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Online estimation and characteristic analysis of double nugget diameters during aluminum/steel resistance spot welding process

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Journal of Iron and Steel Research International 2024年第8期31卷 2053-2067页

作者： Kang Zhou Wen-xiao Yu Bao-kai ren Gang wang School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China

Online estimation of the double nugget diameters was performed by means of a back propagation neural *** double nugget diameters were obtained using actual welding experiment and numerical simulation,according to different characteristics of aluminum nugget and steel *** input of the neural network was some key characteristic parameters extracted from dynamic power signal,which were peak point,knee point and their variation rate over time,as well as heat energy delivered into the welding *** architecture of the neural network was confirmed by confirming the number of neurons in hidden layer through a series of *** key parameters of the neural network were obtained by means of training 81 arrays of data ***,the neural network was used to test the remaining 20 arrays of verifying data set,and the results showed that both of the mean errors for the two nugget diameters were below 3%.In addition,corresponding analyses showed that the accuracy of two nugget diameters was higher than that of tensile-shear strength.

关键词： Resistance spot welding Aluminum Steel Double nugget Dynamic power signal.Neural network

Rbm8a regulates neurogenesis and reduces Alzheimer's disease-associated pathology in the dentate gyrus of 5×FAD mice

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Neural Regeneration Research 2024年第4期19卷 863-871页

作者： Chenlu Zhu xiao ren Chen Liu Yawei Liu Yonggang wang Department of Neurology Lanzhou University Second Hospital Department of Neurology The First Affiliated Hospital of Nanchang University Department of Neurology Xiaogan City Central Hospital Health Service Department of the Guard Bureau of the General Office of the Central Committee of the Communist Party of China Headache Center Department of NeurologyBeijing Tiantan HospitalCapital Medical University

Alzheimer’s disease is a prevalent and debilitating neurodegenerative condition that profoundly affects a patient’s daily functioning with progressive cognitive decline,which can be partly attributed to impaired hippocampal *** in the hippocampal dentate gyrus is likely to persist throughout life but declines with aging,especially in Alzheimer’s *** evidence indicated that RNA-binding protein 8A(Rbm8a)promotes the proliferation of neural progenitor cells,with lower expression levels observed in Alzheimer’s disease patients compared with healthy *** study investigated the hypothesis that Rbm8a overexpression may enhance neurogenesis by promoting the proliferation of neural progenitor cells to improve memory impairment in Alzheimer’s ***,Rbm8a overexpression was induced in the dentate gyrus of 5×FAD mice to validate this *** Rbm8a levels in the dentate gyrus triggered neurogenesis and abated pathological phenotypes(such as plaque formation,gliosis reaction,and dystrophic neurites),leading to ameliorated memory performance in 5×FAD *** sequencing data further substantiated these findings,showing the enrichment of differentially expressed genes involved in biological processes including neurogenesis,cell proliferation,and amyloid protein *** conclusion,overexpressing Rbm8a in the dentate gyrus of 5×FAD mouse brains improved cognitive function by ameliorating amyloid-beta-associated pathological phenotypes and enhancing neurogenesis.

关键词： Adora2a Alzheimer’s disease astrocyte cAMP signaling pathway dentate gyrus dystrophic neurites microglia neurogenesis plaque Rbm8a

Hepatoprotective effects of cathepsin B inhibitor on acute hepatic failure induced by lipopolysaccharide/D-galactosamine in mice

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Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 80-86页

作者： Bing-Zhu Yan Li-Yan Chen Lan Kang xiao-ren wang Man-Ru Bi Wei wang Bao-Shan Yang Department of Infectious Diseases Second Clinical HospitalHarbin Medical University

BACKGROUND:Increasing evidence suggests that the inactivation of cathepsin B attenuates hepatocyte apoptosis and liver *** study aimed to investigate the protective effects of a cathepsin B inhibitor(CA-074me) on lipopolysaccharide(LPS)/D-galactosamine(D-GalN)-induced acute hepatic failure(AHF) in ***:Mice were intraperitoneally injected with a combination of LPS/D-GalN to induce AHF with or without CA-074me *** cumulative survival rates were calculated 48 hours after the induction of *** well as changes in biochemical indicators and liver histology,hepatocyte apoptosis was assessed using a TUNEL *** tumor necrosis factor-α(TNF-α) production,caspase-3,caspase-8,and caspase-9 activity was *** cytochrome c and Bcl-2 expression were measured by Western ***:The marked elevation in serum aminotransferase activity and prothrombin time found in LPS/D-GalN-treated mice was significantly improved by pretreatment with *** efficacy of CA-074me was also confirmed by histological analysis and TUNEL *** survival rate significantly improved in LPS/D-GalN-induced mice given CA-074me compared with untreated ***/D-GalNinduced caspase-3 and caspase-9 activation was remarkably suppressed by ***,the increased levels of serum TNF-α and elevated caspase-8 activity in AHF mice were not significantly reduced by ***,CA074me sharply reduced the increased expression of cytosolic cytochrome c and markedly augmented Bcl-2 ***:These results suggest that CA-074me has a protective effect in acute hepatic failure induced by LPS/D-GalN.

关键词： acute hepatic failure cathepsin B inhibitor hepatocyte apoptosis caspases cytochrome c

Applying Multiquadric Quasi-Interpolation to Solve KdV Equation

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Journal of Mathematical Research and Exposition 2011年第2期31卷 191-201页

作者： Min Lu xiao ren Hong wang Chun Gang ZHU School of Mathematical Sciences Dalian University of Technology Liaoning 116024 P. R. China

Quasi-interpolation is very useful in the study of approximation theory and its applications,since it can yield solutions directly without the need to solve any linear system of *** on the good performance,Chen and Wu presented a kind of multiquadric （MQ） quasi-interpolation,which is generalized from the L D operator,and used it to solve hyperbolic conservation laws and Burgers’ *** this paper,a numerical scheme is presented based on Chen and Wu’s method for solving the Korteweg-de Vries （KdV） *** presented scheme is obtained by using the second-order central divided difference of the spatial derivative to approximate the third-order spatial derivative,and the forward divided difference to approximate the temporal derivative,where the spatial derivative is approximated by the derivative of the generalized L D quasi-interpolation *** algorithm is very simple and easy to implement and the numerical experiments show that it is feasible and valid.

关键词： KdV equation multiquadric(MQ) quasi-interpolation numerical solution

High-Temperature Stability of Mg-1Al-12Y Alloy Containing LPSO Phase and Mechanism of Its Portevin-Le Chatelier(PLC)Effect

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 982-998页

作者： Qian-Long ren Shuai Yuan Shi-Yu Luan Jin-Hui wang xiao-Wei Li xiao-Yu Liu Qinghai Provincial Key Laboratory of New Light Alloys Qinghai Provincial Engineering Research Center of High Performance Light Metal Alloys and FormingQinghai UniversityXining810016China School of Materials Science and Engineering Shenyang University of TechnologyShenyang110870China

In this study,the high-temperature stability and the generation mechanism of the Portevin-Le Chatelier(PLC)effect in solid-solution Mg-1Al-12Y alloy with different heat treatment processes were investigated by adjusting the content of long-period stacking ordered(LPSO)*** was found that the content of LPSO phases in the alloys differed the most after heat treatment at 530℃for 16 h and 24 h,with values of 13.56%and 3.93%***,high-temperature tensile experiments were conducted on these two alloys at temperatures of 150℃,200℃,250℃,and 300℃.The results showed that both alloys exhibited the PLC effect at temperatures ranging from 150 to 250℃.However,at a temperature 300℃,only the alloy with a greater concentration of LPSO phases exhibited the PLC effect,whereas the alloy with a lower proportion of LPSO phases did not exhibit this ***,both alloys exhibited remarkable high-temperature stability,with the alloy containing a greater percentage of LPSO phases also demonstrating superior *** underlying mechanism for this phenomenon lies in the exceptional high-temperature stability exhibited by the second phase within the ***,the LPSO phase effectively obstructs the movement of dislocations,and it also undergoing kinking to facilitate plastic deformation of the *** results indicate that the PLC effect can be suppressed by reducing dislocation pile-up at grain boundaries,which leads to a decrease in alloy plasticity but an increase in *** presence of the PLC effect in the WA121 alloy is attributed to the abundant dispersed second phase within the alloy,which initially hinders the movement of dislocations,leading to an increase in stress,and subsequently releases the dislocations,allowing them to continue their movement and thereby reducing in stress.

关键词： Magnesium alloy Long-period stacking ordered(LPSO)phase Portevin-Le Chatelier effect High temperature

Innovation,financial permeation,and income inequality:From a dynamicperspective in China

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Journal of Management Science and Engineering 2024年第2期9卷 220-238页

作者： Xianming Sun Shiyi xiao Ganlin wang xiaohang ren School of Finance Zhongnan University of Economics and LawWuhan430073China Innovation and Talent Base for Digital Technology and Finance Wuhan430073China School of Business Central South UniversityChangsha410083China

Innovation is a driving force of wealth *** explore its time-varying effect on income inequality,we propose a nonparametric model using the local linear dummy variable estimation(LLDVE)*** on province-level panel data from China spanning from 2006 to 2020,we find that innovation initially reduces income disparity until 2009,then exacerbates it from 2013 to 2016,and alleviates inequality again over *** further verify that financial permeation serves as a catalyst in the inequitable income distribution driven by ***,this moderating effect reverses the relationship between green innovation and income *** suggests that we should enhance the financial service towards all aspects of innovation beyond its support of green innovation.

关键词： Income inequality Innovation Financial permeation Time-varying relationship Local linear dummy variable estimation(LLDVE)

The therapeutic effect of CORM-3 on acute liver failure induced by lipopolysaccharide/D- galactosamine in mice

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Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 73-80页

作者： Bing-Zhu Yan Bao-Shan Yang Hui Li Yan-Fen Zhang Feng-Hua Pei An-Chao Zhu xiao-ren wang Bing-Rong Liu department of infectious diseases the second affiliated hospital of harbin medical universityHarbin 150086China department of gastroenterology and hepatology the second affiliated hospital of harbin medical universityHarbin 150086China department of laboratory diagnosis the second affiliated hospital of harbin medical universityHarbin 150086China department of histology the first hospital of harbin cityHarbin 15000lChina

BACKGROUND： Acute liver failure （ALF） is a severe and life- threatening clinical syndrome resulting in a high mortality and extremely poor prognosis. Recently, a water-soluble CO-releas- ing molecule （CORM-3） has been shown to have anti-inflam- matory effect. The present study was to investigate the effect of CORM-3 on ALF and elucidate its underlying mechanism. METHODS： ALF was induced by a combination of LPS/D-GalN in mice which were treated with CORM-3 or inactive CORM-3 （iCORM-3）. The efficacy of CORM-3 was evaluated based on survival, liver histopathology, serum aminotransferase activi- ties （ALT and AST） and total bilirubin （TBiL）. Serum levels of inflammatory cytokines （TNF-α, IL-6, IL-1β and IL-10） and liver immunohistochemistry of NF-KB-p65 were determined; the expression of inflammatory mediators such as iNOS, COX-2 and TLR4 was measured using Western blotting. RESULTS： The pretreatment with CORM-3 significantly improved the liver histology and the survival rate of mice compared with the controls; CORM-3 also decreased the levels of ALT, AST and TBiL. Furthermore, CORM-3 significantly inhibited the increased concentration of pro-inflammatory cytokines （TNF-α, IL-6 and IL-1β） and increased the anti-in- flammatory cytokine （IL-10） productions in ALF mice. More- over, CORM-3 significantly reduced the increased expression of iNOS and TLR4 in liver tissues and inhibited the nudear ex- pression of NF-KB-p65. CORM-3 had no effect on the increased expression of COX-2 in the ALF mice. An iCORM-3 failed to prevent acute liver damage induced by LPS/D-GalN. CONCLUSION： These findings provided evidence that CORM-3 may offer a novel alternative approach for the management of ALF through anti-inflammatory functions.

关键词： acute liver failure CO-releasing molecule-3 cytokines inflammation

Integrated assessment of yield,nitrogen use efficiency and ecosystem economic benefits of use of controlled-release and common urea in ratoon rice production

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Journal of Integrative Agriculture 2024年第9期23卷 3186-3199页

作者： Zijuan Ding ren Hu Yuxian Cao Jintao Li Dakang xiao Jun Hou Xuexia wang College of Agriculture Yangtze University/MARA Key Laboratory of Sustainable Crop Production in the Middle Reaches of the Yangtze River(Co-construction by Ministry and Province)Jingzhou 434025China College of Life Science Yangtze UniversityJingzhou 434025China Institute of Plant Nutrition Resources and EnvironmentBeijing Agricultural Forestry Academy SciencesBeijing 100097China

Controlled-release urea(CRU)is commonly used to improve the crop yield and nitrogen use efficiency(NUE).However,few studies have investigated the effects of CRU in the ratoon rice *** rice is the practice of obtaining a second harvest from tillers originating from the stubble of the previously harvested main *** this study,a 2-year field experiment using a randomized complete block design was conducted to determine the effects of CRU on the yield,NUE,and economic benefits of ratoon rice,including the main crop,to provide a theoretical basis for fertilization of ratoon *** experiment included four treatments:(i)no N fertilizer(CK);(ii)traditional practice with 5 applications of urea applied at different crop growth stages by surface broadcasting(FFP);(iii)one-time basal application of CRU(BF1);and(iv)one-time basal application of CRU combined with common urea(BF2).The BF1 and BF2 treatments significantly increased the main crop yield by 17.47 and 15.99%in 2019,and by 17.91 and 16.44%in 2020,respectively,compared with FFP *** BF2 treatment achieved similar yield of the ratoon crop to the FFP treatment,whereas the BF1 treatment significantly increased the yield of the ratoon crop by 14.81%in 2019 and 12.21%in 2020 compared with the FFP *** BF1 and BF2 treatments significantly improved the 2-year apparent N recovery efficiency,agronomic NUE,and partial factor productivity of applied N by 11.47-16.66,27.31-44.49,and 9.23-15.60%,respectively,compared with FFP *** BF1 and BF2 treatments reduced the chalky rice rate and chalkiness of main and ratoon crops relative to the FFP ***,emergy analysis showed that the production efficiency of the BF treatments was higher than that of the FFP *** BF treatments reduced labor input due to reduced fertilization times and improved the economic benefits of ratoon *** with the FFP treatment,the BF1 and BF2 treatments increased the net income by 14.21-16

关键词： ratoon rice controlled-release urea yield nitrogen use efficiency economic benefit

Experimental Study on Vortex-Induced Vibration of Rough Risers with Coupling Interference Effect Under Side-by-Side Arrangement

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China Ocean Engineering 2024年第1期38卷 18-28页

作者： HU Ze-bo LIU Zhen LI Peng GUO Hai-yan wang Shu-bing ren xiao-hui HOU Hao wang Ye-shuo College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590China Qingdao Key Laboratory of Marine Civil Engineering Materials and Structures Qingdao 266590China College of Engineering Ocean University of ChinaQingdao 266100China CHEC Dredging Co. LtdShanghai 200136China

A vortex-induced vibration(VIV)experiment of rough risers with coupling interference effect under a side-by-side arrangement was carried out in a wave-current combined *** roughness of the riser was characterized by arranging different specifications of surface attachments on the surface of the *** risers with three different roughnesses were arranged side by side with smooth risers to explore the VIV response of the riser under the combined action of roughness and interference effect,and to reveal the coupling mechanism between roughness and interference *** experimental results show that,compared with that of a smooth riser,the VIV of a rough riser under the coupling interference effect has a wider"lock-in"region,and the displacement decreases more significantly at a high reduced velocity,which is more likely to excite higher-order modes and frequency *** addition,the displacement response and frequency response of the smooth riser are not significantly affected by wake interference from the rough riser,which is caused by the decrease of the wake region due to the delay of the boundary layer separation point of the rough riser.

关键词： marine riser vortex-induced vibration side-by-side arrangement roughness interference effect