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Benefits of the Combined Use of NSAID and Early Exercise on Tendon Healing in a Murine Model

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Open Journal of Animal Sciences 2018年第4期8卷 357-369页

作者： Kelly Biancardini Gomes Barbato Clara Raposo Hanna Dias renata paiva Joao da Costa Libardo Rodriguez Guilherme de Almeida Oscar Rocha-Barbosa Liszt Palmeira de Oliveira Jorge Carvalho School of Medicine State University of Rio de JaneiroRio de JaneiroBrazil Department of Surgical Specialties School of MedicineState University of Rio de JaneiroRio de JaneiroBrazil Department of Zoology Roberto Alcantara Gomes Institute of BiologyState University of Rio de JaneiroRio de JaneiroBrazil Department of Histology and Embriology Roberto Alcantara Gomes Institute of BiologyState University of Rio de JaneiroRio de JaneiroBrazil

Achilles tendon rupture is one of the most frequent tendon injuries. The aim of this experimental study was to evaluate the effect of a non-steroidal anti-inflammatory drug (NSAID) and of aerobic exercise, in an isolated fashion and combined, on cell proliferation and on the biomechanical aspects of the Achilles tendon during healing process after a complete tenotomy in 156 male Wistar rats. Half of the animals received an intra-muscular injection of tenoxicam for 7 days and exercise was initiated on the 8th day for half the animals of each group. Animals were sacrificed at 1, 2, 4 and 8 weeks after the tenotomy and cell proliferation was evaluated by immunohistochemistry for PCNA, biomechanical evaluation was performed with ultimate load and gait cycle analysis was also carried out. Animals were divided into four treatment groups: A) no NSAID and no exercise (control group);B) NSAID plus exercise;C) no NSAID, with exercise;D) NSAID and no exercise. We used the test of two-way analysis of variance with equal cells number, Kruskal-Wallis test and also, Bonferroni method, in the R Project program 3.5.0. The highest intensity of PCNA immunostaining was found at 2 weeks in all groups except for group A (control) that had the highest intensity at 1 week. Animals submitted to exercise had significantly higher (P = 0.02) ultimate loads when compared to animals that were not submitted to exercise at 8 weeks after injury. The animals that received NSAID presented with a more stable gait cycle than the animals that did not receive NSAID. Aerobic exercise, initiated early after a complete Achilles tendon tenotomy, was beneficial to the biomechanical aspects of the tendon that occur during tendon regeneration and the combined use of NSAID improved the gait’s characteristics which could be protective against re-ruptures.

关键词： Achilles Tendon Rupture Experimental Study Non-Steroidal Anti-Inflammatory Drug Aerobic Exercise PCNA Biomechanics

Regional validity of the parameters of a distributed runoff-erosion model in the semi-arid region of Brazil

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Science China(Technological Sciences) 2009年第11期52卷 3348-3356页

作者： SRINIVASAN Vajapeyam Srirangachar paiva Fernanda Maria de Lima Federal University of Campina Grande Post-graduate programme in Civil and Environmental Engineering Campus I 58429-900 Campina Grande PB Brazil

The present paper examines the validity of the application of a distributed rainfall-runoff-erosion model on a regional basis in a semi-arid region of Brazil. The model tested is known as WESP (Water Erosion Simulation Program) developed by Lopes (1987). The model simulates the hydrograph and the sediment graph for individual events and thus, the model when properly calibrated can serve as a predictive tool for runoff and soil erosion on an individual or a continuous basis. The possibility of the existence of regionally applicable values for the parameters of the model WESP would be very interesting from the point of view of predictability of runoff and soil erosion from ungauged basins in the region. For this purpose, data collected in several experimental units in the experimental basin of Sumé as well as in the experimental basin of So Joo de Cariri have been used. The model was calibrated and validated in each of the experimental units (consisting of erosion plots and micro-basins) and the average value from all of the units for each of the parameters was considered to be the regional value. With these average values, all the events in all the experimental units were simulated. The results show that the runoff and erosion values simulated with this single parameter set were very good in all the units, being well within the acceptable deviations.

关键词： regional parameters model WESP experimental basins semi-arid region soil erosion

Landesman–Lazer Type Conditions and Multiplicity Results for Nonlinear Elliptic Problems with Neumann Boundary Values

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Acta Mathematica Sinica,English Series 2014年第2期30卷 229-250页

作者： Edcarlos Domingos DA SILVA Francisco Odair DE paiva Universidade Federal de Gois Departamento de Matemtica Universidade Federal de So Carlos Departamento de Matemtica

We establish the existence and multiplicity of solutions for Steklov problems under non- resonance or resonance conditions using variational methods. In our main theorems, we consider a weighted eigenvalue problem of ... 详细信息

关键词： Neumann-Steklov eigenvalue problems resonance Landesman-Lazer conditions

Short-and long-term effects of architecture on the brain:Toward theoretical formalization

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Frontiers of Architectural Research 2019年第4期8卷 564-571页

作者： Andrea de paiva Richard Jedon Institute for Educational Development Fundagao Getulio VargasFGVSao PauloBrazil Urban Plannins and Development Institute of the City of Pilsen PUsenCzech Republic

The physical environm ent affects people’s behavior and *** effects can be easily noticed through observation,whereas others require an in-depth study to be understood and *** many alterations can be positive,some can also negatively influence wellbeing,decision-m aking,and m ental and physical *** of these effects are not easily associated with physical ***,people may be unaware of the real triggers for changes in behavior,mood,and *** many studies have been performed on environmental psychology,detailed research to understand the im pacts of architecture on the brain using neuroscience is *** difficulties experienced by researchers in this field are on the isolation of each stimulus to understand its effects individually and m easurem ent of brain changes in people interacting with the environm ent because some brain scans,such as fMRI,require people to be inside the ***,the several ways a space can impact its users should be discussed to understand how architecture influences in dividuals and to help architects and urban planners in designing efficient and healthy *** study aims to describe and analyze the results of previous research works and propose a way of organizing them to facilitate further investigation on this field.

关键词： Brain Neuroarchitecture Neuroscience Behavior Short term Long term

Zoonotic transmission of hepatitis E:Implications for public health worldwide

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Asian Pacific Journal of Tropical Medicine 2009年第4期2卷 77-82页

作者： Analia paiva Victoria Rebagliati Alcides Troncoso Department of Microbiology Parasitology and Infectious DiseasesSchool of MedicineUniversity of Buenos AiresArgentina

Since the year 1982,the Hepatitis E virus(HEV),enteric transmission,has been widely spread in many tropical and subtropical *** has multiple routes of transmission,such as food or water contaminated with faecal matter,person-to-person transmission or by the ingestion of raw or undercooked *** is important to consider the significance of zoonotic infections propagation,both in endemic areas as well as in developed countries,where there have been some sporadic *** article summarizes the research conducted to date,which supports the zoonotic transmission of HEV,its risks and how they are often underestimated.

关键词： Human zoonosis HEV Public health

Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation

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International Journal of Oral Science 2020年第3期12卷 199-208页

作者： Mohit Sharma Felipe paiva Fonseca Keith D.Hunter Raghu Radhakrishnan Department of Oral Pathology Sudha Rustagi College of Dental Sciences and ResearchFaridabadHaryanaIndia Department of Oral Surgery and Pathology School of DentistryFederal University of Minas GeraisBelo HorizonteMGBrazil Academic Unit of Oral and Maxillofacial Medicine and Pathology School of Clinical DentistryUniversity of SheffieldClaremont CrescentSheffieldUK Department of Oral Pathology Manipal College of Dental SciencesManipal Academy of Higher EducationManipalKarnatakaIndia

The integrity of the basal stem cell layer is critical for epithelial *** this paper,we review the expression of oral mucosal stem cell markers(OM-SCMs)in oral submucous fibrosis(OSF),oral potentially malignant disorders(OPMDs)and oral squamous cell carcinoma(OSCC)to understand the role of basal cells in potentiating cancer stem cell behaviour in *** the loss of basal cell clonogenicity triggers epithelial atrophy in OSF,the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal *** vacillating expression patterns of OM-SCMs confirm the role of keratins 5,14,19,CD44,β1-integrin,p63,sex-determining region Y box(SOX2),octamer-binding transcription factor 4(Oct-4),c-MYC,B-cell-specific Moloney murine leukaemia virus integration site 1(Bmi-1)and aldehyde dehydrogenase 1(ALDH1)in OSF,OPMDs and *** downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review.

关键词： epithelium malignant mucosal

Evolution of the 3.65-2.58 Ga Mairi Gneiss Complex,Brazil:Implications for growth of the continental crust in the São Francisco Craton

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Geoscience Frontiers 2022年第5期13卷 110-128页

作者： Igor de Camargo Moreira Elson paiva Oliveira Daniel Francisco Martins de Sousa Institute of Geosciences University of Campinas(UNICAMP)CampinasSPBrazil

The composition and formation of the Earth’s primitive continental crust and mantle differentiation are key issues to understand and reconstruct the geodynamic terrestrial evolution,especially during the ***,the scarcity of exposure to these rocks,the complexity of lithological relationships,and the high degree of superimposed deformation,especially with long-lived magmatism,make it difficult to study ancient *** this complexity,exposures of the Archean Mairi Gneiss Complex basement unit in the São Francisco Craton offer important information about the evolution of South America’s primitive ***,here we present field relationships,LA-ICP-SFMS zircon U-Pb ages,and LA-ICP-MCMS Lu-Hf isotope data for the recently identified Eoarchean to Neoarchean gneisses of the Mairi *** Complex is composed of massive and banded gneisses with mafic members ranging from dioritic to tonalitic,and felsic members ranging from TTG(Tonalite-Trondhjemite-Granodiorite)to granitic *** new data point to several magmatic episodes in the formation of the Mairi Gneiss Complex:Eoarchean(ca.3.65–3.60 Ga),early Paleoarchean(ca.3.55–3.52 Ga),middle-late Paleoarchean(ca.3.49–3.33 Ga)and Neoarchean(ca.2.74–2.58 Ga),with no records of Mesoarchean ***-Hf data unveiled a progressive evolution of mantle differentiation and crustal recycling over *** the Eoarchean,rocks are probably formed by the interaction between the pre-existing crust and juvenile contribution from chondritic to weakly depleted mantle sources,whereas mantle depletion played a role in the Paleoarchean,followed by greater differentiation of the crust with thickening and recycling in the middle–late Paleoarchean.A different stage of crustal growth and recycling dominated the Neoarchean,probably owing to the thickening of the continental crust by collision,continental arc growth,and mantle differentiation.

关键词： São Francisco Craton Mairi Gneiss Complex Primitive continental crust Zircon U-Pb dating Lu-Hf isotope geochemistry

Neonates are more vulnerable to symptomatic SARS-CoV-2 infection than children:a matched cohort study in Brazil

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World Journal of Pediatrics 2022年第6期18卷 437-442页

作者： Char Leung Luisamanda Selle Karina Mary de paiva Patricia Haas School of Clinical Medicine Addenbrooke’s HospitalUniversity of CambridgeHills RoadCambridgeCB20QQUK Department of Speech Language and Hearing SciencesFederal University of Santa CatarinaFlorianópolisBrazil

As the causative agent of coronavirus disease 2019(COVID-19),severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is one of the seven coronaviruses pathogenic to human and one of the four human coronaviruses that cause acute respiratory disease *** it affects people of all age groups,the risk of mortality is *** in many other diseases,elderly patients have a higher risk of infection,mortality,and morbidity[1].While it is a common belief that children fare better than adult and elderly,recent evidence merged that neonates and infants are associated with a higher risk of mortality and morbidity,compared to children and adolescents[2,3].For instance,a cross-country study found that the infection–fatality ratio of those aged<5 years was found to be 0.003,higher than those aged between 5 and 14 years of 0.001 despite lower than those aged between 20 and 59 that vary between 0.006 and 0.323[4].However,whether this holds true in the risk of infection is not yet *** this background,the present work aimed to verify whether neonates are more susceptible to COVID-19 using publicly available data of all polymerase chain reaction(PCR)tests performed in the state of São Paulo of Brazil.

关键词： mortality infection acute

Experimental evidence for heritable reproductive time in 2 allochronic populations of pine processionary moth

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Insect Science 2017年第2期24卷 325-335页

作者： Manuela Branco Maria-Rosa paiva Helena Maria Santos Christian Burban Carole Kerdelhue Centro de Estudos Florestais (CEF) Instituto Superior de Agronomia (ISA) Universidade de Lisboa (ULisboa) 1349-017 Lisboa Portugal CENSE Faculty of Sciences and Technology (FCT) Universidade Nova de Lisboa (UNL) 2829-516 Caparica Portugal INRA Centre de Bordeaux UMR1202 BIOGECO Cestas cedex France INRA Centre de Montpellier UMR CBGP F-34988 Montferrier-sur-Lez cedex France

Phenology allows organisms to overcome seasonally variable conditions through life-cycle adjustment. Changes in phenology can drastically modify the evolutionary tra- jectory of a population, while a shift in the reproductive time may cause allochronic differentiation. The hypothesis of heritable reproductive time was experimentally tested, by studying a unique population of the pine processionary moth Thaumetopoeapityocampa （Den. ＆ Schiff.） which has a shifted phenology, and however co-occurs with the typical population following the classical life cycle. When populations of both types were reared under controlled conditions, the reproductive time was maintained asynchronous, as ob- served in the field. The shifted population was manipulated in the laboratory to reproduce later than usual, yet the offspring emerged in the next year at the expected dates thus ＂com- ing back＂ to the usual cycle. Hybrids from crosses performed between the 2 populations showed an intermediate phenology. From the emergence times of parents and offspring, a high heritability of the reproductive time （h = 0.76） was observed. The offspring ob- tained from each type of cross was genetically characterized using microsatellite markers. Bayesian clustering analysis confirmed that hybrids can he successfully identified and separated from the parental genetic classes by genotyping. Findings support the hypothesis that, for this particular population, incipient allochronic speciation is due to a heritable shift in the reproductive time that further causes assortative mating and might eventually cause ecological adaptation/maladaptation in response to environmental changes.

关键词： allochronic speciation experimental crossings heritability phenology reproductive isolation Thaumetopoeapityocampa