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Origin of Traditional Chinese Medicine in Cuba in the 19th Century from Its Main Exponents and Some Notable Medical descendants in the 20th Century

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Chinese Medicine and Culture 2023年第4期6卷 367-376页

作者： Lourdes Bárbara Alpizar Caballero Lourdes de la caridad Borges Oquendo Endocrinology Institute Department of ScienceTechnology and InnovationHavana 10400Cuba Faculty of Medical Sciences“Calixto García” Department of ScienceTechnology and InnovationHavana 10400Cuba

The Cuban people are made up of three major migratory currents, the Chinese are one of them. They brought their culture, the methods, and procedures of traditional Chinese medicine(TCM) in the 19th century. Few were able to return and so they created families in Cuba;some of their descendants dedicated themselves to medicine. In order to investigate the practices that were predecessors of TCM in Cuba in the 19th century, a qualitative phenomenological research was carried out, reviewing what was published by various sources, applying documentary analysis, logical historical analysis, abstraction, synthesis, and systematization of the results on the regularities of the work and human behavior of Chinese doctors in the Cuban 19th and 20th centuries. This made it possible to identify six Chinese doctors in the 19th century in Cuba who gave rise to the beginning of some practices of TCM in Cuba, and five from the 20th century, descendants of coolies who dedicated themselves to other specialties of medicine. It was found that despite their geographical and time disperse, they were all notorious for their outstanding professional and human behavior, with a trail of accumulated successes in achieving “almost the impossible” with the patient. They have left their mark on Cuban culture.

关键词： Chinese doctor Coolies Popular phrase Immigrants Professional behavior Human behavior History

late polymicrobial transjugular intrahepatic portosystemic shunt infection in a liver transplant patient:A case report

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World Journal of Hepatology 2022年第4期14卷 846-853页

作者： Irene de la caridad Perez Ziv J Haskal John I Hogan Curtis K Argo department of Medicine University of Virginia Medical CenterCharlottesvilleVA 22903United States department of Radiology and Medical Imaging Division of Vascular and Interventional RadiologyUniversity of Virginia Medical CenterCharlottesvilleVA 22903United States department of Medicine Division of Infectious Diseases and International HealthUniversity of Virginia Medical CenterCharlottesvilleVA 22903United States department of Medicine Division of Gastroenterology and HepatologyUniversity of Virginia Medical CenterCharlottesvilleVA 22903United States

BACKGROUND Infection of a transjugular intrahepatic portosystemic shunt(TIPS)stent is a rare and serious complication that most commonly occurs during TIPS creation and *** typically present with recurrent bacteremia due to shunt occlusion or *** date there are approximately 58 cases *** present a patient diagnosed with late polymicrobial TIPS infection five years following TIPS *** SUMMARY A 63-year-old female status-post liver transplant with recurrent cirrhosis and portal hypertension presented with sepsis and recurrent extended-spectrum betalactamase Escherichia coli *** tomography of the abdomen revealed an occluded TIPS with thrombus extension into the distal right portal vein,and focal thickening of the cecum and ascending *** revealed patchy ulcers in these areas with histopathology demonstrating ulcerated colonic mucosa with fibrinopurulent *** thrombectomy and revision revealed infected-appearing *** initially cleared her infection with antibacterial therapy and TIPS revision;however,soon after,she developed Enterobacter cloacae bacteremia and Candida glabrata and *** fungemia with recurrent TIPS *** remained on antifungal therapy indefinitely and later developed vancomycin-resistant Enterococcus faecium with recurrent TIPS *** option of liver re-transplant for removal of the infected TIPS was not offered given her critical illness and complex shunt *** patient became intolerant to linezolid and elected hospice *** Clinicians should be aware that TIPS superinfection may occur as long as five years following TIPS creation in an immunocompromised patient.

关键词： Transjugular intrahepatic portosystemic shunt Endotipsitis Colitis Liver cirrhosis Liver transplantation Case report

New Insights into Sinus Venosus defects from Cross-Sectional Imaging

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Congenital Heart Disease 2022年第1期17卷 5-23页

作者： Shi-Joon Yoo Sanga Lee regina de la Mora Ankavipar Saprungruang Christoph Haller Lee N.Benson Vladimiro Vida Alvise Guariento Christopher Z.lam department of Diagnostic Imaging Hospital for Sick ChildrenUniversity of TorontoTorontoCanada Division of Cardiology Department of PaediatricsLabatt Family Heart CentreHospital for Sick ChildrenUniversity of TorontoTorontoCanada department of Diagnostic Imaging Sejong Heart CenterBucheonKorea department of Radiology Instituto Nacional de CardiologíaMexico CityMexico Division of Cardiac Surgery Department of SurgeryLabatt Family Heart CentreHospital for Sick ChildrenUniversity of TorontoTorontoCanada Pediatric and Congenital Cardiac Surgery Unit University of Padua Medical SchoolPaduaItaly

Sinus venosus defects include two varieties,superior and inferior sinus venosus *** superior sinus venosus defect is characterized by abnormal communication between two closely related venoatrial structures:1)the normally positioned superior vena cava-right atrium complex and 2)the right pulmonary vein-left atrium complex that is displaced leftward,forward and *** sinus venosus defects primarily involve the inferior vena cava-right atrial junction while the right pulmonary vein-left atrial junction can also be *** of the rarity and wide variation of the defects,the morphological characterization of sinus venosus defects is inconsistent among investigators and often *** imaging technologies with high spatial and temporal resolutions have allowed accurate and detailed assessment of the pathological anatomy in larger numbers of *** this pictorial essay,we revisit the established and controversial features of the sinus venous defects using twodimensional(2D)and three-dimensional(3D)images obtained by magnetic resonance(MR)or computed tomography(CT)with brief discussion on imaging and treatment strategies.

关键词： Sinus venosus defect superior sinus venosus defect inferior sinus venosus defect anomalous pulmonary venous connection overriding superior vena cava overriding inferior vena cava

Those Responsible for the Pharmacological Actions of Plants are the Active Secondary Metabolites

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Journal of Pharmacy and Pharmacology 2021年第3期9卷 107-114页

作者： regina de caridad Rodríguez muñoz Ana Elena Rodríguez Cadalso Viviana Silvia Rodríguez Jiménez Geuny Vázquez Bandomo Yosimy Seijas delgado Reydilexis Forestal Gonzáles Filial of Medical Sciences Elena Fernández de Castro Unit Trinidad 62600Sanctis SpíritusCuba

Objectives: To relate the presence of the active secondary metabolites in the pharmacological actions and the therapeuticeffects of the plants. Methods: Search about the topic in the last 5 years and present some active secondary metabolites that explainthe pharmacological actions and therapeutic effects of medicinal plants. Conclusions: It was based on the search of articles in theVirtual Library in Health (Spanish: BVS) and using the key words: secondary metabolites, phytotherapy, medicinal plants.

关键词： Metabolites primary metabolites secondary metabolites phytotherapy natural medicine medicinal plants

Discovery of gargantulides B and C,new 52-membered macrolactones from Amycolatopsis *** absolute stereochemistry of the gargantulide family

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Organic Chemistry Frontiers 2022年第2期9卷 462-470页

作者： Daniel Carretero-Molina Francisco Javier Ortiz-López Tetiana Gren Daniel Oves-Costales Jesús Martín Fernando Román-Hurtado Tue Sparholt Jorgensen Mercedes de la Cruz caridad Díaz Francisca Vicente Kai Blin Fernando Reyes Tilmann Weber Olga Genilloud Fundación MEDINA Centro de Excelencia en Investigación de Medicamentos Innovadores en AndalucíaAvda.del Conocimiento 3418016 ArmillaGranadaSpain The Novo Nordisk Foundation Center for Biosustainability Technical University of DenmarkKemitorvetbuilding 2202800 Kgs.LyngbyDenmark

Gargantulides B and C,two new and highly complex 52-membered glycosylated macrolactones,were isolated from Amycolatopsis *** CA-230715 during an antibacterial screening *** structures of these giant macrolides were elucidated by 2D NMR spectroscopy and shown to be related to gargantulide A,although containing additional β-glucopyranose and/orα-arabinofuranose monosaccharides separately attached to their *** sequencing allowed the identification of a strikingly large 216 kbp biosynthetic gene cluster,among the largest type Ⅰ PKS clusters described so far,and the proposal of a previously unreported biosynthetic pathway for gargantulides *** absolute configurations of gargantulides B and C were assigned based on a combination of NMR and bioinformatics analysis of ketoreductase and enoylreductase domains within the multimodular type Ⅰ *** addition,the absolute stereochemistry of gargantulide A has now been revised and *** B and C display potent antibacterial activity against a set of drug-resistant Gram-positive bacteria and moderate activity against the clinically relevant Gram-negative pathogen Acinetobacter baumannii.

关键词： absolute membered backbone

A Look to the Bioenergetic Medicine from the Human Physiology

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Journal of Pharmacy and Pharmacology 2021年第1期9卷 14-20页

作者： Richard MarceloÁlvarez Orbea Ana Elena Rodríguez Cadalso regina de caridad Rodríguez muñoz Viviana Silvia Rodríguez Jímenéz Marelys Calzada Jesús Manuel Cadalso Menéndez The Branch of Medical Sciences“Elena Fernández of Castro”of Trinidad Trinidad 62600Sancti SpíritusCuba

Objective: To relate biochemistry of the human physiology with the application of the bioenergetic medicine. Methods:Search about the topic in the last 5 years and present a general view of some biochemical processes that allow to apply thebioenergetic medicine, due to the need to open new alternatives based on holistic methods. Conclusions: It was based on the searchof articles in the Virtual Library in Health (Spanish: BVS) and using the key words: bioenergetic medicine, vibration, energy,breathing, chakras, biomagnetism, translated into the quality of life’s improvement and the welfare of human being.

关键词： Bioenergetic medicine vibration energy breathing chakras biomagnetism

Application of Medicinal Plants on Menopause Symptoms

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Journal of Pharmacy and Pharmacology 2021年第7期9卷 245-255页

作者： Yosvany Urquiola Martínez Ana Elena Rodríguez Cadalso regina de caridad Rodríguez muñoz Viviana Silvia Rodríguez Jiménez Marelys Medina Barroso Ramón Florencio Duarte Chaviano Filial of Medical Sciences Elena Fernández de Castro Unit Trinidad 62600Sanctis Spíritus.Cuba

Objectives:To relate the symptoms of menopause and the use of medicinal ***:it was carried out a study that applied the qualitative method,by means of a bibliographical and documental revision in sources of digital data of wide reach(Google,SciELO,DOAJ,latindex and SCOPUS).It was kept in mind the quality and the present ***:It was based on the search of articles in Virtual the Library in Health(Spanish:BVS)and using the key words:menopause,medicinal plants,phytotherapy,menopause symptoms.

关键词： Menopause medicinal plants phytotherapy menopause symptoms.

Mechanisms implicated in the contralateral effect in the central nervous system after unilateral injury:focus on the visual system

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Neural Regeneration Research 2021年第11期16卷 2125-2131页

作者： Fernando Lucas-Ruiz caridad Galindo-Romero Virginia Albaladejo-García Manuel Vidal-Sanz Marta Agudo-Barriuso departamento de Oftalmología Facultad de MedicinaUniversidad de Murcia and Instituto Murciano de Investigación Biosanitaria-Virgen de la Arrixaca(IMIBArrixaca)MurciaSpain

The retina,as part of the central nervous system is an ideal model to study the response of neurons to injury and disease and to test new *** the last decade is becoming clear that unilateral lesions in bilateral areas of the central nervous system trigger an inflammatory response in the contralateral uninjured *** effect has been better studied in the visual system where,as a rule,one retina is used as experimental and the other as *** retinas in unilateral models of retinal injury show neuronal degeneration and glial *** mechanisms by which this adverse response in the central nervous system occurs are discussed in this review,focusing primarily on the visual system.

关键词： bilateral effect brain glaucoma inflammation mirror effect optic nerve axotomy optic nerve crush retina spinal cord

Garlic:Medicinal Plant and Natural Aromatic Condiment

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Journal of Pharmacy and Pharmacology 2021年第12期9卷 414-419页

作者： Alexis Ruiz León regina de caridad Rodríguez muñoz Ana Elena Rodríguez Cadalso Luis Pablo Ibáñez Silva Eduardo RafaelÁguila Turiño Lesvia Leonides Rodríguez Galdó Úrsula Cristina Pomares Ortega General Hospital Tomás Carreras Galeano Unit Trinidad 62600Sanctis SpíritusCuba municipal University Center“Julio Antonio Mella”and Filial of Medical Sciences“Elena Fernández de Castro”Units Sanctis SpíritusCuba

Objective:To relate the presence of active metabolites with therapeutic effects of the Allium sativum L whose common name is Garlic,as well as its contraindications and adverse reactions and its use as ***:Searching about the topic in the last 5 years and present a general view of the Allium sativum L whose common name is ***:Technological prevision was based on the search of articles in the Virtual Library in Health(BVS)and using the key words“medicinal plants”/“spice”/Allium sativum L/garlic/adverse reactions and contraindications,and the association among them.

关键词： Medicinal plant Allium sativum L Garlic spice adverse reactions contraindications