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Methionine sources and genotype affect embryonic intestinal development,antioxidants,tight junctions,and growth-related gene expression in chickens

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Animal Nutrition 2024年第1期16卷 218-230页

作者： james K.Lugata Sawadi F.Ndunguru Gebrehaweria K.Reda Xénia E.Ozsváth Eszter Angyal Levente Czeglédi Gabriella Gulyás renáta knop.jános oláh Zoltán Mészár Rita Varga Brigitta Csernus Csaba Szabó Department of Animal Nutrition and Physiology Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Department of Animal husbandry Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Faculty of Agriculture and Food Sciences and Environmental Management Doctoral School of Animal ScienceUniversity of DebrecenDebrecenHungary Institutes for Agricultural Research and Educational Farm University of DebrecenDebrecenHungary Department of Anatomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Evolutionary Zoology and human Biology Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

Methionine(Met)is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and *** present study examined the effect of in ovo injection of DL-Met and L-Met sources and genotypes on chicken embryonic-intestinal development and *** eggs of the two genotypes,TETRA-SL layer hybrid(TSL)—commercial layer hybrid and hungarian Partridge colored hen breed(hPC)—a native genotype,were randomly distributed into four treatments for each *** treatment groups include the following:1)control non-injected eggs(NoIn);2)saline-injected(SaIn);3)DL-Met injected(DLM);and 4)L-Met injected(LM).The in ovo injection was carried out on 17.5 d of embryonic development;after hatching,eight chicks per group were sacrificed,and the jejunum was extracted for *** results showed that both DLM and LM groups had enhanced intestinal development as evidenced by increased villus width,villus height,and villus area(Phe *** DLM group had significantly reduced crypt depth,glutathione(GSh)content,glutathione S-transferase 3 alpha(GST3),occludin(OCLN)gene expression and increased villus height to crypt depth ratio in the TSL genotype than the LM group(Phe hPC genotype has overexpressed insulin-like growth factor 1(IGF1)gene,tricellulin(MD2),occludin(OCLN),superoxide dismutase 1(SOD1),and GST3 genes than the TSL genotype(Phese findings showed that in ovo injection of Met enhanced intestinal development,and function,with genotypes responding differently under normal *** also influenced the expression of intestinal antioxidants,tight junction,and growth-related genes.

关键词： DL-Methionine L-Methionine In ovo injection Intestinal development Poultry

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波兰向中国出口金属及金属制品的比较优势与竞争力研究

波兰向中国出口金属及金属制品的比较优势与竞争力研究

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作者： knop Patrycja Agnieszka 浙江大学

学位级别：硕士

21世纪以来,波兰的出口贸易得到了长足的发展,因此,其国际地位得到提升。波兰与中国建交以来,两国一直保持着良好的经贸合作关系。具体表现为:两国在货物贸易领域的合作规模和增速都在提升,出口结构也在不断优化、贸易发展的联系更加紧... 详细信息

21世纪以来,波兰的出口贸易得到了长足的发展,因此,其国际地位得到提升。波兰与中国建交以来,两国一直保持着良好的经贸合作关系。具体表现为:两国在货物贸易领域的合作规模和增速都在提升,出口结构也在不断优化、贸易发展的联系更加紧密。经过10多年的发展,波兰对中国在金属与金属制品的出口比较优势进一步显现;与此同时,波兰与中国之间的货物贸易往来也不断拓宽和深入。波兰对中国出口贸易存在的主要问题是目前巨大的贸易逆差和货物贸易差异,这也是本研究可以更好地了解当前贸易趋势的原因,其结果可能有助于提高波兰对中国出口能力。从不同阶段来看,波兰在中国出口的产品结构上有所调整和优化,波兰产品比较优势的变化随着本国产业结构的调整而变化。国际上,波兰在金属出口领域面临着激烈的竞争;中国丰富的资源为波兰与中国两国经贸关系的进一步发展提供了新的思路和发展机遇。本文基于显性比较优势与竞争力理论,贸易结构和波兰向中国出口分析方法,描绘了双边贸易结构,重点位于分析波兰对中国的金属和金属产品出口。利用2010—2017年波中贸易数据来分析波兰金属和金属制品对中国市场出口的竞争力和比较优势。同时为了获得精确的结果本文使用显性比较优势指数、区域显性比较优势指数、产业内贸易指数和贸易强度指数衡量波中两国贸易的比较优势与竞争力。结果显示,波兰对全球金属出口有很强的优势,但是对中国的金属领域出口中,只有铜及铜制品显示了比较大的优势。波兰在出口方面有竞争力的制品外,其产业内部贸易在经历了多年下降趋势之后,终于在2016年呈现上升趋势。波兰和中国之间的进出口态势保持稳定,而波兰从中国的进口强度要超过出口的十倍。

关键词：贸易出口金属比较优势竞争力

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Bariatric surgery in patients with non-alcoholic fatty liver disease-from pathophysiology to clinical effects

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World journal of hepatology 2019年第2期11卷 138-149页

作者： Tea L Laursen Christoffer A hagemann Chunshan Wei Konstantin Kazankov Karen L Thomsen Filip K knop henning Grønbæk Department of hepatology and Gastroenterology Aarhus University Hospital Gubra ApS Clinical Metabolic Physiology Steno Diabetes Center CopenhagenGentofte Hospital Department of Clinical Medicine Faculty of Health and Medical SciencesUniversity of Copenhagen Department of hepatology Shenzhen Traditional Chinese Medicine Hospitalthe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical SciencesUniversity of Copenhagen

Non-alcoholic fatty liver disease(NAFLD) is increasingly recognized as a significant liver disease,and it covers the disease spectrum from simple steatosis with a risk of development of non-alcoholic steatohepatitis(NASh) to fibrosis,subsequent cirrhosis,end-stage liver failure,and liver cancer with a potential need for liver *** and NASh are closely related to obesity,metabolic syndrome,and type 2 diabetes(T2 D).The role of gut hormones,especially glucagon-like peptide 1(GLP-1),is important in *** surgery has the potential for inducing great weight loss and may improve the symptoms of metabolic syndrome and T2 *** data demonstrated significant effects of bariatric surgery on GLP-1 and other gut hormones and important lipid metabolic and inflammatory abnormalities in the pathophysiology of ***,bariatric surgery may reverse the pathological liver changes in NAFLD and NASh *** the present review,we describe NAFLD and NASh pathophysiology and the primary effects of bariatric surgery on metabolic *** performed a systematic review of the beneficial and harmful effects and focused on changes in liver disease severity in NAFLD and NASh *** specific focus was liver histopathology as assessed by the invasive liver ***,we reviewed several non-invasive methods used for the assessment of liver disease severity following bariatric surgery.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Bariatric surgery Insulin resistance,Gut hormones Glucagon-like peptide 1 Steatosis Inflammation Fibrosis

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强震发生时间的中期预测

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世界地震译丛 1989年第4期20卷 8-13,35页

作者： knop.,L. 刘冬金

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Reduction and carburization of iron oxides for Fischer–Tropsch synthesis

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journal of Energy Chemistry 2020年第12期29卷 48-61页

作者： Monia Runge Nielsen Asger Barkholt Moss Anton Simon Bjrnlund Xi Liu Axel knop-Gericke Alexander YuKlyushin jan-Dierk Grunwaldt Thomas LSheppard Dmitry EDoronkin Anna Zimina Thomas Eric Lyck Smitshuysen Christian Danvad Damsgaard jakob Birkedal Wagner Thomas Willum hansen DTU Nanolab Technical University of DenmarkDK-2800Kgs.LyngbyDenmark Department of Physics Technical University of DenmarkDK-2800Kgs.LyngbyDenmark SynCat@Beijing Synfuels China Technology Co.LtdBeijing 101407China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Inorganic Chemistry Fritz Haber Institute of the Max Planck SocietyD-14195 BerlinGermany Research Group heterogeneous Reactions.Max Planck Institute for Chemical Energy Conversion D-45470 MulheimGermany Research Group Catalysis for Energy Helmholtz-Zentrum Berlin for Materials and Energy(BESSYⅡ)D-12489 BerlinGermany Institute for Chemical Technology and Polymer Chemistry Karlsruhe Institute of TechnologyD-76131 KarlsruheGermany Institute of Catalysis Research and Technology Karlsruhe Institute of TechnologyD-76344 Eggenstein-LeopoldshafenGermany

The activation of iron oxide Fischer–Tropsch Synthesis(FTS) catalysts was investigated during pretreatment: reduction in hydrogen followed by carburization in either CO or syngas mixture, or simultaneously reduction and carburization in syngas. A combination of different complementary in situ techniques was used to gain insight into the behavior of Fe-based FTS catalysts during activation. In situ XRD was used to identify the crystalline structures present during both reduction in hydrogen and carburization. An increase in reduction rate was established when increasing the temperature. A complete reduction was demonstrated in the ETEM and a grain size dependency was proven, i.e. bigger grains need higher temperature in order to reduce. XPS and XAS both indicate the formation of a small amount of carbonaceous species at the surface of the bulk metallic iron during carburization.

关键词： In situ characterization Fischer–Tropsch Catalyst reduction and carburization Iron oxides

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一切都在掌握之中

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流程工业 2017年第3期 42-43页

作者： Andreas knop Vaisala公司

药品生产过程中，环境监测怎样才能保证产品质量——无论是冷冻柜、冷藏箱、仓库或者恒温室，如何优化药品生产工艺过程、保护产品并最终保护患者的健康？

关键词：生产工艺过程产品质量生产过程环境监测冷冻柜冷藏箱恒温室药品

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Complicated fecal microbiota transplantation in a tetraplegic patient with severe Clostridium difficile infection

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World journal of Gastroenterology 2015年第12期21卷 3736-3740页

作者： Thorsten Brechmann justyna Swol Veronika knop-hammad jrg Willert Mirko Aach oliver Cruciger Wolff Schmiegel Thomas A Schildhauer Uwe hamsen Department of Gastroenterology and hepatology Berufsge-nossenschaftliches Universit?tsklinikum Bergmannsheil Gmb H Ruhr--University Bochum Department of General and Trauma Surgery Berufsgenossens--chaftliches Universit?tsklinikum Bergmannsheil Gmb H Ruhr--University Bochum Institute of Laboratory Medicine Berufsgenossenschaftliches Universit?tsklinikum Bergmannsheil Gmb H Ruhr--University Bochum Department of Neurotraumatology Berufsgenossenschaftliches Universit?tsklinikum Bergmannsheil Gmb H Ruhr--University Bochum

A 65-year-old male suffering from acute spinal cord injury leading to incomplete tetraplegia presented with severe recurrent Clostridium difficile(C. difficile) infection subsequent to antibiotic treatment for pneumonia. After a history of ineffective antimicrobial therapies, including metronidazole, vancomycin, fidaxomicin, rifaximin and tigecycline, leading to several relapses, the patient underwent colonoscopic fecal microbiota transplantation from his healthy son. Four days subsequent to the procedure, the patient showed a systemic inflammation response syndrome. Without detecting an infectious cause, the patient received antimicrobial treatment, including tigecycline, metronidazole, vancomycin via polyethylene glycol and an additional enema for a period of seven days, leading to a prompt recovery and no reported C. difficile infection relapse during a 12 wk follow up.

关键词： Clostridium difficile infection Spinal cord injury

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采用微阵列技术进行变应原组分特异性诊断：过去、现在和未来

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中华检验医学杂志 2010年第11期33卷 1011-1016页

作者： De knop Kj Verweij MM hagendorens MM Bridts Ch De Clerck LS Stevens Wj Ebo DG 比利时安特卫普大学医学院免疫学系-变态反应学及风湿病学科 B-2610 比利时安特卫普大学医学院儿科学系-变态反应学及风湿病学科 B-2610

Ⅰ型变态反应是一项重要的健康问题，对Ⅰ型变态反应的正确诊断是危急时刻抢救生命的先决条件。通常，特异性IgE抗体定量检测以及皮肤试验是用于验证医生的临床疑似诊断。但是，这两项测试均不能绝对保证阳性或阴性结果的预测价值。激... 详细信息

Ⅰ型变态反应是一项重要的健康问题，对Ⅰ型变态反应的正确诊断是危急时刻抢救生命的先决条件。通常，特异性IgE抗体定量检测以及皮肤试验是用于验证医生的临床疑似诊断。但是，这两项测试均不能绝对保证阳性或阴性结果的预测价值。激发试验目前仍是变态反应诊断的金标准。

关键词：特异性诊断微阵列技术变应原 Ⅰ型变态反应特异性IgE抗体组分健康问题抢救生命

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Art@Med专栏Ⅰ心脏的混沌

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临床与病理杂志 2015年第5期35卷 719-720页

作者： Lori Shocket Siegfried knop 刘昱圻 Thousand Oaks 解放军总医院心血管内科

医生不仅是手术匠，也是音乐家与艺术家，在复杂的生理系统中寻找跳动的韵律；医生不仅是修理工，也是画家、诗人，在冰冷的培养基上寻找变幻的图案。脱下白大褂，医生还是儿女、父母……是个平凡而真实的人，在生活中寻找精神标杆，用... 详细信息

医生不仅是手术匠，也是音乐家与艺术家，在复杂的生理系统中寻找跳动的韵律；医生不仅是修理工，也是画家、诗人，在冰冷的培养基上寻找变幻的图案。脱下白大褂，医生还是儿女、父母……是个平凡而真实的人，在生活中寻找精神标杆，用感恩的心歌颂世间美好。AME在一群优秀医生中，发现了诗人、书法家、歌手、漫画家……因此，我们推出Art@Med专栏，带您踏上一场人文之旅，去挖掘医学的艺术，医生的诗意。

关键词：混沌心脏生理系统艺术家漫画家医生音乐家修理工

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Verification of the Passive house Concept to the South of Brazil Climate

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journal of Civil Engineering and Architecture 2016年第8期10卷 937-945页

作者： renata Dalbem Stifany knop Eduardo Grala da Cunha Rui F. oliveira Maria Femanda Rodrigues Romeu Vicente Laboratory of Comfort and Energy Efficiency Faculty of Architecture and Urbanism Federal University of Pelotas Pelotas 96010-020 Brazil Civil Engineering Department University of Aveiro Aveiro 3810-193 Portugal

The high impact of the building＇s sector on energy consumption and on the environment has led to increased concerns on the performance of indoor thermal buildings, and led many countries to define stricter requirements for their building legislation. In 2010, the European Union has established that by the end of 2020 all new buildings must have energy consumption close to zero （NZEBs （nearly zero energy buildings））, increasing the pursue for more efficient building design. One way to achieve buildings with low energy consumption while maintaining a high thermal comfort is the passive house concept. The paper presents an architectural project designed to meet the Passive house requirements for the climate of southern Brazil. The energy balance was carried out using the energy balance toot-PhPP （passive house planning package）, that verified the compliance of the prerequisites required for certification, which are related to the primary energy consumption, heating, cooling demand and overheating rate of the building.

关键词： Energy efficiency NZEB passive house sustainability.

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