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Genes & Diseases 2024年第3期11卷 34-38页

作者： mj Mahesh Kumar Shailendra Arindkar Masum Saini Perumal Nagarajan National Institute of Immunology New Delhi 100067India Center for Cellular and Molecular Biology Hyderabad 500007India Regional Center for Biotechnology Faridabad 121001India

Non-alcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM)are two disease conditions for which obesity is a risk factor.^(1)Due to the close relationship between the three pathologies,researchers frequently use the same mouse models to identify the underlying processes of obesity,NAFLD,and *** instance,leptin(Lep)-null(ob/ob)and leptin receptor(Lepr)-deficient(db/db)mice spontaneously develop NAFLD and show different phenotypes of extreme obesity and diabetes,respectively.

关键词： obesity NAFLD Lep

Development of an experimental method for well-controlled blast induced traumatic limb fracture in rats

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Defence Technology（防务技术） 2024年第4期34卷 168-176页

作者： Luyang Xu Xiancheng Yu Clement DFavier Ibidumo Igah Thuy-Tien Nguyen Warren Macdonald Anthony mj.Bull Centre for Blast Injury Studies Imperial College LondonLondonUnited Kingdom Department of Bioengineering Imperial College LondonLondonUnited Kingdom Dyson School of Design Engineering Imperial College LondonLondonUnited Kingdom Department of Trauma and Orthopaedics Royal Free London National Health Service Foundation TrustLondonUnited Kingdom

Heterotopic ossification(HO)is a consequence of traumatic bone and tissue damage,which occurs in 65%of military casualties with blast-associated ***,the mechanisms behind blast-induced HO remain *** models are used to study blast-induced HO,but developing such models is challenging,particularly in how to use a pure blast wave(primary blast)to induce limb fracture that then requires an *** studies,including our recent study,have developed platforms to induce limb fractures in rats with blast loading or a mixture of blast and impact ***,these models are limited by the survivability of the animal and repeatability of the *** this study,we developed an improved platform,aiming to improve the animal's survivability and injury repeatability as well as focusing on primary blast *** platform exposed only one limb of the rat to a blast wave while providing proper protection to the rest of the rat's *** obtained very consistent fracture outcome in the tibia(location and pattern)in cadaveric rats with a large range of size and ***,the rats did not obviously move during the test,where movement is a potential cause of uncontrolled *** further conducted parametric studies by varying the features of the design of the *** factors,such as how the limb is fixed and how the cavity through which the limb is placed is sealed,significantly affect the resulting *** platform and test setups enable well-controlled limb fracture induced directly by pure blast wave,which is the fundamental step towards a complete in vivo animal model for blast-induced HO induced by primary blast alone,excluding secondary and tertiary blast *** addition,the platform design and the findings presented here,particularly regarding the proper protection of the animal,have implications for future studies investigating localized blast injuries,such as blast induced brain and lung injuries.

关键词： Blast injury Biomechanics Heterotopic ossification Limb fracture Blast wave Animal model

溶栓时间(入院到用药时间)的延迟及其对脑卒中治疗时间与预后的影响

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中华高血压杂志 2017年第4期25卷 328-328页

作者：刘莉叶鹏 Kamal N Sheng S Xian Y Matsouaka R Hill MD Bhatt DL Saver JL reeves mj Fonarow GC Schwamm LH Smith EE

尽管美国心脏协会/美国脑卒中协会关于脑卒中的治疗均提出了倡议,大量急性缺血性脑卒中患者仍然在到达就诊60min后才开始启动组织型纤溶酶原激活剂（阿替普酶）溶栓治疗。该研究旨在描述延迟的原因及其与患者预后之间的关系。

关键词：脑卒中治疗溶栓时间阿替普酶美国心脏协会溶栓适应证时间延迟颅内出血

非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系

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中华高血压杂志 2018年第2期26卷 118-118页

作者：刘青叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH reeves mj Hernandez AF Bhatt DL Peterson ED Fonarow GC

尽管非维生素K拮抗口服抗凝剂（non-vitamin K antagonist oral anticoagulants, NOACs）越来越多地应用于预防血栓栓塞性疾病，但关于NOACs相关性脑出血的数据仍然有限。

关键词：脑出血患者口服抗凝剂维生素K 住院死亡拮抗血栓栓塞性疾病相关性

Non-enzymatic methods for isolation of stromal vascular fraction and adipose-derived stem cells:A systematic review

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World Journal of Methodology 2024年第2期14卷 134-144页

作者： Vamsi Krishna Mundluru mj Naidu Ravi Teja Mundluru Naveen Jeyaraman Sathish Muthu Swaminathan Ramasubramanian Madhan Jeyaraman Department of Orthopaedics MJ Naidu Super Speciality HospitalVijayawada 520002Andhra PradeshIndia Department of Regenerative Medicine StemC ClinicsVijayawada 520002Andhra PradeshIndia Department of Orthopaedics ACS Medical College and HospitalDr.MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Orthopaedics Government Medical College and HospitalKarur 639004Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

BACKGROUND Adipose-derived stem cells(ADSCs)and the stromal vascular fraction(SVF)have garnered substantial interest in regenerative medicine due to their potential to treat a wide range of *** enzymatic methods for isolating these cells face challenges such as high costs,lengthy processing time,and regulatory *** This systematic review aimed to assess the efficacy and practicality of nonenzymatic,mechanical methods for isolating SVF and ADSCs,comparing these to conventional enzymatic *** Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines,a comprehensive literature search was conducted across multiple *** were selected based on inclusion criteria focused on non-enzymatic isolation methods for SVF and ADSCs from adipose *** risk of bias was assessed,and a qualitative synthesis of findings was performed due to the methodological heterogeneity of the included *** Nineteen studies met the inclusion criteria,highlighting various mechanical techniques such as centrifugation,vortexing,and ultrasonic *** review identified significant variability in cell yield and viability,and the integrity of isolated cells across different non-enzymatic methods compared to enzymatic *** some advantages of mechanical methods,including reduced processing time and avoidance of enzymatic reagents,the evidence suggests a need for optimization to match the cell quality and therapeutic efficacy achievable with enzymatic *** Non-enzymatic,mechanical methods offer a promising alternative to enzymatic isolation of SVF and ADSCs,potentially simplifying the isolation process and reducing regulatory ***,further research is necessary to standardize these techniques and ensure consistent,high-quality cell yields for clinical *** development of efficient,safe,and reproducible non-enzymatic isolation methods could signi

关键词： Adipose-derived stem cells Stromal vascular fraction Regenerative medicine Non-enzymatic isolation Mechanical separation techniques

Molecular mechanisms of *** associated gastric carcinogenesis

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World Journal of Gastroenterology 1999年第5期5卷 369-374页

作者： Zhang ZW Farthing mj St Bartholomew's & the Royal London School of Medicine & Dentistry 英国

ON SEVERAL NEW METHODS TO POLAR DECOMPOSITION COMPUTATION

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Acta Mechanica Solida Sinica 1998年第4期11卷 329-340页

作者： Huang, mj Li, M Fu, MF Nanchang Univ Inst Engn Mech Nanchang 330029 Peoples R China

In this paper, the polar decomposition of a deformation gradient tensor is analyzed in detail. The four new methods for polar decompositioncomputation are given: (1) the iterated method, (2) the principal invariant's method, (3) the principal rotation axis' s method, (4) the coordinate transformation's method. The iterated method makes it possible to establish the nonlinear finite element method based on polar decomposition. Furthermore, the material time derivatives of the stretch tensor and the rotation tensor are obtained by explicit and simple expressions.

关键词： polar decomposition deformation gradient stretch tensor rotation tensor large deformation and large rotation

Hip prosthetic loosening:A very personal review

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World Journal of Orthopedics 2021年第9期12卷 629-639页

作者： Bengt mjöberg Department of Orthopedics Lund UniversityLund SE-22100Sweden

Hip prosthetic loosening is often difficult to detect at an early stage,and there has been uncertainty for a long time as to when the loosening occurs and thus to the basic *** comparing different diagnostic methods,we found that loosening is best defined as prosthetic migration and measured by radiostereometric *** evidence indicates that poor interlock,poor bone quality,and resorption of a necrotic bone bed may initiate loosening during or shortly after surgery;this forms the basis of the theory of early *** factors do affect the subsequent progression of loosening,which may increase subclinically during a long period of ***,the loosening may be detected on standard radiographs and may be interpreted as late loosening but should to be interpreted as late detection of *** theory of early loosening explains the rapid early migration,the development of periprosthetic osteolysis and granulomas,the causality between wear and loosening,and largely the epidemiology of clinical failure of hip *** discussed are definition of loosening,the pattern of early migration,the choice of migration threshold,the current understanding of loosening,a less exothermic bone cement,cemented taper-slip stems,a new exciting computed tomography-based technique for simpler implant migration studies,and research suggestions.

关键词： Hip prosthesis Prosthesis failure Radiostereometric analysis Bone resorption Bone cements Radionuclide imaging

In Memorium John ***(1919-2002)

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Episodes 2003年第1期26卷 47-48页

作者： Gryc, G Terman, mj US Geol Survey MS 975 Menlo Pk CA 94025 USA US Geol Survey MS 917 Reston VA USA

Hip prosthetic loosening and periprosthetic osteolysis:A commentary

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World Journal of Orthopedics 2022年第6期13卷 574-577页

作者： Bengt mjöberg Department of Orthopedics Lund UniversityLund SE-22100Sweden

Prosthetic loosening and periprosthetic osteolysis have been debated for decades,both in terms of the timing and nature of the triggering *** hypothesis of wear-particle-induced loosening states that wear particles cause a foreign-body response leading to periprosthetic osteolysis and ultimately to late prosthetic loosening,i.e.,that the osteolysis precedes the *** theory of early loosening,on the other hand,postulates that the loosening is already initiated during or shortly after surgery,i.e.,that the osteolysis is secondary to the *** commentary focuses on the causal relationship between prosthetic loosening and periprosthetic osteolysis.

关键词： Hip prosthesis Radiostereometric analysis Prosthesis failure Osteoclasts Bone resorption Alarmins