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Islet amyloid polypeptide & amyloid beta peptide roles in Alzheimer’s disease:two triggers, one disease

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Neural Regeneration Research 2021年第6期16卷 1127-1130页

作者： Sofia Ferreira Ana F.Raimundo regina Menezes Ivo c.Martins iBET-Instituto de Biologia Experimental e Tecnológica OeirasPortugal cEDOc-chronic Diseases Research center Faculdade de Ciências MédicasUniversidade Nova de LisboaLisboaPortugal ITQB-NOVA Instituto de Tecnologia Química e Biológica António XavierUniversidade Nova de LisboaOeirasPortugal Instituto de Medicina Molecular Faculdade de MedicinaUniversidade de LisboaLisbonPortugal

Alzheimer’s disease(AD)is a neurodegenerative disorder that affects millions *** to population ageing,the incidence of AD is *** patients develop cognitive decline and dementia,features for which is known,requiring permanent *** poses a major socio-economic burden on healthcare systems as AD patients’relatives and healthcare workers are forced to cope with rising numbers of affected *** recent advances,AD pathological mechanisms are not fully ***,it is clear that the amyloid beta(Aβ)peptide,which forms amyloid plaques in AD patients’brains,plays a key *** 2 diabetes,the most common form of diabetes,affects hundreds of million people *** amyloid polypeptide(IAPP)is a hormone coproduced and secreted with insulin in pancreatic β-cells,with a key role in diabetes,as it helps regulate glucose levels and control adiposity and *** to Aβ,IAPP is very amyloidogenic,generating intracellular amyloid deposits that causeβ-cell dysfunction and *** is now clear that IAPP can also have a pathological role in AD,decreasing cognitive *** harms the blood-brain barrier,directly interacts and co-deposits with Aβ,promoting diabetes-associated *** can cause a metabolic dysfunction in the brain,leading to other diabetes-related forms of ***,here we discuss IAPP association with diabetes,Aβand dementia,in the context of what we designate a“diabetes brain phenotype”AD *** approach helps to set a conceptual framework for future IAPP-based drugs against AD.

关键词： aggregation Alzheimer amylin amyloid diabetes islet amyloid polypeptide

computer simulation of the coagulation of suspended solids——The applicability of the Müller–Smoluchowski theory

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Journal of Environmental Sciences 2016年第6期28卷 197-203页

作者： regina Wardzynska Beata Zaleska-chróst Department of chemistry University of Warmia and Mazury in Olsztyn

The results of studies carried out using a computer programme simulating the coagulation of suspensions containing spherical sol particles and spherical coagulant particles are *** influence of the degree of dispersion of the system on the coagulation reaction kinetics was investigated. The obtained results of kinetic studies were tested in the light of classical Müller–Smoluchowski equations. The influence of the physical properties of the coagulant,such as size, density and mass, on the coagulation rate was tested. It was found that within the range described in this paper, the rate of the simulated coagulation process fulfils both the kinetic equation of a first-order reaction, and the kinetic equation of a second-order *** the tested range, a significant influence of the mass and size of the coagulant on the coagulation rate was ascertained. The kinetic Müller–Smoluchowski dependence is fulfilled in a broader range of the degree of dispersion, when the coagulant particle mass and the sol particle mass are equal. When the particle mass increases with an increase in the particle radius, the coagulation rate increases faster that it would result from the Müller＇s dependence.

关键词： Aggregation computer simulation coagulation rate Sol

Nielsen coincidence theory on infra-solvmanifolds of Sol

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Science china Mathematics 2021年第8期64卷 1861-1884页

作者： Jong Bum Lee Karen regina Panzarin Department of Mathematics Sogang UniversitySeoul 121-742Korea Departamento de Matematica Universidade Federal de Sao CarlosSao CarlosSP 13565-905Brazil

We derive averaging formulas for the Lefschetz coincidence numbers,the Nielsen coincidence numbers and the Reidemeister coincidence numbers of maps on infra-solvmanifolds modeled on a connected and simply connected solvable Lie group of type(R).As an application,we compare our formula for the Nielsen coincidence numbers with a result of Jezierski(1992)for pairs of maps on some infra-solvmanifolds of *** all the pairs of self-maps of a nonorientable infra-solvmanifold of Sol,we determine the sets of all the possible values of the Nielsen coincidence numbers and the Reidemeister coincidence numbers.

关键词： averaging formula infra-solvmanifold Lefschetz coincidence number Nielsen coincidence number Reidemeister coincidence number Sol-geometry

Hydrogen Storage Performance During Underground Hydrogen Storage in Depleted Gas Reservoirs:A Review

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Engineering 2024年第9期40卷 211-225页

作者： Lingping Zeng regina Sander Yongqiang chen Quan Xie cSIRO Energy MelbourneVIC 3168Australia Hydrogen Industry Mission CSIROMelbourneVIC 3168Australia cSIRO Energy KensingtonWA 6151Australia Permanent carbon Locking Future Science Platform CSIRO EnergyKensingtonWA 6151Australia WA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityKensingtonWA 6151Australia

Hydrogen has emerged as a promising alternative to meet the growing demand for sustainable and renewable energy *** hydrogen storage(UHS)in depleted gas reservoirs holds significant potential for large-scale energy storage and the seamless integration of intermittent renewable energy sources,due to its capacity to address challenges associated with the intermittent nature of renewable energy sources,ensuring a steady and reliable energy *** the existing infrastructure and well-characterized geological formations,depleted gas reservoirs offer an attractive option for large-scale hydrogen storage ***,significant knowledge gaps regarding storage performance hinder the commercialization of UHS *** deliverability,hydrogen trapping,and the equation of state are key areas with limited *** literature review critically analyzes and synthesizes existing research on hydrogen storage performance during underground storage in depleted gas reservoirs;it then provides a high-level risk assessment and an overview of the techno-economics of *** significance of this review lies in its consolidation of current knowledge,highlighting unresolved issues and proposing areas for future *** these gaps will advance hydrogen-based energy systems and support the transition to a sustainable energy *** efficient and safe deployment of UHS in depleted gas reservoirs will assist in unlocking hydrogen’s full potential as a clean and renewable energy *** addition,this review aids policymakers and the scientific community in making informed decisions regarding hydrogen storage technologies.

关键词： Underground hydrogen storage Storage performance Hydrogen deliverability Hydrogen trapping Risk assessment Techno-economic analysis

Extract of codiaeum luzonicum Merr. overcomes multidrug resistance in human colon cancer cells by modulating P-glycoprotein

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Asian Pacific Journal of Tropical Biomedicine 2022年第9期12卷 400-410页

作者： regina Joyce E.Ferrer Marc Justin c.Ong Sonia D.Jacinto Institute of Biology University of the Philippines DilimanQuezon CityMetro ManilaPhilippines

Objective:To investigate anti-multidrug resistance(MDR)activity and safety of the bioactive fraction(cL11)from codiaeum luzonicum crude leaf ***:cytotoxic activity of cL11 against MDR and nonresistant colon cancer cells was assessed using MTT *** of cell death was investigated by annexin V-propidium iodide staining,TUNEL,and Jc-1 *** examine mechanism of action,the effect on the expression and function of the MDR-implicated protein P-glycoprotein was tested using Western blotting and calcein assay,***:cL11 had an Ec50 of 0.18,1.03 and 38.52µg/mL against HcT-15,HcT-15/Dox and HcT116,*** was mediated by inhibition of P-glycoprotein function and *** mode of cell death involved mitochondrial membrane depolarization and was mostly non-apoptotic at Ec50 concentrations against HcT-15 and HcT-15/***:Fraction cL11 of codiaeum luzonicum induces nonapoptotic cell death in MDR cancer cells by overcoming MDR through inhibition of P-glycoprotein expression and function.

关键词： Natural product Leaf extract codiaeum luzonicum MDR cancer P-gp inhibitor colorectal cancer

Human Rights as Placeholders

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Fudan Journal of the Humanities and Social Sciences 2015年第3期8卷 401-413页

作者： regina Kreide Institute of Political Science I Justus Liebig University Giessen Karl-Glockner Str. 21 E35394 Giessen Germany

Two prevailing ＂traditional＂ notions of human rights also cause the current skeptical mood concerning human rights. Either human rights are seen in a morally exaggerated way as ＂trump cards＂ in political negotiations, or they are pruned back to a purely juridical level, absorbed into legal instances that accord them at most the rank of constitutional rights. In contrast to this, the author defends a political conception of human rights that overcomes the problems besetting both conceptions, but without having to sacrifice their critical, normative content or a realistic role for human rights in international politics. A political conception of human rights assumes, the author argues firstly, that human rights grow out of concrete experiences of injustice and are the product of political struggles. Human rights are, secondly, placeholders for the public thematization of oppression, humiliation, marginalization, and despotism. A third characteristic feature of a political conception of human rights is that human rights raise claims to a rule system that permits access to the freedoms and resources formulated by human rights. And finally, the obligations imposed by human rights are not duties of assistance but institutional duties to realize the conditions for exercising human rights. Human rights, the author concludes, can be ＂used＂ by any person to criticize existing ordering structures and can be activated for political purposes directed to the common good.

关键词： Moral and legal human rights Self-determination criticism International politics

comparative study of polyhydroxyalkanoates production from acidified and anaerobically treated brewery wastewater using enriched mixed microbial culture

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Journal of Environmental Sciences 2019年第4期31卷 137-146页

作者： Pravesh Tamang Rintu Banerjee Stephan K?ster regina Nogueira Institute for Sanitary Engineering and Waste Management Leibniz Universitat Hannover Welfengarten 1D-30167 HannoverGermany Indian Institute of Technology Kharagpur Department of Agricultural and Food Engineering721302 KharagpurIndia

The production of polyhydroxyalkanoates(PHA) from wastewaters using microbial mixed cultures(MMc) has been attracting increased interest because of PHA's biodegradability characteristics. Production of PHA by an MMc enriched with PHA-accumulating bacteria was compared using anaerobically treated and acidified brewery wastewaters under various feeding strategies, namely pulse and batch feed addition. To obtain an enriched MMc, a sequencing batch reactor was inoculated with activated sludge fed with acetate and subjected to aerobic dynamic feeding. The enriched MMc was able to accumulate PHA up to 72.6% of cell dry weight(cDW) with pulse addition of acetate controlled by the dissolved oxygen(DO) concentration in the reactor. In a batch accumulation experiment with acetate,the PHA content achieved(28.5% cDW) was less than that of the pulse feeding strategy with the same amount of acetate(～2000 mg c/L). Using anaerobically treated and acidified brewery wastewater fed in pulses, the maximum PHA accumulated by the enriched MMc was similar for both wastewaters(45% cDW), in spite of the higher volatile fatty acid concentration in acidified brewery wastewater. The pulse feed addition controlled by the DO concentration was difficult to implement for wastewater as compared to acetate because the difference in DO concentration between substrate availability and depletion was low. For the batch addition of acidified wastewater, a slightly lower PHA content(39%cDW) was obtained. These results show that both brewery wastewaters can be utilized for PHA production with a similar maximum PHA storage capacity.

关键词： Polyhydroxyalkanoates PHA-accumulating bacteria Microbial mixed culture Brewery wastewater Aerobic dynamic feeding Pulse feeding and batch feeding

Promotional effects of Ru and Fe on Ni/ZrO_(2) catalyst during cO_(2) methanation:A comparative evaluation of the mechanism

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Journal of Energy chemistry 2023年第11期86卷 351-361,I0008页

作者： Jie Ren Feng Zeng chalachew Mebrahtu Zhandong Wang regina Palkovits Institute for Technical and Macromolecular chemistry RWTH Aachen UniversityWorringerweg 252074 AachenGermany Department of Thermal Science and Energy Engineering University of Science and Technology of ChinaHeifei 230026AnhuiChina State Key Laboratory of Materials-Oriented chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816JiangsuChina National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029AnhuiChina

Ni-based catalysts are widely investigated non-noble metal-based systems for cO_(2)***,their industrial application is still limited due to lower activity at low-temperature and catalyst *** a second metal such as Ru and Fe is considered as a successful strategy to overcome these challenges through alloy formation or the synergies provided by the interplay of two adjacent metallic ***,their promotional effect on the cO_(2)methanation mechanism under similar conditions has not been reported *** this work,Fe and Ru-promoted Ni/ZrO_(2)catalysts were investigated to evaluate their promotional effect on the *** Ni/Fe ratio was first optimized and a cO_(2)conversion rate of 37.7 mmolcO_(2)/(molNi+Fes)and 96.3%cH^(4)selectivity was obtained over the Ni_(0.8)Fe_(0.2)/ZrO_(2)*** comparison with Ni_(0.8)Fe_(0.2)/ZrO_(2),Ni_(0.8)Ru_(0.2)/ZrO_(2)prepared with the same composition showed higher activity and stability in cO_(2)*** results indicate alloys formation and H spillover for Ni_(0.8)Ru_(0.2)/ZrO_(2)to be responsible for ***,in situ DRIFTS studies evidenced the occurrence of both cO_(2)dissociative and associative pathways over Ni_(0.8)Ru_(0.2)/ZrO_(2)catalyst,while solely the cO_(2)associative pathway occurred for Ni_(0.8)Fe_(0.2)/ZrO_(2)

关键词： Ni-based catalyst Alloy formation H spillover cO_(2) methanation Methanation mechanism

Hepatocellular Tumors:Immunohistochemical Analyses for classification and Prognostication

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chinese Journal of cancer Research 2011年第4期23卷 245-253页

作者： regina cheuk-Lam Lo Irene Oi-Lin Ng Department of Pathology and State Key Laboratory for Liver Research The University of Hong Kong

Following the classification of hepatocellular nodules by the International Working Party in 1995 and further elaboration by the International consensus Group for Hepatocellular Neoplasia in 2009, entities under the spectrum of hepatocellular nodules have been better characterized. Research work hence has been done to answer questions such as distinguishing high-grade dysplastic nodules from early hepatocellular carcinoma (Hcc), delineating the tumor cell origin of Hcc, identifying its prognostic markers, and subtyping hepatocellular adenomas. As a result, a copious amount of data at immunohistochemical and molecular levels has emerged. A panel of immunohistochemical markers including glypican-3, heat shock protein 70 and glutamine synthetase has been found to be of use in the diagnosis of small, well differentiated hepatocellular tumors and particularly of Hcc. The use of liver fatty acid binding protein (L-FABP), β-catenin, glutamine synthetase, serum amyloid protein and c-reactive protein is found to be helpful in the subtyping of hepatocellular adenomas. The role of tissue biomarkers for prognostication in Hcc and the use of biomarkers in subclassifying Hcc based on tumor cell origin are also discussed.

关键词： Hepatocellular tumors Immunohistochemical classification