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Chemical Research in Chinese Universities 2007年第3期23卷 319-324页

作者： ZHANG Gui-rong GAO ren-jun ZHANG ai-jun RAO Lang CAO Shu-gui Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education Jilin University Changchun 130021 P. R. China

To identify the desired hypertherrnophilic variants within a mutant esterase library for the resolution of （R, S）-2- octanol acetate, a simple, reliable, and versatile method was developed in this study. We built a screening strategy including two steps, first we selected agar plate with substrate to screen the enzymatic activity; secondly we used a pH indicator to screen the enantioselectivity. This method could rapidly detect favorable mutants with high activity and enantioselectivity. A total of 96. 2% of tedious screening work can be precluded using this screening strategy. It is an effective screening for alkyl ester and can be applied to relative screening researches. The four improved mutants were screened from the mutant esterase library. Their enantioselectivities, activities, and structures were investigated at different temperatures.

关键词： High-throughput screening Enantioselectivity Hyperthermophilic esterase Directed evolution

Types of Maize Virus Diseases and Progress in Virus Identification Techniques in China

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Journal of Northeast Agricultural University(English Edition) 2014年第1期21卷 75-83页

作者： Cui Yu Zhang ai-hong ren ai-jun Miao Hong-qin College of Humanities & Social Science University of Science and Technology of China Institute of Plant Protection Hebei Academy of Agriculture and Forest Sciences/IPM Center of Hebei Province/Key Laboratory of IPM on Crops in Northern Region of North China Ministry of Agriculture

There are a total of more than 40 reported maize viral diseases worldwide. Five of them have reportedly occurred in China. They are maize rough dwarf disease, maize dwarf mosaic disease, maize streak dwarf disease, maize crimson leaf disease, maize wallaby ear disease and corn lethal necrosis disease. This paper reviewed their occurrence and distribution as well as virus identification techniques in order to provide a basis for virus identification and diagnosis in corn production.

关键词： maize virus disease virus species identification technique

Two simple memristive maps with adaptive energy regulation and digital signal process verification

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第5期25卷 382-394页

作者： Feifei YANG Lujie ren jun MA Zhigang ZHU College of Electrical and Information Engineering Lanzhou University of TechnologyLanzhou 730050China Department of Physics Lanzhou University of TechnologyLanzhou 730050China School of Information Science and Engineering Dalian Polytechnic UniversityDalian 116034China

Mathematical models can produce desired dynamics and statistical properties with the insertion of suitable nonlinear terms,while energy characteristics are crucial for practical application because any hardware realizations of nonlinear systems are relative to energy *** involvement of memristive terms relative to memristors enables multistability and initial-dependent property in memristive *** this study,two kinds of memristors are used to couple a capacitor or an inductor,along with a nonlinear resistor,to build different neural *** corresponding circuit equations are derived to develop two different types of memristive oscillators,which are further converted into two kinds of memristive maps after linear *** Hamilton energy function for memristive oscillators is obtained by applying the Helmholz theorem or by mapping from the field energy of the memristive *** Hamilton energy functions for both memristive maps are obtained by replacing the gains and discrete variables for the memristive oscillator with the corresponding parameters and *** two memristive maps have rich dynamic behaviors including coherence resonance under noisy excitation,and an adaptive growth law for parameters is presented to express the self-adaptive property of the memristive maps.A digital signal process(DSP)platform is used to verify these *** scheme will provide a theoretical basis and experimental guidance for oscillator-to-map transformation and discrete map-energy calculation.

关键词： Hamilton energy Discrete memristor Self-adaptive regulation Digital signal process(DSP)implementation

契丹“盐池宴”、“诸弟之乱”与夷离堇任期问题

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史学集刊 2007年第6期 61-69页

作者：任爱君赤峰学院历史系内蒙古赤峰024001

中原史料关于契丹"盐池宴"的记载,始终是学界产生困惑的疑端;但经过南、北史料系统(即《辽史》等代表的北方史料和《新五代史》等代表的中原史料)的分析与研究,可以清晰地辨别出"盐池宴"与"诸弟之乱"存在的史料类同关系,还可发现大夷离... 详细信息

中原史料关于契丹"盐池宴"的记载,始终是学界产生困惑的疑端;但经过南、北史料系统(即《辽史》等代表的北方史料和《新五代史》等代表的中原史料)的分析与研究,可以清晰地辨别出"盐池宴"与"诸弟之乱"存在的史料类同关系,还可发现大夷离堇职务与部落首领世选与任期问题存在的疑端,从而解决辽初史料整理中的一些基本问题。

关键词：契丹辽朝盐池宴诸弟之乱大夷离堇本部夷离堇

Recent progress in single crystal perovskite X-ray detectors

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Science China(Information Sciences) 2024年第3期67卷 5-19页

作者： Xiao LIU jun ren Yu-Ang CHEN Xiangshun GENG Dan XIE Tian-Ling ren School of Integrated Circuits Tsinghua University Beijing National Research Center for Information Science and Technology (BNRist)

Perovskites have attracted extensive attention as radiation detection material due to their long carrier diffusion length and lifetime, high absorption coefficient, and flexible manufacturing process. Compared with polycrystalline structures, single crystal perovskites improve the performance of optoelectronic devices due to their low defect state density, better photoelectric characteristics, and chemical ***, we review the recent progress of single crystal perovskite X-ray detectors. First, we briefly introduced the basic concepts, detection mechanisms, figure of merits of perovskite X-ray detectors, and the preparation methods of single crystal perovskites. Then, we summarized the significant advancements in single crystal perovskite X-ray detectors in recent times. Finally, we discussed the critical challenges and some practicable solutions for developing high-performance X-ray detectors.

关键词： single crystal perovskites carrier transport radiation detection X-ray detectors X-ray imaging

Integral precession calibration method of PIGA on linear vibration table

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Chinese Journal of Aeronautics 2024年第3期37卷 219-236页

作者： Chuang SUN Shun-qing ren jun-wei CAO Ru HUO Department of Automation Tsinghua UniversityBeijing 100084China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China Faculty of Information technology Beijing University of TechnologyBeijing 100124China

Linear vibration table can provide harmonic accelerations to excite the nonlinear error terms of Pendulous Integrating Gyro Accelerometer(PIGA).Integral precession calibration method is proposed to calibrate PIGA on a linear vibration table in this *** on the precise expressions of PIGA’s inputs,the error calibration model of PIGA is *** angular velocity errors of PIGA are suppressed by integer periodic precession and the errors caused by non-integer periods vibrating are *** complete calibration process,including planning,preparation,PIGA testing,and coefficient identification,is designed to optimize the test operations and evaluate the calibration *** effect of the main errors on calibration uncertainty is analyzed and the relative sensitivity function is proposed to further optimize the test *** and simulation results verify that the proposed 10-position calibration method can improve calibration uncertainties after compensating for the related *** order of calibration uncertainties of the second-and third-order coefficients are decreased to 10^(-8)(rad.s^(-1))/g^(2)and 10^(-8)(rad.s^(-1))/g3,*** with the other two classical calibration methods,the calibration uncertainties of PIGA’s nonlinear error coefficients can be effectively reduced and the proportional residual errors are decreased less than 3×10-6(rad.s^(-1))/g by using the proposed calibration method.

关键词： PIGA Linear vibration table Vibration measurement Calibration Error analysis Uncertainty analysis

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考虑恢复依赖的基础设施网络应急恢复决策

中国管理科学 2022年第1期30卷 154-164页

作者：任爱俊冯耕中田军西安交通大学管理学院陕西西安710049

在大规模突发事件发生后,基础设施恢复任务之间会形成复杂的依赖关系,本文考虑了在此条件下基础设施系统的恢复设计与调度决策问题。基于网络流理论,以累积恢复效能最大化与成本最小化为目标,构建了涵盖阻塞依赖、选项依赖和效率依赖三... 详细信息

在大规模突发事件发生后,基础设施恢复任务之间会形成复杂的依赖关系,本文考虑了在此条件下基础设施系统的恢复设计与调度决策问题。基于网络流理论,以累积恢复效能最大化与成本最小化为目标,构建了涵盖阻塞依赖、选项依赖和效率依赖三类恢复依赖关系的集成恢复设计与调度决策混合整数规划模型,并且设计了求解模型的启发式算法。最后,以长沙市真实基础设施数据集为基础,构造了突发事件后的损毁场景实例,利用模型求解得出了受损基础设施的恢复设计与调度决策方案,并且分析了决策周期长度与工作组数量对累积恢复效能和成本的影响。结果表明:(1)该模型在突发事件后的基础设施恢复决策中具有应用可行性;(2)决策周期长度显著影响累积恢复效能,随着决策周期长度与恢复过程中各组件恢复耗时契合度的提升,累积恢复效能获得有效增长,并且,在决策周期长度的取值范围内,总成本存在最小值;(3)随工作组数量的增加,累积恢复效能呈增长趋势,增长率逐渐减小,同时,总成本呈减少趋势,减少率也逐渐减小。

关键词：基础设施网络流恢复依赖恢复效能决策

Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook

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Chinese Journal of Integrative Medicine 2024年第1期30卷 62-74页

作者： JIANG Xiao-ying SHI Li-ping ZHU jun-long Bai ren-ren XIE Tian School of Pharmacy Hangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Good Clinical Practice Center Affliliated Hospital of Nanjing University of Chinese MedicineNanjing(210000)China

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".

关键词： molecular compatibility theory Chinese integrative medicine elemene antitumor activity drug delivery structural modification

Construction and validation of a neovascular glaucoma nomogram in patients with diabetic retinopathy after pars plana vitrectomy

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World Journal of Diabetes 2024年第4期15卷 654-663页

作者： Yi Shi Yan-Xin Zhang Ming-Fei Jiao Xin-jun ren Bo-Jie Hu ai-Hua Liu Xiao-Rong Li Surgical Retina Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China Glaucoma Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China Ocular Trauma Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China

BACKGROUND Neovascular glaucoma(NVG)is likely to occur after pars plana vitrectomy(PPV)for diabetic retinopathy(DR)in some patients,thus reducing the expected *** the risk factors for NVG occurrence and building effective risk prediction models are currently required for clinical *** To develop a visual risk profile model to explore factors influencing DR after *** We retrospectively selected 151 patients with DR undergoing *** patients were divided into the NVG(NVG occurrence)and No-NVG(No NVG occurrence)groups according to the occurrence of NVG within 6 months after *** risk factors for postoperative NVG were screened by logistic regression.A nomogram prediction model was established using R software,and the model’s prediction accuracy was verified internally and externally,involving the receiver operator characteristic curve and correction *** After importing the data into a logistic regression model,we concluded that a posterior capsular defect,preoperative vascular endothelial growth factor≥302.90 pg/mL,glycosylated hemoglobin≥9.05%,aqueous fluid interleukin 6(IL-6)≥53.27 pg/mL,and aqueous fluid IL-10≥9.11 pg/mL were independent risk factors for postoperative NVG in patients with DR(P<0.05).A nomogram model was established based on the aforementioned independent risk factors,and a computer simulation repeated sampling method was used to internally and externally verify the nomogram *** area under the curve(AUC),sensitivity,and specificity of the model were 0.962[95%confidence interval(95%CI):0.932-0.991],91.5%,and 82.3%,*** AUC,sensitivity,and specificity of the external validation were 0.878(95%CI:0.746-0.982),66.7%,and 95.7%,*** A nomogram constructed based on the risk factors for postoperative NVG in patients with DR has a high prediction *** study can help formulate relevant preventive and treatment measures.

关键词： Diabetic retinopathy Retinopathy Neovascular Glaucoma Risk factors Nomogram

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时间敏感选项依赖下的基础设施恢复决策研究

运筹与管理 2019年第5期28卷 8-16页

作者：任爱俊田军冯耕中西安交通大学管理学院

突发事件发生后,基础设施之间的恢复依赖为恢复过程带来了严重挑战。为了能够在突发事件后高效而有序的实现基础设施恢复运行,根据相互之间的恢复依赖关系制定合理的恢复决策非常关键。本文基于网络流理论,以累积恢复效能最大化为目标,... 详细信息

突发事件发生后,基础设施之间的恢复依赖为恢复过程带来了严重挑战。为了能够在突发事件后高效而有序的实现基础设施恢复运行,根据相互之间的恢复依赖关系制定合理的恢复决策非常关键。本文基于网络流理论,以累积恢复效能最大化为目标,建立了时间敏感选项依赖下的恢复设计与调度决策混合整数规划模型。然后,讨论了模型在完全中心化、完全分散和信息共享决策环境下的应用方法。最后,通过真实基础设施数据集测试了模型,结果表明:(1)该模型在突发事件后的基础设施恢复决策中具有应用可行性;(2)决策环境显著影响存在恢复依赖的基础设施网络整体累积恢复效能;(3)与完全分散决策环境相比,在信息共享决策环境下独立决策的整体累积恢复效能可以得到大幅提升。

关键词：基础设施时间敏感选项恢复依赖决策