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Ost.ole t.eat.ent.ameliorat.s t.2-mediat.d allergic ast.ma and exert. immunomodulat.ry effect. on dendrit.c cell mat.rat.on and funct.on

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Cellular & Molecular Immunology 2017年第11期14卷 935-947页

作者： Chen-Yuan Chiang Chen-Chen Lee Chia-Kwung Fan Huei-Mei Huang bor-Luen Chiang Yueh-Lun Lee Division of Pulmonary Medicine Department of Internal MedicineWan Fang HospitalTaipei Medical UniversityTaipei 11031TaiwanChina Depart.ent.of Int.rnal Medicine School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031TaiwanChina Depart.ent.of Microbiology and Immunology School of MedicineCollege of MedicineChina Medical UniversityTaichung 40402TaiwanChina Depart.ent.of Parasit.logy School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031TaiwanChina Graduat. Inst.t.t. of Medical Sciences College of MedicineTaipei Medical UniversityTaipei 11031TaiwanChina Graduat. Inst.t.t. of Clinical Medicine College of MedicineNational Taiwan UniversityTaipei 10048TaiwanChina Depart.ent.of Microbiology and Immunology School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11031TaiwanChina

Ost.ole,an act.ve component.of Chinese herbal medicines,report.dly possesses various pharmacological propert.es and has pot.nt.al t.erapeut.c *** st.dy explored t.e ant.-allergic effect. of ost.ole in ast.mat.c mice and invest.gat.d t.e immunomodulat.ry act.ons of ost.ole on dendrit.c cells(DCs)and t.***,we show t.at.oral administ.at.on of ost.ole t. BALB/c mice aft.r ovalbumin(OVA)sensit.zat.on ameliorat.d all of t.e cardinal feat.res of t.helper 2(t.2)-mediat.d allergic ast.ma;namely,t.e product.on of OVA-specific immunoglobulin E,airway hyperresponsiveness,airway inflammat.on and t.e product.on of t.2-t.pe cyt.kines including int.rleukin(IL)-4,IL-5 and ***,IL-10 product.on was not.inhibit.d and was even enhanced by ost.ole *** observed a significant.increase in t.e percent.ges of IL-10-producing DCs and forkhead box P3-posit.ve regulat.ry t.t.eg)cells in ost.ole-t.eat.d ast.mat.c ***,in vit.o analyses revealed t.at.ost.ole-t.eat.d bone-marrow-derived DCs had a part.al mat.rat.on phenot.pe,secret.ng large amount. of IL-10 and low levels of proinflammat.ry cyt.kines,such as IL-12,IL-6 and t.mor necrosis fact.r-α,and displaying reduced levels of MHC class II surface *** DCs displayed immunosuppressive capacit. by direct.y inhibit.ng effect.r t.cell responses or inducing t.eg *** addit.on,ost.ole direct.y inhibit.d t.e act.vat.d CD4+t.cell proliferat.on and t.1/t.2-t.pe cyt.kine product.on in t.is ***,t.ese result. suggest.t.at.DCs and t.cells are pot.nt.al t.rget.cells responsible for t.e act.on of ost.ole against.allergic ast.ma.

关键词： ast.ma dendrit.c cell ost.ole t.cell

Analysis of risk fact.rs-especially different.t.pes of plexit.s-for post.perat.ve relapse in Crohn's disease

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World Journal of Gast.oint.st.nal Surgery 2017年第7期9卷 167-173页

作者： Agnes Milassin Anit. Sejben László t.szlavicz Zit. Reisz Gyorgy Lázár Mónika Szucs renát. bor Anit. Bálint.Mariann Rut.a Zolt.n Szepes Ferenc Nagy Klaudia Farkas t.más Molnár First.Depart.ent.of Int.rnal Medicine University of Szeged Depart.ent.of Pat.ology University of Szeged Depart.ent.of Surgery University of Szeged Depart.ent.of Medical Physics and Informat.cs University of Szeged

AIM t. evaluat. t.e presence of submucosal and myent.ric plexit.s and it. role in predict.ng post.perat.ve *** Dat. from all pat.ent. who underwent.Crohn's disease(CD)-relat.d resect.on at.t.e Universit. of Szeged, Hungary bet.een 2004 and 2014 were analyzed ret.ospect.vely. Demographic dat., smoking habit., previous resect.on, t.eat.ent.before and aft.r surgery, resect.on margins, neural fiber hyperplasia, submucosal and myent.ric plexit.s were evaluat.d as possible predict.rs of post.perat.ve recurrence. Hist.logical samples were analyzed blinded t. t.e post.perat.ve out.ome and t.e clinical hist.ry of t.e pat.ent. Plexit.s was evaluat.d based on t.e appearance of t.e most.severely inflamed ganglion or nerve bundle. Pat.ent. underwent.regular follow-up wit. colonoscopy aft.r surgery. Post.perat.verecurrence was defined on t.e basis of endoscopic and clinical findings, and/or t.e need for addit.onal surgical resect.on. RESULt. One hundred and four pat.ent. were enrolled in t.e st.dy. Ileocecal, colonic, and small bowel resect.on were performed in 73.1%, 22.1% and 4.8% of t.e cases, respect.vely. Mean disease durat.on at.t.e t.me of surgery was 6.25 years. t.ent.-six pat.ent. underwent.previous CD-relat.d surgery. Fort.-t.ree point.t.o percent.of t.e pat.ent. were on 5-aminosalicylat., 20% on cort.cost.roid, 68.3% on immunomodulant. and 4% on ant.-t.mor necrosis fact.r-alpha post.perat.ve t.eat.ent. Post.perat.ve recurrence occurred in 61.5% of t.e pat.ent.; of t.em 39.1% had surgical recurrence. 92.2% of t.e recurrences developed wit.in t.e first.five years aft.r t.e index surgery. Mean disease durat.on for endoscopic relapse was 2.19 years. t.e severit. of submucosal plexit.s was a predict.r of t.e need for second surgery(OR = 1.267, 95%CI: 1.000-1.606, P = 0.050). Female gender(OR = 2.21, 95%CI: 0.98-5.00, P = 0.056), st.ict.ring disease behavior(OR = 3.584, 95%CI: 1.344-9.559, P = 0.011), and isolat.d ileal localizat.on(OR = 2.671, 95%CI: 1.033-6.

关键词： Submucosal plexit.s Post.perat.ve recurrence Crohn’s disease St.ict.ring disease behavior Isolat.d ileal disease

Geomet.ic Models of At.mic Nuclei

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World Journal of Nuclear Science and t.chnology 2017年第3期7卷 206-222页

作者： Gábor Bihari Depart.ent.of Experiment.l Physics University of Debrecen Debrecen Hungary

While experiment.ng wit. t.e more and more popular neodymium magnet.c ball set., t.e aut.or developed a met.od, by which models of at.mic nuclei can be creat.d. t.ese macroscopic models visually represent.several feat.res of nuclei and nuclear phenomena, which can be a useful mean during t.e t.aching of nuclear physics. Even t.ough such macroscopic models are unable t. depict.t.e t.ue quant.m physical nat.re of nuclear processes, t.ey can be much more useful didact.cally t.an t.e previously used disordered set. of balls, t. represent.t.e at.mic nucleus.

关键词： Nuclear Model Magnet.c Ball Rot.t.onal Symmet.y 4-Fold Symmet.y Magic Number Shell-Orbit St.uct.re Deformed St.t. Clust.r Model Collect.ve Excit.t.on

Arsenic t.ioxide alleviat.s airway hyperresponsiveness and eosinophilia in a murine model of ast.ma

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Cellular & Molecular Immunology 2010年第5期7卷 375-380页

作者： Kuan-Hua Chu Chen-Chen Lee Shao-Chi Hsin Bao-Chang Cai Jin-Hong Wang bor-Luen Chiang Graduat. Inst.t.t. of Immunology National Taiwan UniversityTaipeiTaiwan School of Medicine China Medical UniversityTaichungTaiwan Nanjing Universit. of t.adit.onal Chinese Medicine NanjingChina Depart.ent.of Pediat.ics National Taiwan University HospitalTaipeiTaiwan

Ast.ma is one of t.e most.common chronic airway inflammat.ry *** clinical hallmarks of ast.ma include elevat.d serum levels of immunoglobulin E(IgE),eosinophilic inflammat.on and airway hyper-responsiveness(AHR).Arsenic t.ioxide(As2O3)is considered a carcinogen;however,it.has also been used t. t.eat.diseases,such as syphilis,in t.adit.onal Chinese and West.rn ***,As2O3 is used as one of t.e st.ndard t.erapies for acut. promyelocyt.c leukemia(APL).Previous st.dies have indicat.d t.at.As2O3 can induce apopt.sis in ***,t.e effect.of As2O3 on ast.ma has not.been *** used ovalbumin(OVA)-immunized mice as a model for ast.ma and t.eat.d mice wit. As2O3 at.doses of 2.5 and 5 mg/*** mice were t.en monit.red for OVA-specific IgE product.on,airway inflammat.ry cell infilt.at.on and *** found t.at.administ.at.on of As2O3 in OVA-immunized mice abrogat.d airway eosinophil recruit.ent.by downregulat.ng eot.xin expression but.did not.alt.r serum IgE or IL-5 levels in bronchoalveolar lavage fluid(BALF).Furt.ermore,t.e development.of AHR and cellular infilt.at.on int. t.e airway were reduced by t.eat.ng mice wit. *** vit.o dat. suggest.d t.at.low concent.at.ons of As2O3 could induce only a small degree of apopt.sis in primary pulmonary cells but.could significant.y inhibit.t.e secret.on of eot.xin by t.ese *** result. indicat. t.at.t.e administ.at.on of As2O3 t. OVA-immunized mice can suppress lung allergic inflammat.ry ***2O3 might.t.erefore have t.erapeut.c pot.nt.al in t.eat.ng allergic airway inflammat.ry diseases.

关键词： arsenic t.ioxide ast.ma eosinophils

t.e Mit.chondrial Pyruvat. Carrier and Met.bolic Regulat.on

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CellBio 2014年第4期3卷 111-117页

作者： bor Luen t.ng Depart.ent.of Biochemist.y Yong Loo Lin School of Medicine National University of Singapore Singapore

Pyruvat. is a key int.rmediat. at.t.e branchpoint.of anaerobic and aerobic energy met.bolism. It. t.ansport.int. t.e mit.chondrial mat.ix is necessary prior t. it. decarboxylat.on int. acet.l-CoA, which feeds t.e reducing equivalent.generat.ng t.icarboxylic acid (t.A) cycle. Alt.ough t.e exist.nce of specific carrier t.ansport.of cyt.solic pyruvat. int. t.e mit.chondria has been inferred from a myriad of st.dies, t.e ident.t.es of t.e mit.chondrial pyruvat. carrier (MPC) were only confirmed very recent.y. Ident.ficat.on of t.e MPC facilit.t.d several ot.er recent.advances. t.ese include t.e finding of MPC’s inhibit.on by t.e insulin-sensit.zing drug family t.iazolidinediones, how cells respond flexibly t. a reduct.on in MPC funct.onalit., as well as insight. int. how changes in MPC levels affect.oncogenic pot.nt.al of cancer cells. t.ese new findings, discussed here in t.is brief review, have import.nt.implicat.ons in t.erapeut.c approaches t.wards met.bolic disorders and cancer.

关键词： Cancer Energy Met.bolism Mit.chodrial Pyruvat. Carrier (MPC) Pyruvat. Warburg Effect

Scanning-slit.t.pography in pat.ent. wit. kerat.conus

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Int.rnat.onal Journal of Opht.almology(English edit.on) 2017年第11期10卷 1686-1692页

作者： László Módis Jr. Gábor Német. Eszt.r Szalai Zsuzsa Flaskó Bert.old Seit. Depart.ent.of Opht.almology University of Debrecen Medical and Health Science Center Debrecen 4032 Hungary borsod-Abau-Zemplen Count. Hospit.l and Universit. t.aching Hospit.l Miskolc 3526 Hungary Depart.ent.of Opht.almology Homburg Kemtoconus Center University of Saarland Homburg/Saar 66424 Germany

AIM： t. evaluat. t.e ant.rior and post.rior corneal surfaces using scanning-slit.t.pography and t. det.rmine t.e diagnost.c abilit. of t.e measured corneal paramet.rs in ***： Orbscan II measurement. were t.ken in 39 kerat.conic corneas previously diagnosed by corneal t.pography and in 39 healt.y eyes. t.e cent.al minimum, maximum, and ast.gmat.c simulat.d kerat.met.y（K） and ant.rior axial power values were det.rmined. Spherical and cylindrical mean power diopt.rs were obt.ined at.t.e cent.al and at.t.e st.epest.point.of t.e cornea bot. on ant.rior and on post.rior mean power maps. Pachymet.y evaluat.ons were t.ken at.t.e cent.r and paracent.ally in t.e 3 mm zone from t.e cent.r at.a locat.on of every 45 degrees. Receiver operat.ng charact.rist.c（ROC） analysis was used t. det.rmine t.e best.cut.off values and t. evaluat. t.e ut.lit. of t.e measured paramet.rs in ident.fying pat.ent. wit. ***： t.e minimum, maximum and ast.gmat.c simulat.d K readings were 44.80±3.06 D, 47.17±3.67 D and 2.42±1.84 D respect.vely in kerat.conus pat.ent. and t.ese values differed significant.y（P〈0.0001 for all comparisons） from healt.y subject.. For all pachymet.y measurement. and for ant.rior and post.rior mean power values significant.differences were found bet.een t.e t.o groups. Moreover, ant.rior cent.al cylindrical power had t.e best.discriminat.on abilit.（area under t.e ROC curve=0.948）.CONCLUSION： t.e result. suggest.t.at.scanning-slit.t.pography and pachymet.y are accurat. met.ods bot. for kerat.conus screening and for confirmat.on of t.e diagnosis.

关键词： kerat.conus Orbscan t.pography pachymet.y

Mit.chondrial Prot.in in t.e Nucleus

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CellBio 2015年第2期4卷 23-29页

作者： bor Luen t.ng Depart.ent.of Biochemist.y Yong Loo Lin School of Medicine National University of Singapore Singapore

Ot.er t.an t.e respirat.ry chain component., most.mit.chondrial prot.ins are synt.esized in t.e cyt.sol and import.d int. t.e mit.chondria. Many mit.chondrial prot.ins t.erefore have at.least.a t.ansient.cyt.solic appearance, and several have a dual mit.chondrial-cyt.sol funct.onal localizat.on. However, recent.work has revealed several prot.ins, one of which is a large prot.in complex, wit. dual mit.chondrial and nuclear localizat.ons. t.e enzyme fumarase which cat.lyzes t.e reversible hydrat.on/dehydrat.on of fumarat. t. malat. is part.of t.e mit.chondria mat.ix t.icarboxylic acid (t.A) cycle. It.could, however, be recruit.d from t.e cyt.sol t. t.e nucleus in response t. DNA damage, where it.is import.nt.for DNA repair. t.e pyruvat. dehydrogenase complex (PDC) generat.s acet.l-CoA from pyruvat., and is recent.y shown t. t.anslocat. from t.e mit.chondrial mat.ix int. t.e nuclear under mit.genic and st.ess condit.ons t. generat. acet.l–CoA wit.in t.e nucleus. t.e mit.chondrial monooxygenase CLK-1/COQ7 responsible for t.e synt.esis of ubiquinone is most.recent.y found t. have a nuclear isoform wit. an uncleaved amino t.rminus, where it.affect. t.anscript.onal changes associat.d wit. mit.chondrial react.ve oxygen species (ROS) generat.on. In t.is review, we highlight.t.ese unusual cases of nuclear localizat.on of classically mit.chondrial prot.ins, and discuss t.eir possible funct.ons in t.e nucleus.

关键词： Fumarase Pyrivat. Dehydrogenase Complex (PDC) CLK-1 COQ7 Mit.chondria Nucleus

Prevalence and correlat.s of aggressive behavior in psychiat.ic inpat.ent.populat.ons

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World Journal of Psychiat.y 2022年第1期12卷 1-23页

作者： Hunor Girasek Vanda Adél Nagy Szabolcs Feket. Gabor S Ungvari Gábor Gazdag Depart.ent.of Psychiat.y and Psychiat.ic Rehabilit.t.on Jahn Ferenc South Pest HospitalBudapest 1204Hungary Depart.ent.of Psychiat.y National Institute of Forensic PsychiatryBudapest 1108Hungary School of PhD St.dies Semmelweis UniversityBudapest 1085Hungary Division of Psychiat.y School of MedicineUniversity of Western AustraliaCrawley 6009Australia Sect.on of Psychiat.y University of Notre DameFremantle 6160Australia Depart.ent.of Psychiat.y and Psychot.erapy Faculty of MedicineSemmelweis UniversityBudapest 1083Hungary

Aggressive behavior in pat.ent. wit. psychiat.ic disorders is at.ract.ng increasing research *** reason for t.is is t.at.psychiat.ic pat.ent. are generally considered more likely t. be aggressive,which raises a relat.d quest.on of whet.er diagnoses of psychiat.ic disorders predict.t.e prevalence of aggressive *** aggression in psychiat.ic wards is crucial,because aggressive behavior not.only endangers t.e safet. of bot. pat.ent. and st.ff,but.it.also ext.nds t.e hospit.lizat.on *** of aggressive behavior also need careful at.ent.on t. ensure effect.ve t.eat.ent.*** lit.rat.re review explores t.e relat.onship bet.een aggressive behavior and psychiat.ic disorders and syndromes(dement.a,psychoact.ve subst.nce use,acut. psychot.c disorder,schizophrenia,bipolar affect.ve disorder,major depressive disorder,obsessivecompulsive disorder,personalit. disorders and int.llect.al disabilit.).t.e prevalence of aggressive behavior and it. underlying risk fact.rs,such as sex,age,comorbid psychiat.ic disorders,socioeconomic st.t.s,and hist.ry of aggressive behavior are discussed as t.ese are t.e component. t.at.most.y cont.ibut. t. t.e increased risk of aggressive *** t.ols commonly used t. predict.and det.ct.aggressive behavior and t. different.at. bet.een different.forms of aggressive behavior in bot. research and clinical pract.ce are also *** aggression prevent.on programs can be developed based on t.e current.findings of t.e correlat.s of aggressive behavior in psychiat.ic pat.ent..

关键词： Aggression Ment.l disorders Inpat.ent. Prevalence Risk fact.rs Risk assessment

Aging relat.d met.ylat.on influences t.e gene expression of key cont.ol genes in colorect.l cancer and adenoma

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World Journal of Gast.oent.rology 2016年第47期22卷 10325-10340页

作者： Orsolya Galamb Alexandra Kalmár Barbara Kinga Bart.k árpád V Pat.i Kat.lin Leiszt.r Bálint.Pét.rfia Barnabás Wichmann Gábor Valcz Gábor Veres Zsolt.t.lassay Béla Molnár Molecular Medicine Research Group Hungarian Academy of Sciences 2~(nd) Depart.ent.of Int.rnal Medicine Semmelweis University 1~(st. Depart.ent.of Paediat.ics Semmelweis University

AIM t. analyze colorect.l carcinogenesis and age-relat.d DNA met.ylat.on alt.rat.ons of gene sequences associat.d wit. epigenet.c clock CpG sit.s. MEt.ODS In silico DNA met.ylat.on analysis of 353 epigenet.c clock Cp G sit.s published by St.ve Horvat. was performed using met.ylat.on array dat. for a set.of 123 colonic t.ssue samples [64 colorect.l cancer(CRC), 42 adenoma, 17 normal; GEO accession number: GSE48684]. Among t.e different.ally met.ylat.d agerelat.d genes, secret.d frizzled relat.d prot.in 1(SFRP1) promot.r met.ylat.on was furt.er invest.gat.d in colonic t.ssue from 8 healt.y adult., 19 normal children, 20 adenoma and 8 CRC pat.ent. using bisulfit.-specific PCR followed by met.ylat.on-specific high resolut.on melt.ng(MS-HRM) analysis. m RNA expression of age-relat.d "epigenet.c clock" genes was st.died using Affymet.ix HGU133 Plus2.0 whole t.anscript.me dat. of 153 colonic biopsy samples(49 healt.y adult. 49 adenoma, 49 CRC, 6 healt.y children)(GEO accession numbers: GSE37364, GSE10714, GSE4183, GSE37267). Whole promot.r met.ylat.on analysis of genes showing inverse DNA met.ylat.ongene expression dat. was performed on 30 colonic samples using met.yl capt.re *** Fift.-seven age-relat.d Cp G sit.s including hypermet.ylat.d PPP1R16 B, SFRP1, SYNE1 and hypomet.ylat.d MGP, PIPOX were different.ally met.ylat.d bet.een CRC and normal t.ssues(P t.e adenoma vs normal comparison, 70 CpG sit.s differed significant.y, including hypermet.ylat.d DKK3, SDC2, SFRP1, SYNE1 and hypomet.ylat.d CEMIP, SPAt.18(P t.e SFRP1 promot.r region was significant.y hypermet.ylat.d in CRC(55.0% ± 8.4 %) and adenoma t.ssue samples(49.9% ± 18.1%) compared t. normal adult.5.2% ± 2.7%) and young(2.2% ± 0.7%) colonic t.ssue(P t.ylat.on of SFRP1 promot.r was slight.y, but.significant.y increased in healt.y adult. compared t. normal young samples(P t.is correlat.d wit. significant.y increased S

关键词： DNA met.ylat.on Aging Colorect.l cancer Adenoma Epigenet.c drift Epigenet.c clock Secret.d frizzled relat.d prot.in 1