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Amniotic membrane as a potent source of stem cells and a matrix for engineering heart tissue

Journal of Biomedical Science and Engineering 2013年第12期6卷 1178-1185页

作者： Julio Cesar Francisco Ricardo Correa Cunha Rossana Baggio Simeoni Luiz Cesar Guarita-Souza reginaldo justino ferreira Ana Carolina Irioda Carolina Maria C.Oliveira Souza Garikipati Venkata Naga Srikanth Soniya Nityanand Juan Carlos Chachques Katherine Athayde Teixeira de Carvalho Bioprocess Engineering and Biotechnology Department Federal University of ParanáCuritibaBrazil Cell Therapy and Biotechnology in Regenerative Medicine Research Group Pele Pequeno Príncipe InstituteCuritibaBrazil Experimental Laboratory of Institute of Biological and Health Sciences Pontificial Catholic University of Paraná(PUCPR)Rua Imaculada ConceicaoCuritibaBrazil Federal University of Technology CuritibaBrazil Department of Hematology Stem Cell Research FacultySanjay Gandhi Post-Graduate Institute of Medical SciencesLucknowIndia Laboratory of Biosurgical Research Pompidou HospitalUniversity of Paris DescartesParisFrance

Existing therapies for the treatment of chronic heart failure still have some limitations and there is a pressing need for the development of new therapeutic modalities. The amniotic membrane has been used for the treatment of various diseases, such as conjunctive defects;however, the mechanisms behind its repair functions are still unclear. Regenerative medicine is seeking newer alternatives and among them, biomaterials have emerged in recent years for developing and manipulating molecules, cells, tissues or organs grown in laboratories in order to replace human body parts. Many such materials have been used for this purpose, either synthetically or biologically, in order to provide new medical devices. This review provides a wider view of the regeneration potential of the use of amniotic membrane as a potential biomaterial to facilitate the implementation of new research in surgical procedures. Amniotic membrane appears to be an alternative source of stem cells as well as an excellent biomaterial for cell-based therapeutic applications in engineering heart tissue.

关键词： Amniotic Membrane Heart Tissue Engineering Stem Cells

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Preclinical stem cell therapy in Chagas Disease: Perspectives for future research

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World Journal of Transplantation 2013年第4期3卷 119-126页

作者： Katherine Athayde Teixeira de Carvalho Eltyeb Abdelwahid reginaldo justino ferreira Ana Carolina Irioda Luiz Cesar Guarita-Souza Cell Therapy and Biotechnology in Regenerative Medicine Research Group Pequeno Príncipe FacultyPelé Pequeno Príncipe InstituteCuritiba 80250-200ParanáBrazil Bioprocess Engineering and Biotechnology Department Federal University of ParanáCuritiba 81531-970ParanáBrazil CBRC Massachusetts General Hospital/Harvard Medical SchoolCharlestownMa 02129United States Federal University of Technology Curitiba 80230-901ParanáBrazil Experimental Laboratory of Institute of Biological and Health Sciences of Pontifical Catholic University of Parana Curitiba 80215-901ParanáBrazil

Chagas cardiomyopathy still remains a challenging problem that is responsible for high morbidity and mortality in Central and Latin America. Chagas disease disrupts blood microcirculation via various autoimmune mechanisms, causing loss of cardiomyocytes and severe impairment of heart function. Different cell types and delivery approaches in Chagas Disease have been studied in both preclinical models and clinical trials. The main objective of this article is to clarify the reasons why the benefits that have been seen with cell therapy in preclinical models fail to translate to the clinical setting. This can be explained by crucial differences between the cellular types and pathophysiological mechanisms of the disease, as well as the differences between human patients and animal models. We discuss examples that demonstrate how the results from preclinical trials might have overestimated the efficacy of myocardial regeneration therapies. Future research should focus, not only on studying the best cell type to use but, very importantly, understanding the levels of safety and cellular interaction that can elicit efficient therapeutic effects in human tissue. Addressing the challenges associated with future research may ensure the success of stem cell therapy in improving preclinical models and the treatment of Chagas disease.

关键词： Chagas Disease preclinical stem cell therapy co-cultured translation pathophysiologie myoblasts

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