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Electrom.gnetic Stim.lation Com.ined with Aloe vera Increases Collagen Reorganization in Burn Repair

Journal of Pharm.cy and Pharm.cology 2018年第7期6卷 633-646页

作者： Sofia Poletti Leticia D. Lucke Fernanda O Bortolazzo renata m. acunha m.rcos G. m.ttos Fem.nda OG. Gaspi Thiago A. m. Andrade m.ria Esm.ria C. Am.ral Andrea A .Aro Edson R Pim.ntel m.rcelo Am. Esquisatto Fernanda A. S. m.ndonga Glaucia m. T. Santos Graduate Program.in Biom.dical Sciences of the Herm.nio Om.tto University Center UIVIARARAS Araras Sao Paulo13607-339 Brazil Departm.nt of Structural and Functional Biology Institute of Biology University of Campinas-UNICAMP Campinas Sao Paulo13083-970 Brazil

Objectives： Burns are shown as a clinical problem.for their severity and m.ltiple com.lications due to the tim. required to heal. Therapies that im.rove their healing are of great im.ortance, especially for being m.nim.lly invasive, of low cost and best perform.nce, all related to the speed and quality of healing. This study investigated the effects of the m.gnetic electro stim.lator Haihuá CD9 isolated or in association with Aloe vera in rats skin burns. m.thods： Experim.ntal groups （n = 30/group） were：（C） Carbopol gel; （F） A. vera/Carbopol gel; （H） Haihuá＋Carbopol gel; （H＋F） Haihuá＋A. vera/Carbopol gel. Sam.les were collected on the 7th, 14th, and 21st experim.ntal days for structural and m.rphom.tric analysis, hydroxyproline and glycosam.noglycans quantification, zym.graphy for m.P-2 and m.P-9 and Western Blotting for TGF-β1, VEGF, Collagen I and III. Key findings： The expression of TGF-β1 in H＋F was increased on the 7th day and of m.P-9 on the 7th and 14th days. The expression of VEGF increased in the first experim.ntal periods and decreased in the last for the treated groups. There was an increase in the fibroblasts and birefringent collagen fibers in groups treated with Haihuá isolated or in association with A. vera in all periods. The quantification of collagen I increased, while collagen III decreased in H＋F. The higher am.unt of GAGs and m.P-2 active isoform.was detected in H and H＋F during all periods. Conclusions： Considering the results of the present study, electrom.gnetic stim.lation in association with the A. vera extract prom.ted an increase in the num.er of fibroblasts, GAGs content, m.P-2 activity, the deposition and organization of collagen fibers, favoring the repair of injuries to second degree burns, and m.y also present therapeutic potential in this injury type.

关键词： Burns repair herbal m.dicine electrom.gnetic stim.lation rats

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