战线 2022年第11期 35-45页

作者： [荷兰]约斯·德·穆尔马妮(译) 邢立军(校译) 鹿特丹伊拉斯谟大学哲学系北荷兰省鹿特丹PO107 吉林省社会科学院深圳大学马克思主义学院

康德认为,在先验哲学中,构成我们经验世界的现象,是物自体和我们直观的先天形式(时间和空间)以及先天概念(如因果性)的综合。费希特的先验唯心主义仍忠于康德,他不认为人类自由的实现是既定的,相反,人类自由是有待完成的任务。谢林整合... 详细信息

康德认为,在先验哲学中,构成我们经验世界的现象,是物自体和我们直观的先天形式(时间和空间)以及先天概念(如因果性)的综合。费希特的先验唯心主义仍忠于康德,他不认为人类自由的实现是既定的,相反,人类自由是有待完成的任务。谢林整合了康德、费希特以及希勒“以游戏冲动调和感性冲动与形式冲动”的思想,在《先验唯心论体系》中,试图证明“无限精神的有意识活动”与“有限自然的无意识活动”的原始统一性,即“绝对”。人类精神无法接触绝对,但艺术作品则体现了“有限的自然”与“无限的精神”的统一。赫伊津哈提出游戏本体论,表现出与谢林同样的浪漫主义情愫,只是希勒与谢林以艺术调和自然与自由,而赫伊津哈代之以游戏,认为“文明在游戏中生长,并作为游戏存在”。文章在这些理论基础上,提出应将游戏理解为一种双重现象,正是游戏的永恒循环、无尽重复,体现了有限性的自然和无限性的精神的统一。

关键词：游戏谢林赫伊津哈艺术有限性无限性

Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C

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World Journal of Gastroenterology 2012年第2期18卷 188-191页

作者： Roberto J Carvalho-Filho Janaína Luz Narciso-Schiavon Luciano HL Tolentino Leonardo L Schiavon Maria Lucia G Ferraz Antonio Eduardo B silva Division of Gastroenterology Hepatitis SectionFederal University of Sao Paulo04037-003 Sao PauloBrazil

Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected ***,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-negative *** describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without *** improvement was observed after antiviral *** discuss the spectrum of neurological manifestations of HCV infection and review the literature.

关键词： Hepatitis C Central nervous system Poly-neuropathy Interferon-α

Can gadoxetic acid–enhanced magnetic resonance imaging be used to avoid liver biopsy in patients with nonalcoholic fatty liver disease?

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World Journal of Hepatology 2020年第9期12卷 661-671页

作者： Viviane Brandão Amorim Daniella Braz Parente Fernando Fernandes Paiva Jaime Araújo oliveira Neto Amanda Almeida Miranda Cláudia Cravo Moreira Flávia Ferreira Fernandes Carlos Frederico FerreiraCampos Nathalie Carvalho Leite Renata de Mello Perez Rosana Souza Rodrigues Research Department D’Or Institute for Research and EducationRio de Janeiro 22281Brazil Radiology Department Brazilian National Cancer InstituteRio de Janeiro 20230-130Brazil Radiology Department Fleury Group S.A.Rio de Janeiro 20765-000Brazil Radiology Department Hospital Universitário Clementino Fraga FilhoFederal University of Rio de JaneiroRio de Janeiro 21941-590Brazil São Carlos Institute of Physics University of São PauloSão Carlos 13560-970Brazil Radiology Department Quinta D'Or HospitalRio de Janeiro 20941-150Brazil Radiology Department Centro de Diagnóstico Médico do MaranhãoMaranhão 65074-441Brazil Department of Clinical Medicine Hospital Universitário Clementino Fraga FilhoFederal University of Rio de JaneiroRio de Janeiro 21941-590Brazil Gastroenterology and Hepatology Department Hospital Federal de BonsucessoRio de Janeiro 21041-030Brazil Department of Pathology and Laboratories University of the State of Rio de JaneiroRio de Janeiro 20551-030Brazil Internal Medicine Department Hospital Universitário Clementino Fraga FilhoFederal University of Rio de JaneiroRio de Janeiro 21941-590Brazil Gastroenterology Department Hospital Universitário Pedro ErnestoUniversity of the State of Rio de JaneiroRio de Janeiro 20551-030Brazil

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a major cause of liver disease *** diagnosis of nonalcoholic steatohepatitis(NASH),the most severe form of NAFLD,is crucial and has prognostic and therapeutic ***,currently this diagnosis is based on liver biopsy and has several *** To evaluate the performance of gadoxetic acid–enhanced magnetic resonance imaging(GA-MRI)in differentiating isolated steatosis from NASH in patients with *** In this prospective study,56 patients with NAFLD(18 with isolated steatosis and 38 with NASH)underwent *** contrast enhancement index(CEI)was calculated as the rate of increase of the liver-to-muscle signal intensity ratio from before and 20 min after intravenous GA ***-group differences in mean CEI were examined using Student's t *** area under the receiver operator characteristic curve and the diagnostic performance of gadoxetic acid–enhanced magnetic resonance imaging were *** The mean CEI for all subjects was 1.82±*** mean CEI was significantly lower in patients with NASH than in those with isolated steatosis(P=0.008).Two CEI cut-off points were used:2.00(89%sensitivity)to characterize isolated *** values between 1.66 and 2.00 indicated liver biopsy,and the procedure could be avoided in 40%of patients with *** GA-MRI is an effective noninvasive method that may be useful for the differentiation of NASH from isolated steatosis,and could help to avoid liver biopsy in patients with NAFLD.

关键词： Fatty liver Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Gadoxetic

The likely impact of genetically modified soybeans in the Brazilian collective feeding service

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Agricultural Sciences 2013年第12期4卷 721-728页

作者： Silvia Magalhaes Couto Gabriela Morgado de oliveira Coelho Marina de Figueiredo Ferreira Victor Augustus Marin Regina Serrao Lanzillotti Haydée Serrao Lanzillotti josuéde Castro Nutrition Institute Federal University of Rio de JaneiroRio de Janeiro(RJ)Brazil Nutrition Institute Rio de Janeiro State UniversityRio de Janeiro(RJ)Brazil National Institute of Quality Control on Health-Fiocruz Rio de Janeiro(RJ)Brazil Mathematics and Statistics Institute Rio de Janeiro State UniversityRio de Janeiro(RJ)Brazil

Objective: To expose the likely impact of genetically modified foods in Collective Feeding. Methods: This was a case study conducted on a steel company (SC) in Rio de Janeiro State. The likely impact recognition began with the preparation of a soy food products’ list. Then, we verified these products’ frequency on the Food and Nutrition Unit (FNU) menu from the SC, outlining the offer profile. We calculated odds ratios and binomial distribution probability for assessing exposure to soy that may be transgenic. Food frequency questionnaire (FFQ) regarding soy products was applied. The convergence of daily products’ relative frequency of this population and the population from a reference study about FFQ validation in Rio de Janeiro was verified. Confrontation took place between the classification of foods by the consumers’ likely exposure to soy and the percentage deviation between observed relative frequency of products’ intake offered on the FNU and on the reference study. Results: A list of 51 products were created and 16 of them integrated the menu, e.g. flour, chicken, sausage, maize, instant pudding, bologna, hot dogs and peanuts. Food usually consumed by FNU users and concomitantly consumed in reference study were cookies, flour, spaghetti, bread, cake, instant pudding, sausage and hot dogs. By the classification and percentage deviations results, cookies, breads and pasta were the “villains” of soy’s susceptibility. Coclusion: It was possible to show the likely impact of genetically modified foods in Collective Feeding, confirming that these consumers were exposed to soybeans that may be transgenic.

关键词： Food Security Genetically Modified Food Biotechnology Collective Feeding Food Services

Healthcare use among people with diabetes mellitus in Europe:a population-based cross-sectional study

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Family Medicine and Community Health 2022年第4期10卷 16-23页

作者： Álvaro Fuentes-Merlos joséAntonio Quesada-Rico Raul Reina Domingo Orozco-Beltrán Faculty of Medicine Miguel Hernandez University of ElcheSant Joan D'AlacantSpain Department of Sports Sciences Sport Research CentreMiguel Hernandez University of ElcheElcheSpain

Objective This study aimed to determine the association of health determinants,lifestyle and socioeconomic variables on healthcare use in people with diabetes in *** A cross-sectional study was conducted using data from the European Health Interview Survey wave 2(ie,secondary analysis).Setting The sample included data from 25 European *** The sample included 16270 patients with diabetes aged 15 years or older(49.1%men and 50.9%women).Results The survey data showed that 58.2%of respondents had seen their primary care physician in the past month and 22.6%had been admitted to the hospital in the past *** of primary care was associated with being retired(prevalence ratio(PR)1.13,95%CI 1.07 to 1.19)and having very poor self-perceived health(PR 1.80,95%CI 1.51 to 2.15),long-standing health problems(PR 1.14,95%CI 1.04 to 1.24),high blood pressure(PR 1.06,95%CI 1.03 to 1.10)and chronic back pain(PR 1.07,95%CI 1.04 to 1.11).Hospital admission was associated with very poor self-perceived health(PR 3.03,95%CI 2.14 to 4.31),accidents at home(PR 1.54,95%CI 1.40 to 1.69),chronic obstructive pulmonary disease(COPD)(PR 1.34,95%CI 1.22 to 1.47),high blood pressure(PR 1.08,95%CI 1.01 to 1.17),chronic back pain(PR 0.91,95%CI 0.84 to 0.98),moderate difficulty walking(PR 1.33,95%CI 1.21 to 1.45)and severe difficulty walking(PR 1.67,95%CI 1.51 to 1.85).Conclusions In the European diabetic population,the high cumulative incidences of primary care visits and hospital admissions are associated with labour status,alcohol consumption,self-perceived health,long-standing health problems,high blood pressure,chronic back pain,accidents at home,COPD and difficulty walking.

关键词： admitted sectional difficulty

成土作用产生的细粒亚铁磁性矿物的粒径分布及意义

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成土作用产生的细粒亚铁磁性矿物的粒径分布及意义

Surface Modification of Commercial Activated Carbon (CAG) for the Adsorption of Benzene and Toluene

中国地球物理学会第二十四届年会

作者：刘青松 josé Torrent 中国科学院地质与地球物理研究所岩石圈演化国家重点实验室

＜正＞土壤所含的磁性矿物来源比较复杂,既包括原生磁性矿物,又包含经成土作用改造生成的次生磁性矿物。尤其后者的生成及转化与其所处的环境密切相关,因此,在一定程度上,可以根据土壤磁性来定性或者半定量地研究与之相关的环境演化信息。

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American Journal of Analytical Chemistry 2015年第6期6卷 528-538页

作者： Anna Sylmara da Costa Lopes Samira Maria Leao de Carvalho Davi do Socorro Barros Brasil Rosivaldo de Alcantara Mendes Marcelo oliveira Lima Universidade Federal do Para BelemBrasil Instituto Evandro Chagas AnanindeuaBrasil

In this work, we determined the surface characteristics of natural (CA-1) and HNO3 treated (CA-2) CAG. Equilibrium, kinetics and breakthrough for adsorption of benzene and toluene by CA-1 and CA-2 were studied. Concentrations of benzene and toluene (mg/L) were determined by gas chromatography with headspace extraction. The data of adsorption kinetic and equilibrium were best fitted by pseudo-second order model and Langmuir isotherm, respectively. The best results of benzene and toluene adsorption from fixed bed were obtained at volumetric flow rate (Q1 = 70 mL/min) using adsorbent CA-2. The study of inferential statistics revealed that CA-1 and CA-2 adsorbents are statistically different at a 5% significance level.

关键词： Adsorption Activated Carbon Surface Modification Benzene Toluene