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Native and prosthetic septic arthritis in a university hospital in Saudi Arabia:A retrospective study

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World Journal of Orthopedics 2024年第8期15卷 722-733页

作者： reham Kaki Department of Internal Medicine King Abdulaziz UniversityJeddah 22230Saudi Arabia

BACKGROUND Septic arthritis,whether native or prosthetic,poses a significant challenge in clinical practice due to its potentially devastating *** its clinical importance,there remains a dearth of comprehensive studies and standardized diagnostic criteria,particularly in the Kingdom of Saudi *** To investigate the epidemiology,microbiological profiles,and clinical characteristics of native and prosthetic septic joints in the Saudi Arabian *** Medical records of patients diagnosed with septic arthritis between January 1,2015,and December 31,2022,were retrospectively *** regarding patient demographics,clinical presentation,microbiological cultures,treatment modalities,and outcomes were *** In a retrospective review of 52 cases of septic arthritis,a balanced gender distribution was observed(1:1 ratio),with the knee being the most commonly affected joint(80.8%).Methicillin-resistant Staphylococcus aureus predominated in native joints(24.2%),while Brucella *** more prevalent in prosthetic joints(21.1%).Joint preservation was achieved in most cases(84.6%),with no significant difference in clinical features between native and prosthetic ***,certain comorbidities were more common in native joint cases,including renal impairment(P=0.002),hemodialysis(P=0.004),heart disease(P=0.013),and chronic liver disease(P=0.048).At the same time,osteoarthritis was more prevalent in prosthetic joint cases(P=0.013).Vancomycin was the most frequently used antibiotic(26.9%),and most patients received antibiotics before joint aspiration(57.7%).Surgical intervention,predominantly arthrotomy,was required in most cases(32.7%).Notably,a significant association was found between joint type and mortality(odds ratio=0.587,P=0.048),as well as the Charlson comorbidity index and mortality(P=0.001).CONCLUSION This study highlighted distinctive microbiological profiles and etiological factors in septic arthritis cases in the Sau

关键词： Septic arthritis Native joint Prosthetic joint Epidemiology Diagnostic criteria Saudi Arabia

The Protective Effect of Moringa oleifera Leaves Extract on Paracetamol Hepatotoxicity in Male Rats

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Journal of Biomedical Science and Engineering 2024年第3期17卷 72-82页

作者： reham M. Al-Sultan Noorah Saleh Al-Sowayan Department of Biology College of Science Qassim University Buraydah Saudi Arabia

In recent years, there has been an increase in concern regarding the effects of paracetamol poisoning on liver tissues, particularly when consumed in large amounts. Some studies have estimated that paracetamol is involved in 56% of acute liver diseases, whereas 0.4% of paracetamol overdose cases result in fatal-ity. In this study, the effects of Moringa oleifera on paracetamol toxicity in the liver were explored. It has been demonstrated that Moringa oleifera is highly nu-tritious, contains bioactive molecules, and is therapeutically beneficial. Many studies have shown that Moringa oleifera leaves possess a wide range of biologi-cal properties, including antioxidant, tissue protection, analgesic, antihyperten-sive, and immunomodulatory activities. This study highlights the protective role of Moringa oleifera on handling possible paracetamol hepatotoxicity in male rats. .

关键词： Moringa oleifera Paracetamol Hepatotoxicity Oxidative Stress

Occupational health risks among healthcare workers during the COVID-19 pandemic in Saudi Arabia: preparing for the future pandemics

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Nursing Communications 2024年第2期8卷 1-5页

作者： reham Suliman Al Kharyef Aisha Ali Al Harbi Mohammed Abdelhamied Genedy Mohamed K.M.Khalil Suliman Mohamed Al Eidi Ministry of Health Riyadh 13352Saudi Arabia Consultant Public Health and Research Development.Cairo 11728 Egypt

Background:This study aimed to assess the occupational risks encountered by Healthcare Workers(HCWs)in Saudi Arabia during the COVID-19 ***:A cross-sectional survey was carried out from May to October *** a multi-stage stratified random sampling technique,an online questionnaire was sent to the recruited HCWs,across Saudi ***:Of the 768 HCWs recruited,702 participated in the survey.A significant majority(over 80%)reported working beyond 8 hours ***-19 infection,confirmed via PCR,was identified in 25%of the ***,infection was significantly correlated with direct or close contact(p=0.0007).Psychological distress was reported by 81%,with anxiety being the most prevalent(33%),followed by stress(19%),depression(17%),and insomnia(12%).Around 20%experienced headaches post-PPE use,while 14%reported adverse skin reactions,predominantly allergy and dermatitis.A concerning one-third of respondents reported exposure to ***:High infection rate,physical and psychological risks among HCWs especially those in direct contact with patients,reflect the need for enhancing the entirety of outbreak preparedness and response,specifically *** surveillance system,is crucial to adequately monitor and support HCWs during pandemic scenarios.

关键词： COVID-19 pandemic healthcare worker risk Saudi Arabia

Infectious causes of fever of unknown origin in developing countries: An international ID-IRI study

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Journal of Intensive Medicine 2024年第1期4卷 94-100页

作者： Hakan Erdem Jaffar AAl-Tawfiq Maha Abid Wissal Ben Yahia George Akafity Manar Ezzelarab Ramadan Fatma Amer Amani El-Kholy Atousa Hakamifard Bilal Ahmad Rahimi Farouq Dayyab Hulya Caskurlu reham Khedr Muhammad Tahir Lysien Zambrano Mumtaz Ali Khan Aun Raza Nagwa Mostafa El-Sayed Magdalena Baymakova Aysun Yalci Yasemin Cag Umran Elbahr Aamer Ikram Department of Infectious Diseases&Clinical Microbiology Gulhane School of MedicineTurkish Health Sciences UniversityAnkaraTurkey Specialty Internal Medicine and Quality and Patient Safety Department Johns Hopkins Aramco HealthcareDhahranSaudi Arabia Division of Infectious Diseases Indiana University School of MedicineIndianapolisINUSA Department of Infectious Diseases Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Internal Medicine Department Farhat Hached University HospitalIbn El Jazzar Medical SchoolUniversity of SousseSousseTunisia Cape Coast Teaching Hospital Cape CoastGhana Medical Parasitology Faculty of MedicineSuez UniversitySuezEgypt Department of Medical Microbiology and Immunology Faculty of MedicineZagazig UniversityZagazigEgypt Department of Clinical Pathology Faculty of MedicineCairo UniversityGizaEgypt Department of Infectious Diseases School of MedicineIsfahan University of Medical SciencesIsfahanIran Department of Infectious Diseases Kandahar University Medical FacultyTeaching HospitalKandaharAfghanistan Department of Infectious Diseases Mohammed Bn Khalifa Bn Salman Alkhalifa Specialist Cardiac CenterAwaliBahrain Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineIstanbul Medeniyet UniversityIstanbulTurkey Department of Pediatric Oncology National Cancer Institute–Cairo UniversityChildren Cancer Hospital EgyptCairoEgypt Department of Medicine Federal General HospitalIslamabadPakistan Institute for Research in Medical Sciences and Right to Health(ICIMEDES) Scientific Research Unit(UIC)Faculty of Medical Sciences(FCM)National Autonomous University of Honduras(UNAH)TegucigalpaHonduras National Institute of Health IslamabadPakistan Shaukat Khanum Memorial Cancer Hospital and Research Center LahorePakistan Medical Parasitology Department Research Institute of OphthalmologyGizaEgypt Department of Infectious Diseases Military Medical AcademySofiaBulgaria Department of Infecti

Background:Fever of unknown origin(FUO)in developing countries is an important dilemma and further research is needed to elucidate the infectious causes of ***:A multi-center study for infectious causes of FUO in lower middle-income countries(LMIC)and lowincome countries(LIC)was conducted between January 1,2018 and January 1,*** total,15 participating centers from seven different countries provided the data,which were collected through the Infectious DiseasesInternational Research Initiative *** adult patients with confirmed infection as the cause of FUO were included in the *** severity parameters were quick Sequential Organ Failure Assessment(qSOFA)≥2,intensive care unit(ICU)admission,vasopressor use,and invasive mechanical ventilation(IMV).Results:A total of 160 patients with infectious FUO were included in the ***,148(92.5%)patients had community-acquired infections and 12(7.5%)had hospital-acquired *** most common infectious syndromes were tuberculosis(TB)(n=27,16.9%),infective endocarditis(n=25,15.6%),malaria(n=21,13.1%),brucellosis(n=15,9.4%),and typhoid fever(n=9,5.6%).Plasmodium falciparum,Mycobacterium tuberculosis,Brucellae,Staphylococcus aureus,Salmonella typhi,and Rickettsiae were the leading infectious agents in this study.A total of 56(35.0%)cases had invasive procedures for *** mean qSOFA score was 0.76±0.94{median(interquartile range[IQR]):0(0–1)}.ICU admission(n=26,16.2%),vasopressor use(n=14,8.8%),and IMV(n=10,6.3%)were not ***,38(23.8%)patients had at least one of the severity *** mortality rate was 15(9.4%),and the mortality was attributable to the infection causing FUO in 12(7.5%)***:In LMIC and LIC,tuberculosis and cardiac infections were the most severe and the leading infections causing FUO.

关键词： Developing countries Fever of unknown origin Infection

Galectins dysregulation: A way for cancer cells to invade and pervade

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Oncology Research 2022年第3期30卷 129-135页

作者： MAHMOUD M.ABDELFATTAH reham HELWA Molecular Cancer Biology Group Zoology DepartmentFaculty of ScienceAin Shams UniversityCairoEgypt Faculty of Basic Science King Salman International UniversitySouth SinaiEgypt

Galectins are sticky molecules that bind toβ-*** interactions render them essential players in many cellular *** imbalance of galectin expression was reported in many *** cancer,galectins interact with the extracellular matrix,evade the immune system,and potentially have broad interactions with blood *** the last ten years,since 2010,we did focus on galectin research in different cancer ***ﬁndings showed an interaction between cancer cells and erythrocytes via ***,we found that upregulation of galectins was associated with lymph node metastasis in ovarian ***,with this,we shortly review some important aspects of galectins and their potential importance in more profound understanding of cancer progression and theﬁeld of cancer biomarkers.

关键词： Galectins Cancer Metastasis Erythrocytes Invasion

A New Hybrid Model for Segmentation of the Skin Lesion Based on Residual Attention U-Net

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Computers, Materials & Continua 2023年第6期75卷 5177-5192页

作者： Saleh Naif Almuayqil reham Arnous Noha Sakr Magdy M.Fadel Department of Information Systems College of Computer and Information SciencesJouf UniversitySakakaSaudi Arabia Department of Communications and Electronics Delta Higher Institute for Engineering and Technology(DHIET)MansouraEgypt Computers Engineering and Control Systems Department Faculty of EngineeringMansoura UniversityMansouraEgypt

Skin segmentation participates significantly in various biomedical applications,such as skin cancer identification and skin lesion *** paper presents a novel framework for segmenting the *** framework contains two main stages:The first stage is for removing different types of noises from the dermoscopic images,such as hair,speckle,and impulse noise,and the second stage is for segmentation of the dermoscopic images using an attention residual U-shaped Network(U-Net).The framework uses variational Autoencoders(VAEs)for removing the hair noises,the Generative Adversarial Denoising Network(DGAN-Net),the Denoising U-shaped U-Net(D-U-NET),and Batch Renormalization U-Net(Br-U-NET)for remov-ing the speckle noise,and the Laplacian Vector Median Filter(MLVMF)for removing the impulse *** the second main stage,the residual attention u-net was used for *** framework achieves(35.11,31.26,27.01,and 26.16),(36.34,33.23,31.32,and 28.65),and(36.33,32.21,28.54,and 27.11)for removing hair,speckle,and impulse noise,respectively,based on Peak Signal Noise Ratio(PSNR)at the level of(0.1,0.25,0.5,and 0.75)of *** framework also achieves an accuracy of nearly 94.26 in the dice score in the process of segmentation before removing noise and 95.22 after removing different types of *** experiments have shown the efficiency of the used model in removing noise according to the structural similarity index measure(SSIM)and PSNR and in the segmentation process as well.

关键词： Skin tumor speckle noise impulse noise hair noise deep learning segmentation

Residual Attention Deep SVDD for COVID-19 Diagnosis Using CT Scans

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Computers, Materials & Continua 2023年第2期74卷 3333-3350页

作者： Akram Ali Alhadad Omar Tarawneh reham R.Mostafa Hazem M.El-Bakry Information Systems Department Faculty of Computers and InformationMansoura UniversityMansoura35511Egypt Computer Science Department Ibb UniversityIbbYemen SE Department Faculty of Computer Sciences and InformaticsAmman Arab UniversityAmman11953Jordan

COVID-19 is the common name of the disease caused by the novel coronavirus(2019-nCoV)that appeared in Wuhan,China in *** the infected people is the most important factor in the fight against the *** gold-standard test to diagnose COVID-19 is polymerase chain reaction(PCR),but it takes 5–6 h and,in the early stages of infection,may produce false-negative *** Computed Tomography(CT)images to diagnose patients infected with COVID-19 has become an urgent *** this study,we propose a residual attention deep support vector data description SVDD(RADSVDD)approach to diagnose *** is a novel approach combining residual attention with deep support vector data description(DSVDD)to classify the CT *** the best of our knowledge,we are the first to combine residual attention with DSVDD in general,and specifically in the diagnosis of *** attention with DSVDD naively may cause model *** in the proposed RADSVDD guides the network during training and enables quick learning,residual connectivity prevents vanishing *** approach consists of three models,each model is devoted to recognizing one certain disease and classifying other diseases as *** models learn in an end-to-end *** proposed approach attained high performance in classifying CT images into intact,COVID-19,and non-COVID-19 *** evaluate the proposed approach,we created a dataset from published datasets and had it assessed by an experienced *** proposed approach achieved high performance,with the normal model attained sensitivity(0.96–0.98),specificity(0.97–0.99),F1-score(0.97–0.98),and area under the receiver operator curve(AUC)0.99;the COVID-19 model attained sensitivity(0.97–0.98),specificity(0.97–0.99),F1-score(0.97–0.99),and AUC 0.99;and the non-COVID pneumoniamodel attained sensitivity(0.97–1),specificity(0.98–0.99),F1-score(0.97–0.99),and AUC 0.99.

关键词： Deep learning deep SVDD residual attention anomaly detection COVID-19 Coronavirus

Fibrosis regression following hepatitis C antiviral therapy

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World Journal of Hepatology 2022年第6期14卷 1120-1130页

作者： Aisha Elsharkawy reham Samir Mohamed El-Kassas Department of Endemic Medicine and Hepatogastroenterology Faculty of MedicineCairo UniversityCairo 11566Egypt Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt

Hepatitis C virus(HCV)infection is one of the most common causes of liver *** is a major etiological factor of continuous liver injury by triggering an uncontrolled inflammatory response,causing liver fibrosis and *** fibrosis is a dynamic process that can be reversible upon timely cessation of the injurious agent,which in cases of HCV is represented by the sustained virological response(SVR)following antiviral ***-acting antiviral therapy has recently revolutionized HCV therapy and minimized *** fibrosis can be assessed with variable invasive and non-invasive methods,with certain *** the broad validation of the diagnostic and prognostic value of non-invasive modalities of assessment of liver fibrosis in patients with HCV,the proper interpretation of liver stiffness measurement in patients after SVR remains *** is also still a debate whether this regression is caused by the resolution of liver injury following treatment of HCV,rather than true fibrosis *** of liver fibrosis can possess a positive impact on patient's quality of life reducing the incidence of ***,fibrosis regression does not abolish the risk of developing hepatocellular carcinoma,which mandates regular screening of patients with advanced fibrosis.

关键词： Fibrosis regression Hepatitis C virus Direct-acting antivirals Hepatocellular carcinoma Liver fibrosis Cirrhosis

An IoT-Aware System for Managing Patients’ Waiting Time Using Bluetooth Low-Energy Technology

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Computer Systems Science & Engineering 2022年第1期40卷 1-16页

作者： reham Alabduljabbar Information Technology Department College of Computer and Information SciencesKing Saud UniversityRiyadhSaudi Arabia

It is a common observation that whenever patients arrives at the front desk of a hospital,outpatient clinic,or other health-associated centers,they have to first queue up in a line and wait to fill in their registration form to get *** long waiting time without any status updates is the most common complaint,concerning health *** this paper,UrNext,a location-aware mobile-based solution using Bluetooth low-energy(BLE)technology is presented to solve the ***,a technology-oriented method,the Internet of Things(IoT),has been gaining popularity in helping to solve some of the healthcare sector’s *** implementation of this solution could be illustrated through a simple example of when a patient arrives at a clinic for a *** of having to wait in long lines,that patient will be greeted automatically,receive a push notification of an admittance along with an estimated waiting time for a consultation *** will not only provide the patients with a sense of freedom but would also reduce the uncertainty levels that are generally observed,thus saving both time and *** work aims to improve the clinics’quality of services,organize queues and minimize waiting times,leading to patients’comfort while reducing the burden on nurses and *** results demonstrate that the presented system is successful in its performance and helps achieves a plea-sant and conducive clinic visitation process with higher productivity.

关键词： Internetofthings(IoT) location-aware Bluetoothlowenergy beacon