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Gut virome:New key players in the pathogenesis of inflammatory bowel disease

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World Journal of Methodology 2025年第2期15卷 27-43页

作者： Helal f Hetta rehab Ahmed Yasmin N Ramadan Hayam fathy Mohammed Khorshid Mohamed M Mabrouk Mai Hashem Department of Medical Microbiology and Immunology Faculty of MedicineAssiut UniversityAssiut 71515Egypt Division of Microbiology Immunology and BiotechnologyFaculty of pharmacyUniversity of TabukTabuk 71491Saudi Arabia Division of Microbiology Immunology and BiotechnologyDepartment of Natural Products and Alternative MedicineFaculty of PharmacyUniversity of TabukTabuk 71491Saudi Arabia Department of Internal Medicine Division HepatogastroenterologyAssiut UniversityAssiut 71515Egypt Department of Clinical Research Egyptian Developers of Gastroenterology and Endoscopy FoundationCairo 11936Egypt Department of Internal Medicine Faculty of Medicine.Tanta UniversityTanta 31527Egypt Department of Tropical Medicine Gastroenterology and HepatologyAssiut University HospitalAssiut 71515Egypt

Inflammatory bowel disease(IBD)is a chronic inflammatory illness of the *** the mechanism underlying the pathogenesis of IBD is not fully under-stood,it is believed that a complex combination of host immunological response,environmental exposure,particularly the gut microbiota,and genetic suscept-ibility represents the major *** gut virome is a group of viruses found in great frequency in the gastrointestinal tract of *** gut virome varies greatly among individuals and is influenced by factors including lifestyle,diet,health and disease conditions,geography,and *** majority of research has focused on the significance of gut bacteria in the progression of IBD,although viral populations represent an important component of the *** conducted this review to highlight the viral communities in the gut and their expected roles in the etiopathogenesis of IBD regarding published research to date.

关键词： Inflammatory bowel disease Pathogenesis Gut virome Bacteriophage Eukaryotic viruses

A New Decision-Making Model Based on Plithogenic Set for Supplier Selection

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Computers, Materials & Continua 2021年第3期66卷 2751-2769页

作者： Mohamed abdel-Basset rehab Mohamed florentin Smarandache Mohamed Elhoseny faculty of Computers and Informatics Zagazig UniversityZagazig44519Egypt Math&Science Department University of New MexicoGallupNew Mexico87301USA College of Computer Information Technology American University in the EmiratesDubaiThe United Arab Emirates

Supplier selection is a common and relevant phase to initialize the supply chain processes and ensure its *** choice of supplier is a multicriteria decision making(MCDM)to obtain the optimal decision based on a group of *** health care sector faces several types of problems,and one of the most important is selecting an appropriate supplier that fits the desired performance *** development of service/product quality in health care facilities in a country will improve the quality of the life of its *** paper proposes an integrated multi-attribute border approximation area comparison(MABAC)based on the best-worst method(BWM),plithogenic set,and rough *** is applied to regulate the weight vector of the measures in group decision-making problems with a high level of *** the treatment of uncertainty,a plithogenic set and rough number(RN)are used to improve the accuracy of *** set operations are used to deal with information in the desired manner that handles uncertainty and ***,based on the plithogenic aggregation and the results of BWM evaluation,we use MABAC to find the optimal alternative according to defined *** examine the proposed integrated algorithm,an empirical example is produced to select an optimal supplier within five options in the healthcare industry.

关键词： Supplier selection rough set theory MABAC MCDM BWM plithogenic set

Efficient Model for Emergency Departments:Real Case Study

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Computers, Materials & Continua 2022年第2期70卷 4053-4073页

作者： Mohamed abdel-Basset Abduallah Gamal rehab Mohamed Mohamed Abouhawwash Abdulwahab Almutairi Osama M.ELkomy faculty of Computers and Informatics Zagazig UniversityZagazig44519Egypt Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA School of Mathematics Unaizah College of Sciences and ArtsQassim University51452Saudi Arabia

There are several challenges that hospitals are facing according to the emergency department(ED).Themain two issues are department capacity and lead ***,the lack of consensus on performance criteria to evaluateEDincreases the complication of this ***,this study aims to evaluate the efficiency of the emergency department in 20 Egyptian hospitals(12 private and 8 general hospitals)based on 13 performance *** research suggests an integrated evaluation model assess ED under a framework of plithogenic *** proposed framework addressed uncertainty and ambiguity in information with an efficient manner via presenting the evaluation expression by plithogenic *** Envelopment Analysis(DEA)technique is used in order to measure the efficiency of the emergency department of 20 hospitals according to the number of treated patients and effect on patient’s life quality based on 11 *** the Analytic Hierarchy Process(AHP),the weight of efficiency factors will be measured based on neutrosophic linguistic scale pairwise *** operations provide more accurate aggregation result according to contradiction degree between criteria *** results show that ten of the hospitals are providing efficient service in their emergency department,while the other ten are less *** analysis of the results shows that 58%of private hospitals emergency department is operating efficiently,while the efficient general hospitals represent 38%.

关键词： Emergency department plithogenic set data envelopment analysis analytic hierarchy process

Protective and therapeutic potentials of Dunaliella salina on aging-associated cardiac dysfunction in rats

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Asian Pacific Journal of Tropical Biomedicine 2018年第8期8卷 403-410页

作者： farouk K.El-Baz Gehad A.abdel Jaleel Dalia O.Saleh rehab A.Hussein Plant Biochemistry Department National Research Centre (NRC) Pharmacology Department National Research Centre (NRC) Pharmacognosy Department National Research Centre (NRC)

Objective: To investigate the possible protective and/or therapeutic potentials of Dunaliella salina(D. salina) biomass, its carotenoid and polar fractions on cardiac dysfunction associated with D-galactose(D-GAL) induced aging in rats. Methods: Aging associated cardiac dysfunction was induced in rats by injection of D-GAL(200 mg/kg; i.p) for 8 weeks. D-GAL injected rats were treated with two regimens; protective regimen where D. salina biomass(250 mg/kg), its carotenoid(250 μg/kg) and polar(250 μg/kg) fractions were given orally for two weeks concurrently with D-GAL injection as well as treatment regimen where the three treatments were given orally for 28 consecutive days after D-GAL injection. Results: D-GAL injection for 8 weeks was accompanied with dramatic electrocardiographic changes as well as profound elevation in serum levels of homocysteine, creatinine kinase isoenzyme and lactate dehydrogenase in addition to the reduction of the cardiac content of glucose trasporter 4. D-GAL also induced reduction in cardiac superoxide dismutase activity and elevation of inducible nitric oxide synthetase and interleukin-6. On the other hand, oral administration of D. salina carotenoid fraction as well as the total biomass significantly attenuated the D-GAL-induced disturbances in the above mentioned parameters where the protective regimen appeared more successful in controlling the manifestations of cardiac dysfunction. The histopathological examination further emphasized the promising results. Besides, the HPLC analysis of the carotenoid fraction of D. salina revealed the presence of 2.31%. salina carotenoid fraction as well as the total biomass amelior β-carotene. Conclusions: Date D-GAL-induced aging associated cardiac dysfunction which is attributed to the potent antioxidant activity of β-carotene.

关键词： Aging Cardiac dysfunction Dunaliella salina Rats

Histopathological,histochemical and biochemical postmortem changes in induced fatal hypothermia in rats

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forensic Sciences Research 2022年第2期7卷 211-227页

作者： Mahrous abdelbasset Ibrahim Sally Salem Mohammed Hany Goda Tammam rehab Ibrahim abdel-Karim Medhat Mohammed farag forensic Medicine&Clinical Toxicology College of MedicineJouf UniversitySakakahSaudi Arabia forensic Medicine&Clinical Toxicology Department Faculty of MedicineSuez Canal UniversityIsmailiaEgypt Histology and Cell Biology Department Faculty of MedicineSuez Canal UniversityIsmailiaEgypt forensic Medicine and Clinical Toxicology Department Faculty of MedicineAl-Azhar UniversityCairoEgypt Medical biochemistry Department College of MedicineShaqra UniversityShaqraaSaudi Arabia Medical Biochemistry&Molecular Biology Department Faculty of MedicineBenha UniversityBenhaEgypt

Reaching a postmortem diagnosis of hypothermia is challenging in forensic ***,this study was conducted to detect the histopathological,histochemical and biochemical changes that occur in adult albino rats following exposure to induced fatal ***-four adult albino rats were divided into the negative control,moderate hypothermia,severe hypothermia and hypoxia *** in the control group were euthanized when those in the moderate hypothermic group *** samples were collected via heart puncture,and the cerebrum,heart,suprarenal gland,kidney,liver and skeletal muscle were removed to investigate the biochemical,histochemical and histopathological *** assessment depicted significant changes in lipid peroxidation,represented by increased malondialdehyde levels in the studied organs of the rats in hypothermic and hypoxia *** examination of the rats’organs revealed degeneration and necrosis in the hypothermia and hypoxia *** taken from the severe hypothermic rats revealed a loss of normal cardiac tissue architecture,necrotic changes in the pyramidal cells in the cerebral cortex,and massive necrosis,mainly in the tubules of the renal cortex and *** findings suggest that histological changes might be used as biochemical markers for postmortem diagnosing of fatal hypothermia,particularly in severe hypothermic conditions.

关键词： forensic sciences forensic medicine legal medicine autopsy forensic pathology histochemical hypothermia

flare of the silent pandemic in the era of the COVID-19 pandemic:Obstacles and opportunities

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World Journal of Clinical Cases 2023年第6期11卷 1267-1274页

作者： rehab A Rayan Department of Epidemiology High Institute of Public HealthAlexandria UniversityAlexandria 55555Egypt

A noteworthy public health problem,antimicrobial resistance(AMR)has been impeded in many ways by the coronavirus disease 2019(COVID-19)*** narrative review discusses the two-sided impact of COVID-19 on the magnitude of *** pandemic has put tremendous strain on healthcare systems,diverting resources,personnel,and attention away from AMR diagnosis and management toward COVID-19 diagnosis and contact tracking and *** research has been severely hampered,and surveillance and antimicrobial stewardship(AMS)programs have been de-emphasized,delayed,or ***,particularly broad-spectrum,were prescribed more frequently without diagnostic confirmation of bacterial infection than before the ***,the COVID-19 pandemic has highlighted the vulnerability of healthcare systems in controlling infectious disease threats and raised awareness of the importance of infection prevention and ***,the pandemic has created opportunities to capitalize on positive effects on AMR *** review concludes that it is now more important than ever to focus on AMR and strengthen AMS programs to ensure appropriate antibiotic use and other AMR prevention measures in *** must ensure that one of the COVID-19 legacies is increased support for AMR research,diagnostic implementation,appropriate diagnostic stewardship,and the strengthening of our health *** COVID-19 pandemic has demonstrated that prevention is better than *** will need to step up their efforts to combat AMR as a multidisciplinary *** must prepare our public health systems to combat multiple threats at the same time.

关键词： One Health Antimicrobial resistance Coronavirus pandemic Antimicrobials Antibiotics Antimicrobial stewardship

Anomaly Detection for Industrial Internet of Things Cyberattacks

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Computer Systems Science & Engineering 2023年第3期44卷 2361-2378页

作者： rehab Alanazi Ahamed Aljuhani College of Computing and Information Technology University of TabukTabuk71491Saudi Arabia

The evolution of the Internet of Things(IoT)has empowered modern industries with the capability to implement large-scale IoT ecosystems,such as the Industrial Internet of Things(IIoT).The IIoT is vulnerable to a diverse range of cyberattacks that can be exploited by intruders and cause substantial reputational andfinancial harm to *** preserve the confidentiality,integrity,and availability of IIoT networks,an anomaly-based intrusion detection system(IDS)can be used to provide secure,reliable,and efficient IIoT *** this paper,we propose an anomaly-based IDS for IIoT networks as an effective security solution to efficiently and effectively overcome several IIoT *** proposed anomaly-based IDS is divided into three phases:pre-processing,feature selection,and *** the pre-processing phase,data cleaning and nor-malization are *** the feature selection phase,the candidates’feature vectors are computed using two feature reduction techniques,minimum redun-dancy maximum relevance and neighborhood components *** thefinal step,the modeling phase,the following classifiers are used to perform the classi-fication:support vector machine,decision tree,k-nearest neighbors,and linear discriminant *** proposed work uses a new data-driven IIoT data set called *** experimental evaluation demonstrates our proposed model achieved a high accuracy rate of 99.58%,a sensitivity rate of 99.59%,a specificity rate of 99.58%,and a low false positive rate of 0.4%.

关键词： Anomaly detection anomaly-based IDS Industrial Internet of Things(IIoT) IoT industrial control systems(ICSs) X-IIoTID

Paleontological Records of Holocene Environmental Changes offshore, Egypt

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Journal of Ocean University of China 2019年第6期18卷 1382-1394页

作者： rehab ELSHANAWANY Yousra MOHAMED Mohamed IAIBRAHIM MARUM Leobener StraβeUniversity of BremenD-28359 BremenGermany faculty of Science Alexandria UniversityMoharam Bey 21511Egypt

Paleontological and sedimentological analyses were carried out in sediment core from southeastern Mediterranean Sea,offshore Egypt to reconstruct the past environmental changes in trophic state and temperature during *** achieve our goals,grain size,total organic carbon,planktic and benthic foraminifera,dinoflagellate cysts have been *** micropalaentological studies have been done in the studied area and none of them used the combined proxies of benthic foraminifera and dinoflagellate *** combined proxies reflects more comprehensive paleoenvironmental *** and abiotic data have been analysed with multivariate technique including Redundancy Analysis(RDA).Diversity indices such as:fisher alpha index(α)and Shannon index(H)have been *** foraminiferal study yields 9 planktic species and 10 benthic *** assemblages have low species diversity indices especially at sapropel layer *** sapropels are layers with elevated organic carbon concentrations that contrast with surrounding organic poor *** occur periodically in sedimentary sequences of the last millions years,which have been the subject of extensive previous *** Analysis(RDA)yields two groups of foraminiferal assemblages depending on the changes of total organic carbon and clay *** dinocysts study yields 15 species,the majority of cyst types belonging to the order *** association of dinoflagellate cyst shows two depositional phases in the *** sapropel layer S1,with anoxic condition and warmer temperature,is recorded at depth 28-46 cm where heterotrophic taxa dominate and the post-sapropel layer is recorded at depth 0-28 cm;where autotrophic taxa dominate.

关键词： dinoflagellate cysts paleoenvironmental changes planktic and benthic foraminifera offshore Egypt

Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and forkhead box O3a expression in breast cancer cells

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Genes & Diseases 2017年第4期4卷 240-246页

作者： Hanan abdelmawgoud rehab Refaat El Awady Biochemistry Department Faculty of PharmacyAl-Azhar UniversityCairoEgypt

Breast cancer is the most common invasive cancer in women *** 1(SIRT1)has recently been shown to have implications in regulating cancer cell growth and ***1 regulates forkhead box O3a(fOXO3a)by both inhibiting fOXO3-induced apoptosis and potentiating the ability of fOXO3a to resist oxidative *** metalloproteinase 2(MMP2)participates in tumor invasion and metastasis by degrading extracellular ***1 up regulates MMP2 expression by its deacetylation *** study aimed to investigate the expression of SIRT1,fOXO3a and MMP2 in breast tissues of women with breast *** addition,the effect of SIRT1 inhibition on both fOXO3a and MMP2 expression in breast cancer(MCf-7)cells was *** expression levels of SIRT1,fOXO3a and MMP2 in the breast tissues were determined by real-time PCR in 60 patients with malignant tumor and in 24 patients with benign *** SIRT1 inhibition,protein levels of SIRT1 and fOXO3a were assessed by Western Blot and levels of MMP2 by ELISA in MCf-7 *** expression levels of SIRT1,fOXO3a and MMP2 were significantly higher in breast cancer tissues compared to in benign breast tumor and adjacent normal ***1,MMP2 and fOXO3a expression were associated directly with each ***1 inhibition suppresses MMP2 and fOXO3a expression compared to control ***(SIRT1 inhibitor)effectively induced inhibition of MMP2 and fOXO3a expression in MCf-7 cells,indicating the promising therapeutic strategy of targeting SIRT1 for breast cancer.

关键词： Breast cancer fOXO3a MMP2 SIRT1 Sirtinol