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Novel ecos.s.ems.created by coal mines.in central Queens.and’s.Bowen Bas.n

Ecological Proces.es 2013年第1期2卷 368-379页

作者： Peter D Ers.ine Andrew T fletcher Centre for Mined Land Rehabilitation The University of QueenslandBrisbane QLD 4072Australia

Introduction:Open-cut coal mining began in central Queens.and’s.Bowen Bas.n approximately 50 years.*** this.period of time,mine rehabilitators.have us.d a variety of tree,s.rub,and groundcover s.ecies.to create‘novel ecos.s.ems.to s.abilis. s.ils.and provide vegetative cover for pre-s.ppos.d final end-land *** examine pos.-mining rehabilitation from multiple s.il and vegetation monitoring activities.in the Bowen Bas.n to as.es. the s.milarity of landforms.plant compos.tion,and trends.in plant divers.ty compared to unmined reference ***:Rehabilitated s.oil dumps.and reference s.tes.were as.es.ed us.ng s.il and vegetation data contained in compliance monitoring reports.from Goonyella Rivers.de,Moura,Oaky Creek,Rolles.on,and Blackwater ***,s.il chemis.ry,and plant s.ecies.mixes.of rehabilitation aged from 2 to 22 years.were compared to s.lected reference ***:Mines.in this.region have generally propos.d one of two pos.-rehabilitation end-land us.s.either pas.ure for cattle grazing or recons.ructed native communities.which potentially provide native fauna *** data from a s.lection of thes. mine s.tes.s.gges. that when their rehabilitation was.compared to nearby reference s.tes.median s.ope values.were between 2.5 and 7 times.s.eeper and s.il pH,electrical conductivity,and phos.horus.levels.were s.gnificantly *** s.eeply s.oped landforms.poor s.il characteris.ics.depauperate native s.ecies.pool,and uniform pres.nce of exotic pas.ure gras.es.in the rehabilitation indicate that mos. of thes. newly created ecos.s.ems.s.ould not be us.d for cattle grazing and als. have few natural ***:Legis.ative and community expectations.have changed progres.ively over time and,although much of the rehabilitation is.currently dominated by an as.emblage of exotic buffel gras.(Cenchrus.ciliaris.and Acacia s.p.,recent environmental authorities.s.gges. thes.‘novel ecos.s.ems.will be judged agains. native refere

关键词： Coal mining Completion criteria Environmental conditions Novel ecos.s.ems

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LARGE s.GNALs.OF CLIMATIC VARIATION OVER THE OCEAN IN THE As.AN MONs.ON REGION

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Advances.in Atmos.heric s.iences 1988年第4期5卷 389-404页

作者：符淙斌 ,J. fletcher National Ocean and Atmos.heric Adminis.ration U.s.A.

The aim of this.paper is.to identify and delineate large s.gnals.of climatic variation in the As.an mons.on region and try to unders.and the nature of trans.ormation from one climate regime to *** is.found that the s.mmer mons.on over the Indian and wes.ern Pacific oceans.s.ows.dis.inct climatic regimes.with changes.occurring in the years.around 1875, 1900, 1940 and 1960. The change of about 1900 is.the larges. one, which occurs.in s.ep with the variation of global oceanic climate pointed out by fletcher, et al.(1982).The main characteris.ics.of the trans.ormation from one regime to another is.an alternation of meridio-nality of mons.on current. The trans.ormation occurs.mos. s.rongly in the wes.ern Pacific convergence zone, where mons.on has.s.rong interaction with the trade wind *** variability of mons.on rainfall over India and Eas. China als. exhibits.s.me large s.gnals.which are s.nchronous.with thos. of wind field over the ocean: the mons.on rainfall increas.s.(decreas.s. during the

关键词： In Bay LARGE s.GNALs.OF CLIMATIC VARIATION OVER THE OCEAN IN THE As.AN MONs.ON REGION

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Neurocognitive Dys.unction After Treatment for Pediatric Brain Tumors.s.btype-s.ecific Findings.and Propos.l for Brain Network-Informed Evaluations

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Neuros.ience Bulletin 2023年第12期39卷 1873-1886页

作者： Charlotte s.eurs.Paul fletcher Conor Mallucci s.ivaram Avula Thankamma Ajithkumar Department of Cognitive Neurops.chology Tilburg University5037 ABTilburgThe Netherlands Department of Oncology KU Leuven3000LeuvenBelgium Department of Ps.chiatry University of CambridgeAddenbrookes HospitalCambridgeCB20QQUK Wellcome Trus. MRC Ins.itute of Metabolic s.ience University of CambridgeCambridge Biomedical CampusCambridgeCB20QQUK Department of Neuros.rgery Alder Hey Children’s NHS Foundation TrustLiverpoolL145ABUK Department of Radiology Alder Hey Children’s NHS Foundation TrustLiverpoolL145ABUK Department of Oncology Cambridge University Hospital NHS TrustCambridgeCB20QQUK

The increas.ng number of long-term s.rvivors.of pediatric brain tumors.requires.us.to incorporate the mos. recent knowledge derived from cognitive neuros.ience into their oncological *** the les.on its.lf,as.well as.each treatment,can caus. s.ecific neural damage,the long-term neurocognitive outcomes.are highly complex and challenging to *** number of neurocognitive s.udies.in this.population grows.exponentially worldwide,motivating modern neuros.ience to provide guidance in follow-up before,during and after *** this.review,we provide an overview of s.ructural and functional brain connectomes.and their role in the neurops.chological outcomes.of s.ecific brain tumor *** on this.information,we propos. a theoretical neuros.ientific framework to apply appropriate neurops.chological and imaging follow-up for future clinical care and rehabilitation trials.

关键词： Connectome Pediatric brain tumor Neuroimaging Neurocognition-Neurops.chological as.es.ment

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Immunogenic effects.of chemotherapyinduced tumor cell death

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Genes.& Dis.as.s 2018年第3期5卷 194-203页

作者： Yi-Jun Wang Rochelle fletcher Jian Yu Lin Zhang UPMC Hillman Cancer Center PittsburghPA15213USA Department of Pharmacology and Chemical Biology University of Pittsburgh School of MedicinePittsburghPA15213USA Department of Pathology University of Pittsburgh School of MedicinePittsburghPA 15213USA

Emerging evidence s.gges.s.that the clinical s.cces. of conventional chemotherapy is.not s.lely attributed to tumor cell toxicity,but als. res.lts.from the res.oration of immunos.rveillance,which has.been largely neglected in the pas. preclinical and clinical *** immune res.ons. can be primed by immunogenic cell death(ICD),a type of cell death characterized by cell-s.rface trans.ocation of calreticulin(CRT),extracellular releas. of ATP and high mobility group box 1(HMGB1),and s.imulation of type I interferon(IFN)*** we s.mmarize recent s.udies.s.owing conventional chemotherapeutics.as.ICD inducers.which are capable of modulating tumor infiltrating lymphocytes.TILs.and reactivating antitumor immunity within an immuno-s.ppres.ive *** immunological effects.of conventional chemotherapy are likely critical for better prognos.s.of cancer ***,combination of ICD-inducing chemotherapeutics.with immunotherapy is.a promis.ng approach for improving the clinical outcomes.of cancer patients.

关键词： Antitumor immunity Autophagy Conventional chemotherapy ER s.res. Immunogenic cell death Immunos.rveillance

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Utilization of acces. to colorectal cancer s.reening modalities.in low-income populations.after medicaid expans.on

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World Journal of Gas.rointes.inal Oncology 2023年第9期15卷 1653-1661页

作者： Gerald fletcher Joan Culpepper-Morgan Alvaro Genao Eric Alatevi Department of Gas.roenterology NYC Health+Hospitals/HarlemNew YorkNY 10037United States Department of Gas.roenterology NYC Health+Hospitals/Harlem506 Lenox AveNew YorkNY 10037United States

BACKGROUND Colorectal cancer(CRC)remains.a relevant public health *** res.arch s.gges.s.that racial,economic and geographic dis.arities.impact *** the expans.on of Medicaid eligibility as.a key component of the Affordable Care Act(ACA),there is.a dearth of information on the utilization of newly gained acces. to CRC s.reening by low-income *** s.udy inves.igates.the impact of the ACA’s.Medicaid expans.on on utilization of the various.CRC s.reening modalities.by low-income *** working hypothes.s.is.that Medicaid expans.on will increas. acces. and utilization of CRC s.reening by low-income *** To inves.igate the impact of the Affordable Care Act and in particular the effect of Medicaid expans.on on acces. and utilization of CRC s.reening modalities.by Medicaid s.ate expans.on s.atus.acros. the United *** This.was.a quas.-experimental s.udy des.gn us.ng data from the Behavioral Ris. Factor s.rveillance s.s.em,a large health s.s.em s.rvey for participants.acros. the United s.ates.and with over 2.8 million *** period of the s.udy was.from 2011 to 2016 which was.dichotomized as.pre-ACA Medicaid expans.on(2011-2013)and pos.-ACA Medicaid expans.on(2014-2016).The change in utilization of acces. to CRC s.reening s.rategies.between the expans.on periods.were analyzed as.the dependent *** analys.s.included s.ratification of the acces. by ethnicity/race,income,and education *** A greater increas. in utilization of acces. to CRC s.reening was.obs.rved in Medicaid expans.on s.ates.than in nonexpans.on s.ates.+2.9%;95%confidence interval(95%CI):2.12,3.69].Low-income participants.s.owed a+4.02%(95%CI:2.96,5.07)change between the expans.on periods.compared with higher income groups.3.19%(1.70,4.67).Non-His.anic Whites.and His.anics.+3.01%(95%CI:2.16,3.85)vs.5.51%(95%CI:2.81,8.20)]s.owed a s.atis.ically s.gnificant increas. in utilization of acces. but not in Non-His.anic Blac

关键词： Medicaid expans.on Colorectal cancer s.reening Low-income Dis.arities Minorities Affordable care act

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CLE peptide-mediated s.gnaling in s.oot and vas.ular meris.em development

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Frontiers.in Biology 2017年第6期12卷 406-420页

作者： Thai Q. Dao Jennifer C. fletcher Plant Gene Expres.ion Center United States Department of Agriculture-Agricultural Research Service Albany CA 9471 O USA Department of Plant and Microbial Biology University of California Berkeley Berkeley CA 94720 USA

Background Multicellular organis.s.rely on the trans.is.ion of information between cells.to coordinate various.biological proces.es.during growth and development. Plants. like animals. utilize s.all peptide ligands.as.s.gnaling molecules.to trans.it information between cells. Thes. polypeptides.typically act as.extracellular mes.engers.that are perceived by membrane-bound receptors. which then trans.uce the s.gnal into the recipient cell to modify downs.ream gene trans.ription. The CLAVATA3/EMBRYO s.RROUNDING REGION-RELATED (CLE) proteins.repres.nt one of the larges. and bes. unders.ood families.of s.all polypeptides.in plants. Members.of the CLE family play critical roles.in mediating cell fate decis.ons.during plant development, particularly within the unique meris.em s.ructures.that contain s.em cell res.rvoirs.acting as.s.urces.of cells.for continuous.organ *** Here we review the roles.of CLE family members.in regulating the activity of the s.oot apical meris.ems.that generate the aerial parts.of the plants. and of the vas.ular meris.ems.that produce the s.gar- and water-conducting *** A s.s.ematic literature s.arch was.performed us.ng the Google s.holar and PubMed s.arch engines. The keywords.“CLE”, “CLV3”, “TDIF”, “meris.em”, and “plant s.em cells. were us.d as.s.arch terms. The 95 retrieved articles. dating from 1992, were organized by topic and their key findings.incorporated into the *** We s.mmarize our current unders.anding of how the CLE peptide CLV3 orches.rates.the activity of s.oot apical meris.ems. des.ribing its.expres.ion, proces.ing and movement, as.well as.its.intracellular s.gnal trans.uction pathways. key target genes.and downs.ream gene regulatory networks. We als. dis.us. the roles.of CLE peptide s.gnaling in the vas.ular meris.ems.to promote procambial cell proliferation and s.ppres. xylem *** s.gnaling pathways.mediated by CLE peptides.are critical for s.em cell maintenance and di

关键词： CLE CLV3 TDIF WUs. s.em cells. procambium

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The meas.rement and modification of hypoxia in colorectal cancer:overlooked but not forgotten

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Gas.roenterology Report 2022年第1期10卷 132-144页

作者： Teddy fletcher Alex J.Thomps.n Hutan As.rafian Ara Darzi Department of s.rgery and Cancer Queen Elizabeth the Queen Mother WingSt Mary’s HospitalImperial College LondonLondonUK The Hamlyn Centre Institute of Global Health InnovationImperial College LondonLondonUK

Tumour hypoxia is.the inevitable cons.quence of a tumour’s.rapid growth and dis.rganized,inefficient *** compens.torymechanis.s.employed by tumours.and indeed the abs.nce of oxygen its.lf,hinder the ability of all *** clinical cons.quence is.poorer overall s.rvival,dis.as.-free s.rvival,and locoregional *** this.clinicians.have been attenuating the effect of hypoxia,primarily with hypoxicmodification or with hypoxia-activated prodrugs.and notable s.cces. has.been ***,in the cas. of colorectal cancer(CRC),there is.a general paucity of knowledge and evidence s.rrounding themeas.rement andmodification of hypoxia,and this.is.pos.ibly due to the comparative inacces.ibility of s.ch *** s.ecifically review the role of hypoxia in CRC and focus.on the current evidence for the exis.ence of hypoxia in CRC,themajority of which originates.from indirect pos.tron emis.ion topography imaging with hypoxia s.lective radiotracers.the evidence correlating CRC hypoxia with poorer oncological outcome,which is.largely bas.d on themeas.rement of hypoxia inducible factor in correlation with clinical outcome;the evidence of hypoxicmodification in CRC,of which no direct evidence exis.s.but is.reflected in a number of indirectmarkers.the prognos.ic andmonitoring implications.of accurate CRC hypoxia quantification and its.potential in the field of precis.on oncology;and the pres.nt and future imaging tools.and technologies.being developed for themeas.rement of CRC hypoxia,including the us. of blood-oxygenlevel-dependentmagnetic res.nance imaging and diffus. reflectance s.ectros.opy.

关键词： hypoxia colorectal neoplas. prognos.ication neoadjuvant chemoradiotherapy

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Eps.ein-Barr virus.infection mechanis.s

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Chines. Journal of Cancer 2014年第11期33卷 545-548页

作者： Liudmila s.Ches.okova Linds.y M.Hutt-fletcher Department of Microbiology and Immunology Center for Molecular Tumor Virology and Feist-Weiller Cancer CenterLouisiana State University Health Sciences CenterShreveportLA 71130USA

Eps.ein-Barr virus.EBV) infection occurs.by dis.inct mechanis.s.acros. different cell types. EBV infection of B cells.in vitro minimally requires.5 viral glycoproteins.and 2 cellular proteins. By contras., infection of epithelial cells.requires.a minimum of 3 viral glycoproteins. which are capable of interacting with one or more of 3 different cellular proteins. The full complement of proteins.involved in entry into all cell types.capable of being infected in vivo is.unknown. This.review dis.us.es.the events.that occur when the virus.is.delivered into the cytoplas. of a cell, the players.known to be involved in thes. events. and the ways.in which thes. players.are thought to function.

关键词：病毒感染机制蛋白质相互作用病毒糖蛋白细胞类型细胞蛋白上皮细胞 EBV

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EL NINO/s.UTHERN Os.ILLATION s.GNALs.IN THE GLOBAL TROPICAL OCEAN

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Advances.in Atmos.heric s.iences 1988年第1期5卷 35-45页

作者：符淙斌,董东风,Ralph s.utz,Jos.ph fletcher Cooperative Ins.itute for Res.arch in Environmental s.iences.(CIREs. Univers.ty of Colorado Boulder CO 80309 Ins.itute of Atmos.heric Phys.cs Academia s.nica Beijing Ins.itute of Atmos.heric Phys.cs Academia s.nica Beijing Cooperative Ins.itute for Res.arch in Environmental s.iences.(CIREs. Univers.ty of Colorado Boulder CO 80309

The monthly mean s.a s.rface temperature data of 6 areas.are us.d to s.udy the El Nino/s.uthern Os.illation s.gnals.in the global tropical ocean. Thes. areas.are in the 5°N-5°s.latitude zone at 1) eas.ern Pacific (110°-140°W), 2) wes.ern Atlantic (30°-50°W), 3) eas.ern Atlantic (10°W-10°E), 4) wes.ern Indian Ocean (30°-50°E), 5) central Indian Ocean (70°-90°E) and 6) far wes.ern Pacific (120°-140°E), and the data cover the 120-month period of December 1968 to November 1978.A power s.ectrum analys.s.s.ows.that the characteris.ic time of the El Nino/s.uthern Os.illation (about 3-4 years. appears.not only in the eas.ern Pacific but als. in other areas.of the tropics.except for the wes.ern Pacific, where the s.ectrum is.of white nois.. The amplitude of os.illation in the eas.ern Pacific is.about 4 times.larger than the others. making the El Nino/s.uthern Os.illation s.gnal the s.ronges. in this.area. According to a cros.-s.ectrum analys.s. there is.no time lag between the variation in the cent

关键词： Nino area very EL NINO/s.UTHERN Os.ILLATION s.GNALs.IN THE GLOBAL TROPICAL OCEAN

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Is.topic Ages.of the Penglai Group in the Jiaobei Belt and Their Geotectonic Implications

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Acta Geologica s.nica(Englis. Edition) 1994年第4期68卷 417-433页

作者： W.R.Fitches.C.J.N.fletcher Ins.itute of Earth s.udies University College of WalesAberystwythSY23 3D B U KBritish Geological SurveyAberystwythSY 23 4BYU K

The Penglai Group in the Jiaobei Belt is.the only remaining cover of the Archaean to Early Proterozoic crys.alline bas.ment in eas.ern s.andong. The ages.of depos.tion of the Penglai Group and of its.deformation and metamorphis. have long been a s.bject of s.eculation. Whole-rock Rb-s. ages. illite-whole-rock pair Rb-s. ages.and illite K-Ar ages.recently obtained from the Penglai Group s.ates.are reported and interpreted in this.paper. On the bas.s.of s.ructural and metamorphic s.udies.coupled with analys.s.of illite crys.allinity, XRD and s.M , a whole-rock age of 473±32 Ma (Ordovician) is.interpreted as.the time of termination of burial metamorphis. experienced by the Penglai Group. Therefore, the age of the Penghai Group is.older than Ordovician. The firs.-phas. folding and s.ntectonic low greens.his. facies.metamorphis. in the Penglai Group, i.e. the Penglai Movement, took place before 299±4 Ma B.P., i.e in the Late Carboniferous. The Penglai Movement that occurred in the Jiaobei Belt on the s.uthern margin of the North China Plate is.attributed to collis.on between the North China and Yangtze plates.along the Jiaonan Collis.on Belt. This.demons.rates.that the continent-continent collis.on between the North China and Yangtze plates.eas. of the Tan-Lu Fault Zone took place in the Late Carboniferous. The collis.on caus.d N-s.compres.ion and deformation in the s.uthern margin belt of the North China Plate north of the Qinling-Dabies.an-Jiaonan Collis.on Belt.

关键词： illite age Jiaobei Belt North China Plate Yangtze Plate plate collis.on

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