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林业科技开发 1992年第3期6卷 43-44页

作者： george Stenzel thomas A.Walliridge Jr. J.Kennath Pearce 周新年邱仁辉福建林学院

造材是将伐倒木锯截成原木、短圆材或任意长度木材的过程,造材在木材采运作业中为木材拖曳集材、全载集材或索道集材作准备。大多数的造材作业使用链锯进行,伐木与造材一般使用一台汕锯。已被逐渐普遍采用的原条和长原木拖集,导致了造... 详细信息

造材是将伐倒木锯截成原木、短圆材或任意长度木材的过程,造材在木材采运作业中为木材拖曳集材、全载集材或索道集材作准备。大多数的造材作业使用链锯进行,伐木与造材一般使用一台汕锯。已被逐渐普遍采用的原条和长原木拖集,导致了造材更多地在装车场进行,相应地林中造材就减少了。

关键词：油锯造材

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Outcomes Associated with a Screening and Treatment Pathway for Occult Hypoperfusion Following Cardiac Surgery

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World Journal of Cardiovascular Surgery 2013年第2期3卷 34-41页

作者： Ran Xu Greg A. Laine BeeBee Y. Hu R. thomas Solis Arthur W. Bracey Jr. James M. Wilson Amy R. Miclat Susan Baimbridge george J. Reul Jr. Comprehensive Pharmacy Services St Luke’s The Woodlands Hospital The Woodlands USA St Luke’s Episcopal Hospital Houston USA Texas Heart Institute Houston USA

Introduction: Routinely monitored parameters such as blood pressure (BP) and heart rate may not reliably detect per- fusion abnormalities. However, central venous oxygen saturation (ScvO2) and lactate levels can detect occult hypoper- fusion (OH) and identify patients at risk for complications. The study objective was to assess the impact of an OH treatment pathway on morbidity and length of stay (LOS) post coronary bypass and valve surgery. Methods: This is a prospective cohort observational study following the implementation of a treatment pathway for OH, defined by ScvO2 2 mMol/L with systolic BP ≥ 90 mmHg. Initial treatment included volume resuscitation and/or blood transfusion, followed by additional interventions when ScvO2 remained hours postoperatively. Primary outcomes were intensive care unit (ICU)/hospital LOS and complications. Results: Comparing 53 patients managed by the OH pathway against 21 historical controls, median ICU LOS was 40.4 vs. 49.2 hours (p = 0.122), median hospital LOS 9.2 vs. 11.0 days (p = 0.0093), ICU readmission rate 7.5% vs. 28.6% (p = 0.026), and complication rate 26.4% vs. 47.6% (p = 0.101). Repeat lactate was checked 18 hours postoperatively in 47 of the 53 patients. Comparing 33 patients with repeat lactate at goal ( 2 mMoL/L) with 14 patients not at goal, median ICU LOS was 35.3 vs. 68.4 hours (p = 0.061), median hospital LOS 8.9 vs. 11.2 days (p = 0.058), median length of mechanical ventilation (LOMV) 13.3 vs. 28.4 hours (p = 0.0038), and complication rate 15.2% vs. 50.0% (p = 0.025). Conclusions: An OH screening and treatment pathway following cardiovascular surgery was associated with signifi- cantly shorter hospital LOS and lower ICU readmission rate. Among the OH pathway patients, achieving lactate goal 18 hours postoperatively was associated with significantly shorter LOMV and lower complication rate.

关键词： Occult Hypoperfusion Cardiovascular Surgery Lactate Central Venous Oxygen Saturation Outcomes

Milestones in the history of diabetes mellitus:The maincontributors

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World Journal of Diabetes 2016年第1期7卷 1-7页

作者： Marianna Karamanou Athanase Protogerou Gregory Tsoucalas george Androutsos Effie Poulakou-Rebelakou Department of History of Medicine Medical SchoolUniversity of Athens11527 AthensGreece Department of Pathophysiology “Laiko”HospitalMedical SchoolUniversity of Athens11527 AthensGreece

Diabetes mellitus is a group of metabolic diseases involving carbohydrate, lipid, and protein metabolism. It is characterized by persistent hyperglycemia which results from defects in insulin secretion, or action or both. Diabetes mellitus has been known since antiquity. Descriptions have been found in the Egyptian papyri, in ancient Indian and Chinese medical literature, as well as, in the work of ancient Greek and Arab physicians. In the 2^(nd) century AD Aretaeus of Cappadocia provided the first accurate description of diabetes, coining the term diabetes, while in 17^(th) century thomas Willis added the term mellitus to the disease, in an attempt to describe the extremely sweet taste of the urine. The important work of the 19^(th) century French physiologist Claude Bernard, on the glycogenic action of the liver, paved the way for further progress in the study of the disease. In 1889, Oskar Minkowski and Joseph von Mering performed their famous experiment of removing the pancreas from a dog and producing severe and fatal diabetes. In 1921, Frederick Banting and Charles Best extended Minkowski's and Mering's experiment. They isolated insulin from pancreatic islets and administrated to patients suffering from type 1 diabetes, saving thus the lives of millions and inaugurating a new era in diabetes treatment.

关键词： History of endocrinology Metabolic disorder Diabetes mellitus Aretaeus of Cappadocia Insulin

Non-small cell lung carcinoma(NSCLC):Implications on molecular pathology and advances in early diagnostics and therapeutics

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Genes & Diseases 2023年第3期10卷 960-989页

作者： Hafiza Padinharayil Jinsu Varghese Mithun Chacko John Golgodu Krishnamurthy Rajanikant Cornelia M.Wilson Minnatallah Al-Yozbaki Kaviyarasi Renu Saikat Dewanjee Rupa Sanyal Abhijit Dey Anirban Goutam Mukherjee Uddesh Ramesh Wanjari Abilash Valsala Gopalakrishnan Alex george Jubilee Centre for Medical Research Jubilee Mission Medical College and Research InstituteThrissurKerala 680005India PG&Research Department of Zoology St.Thomas CollegeKozhencheryPathanamthittaKerala 689641India Department of Medical Oncology Jubilee Mission Medical College and Research InstituteThrissurKerala 680005India School of Biotechnology National Institute of TechnologyCalicutKerala 673601India Canterbury Christ Church University Natural Applied SciencesLife Sciences Industry Liaison LabDiscovery ParkSandwich CT139FFUnited Kingdom Centre of Molecular Medicine and Diagnostics(COMManD) Department of BiochemistrySaveetha Dental College&HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennaiTamil Nadu 600077India Department of Pharmaceutical Technology Jadavpur UniversityKolkataWest Bengal 700032India Department of Botany Bhairab Ganguly CollegeFeeder RoadBelghoriaKolkataWest Bengal 700056India Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Department of Biomedical Sciences School of Bio-Sciences and TechnologyVellore Institute of Technology(VIT)VelloreTamil Nadu 632014India

Continuous revision of the histologic and stage-wise classification of lung cancer by the World Health Organization (WHO) provides the foundation for therapeutic advances by promoting molecular targeted and immunotherapies and ensuring accurate diagnosis. Cancer epidemiologic data provide helpful information for cancer prevention, diagnosis, and management, supporting health-care interventions. Global cancer mortality projections from 2016 to 2060 show that cancer will overtake ischemic heart diseases (IHD) as the leading cause of death (18.9 million) immediately after 2030, surpassing non-small cell lung cancer (NSCLC), which accounts for 85 percent of lung cancers. The clinical stage at the diagnosis is the main prognostic factor in NSCLC therapies. Advanced early diagnostic methods are essential as the initial stages of cancer show reduced mortality compared to the advanced stages. Sophisticated approaches to proper histological classification and NSCLC management have improved clinical efficiency. Although immune checkpoint inhibitors (ICIs) and targeted molecular therapies have refined the therapeutic management of late-stage NSCLC, the specificity and sensitivity of cancer biomarkers should be improved by focusing on prospective studies, followed by their use as therapeutic tools. The liquid biopsy candidates such as circulating tumor cells (CTCs), circulating cell-free tumor DNA (cfDNA), tumor educated platelets (TEP), and extracellular vesicles (EVs) possess cancer-derived biomolecules and aid in tracing: driver mutations leading to cancer, acquired resistance caused by various generations of therapeutic agents, refractory disease, prognosis, and surveillance.

关键词： Biomarker Clinical trial Epidemiology Histology Liquid biopsy NSCLC Targeted therapy

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蒸气分解法测定海洋湖泊沉积物中的可浸取铀

国外铀金地质 1993年第4期10卷 378-382页

作者： Darrin K.Mann thomas J. Oatts george T. F.Wong 俞宗寿安徽省地质矿产局区域地质调查所合肥230011

1g海洋或湖泊沉积物中的铀,可用硝酸和高氯酸混合物,使用压热锅,在275℃2个大气压下,4h内浸取出来.这种蒸气分解法得引的浸取物,可用同应素稀释-α光谱法测定,其精密度为±7％.较之于在敞口烧杯中进行湿法分解的常规浸取方法,本法节时... 详细信息

1g海洋或湖泊沉积物中的铀,可用硝酸和高氯酸混合物,使用压热锅,在275℃2个大气压下,4h内浸取出来.这种蒸气分解法得引的浸取物,可用同应素稀释-α光谱法测定,其精密度为±7％.较之于在敞口烧杯中进行湿法分解的常规浸取方法,本法节时、省力、耗酸量较少,同时,获取的数据准确度和精密度相当不错.对采集于各种沉积环境中的一组样品分析中,本法所获得的结果较之于常规方法差别甚微.

关键词：沉积物铀样品浸取液蒸气分解法

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Enhanced ion acceleration from transparency-driven foils demonstrated at two ultraintense laser facilities

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Light(Science & Applications) 2023年第4期12卷 593-604页

作者： Nicholas P.Dover Tim Ziegler Stefan Assenbaum Constantin Bernert Stefan Bock Florian-Emanuel Brack thomas E.Cowan Emma J.Ditter Marco Garten Lennart Gaus Ilja Goethel george S.Hicks Hiromitsu Kiriyama thomas Kluge James K.Koga Akira Kon Kotaro Kondo Stephan Kraft Florian Kroll Hazel F.Lowe Josefine Metzkes-Ng Tatsuhiko Miyatake Zulfikar Najmudin thomas Püschel Martin Rehwald Marvin Reimold Hironao Sakaki Hans-Peter Schlenvoigt Keiichiro Shiokawa Marvin E.P.Umlandt Ulrich Schramm Karl Zeil Mamiko Nishiuchi Kansai Photon Science Institute National Institutes for Quantum Science and Technology8-1-7 UmemidaiKizugawaKyoto 619-0215Japan The John Adams Institute for Accelerator Science Blackett LaboratoryImperial College LondonLondon SW72AZUnited Kingdom Helmholtz-Zentrum Dresden-Rossendorf 01328 DresdenGermany Technische Universitat Dresden 01069 DresdenGermany Interdiscipllinary Graduate School of Engineering Sciences Kyushu University6-1Kasuga-KoenKasugaFukuoka 816-8580Japan

Laser-driven ion sources are a rapidly developing technology producing high energy,high peak current *** suitability for applications,such as compact medical accelerators,motivates development of robust acceleration schemes using widely available repetitive ultraintense femtosecond *** applications not only require high beam energy,but also place demanding requirements on the source stability and *** can be seriously affected by the laser temporal contrast,precluding the replication of ion acceleration performance on independent laser systems with otherwise similar ***,we present the experimental generation of>60 MeV protons and>30 MeV u-1 carbon ions from sub-micrometre thickness Formvar foils irradiated with laser intensities>1021 *** are accelerated by an extreme localised space charge field≥30TVm-1,over a million times higher than used in conventional *** field is formed by a rapid expulsion of electrons from the target bulk due to relativistically induced transparency,in which relativistic corrections to the refractive index enables laser transmission through normally opaque *** replicate the mechanism on two different laser facilities and show that the optimum target thickness decreases with improved laser contrast due to reduced *** demonstration that energetic ions can be accelerated by this mechanism at different contrast levels relaxes laser requirements and indicates interaction parameters for realising application-specific beam delivery.

关键词： acceleration intense transparency

Rethinking phonons:The issue of disorder

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npj Computational Materials 2017年第1期3卷 44-51页

作者： Hamid Reza Seyf Luke Yates thomas L.Bougher Samuel Graham Baratunde A.Cola Theeradetch Detchprohm Mi-Hee Ji Jeomoh Kim Russell Dupuis Wei Lv Asegun Henry george W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGAUSA Heat Lab Georgia Institute of TechnologyAtlantaGAUSA School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGAUSA School of Electrical Engineering and Computer Science Georgia Institute of TechnologyAtlantaGAUSA

Current understanding of phonons treats them as plane waves/quasi-particles of atomic vibration that propagate and *** problem is that conceptually,when any level of disorder is introduced,whether compositional or structural,the character of vibrational modes in solids changes,yet nearly all theoretical treatments continue to assume phonons are still *** example,the phonon contributions to alloy thermal conductivity(TC)rely on this assumption and are most often computed from the virtual crystal approximation(VCA).Good agreement is obtained in some cases,but there are many instances where it fails—both quantitatively and ***,we show that the conventional theory and understanding of phonons requires revision,because the critical assumption that all phonons/normal modes resemble plane waves with well-defined velocities is no longer valid when disorder is *** we show,surprisingly,that the character of phonons changes dramatically within the first few percent of impurity concentration,beyond which phonons more closely resemble the modes found in amorphous *** then utilize a different theory that can treat modes with any character and experimentally confirm its new insights.

关键词： alloy character utilize

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亚利桑那州中部岩黄松林的天然更新

福建林业科技 1983年 60-63页

作者： L.J.Heidmann ,thomas ,N.Johnsen ,Jr.Quinten ,W.Cole ,george ,Cullum ,陈云征福建省林科所

1988年以来,美国APache-Sitgreaves国有林chevelon林管区中的11,000多英亩落矶山岩黄松(Pinus Ponderosa *** Engelm.)林的天然更新通过适时准备林地和防治啮齿动物(如兔、鼠等—译注)对散落种子的为害已经成功了。更新区,禁止牲畜进入... 详细信息

1988年以来,美国APache-Sitgreaves国有林chevelon林管区中的11,000多英亩落矶山岩黄松(Pinus Ponderosa *** Engelm.)林的天然更新通过适时准备林地和防治啮齿动物(如兔、鼠等—译注)对散落种子的为害已经成功了。更新区,禁止牲畜进入,天然更新的费用,按现行价格平均每英亩约为41美元,较西南部植树造林的费用每英亩节省了218美元。

关键词：天然更新黄松西南部森林更新林管区松林亚利桑那州

骨形成蛋白(BMP-5)与IA型BMP受体在口腔鳞癌中的表达及意义

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福建医药杂志 2001年第2期23卷 2-4,F003页

作者：傅升金岩何黎升 george L thomasY.H.LAU 南京军区福州总医院口腔科 350001 第四军医大学口腔医学院 710032 香港大学医学院解剖系香港理工大学视光及放射学系

目的　认识和分析 BMP及其受体 BMPR- IA与口腔鳞癌发生、发展的可能关系。方法　用免疫组织化学方法分析 BMP- 5、BMP受体 BMPR- IA在口颊部粘膜正常上皮、慢性炎症和癌变中的表达 ,标本为 18例正常上皮(normal buccal mucosa,NB) ,2 ... 详细信息

目的　认识和分析 BMP及其受体 BMPR- IA与口腔鳞癌发生、发展的可能关系。方法　用免疫组织化学方法分析 BMP- 5、BMP受体 BMPR- IA在口颊部粘膜正常上皮、慢性炎症和癌变中的表达 ,标本为 18例正常上皮(normal buccal mucosa,NB) ,2 4例慢性炎症 (nonspecofic chronic ***) ,5 8例鳞癌 (squamous cellcarcinoma,SCC)。结果　 BMP- 5、 BMPR- IA在口腔粘膜的正常与慢性炎症上皮中有弱表达 ,NB与 NCI无明显差别 ;在鳞癌上皮中除 2例 BMP- 5表达为阴性外 ,其余均有阳性或强阳性表达 ,明显高于 NB、NCI两组 ;鳞癌中高分化、中分化、低分化三组间的表达无明显差别。结论　BMP- 5、 BMPR- IA可能参与对口腔鳞癌发生。

关键词：骨形成蛋白受体口腔上皮鳞癌 BMP-5 IA型 BMP受体

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