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季节划分和变化研究进展

地理科学进展 2024年第4期43卷 826-840页

作者：林蔚孙秀宝任国玉张键彬福建理工大学智慧海洋科学技术学院福州350118 中国科学院南海海洋研究所热带海洋环境国家重点实验室广州510301 中国地质大学(武汉)环境学院武汉430074 国家气候中心气候研究开放实验室北京100081 中国科学院大学北京100049

季节是全球和区域人类农业生产活动遵循的重要气候年内变化规律。近半个世纪以来全球地表气温明显升高,与地表气温相关联的季节起讫和持续时间等参数也随之发生显著变化。首先,论文总结了目前广泛应用的三大类季节定义方式,包括从行星... 详细信息

季节是全球和区域人类农业生产活动遵循的重要气候年内变化规律。近半个世纪以来全球地表气温明显升高,与地表气温相关联的季节起讫和持续时间等参数也随之发生显著变化。首先,论文总结了目前广泛应用的三大类季节定义方式,包括从行星角度出发的固定长度季节定义法、气温的绝对和相对阈值季节定义法、区域地理因素和天气平均态转变的季节定义法;其次,回顾了当前利用不同动态指标定义季节主要获得的历史时期冷季缩短、暖季变长的时空规律,以及气候变暖背景下自然变率和外强迫对季节长度变化原因的解释;最后,从季节定义方法的应用领域和空间上通用性角度评述了各个方法的优缺点,并从数据偏差影响、通用指数发展、气候变暖背景下变化机理三方面对未来进行了展望。研究结果明确了季节划分方式间的差别、季节变化特征及原因,不仅有利于指导农业生产,也可以为妥善应对气候变化提供可靠科学信息。

关键词：季节划分季节长度变化原因全球气候变暖

胃窦癌组织中LAG-3 FGL1 MHC-Ⅱ的表达与预后的关系

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中国肿瘤临床 2024年第2期51卷 64-69页

作者：戚颖黄子祺别鸿宇颜次慧任秀宝天津医科大学肿瘤医院生物技术研究室国家恶性肿瘤临床医学研究中心天津市恶性肿瘤临床医学研究中心天津市肿瘤免疫与生物治疗重点实验室天津市300060

目的:探索新型免疫检查点淋巴细胞激活基因3(lymphocyte-activation gene 3,LAG-3)、纤维蛋白原样蛋白1(fibrinogenlike protein 1,FGL1)、主要组织相容性复合体Ⅱ类分子(major histocompatibility complex classⅡ,MHC-Ⅱ)在胃窦癌(gastric antral cancer,GAC)中的表达情况与预后的相关性。方法:收集2012年1月至2014年12月于天津医科大学肿瘤医院诊断为GAC的67例患者病理标本,分别进行石蜡切片制作,采用免疫组织化学法检测LAG-3、FGL1、MHC-Ⅱ三个指标的表达情况,并用统计学方法分析组间差异。采用Kaplan-Meier法评估LAG-3、FGL1、MHC-Ⅱ的表达水平与GAC患者预后之间的关系并绘制生存曲线。结果:GAC患者中,肿瘤大小0.05)。结论:GAC患者LAG-3、MHC-Ⅱ在不同区域的表达量存在差异,GAC患者LAG-3及其配体在免疫细胞的表达对预后产生积极影响,提示免疫细胞中LAG-3/MHC-Ⅱ可以作为GAC患者预后标志物,为临床个体化免疫治疗提供新的依据。

关键词：胃窦癌淋巴细胞激活基因3 纤维蛋白原样蛋白1 主要组织相容性复合体Ⅱ类分子生存预后

Neutrophils in the era of single-cell RNA sequencing: functions and targeted therapies in cancer

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Cancer Biology & Medicine 2023年第12期20卷 903-914页

作者： Jing Qin Feng Wei xiubao ren National Clinical Research Center for Cancer Tianjin Medical University Cancer Institute&HospitalTianjin 300060China Tianjin’s Clinical Research Center for Cancer Tianjin 300060China Key Laboratory of Cancer Prevention and Therapy Tianjin 300060China Key Laboratory of Cancer Immunology and Biotherapy Tianjin 300060China Department of Immunology Tianjin Medical University Cancer Institute&HospitalTianjin 300060China Department of Biotherapy Tianjin Medical University Cancer Institute&HospitalTianjin 300060China

Introduction Neutrophils,a crucial component of the innate immune system,are the most abundant bone marrow-derived eukaryotic cell in human blood.The functional importance of neutrophils is often overlooked because neutrophils are short-lived,terminally differentiated,and do not proliferate.Although traditionally considered anti-bacterial cells,research has demonstrated the multifaceted roles of neutrophils in cancer.Studies have suggested that neutrophils with normal functions co-exist with pathologically activated neutrophils that support tumorprogression and metastasis in the context of cancer.

关键词： metastasis targeted traditionally

Immunosuppressive checkpoint Siglec-15:a vital new piece of the cancer immunotherapy jigsaw puzzle

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Cancer Biology & Medicine 2019年第2期16卷 205-210页

作者： xiubao ren Department of Biotherapy Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin Key Laboratory of Cancer Immunology and Biotherapy Tianjin’s Clinical Research Center for Cancer

On March 5th, a novel immunosuppressive molecule,Siglec-15, was reported in Nature Medicine by Professor Lieping Chen1. Siglec-15 was reported in a wide variety of tumors. The molecule is not a simple replica of PD-1/PD-L1.Rather, the expressions of Siglec-15 and PD-L1 are mutually exclusive1, suggesting that Siglec-15 antibodies may be effective on tumors that are not responsive to anti-PD-1/PDL1 therapy. Siglec-15 potentially serves as a complementary therapeutic target and offers alternative treatments for many anti-PD-l/PD-Ll therapy unresponsive patients. This discovery generated a huge response.

关键词： cancer immunotherapy

Cancer immunology and immunotherapy

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Cancer Biology & Medicine 2021年第4期18卷 931-933页

作者： xiubao ren Department of Immunology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China Department of Biotherapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China Key Laboratory of Cancer Prevention and Therapy Tianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China

At the beginning of the last century,Dr.William Coley introduced“Coley’s toxin”to the scientific community after observing that a small number of patients with sarcoma with infections developed spontaneous tumor regression.“Coley’s toxin”consisted of bacteria or bacterial products and achieved a durable response in a small group of patients with cancer,most of whom had inoperable sarcoma.However,this response was usually unpredictable because of the lack of understanding of the immune response at that time.Since then,researchers have continued to study the relationship between cancer and the host immune system,and the discovery of“Coley’s toxin”marked the beginning of cancer immunotherapy^(1).

关键词： immunotherapy sarcoma cancer

Somatic copy number alterations are predictive of progression-free survival in patients with lung adenocarcinoma undergoing radiotherapy

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Cancer Biology & Medicine 2022年第5期19卷 685-695页

作者： Fan Kou Lei Wu Yan Guo Bailu Zhang Baihui Li Ziqi Huang xiubao ren Lili Yang Department of Immunology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China Department of Biotherapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin 300060China

Objective:Lung cancer is the most common cause of cancer-related deaths worldwide.Somatic copy number alterations(SCNAs)have been used to predict responses to therapies in many cancers,including lung cancer.However,little is known about whether they are predictive of radiotherapy outcomes.We aimed to understand the prognostic value and biological functions of SCNAs.Methods:We analyzed the correlation between SCNAs and clinical outcomes in The Cancer Genome Atlas data for 486 patients with non-small cell lung cancer who received radiotherapy.Gene set enrichment analyses were performed to investigate the potential mechanisms underlying the roles of SCNAs in the radiotherapy response.Our results were validated in 20 patients with lung adenocarcinoma(LUAD)receiving radiotherapy.Results:SCNAs were a better predictor of progression-free survival(PFS)in LUAD(P=0.024)than in lung squamous carcinoma(P=0.18)in patients treated with radiotherapy.Univariate and multivariate regression analyses revealed the superiority of SCNAs in predicting PFS in patients with LUAD.Patients with stage I cancer and low SCNA levels had longer PFS than those with high SCNA levels(P=0.022).Our prognostic nomogram also showed that combining SCNAs and tumor/node/metastasis provided a better model for predicting long-term PFS.Additionally,high SCNA may activate the cell cycle pathway and induce tumorigenesis.Conclusions:SCNAs may be used to predict PFS in patients with early-stage LUAD with radiotherapy,in combination with TNM,with the aim of predicting long-term PFS.Therefore,SCNAs are a novel predictive biomarker for radiotherapy in patients with LUAD.

关键词： SCNA radiotherapy lung cancer progression-free survival immune infiltration

Exhausted T cells and epigenetic status

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Cancer Biology & Medicine 2020年第4期17卷 923-936页

作者： Ziqing Zeng Feng Wei xiubao ren Department of Immunology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China Department of Biotherapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China

Exhausted T cells are a group of dysfunctional T cells,which are present in chronic infections or tumors.The most significant characteristics of exhausted T cells are attenuated effector cytotoxicity,reduced cytokine production,and upregulation of multiple inhibitory molecular receptors(e.g.,PD-1,TIM-3,and LAG-3).The intracellular metabolic changes,altered expression of transcription factors,and a unique epigenetic landscape constitute the exhaustion program.Recently,researchers have made progress in understanding exhausted T cells,with the definition and identification of exhausted T cells changing from phenotypebased to being classified at the transcriptional and epigenetic levels.Recent studies have revealed that exhausted T cells can be separated into two subgroups,namely TCF1^(+)PD-1^(+)progenitor-like precursor exhausted cells and TCF1-PD-1^(+)terminally differentiated exhausted T cells.Moreover,the progenitor-like precursor cell population may be a subset of T cells that can respond to immunotherapy.Studies have also found that TOX initiates and dominates the development of exhausted T cells at the transcriptional and epigenetic levels.TOX also maintains T cell survival and may affect decisions regarding treatment strategies.In this review,we discuss the latest developments in T cell exhaustion in regards to definitions,subpopulations,development mechanisms,differences in diverse diseases,and treatment prospects for exhausted T cells.Furthermore,we hypothesize that the epigenetic state regulated by TOX might be the key point,which can determine the reversibility of exhaustion and the efficacy of immunotherapy.

关键词： T cell exhaustion TOX tumor immunity epigenetic landscape immunotherapy

Comprehensive insights into the effects and regulatory mechanisms of immune cells expressing programmed death-1/programmed death ligand 1 in solid tumors

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Cancer Biology & Medicine 2020年第3期17卷 626-639页

作者： Min Liu Qian Sun Feng Wei xiubao ren Department of Immunology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinKey Laboratory of Cancer Immunology and BiotherapyTianjin's Clinical Research Center for CancerTianjin 300060China

The programmed cell death-1(PD-1)/programmed cell death ligand 1(PD-L1)signaling pathway is an important mechanism in tumor immune escape,and expression of PD-L1 on tumor cells has been reported more frequently.However,accumulating evidence suggests that PD-1/PD-L1 is also widely expressed on immune cells,and that regulation is also critical for tumor immune responses.In this review,we emphasized that under solid tumor conditions,the immunoregulatory effects of immune cells expressing PD-1 or PD-L1,affected the prognoses of cancer patients.Therefore,a better understanding of the mechanisms that regulate PD-1 or PD-L1 expression on immune cells would provide clear insights into the increased efficacy of anti-PD antibodies and the development of novel tumor immunotherapy strategies.

关键词： Immune cell immunotherapy programmed cell death ligand 1 programmed cell death-1 solid tumor

Global land-surface air temperature change based on the new CMA GLSAT data set

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Science Bulletin 2017年第4期62卷 236-238页

作者： xiubao Sun Guoyu ren Wenhui Xu Qingxiang Li Yuyu ren College of Atmospheric Science Nanjing University of Information Science & TechnologyNanjing 210044China Department of Atmospheric Science School of Environmental StudiesChina University of GeosciencesWuhan 430074China Laboratory for Climate Studies National Climate CenterChina Meteorological AdministrationBeijing 100081 Chinad National Meteorological Information Center China Meteorological AdministrationBeijing 100081China

The China Meteorological Administration(CMA)has recently developed a new global monthly homogenized land-surface air temperature data set.Based on this data set,we reanalyzed the change in global annual mean land-surface air temperature(LSAT)during three time periods(1901–2014,1979–2014 and 1998–2014).The results show that the linear trends of global annual mean LSAT were 0.104°C/decade,0.247°C/decade and 0.098°C/decade for the three periods,respectively.The trends were statistically significant except for the period 1998–2014,the period that

关键词：地表气温数据集 CMA 气温变化豪华型中国气象局