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Potential of phloroglucinol to improve erectile dysfunction associated with streptozotocin-induced diabetes in rats

Journal of Integrative Medicine 2019年第4期17卷 282-287页

作者： Syed Kashif rema razdan Ramanaiah Illuri Department of Pharmacology Al-Ameen College of Pharmacy Bengaluru Karnataka 560027 India PG and Research Centre in Biotechnology MGR College Hosur Tamil Nadu 635109 India

Objective: Diabetes is a common metabolic disease with several complications in its patients. Often, people living with diabetes develop erectile dysfunction (ED). The primary aim of this work was to investigate the effect of phloroglucinol in diabetes-induced ED in rats. Methods: Male Wistar rats were given 52 mg/kg of streptozotocin, by intraperitoneal injection, to induce diabetes and ED. Subsequently, animals were grouped into three groups: group 1, diabetic control;group 2, low-dose phloroglucinol (150 mg/kg body weight);and group 3, high-dose phloroglucinol (250 mg/kg body weight). A group of six normal rats served as a normal control. The rats were treated with phloroglucinol for six weeks and then were assessed for treatment effects. Sexual behavior, glycosylated hemoglobin Ale (HbAlc) values, serum testosterone, serum nitric oxide (NO), blood pressure and sperm count were measured after the end of treatment. Results: After a 6-week treatment period, the high dose of phloroglucinol significantly decreased HbAlc values in diabetic rats. Rats treated with phloroglucinol had increased serum testosterone, NO and sperm count. Animals treated with 250 mg/kg phloroglucinol performed similar to normal rats in the sexual behavioral study, suggesting the reversal of complications of ED. Conversely, a decrease in the blood pressure in treated groups was observed. Conclusion: The results highlight the protective effect of phloroglucinol in diabetes-induced ED in rats warranting further studies.

关键词： Diabetes Streptozotocin Erectile dysfunction Phloroglucinol Glycated hemoglobin A

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Allantoin attenuates deficits of behavioural and motor nerve conduction in an animal model of cisplatin-induced neurotoxicity in rats

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Animal Models and Experimental Medicine 2019年第2期2卷 114-120页

作者： Vindya N S Aqib Mohamad rema razdan Department of Pharmacology Al-Ameen College of Pharmacy

Background: The aim of the present study was to evaluate the neuroprotective effect of allantoin in cisplatin‐induced toxicity in rats. Methods: Adult male Wistar rats weighing 160‐200 g were used. Neuropathy was induced by injecting cisplatin (2 mg/kg, ip, twice a week for 6 weeks) and the rats were concurrently treated with allantoin (200 and 400 mg/kg, po) for 8 weeks. At the end of the study, body weight and hemogram were measured. Behavioural tests were performed, including tests for cold and hot hyperalgesia, motor co‐ordination, locomotor activity, mechano‐tactile allodynia and mechanical hyperalgesia. The rats were then sacrificed and sciatic nerve conduction velocity was determined. The antioxidant enzyme and nitric oxide levels in sciatic nerve homogenates were measured. Results: In this study, allantoin restored the motor nerve conduction velocity deficits induced by cisplatin, and the allantoin‐treated rats showed improvement in cold and thermal hyperalgesia, mechano‐tactile allodynia, and mechanical hyperalgesia. Allantoin treatment also improved the rats’ hematological status, increasing haemoglobin, platelet and RBC counts compared to the cisplatin‐treated group. Allantoin treatment also mitigated the functional abnormalities seen in the cisplatin neuropathy group, protecting neurons from the neurotoxic effects of cisplatin. Conclusion: Allantoin shows promise for use as an adjuvant drug in cancer treatment to protect against cisplatin‐induced neuropathy.

关键词： allantoin cisplatin neurotoxicity rats

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Phloroglucinol, a nutraceutical for IR-induced cardiac damage in diabetic rats

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Animal Models and Experimental Medicine 2019年第3期2卷 210-216页

作者： B.Pranav Nayak K.R.Ganesha Nathani Minaz rema razdan Sumanta Kumar Goswami Department of Pharmacology Al‐Ameen College of PharmacyBengaluruKarnatakaIndia Department of Pharmaceutical sciences Northeastern UniversityBostonMAUSA

Background:Myocardial injury due to ischemia‐reperfusion(IR)is aggravated in diabetes which is associated with oxidative *** oxidative stress via use of antioxidants has been shown to be effective at minimizing myocardial cell death and improving cardiac *** aim of the present study was to evaluate the cardioprotective effect of phloroglucinol against myocardial reperfusion injury(MRI)in diabetic ***:Diabetes was induced in female rats with streptozotocin(50 mg/kg).The diabetic rats were orally treated with phloroglucinol(100 and 200 mg/kg daily for 28 days).After treatment the hearts were isolated and mounted on a Langendorff *** hearts were subjected to 15 minutes of IR to induce myocardial *** functions including heart rate(HR),resting and developed tension,and rate of change of contraction(+dP/dtmax)were *** injury biomarkers lactate dehydrogenase(LDH)and creatine kinase(CK‐MB)were measured in the heart *** of the antioxidant enzymes reduced glutathione(GSH)and malondialdehyde(MDA)were *** and eosin(H&E)staining was also ***:After IR injury,a decrease in HR and+dP/dtmax in hearts from diabetic rat was seen compared to healthy rat hearts,which was reversed by phloroglucinol *** infarct size,measured by H&E staining,was increased in diabetic rats compared to healthy rats and an increase in the activity of LDH and CK‐MB in the heart perfusate in diabetic rats was decreased by phloroglucinol *** increase in MDA levels and a decrease in levels of antioxidant enzymes were observed in diabetic rats,which was reversed with phloroglucinol ***:Phloroglucinol treatment has potential therapeutic promise in the treatment of MRI in diabetes.

关键词： Langendroff apparatus myocardial reperfusion injury phloroglucinol streptozotocin

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