Phloroglucinol, a nutraceutical for IR-induced cardiac damage in diabetic rats

作     者：B.Pranav Nayak K.R.Ganesha Nathani Minaz Rema Razdan Sumanta Kumar Goswami 

作者机构：Department of PharmacologyAl‐Ameen College of PharmacyBengaluruKarnatakaIndia Department of Pharmaceutical sciencesNortheastern UniversityBostonMAUSA 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学（英文）)

年 卷 期：2019年第2卷第3期

页      面：210-216页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Langendroff apparatus myocardial reperfusion injury phloroglucinol streptozotocin 

摘      要：Background:Myocardial injury due to ischemia‐reperfusion(IR)is aggravated in diabetes which is associated with oxidative *** oxidative stress via use of antioxidants has been shown to be effective at minimizing myocardial cell death and improving cardiac *** aim of the present study was to evaluate the cardioprotective effect of phloroglucinol against myocardial reperfusion injury(MRI)in diabetic ***:Diabetes was induced in female rats with streptozotocin(50 mg/kg).The diabetic rats were orally treated with phloroglucinol(100 and 200 mg/kg daily for 28 days).After treatment the hearts were isolated and mounted on a Langendorff *** hearts were subjected to 15 minutes of IR to induce myocardial *** functions including heart rate(HR),resting and developed tension,and rate of change of contraction(+dP/dtmax)were *** injury biomarkers lactate dehydrogenase(LDH)and creatine kinase(CK‐MB)were measured in the heart *** of the antioxidant enzymes reduced glutathione(GSH)and malondialdehyde(MDA)were *** and eosin(H&E)staining was also ***:After IR injury,a decrease in HR and+dP/dtmax in hearts from diabetic rat was seen compared to healthy rat hearts,which was reversed by phloroglucinol *** infarct size,measured by H&E staining,was increased in diabetic rats compared to healthy rats and an increase in the activity of LDH and CK‐MB in the heart perfusate in diabetic rats was decreased by phloroglucinol *** increase in MDA levels and a decrease in levels of antioxidant enzymes were observed in diabetic rats,which was reversed with phloroglucinol ***:Phloroglucinol treatment has potential therapeutic promise in the treatment of MRI in diabetes.