Bariatric surgery in patients with non-alcoholic fatty liver disease-from pathophysiology to clinical effects
作者机构：Department of Hepatology and GastroenterologyAarhus University Hospital Gubra ApS Clinical Metabolic PhysiologySteno Diabetes Center CopenhagenGentofte Hospital Department of Clinical MedicineFaculty of Health and Medical SciencesUniversity of Copenhagen Department of HepatologyShenzhen Traditional Chinese Medicine Hospitalthe Fourth Clinical Medical College of Guangzhou University of Chinese Medicine Novo Nordisk Foundation Center for Basic Metabolic ResearchFaculty of Health and Medical SciencesUniversity of Copenhagen
出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)
年 卷 期：2019年第11卷第2期
页 面：138-149页
主 题：Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Bariatric surgery Insulin resistance,Gut hormones Glucagon-like peptide 1 Steatosis Inflammation Fibrosis
摘 要：Non-alcoholic fatty liver disease(NAFLD) is increasingly recognized as a significant liver disease,and it covers the disease spectrum from simple steatosis with a risk of development of non-alcoholic steatohepatitis(NASH) to fibrosis,subsequent cirrhosis,end-stage liver failure,and liver cancer with a potential need for liver *** and NASH are closely related to obesity,metabolic syndrome,and type 2 diabetes(T2 D).The role of gut hormones,especially glucagon-like peptide 1(GLP-1),is important in *** surgery has the potential for inducing great weight loss and may improve the symptoms of metabolic syndrome and T2 *** data demonstrated significant effects of bariatric surgery on GLP-1 and other gut hormones and important lipid metabolic and inflammatory abnormalities in the pathophysiology of ***,bariatric surgery may reverse the pathological liver changes in NAFLD and NASH *** the present review,we describe NAFLD and NASH pathophysiology and the primary effects of bariatric surgery on metabolic *** performed a systematic review of the beneficial and harmful effects and focused on changes in liver disease severity in NAFLD and NASH *** specific focus was liver histopathology as assessed by the invasive liver ***,we reviewed several non-invasive methods used for the assessment of liver disease severity following bariatric surgery.
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