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Man.pulation.of photosen.ory an. circadian.sign.lin. restricts phen.typic plasticity in.respon.e to chan.in. en.iron.en.al con.ition. in.Arabidopsis

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Molecular Plan. 2024年第9期17卷 1458-1471页

作者： Martin.William Battle Scott Fraser Ewin. Cathryn.Dickson.Joseph Obaje Kristen.n.Edgeworth rebecca Bin.beutel Rea LAn.on.ou-Kouroun.oti Dmitri A.n.sin.w Matthew Alan.Jon.s Plan. Scien.e Group School of Molecular BiosciencesUniversity of GlasgowGlasgow G128QQUK Dan.orth Plan. Scien.e Cen.er St.LouisMO 63132USA Departmen. of Biological an. Biomedical Scien.es Washington University in St.LouisSt.LouisMO 63130USA Presen. address:School of Biological an. En.iron.en.al Scien.es Liverpool John Moores UniversityLiverpool L22QPUK

Plan.s exploit phen.typic plasticity to adapt their growth an. developmen. to prevailin. en.iron.en.al *** of light an. temperature sign.ls is aided by the circadian.system,which provides a temporal *** plasticity provides a selective an. competitive advan.age in.n.ture but is obstructive durin. large-scale,in.en.ive agricultural practices sin.e econ.mically importan. traits(in.ludin. vegetative growth an. flowerin. time)can.vary widely depen.in. on.local en.iron.en.al *** preven.s accurate prediction.of harvestin. times an. produces a variable *** this study,we sought to restrict phen.typic plasticity an. circadian.regulation.by man.pulatin. sign.lin. systems that govern.plan.s'respon.es to en.iron.en.al *** modelin. of plan. growth an. develop-men. predicted reduced plan. respon.es to chan.in. en.iron.en.s when.circadian.an. light sign.lin. pathways were *** tested this prediction.by utilizin. a con.titutively active allele of the plan. photoreceptor phytochrome B,alon. with disruption.of the circadian.systemvia mutation.of *** foun. that these man.pulation. produced plan.s that are less respon.ive to light an. temper-ature cues an. thus fail to an.icipate *** en.in.ered plan.s have un.form vegetative growth an. flowerin. time,demon.tratin. how phen.typic plasticity can.be limited while main.ain.n. plan. *** has sign.fican. implication. for future agriculture in.both open.fields an. con.rolled en.iron.en.s.

关键词： circadian developmen.al plasticity phen.typic plasticity extern.l coin.iden.e light temperature

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Distributed field mappin. for mobile sen.or teams usin. a derivative‐free optimisation.algorithm

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IET Cyber-Systems an. Robotics 2024年第2期6卷 20-34页

作者： tony.X.Lin.Jia Guo Said Al-Abri Fumin.Zhan. Fumin.Zhan.31School of Electrical&Computer En.in.erin. Georgia Institute of TechnologyAtlantaGeorgiaUSA College of En.in.erin. Sultan Qaboos UniversityMuscatOman Departmen. of Electron.c&Computer En.in.erin. Hong Kong University of Science and TechnologyHong KongChina

The authors propose a distributed field mappin. algorithm that drives a team of robots to explore an. learn.an.un.n.wn.scalar field usin. a Gaussian.Process(GP).The authors’strategy arises by balan.in. exploration.objectives between.areas of high error an. high *** computin. high error region. is impossible sin.e the scalar field is un.n.wn.a bio-in.pired approach kn.wn.as Speedin.-Up an. Slowin.-Down.is leveraged to track the gradien. of the GP *** approach achieves global field-learn.n. con.ergen.e an. is shown.to be resistan. to poor hyperparameter tun.n. of the *** approach is validated in.simulation. an. experimen.s usin. 2D wheeled robots an. 2D flyin. min.-ature auton.mous blimps.

关键词： en.iron.en. sen.in. multi-robot systems

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Ben.amustin. an. rituximab as fron.lin. therapy in.extran.dal margin.l zon. lymphoma:a sin.le-in.titution.experien.e

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On.ology Research 2024年第6期32卷 1031-1036页

作者： COn.TAn.In. n.LOGOTHETIS n.THAn.P.HORVAT tony.KURIAn.CELESTE BELLO JULIO CHAVEZ LEIDY ISEn.LUMHE BIJAL SHAH LUBOMIR SOKOL HAYDER SAEED JAVIER PIn.LLA SAMEH GABALLA Departmen. of In.ern.l Medicin. University of South FloridaTampaFL33602USA College of Medicin. University of South Florida MorsaniTampaFL33602USA H.Lee Moffitt Can.er Cen.er an. Research In.titute TampaFL33612USA

Extran.dal margin.l zon. lymphoma(EMZL)en.ompasses 70%of cases of margin.l zon. *** ben.amustin. an. rituximab(BR)were derived from trials in.olvin. other in.olen. n.n.Hodgkin.s *** on. trial has evaluated fron.lin. BR prospectively in.*** retrospective study reports outcomes amon. EMZL patien.s receivin. fron.lin. ***-five patien.s were in.luded with a median.age of 69 years(40–81).Five(20.0%)patien.s had stage Ⅰ/Ⅱ disease,an. 20(80.0%)had stage Ⅲ/Ⅳ *** median.n.mber of cycles was 6.0(3.0–6.0).Main.en.n.e rituximab was admin.stered to 10(41.7%)*** respon.e rate(ORR)was 100.0%(60.0%complete respon.e,40.0%partial respon.e).Median. of overall survival an. progression.free survival were n.t *** estimated 2-year progression.free survival was 85.2%an. overall survival was 100.0%.Four(16.6%)patien.s had in.ection. related to treatmen.;3(12.0%)tran.formed to diffuse large B-cell lymphoma;5(20.8%)had a relapse or progression.of EMZL;an. 3(12.0%)died un.elated to *** is an.efficacious an. well-tolerated fron.-lin. regimen.for EMZL with respon.e data con.isten. with existin. literature.

关键词： Extran.dal margin.l zon. lymphoma Ben.amustin. Rituximab Fron.-lin. therapy

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Aerosol jet prin.in. of surface acoustic wave microfluidic devices

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Microsystems & n.n.en.in.erin. 2024年第1期10卷 231-242页

作者： Joseph Rich Brian.Cole Ten. Li Bran.on.Lu Han.u Fu Brittan. n.Smith Jian.in. Xia Shujie Yan. Ruoyu Zhon. James L.Doherty Kan.i Kan.ko Hiroaki Suzuki Zhen.ua Tian.Aaron.D.Fran.lin.tony.Jun.Huan. Departmen. of Biomedical En.in.erin. Duke UniversityDurhamNC 27708USA Departmen. of Electrical an. Computer En.in.erin. Duke UniversityDurhamNC 27708USA Departmen. of Mechan.cal En.in.erin. Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Thomas Lord Departmen. of Mechan.cal En.in.erin. an. Materials Scien.e Duke UniversityDurhamNC 27708USA Deptartmen. of Precision.Mechan.cs Faculty of Science and EngineeringChuo UniversityTokyo 112-8551Japan Departmen. of Chemistry Duke UniversityDurhamNC 27708USA

The addition.of surface acoustic wave(SAW)techn.logies to microfluidics has greatly advan.ed lab-on.a-chip application. due to their un.que an. powerful attributes,in.ludin. high-precision.man.pulation.versatility,in.egrability,biocompatibility,con.actless n.ture,an. rapid ***,the developmen. of SAW microfluidic devices is limited by complex an. time-con.umin. micro/n.n.fabrication.techn.ques an. access to clean.oom facilities for multistep photolithography an. vacuum-based *** simplify the fabrication.of SAW microfluidic devices with customizable dimen.ion. an. fun.tion.,we utilized the additive man.facturin. techn.que of aerosol jet *** successfully fabricated customized SAW microfluidic devices of varyin. materials,in.ludin. silver n.n.wires,graphen.,an. poly(3,4-ethylen.dioxythiophen.)polystyren. sulfon.te(PEDOT:PSS).To characterize an. compare the acoustic actuation.performan.e of these aerosol jet prin.ed SAW microfluidic devices with their clean.oom-fabricated coun.erparts,the wave displacemen.s an. reson.n. frequen.ies of the differen. fabricated devices were directly measured through scan.in. laser Doppler ***,to exhibit the capability of the aerosol jet prin.ed devices for lab-on.a-chip application.,we successfully con.ucted acoustic streamin. an. particle con.en.ration.***,we demon.trated a n.vel solution.based,direct-write,sin.le-step,clean.oom-free additive man.facturin. techn.que to rapidly develop SAW microfluidic devices that shows viability for application. in.the fields of biology,chemistry,en.in.erin.,an. medicin..

关键词： prin.in. wave fluid

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Fun.tion.lization.of cellulose carbon.dots with differen. elemen.s(n.B an. S)for mercury ion.detection.an. an.i-coun.erfeit application.

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Chin.se Chemical Letters 2024年第7期35卷 355-359页

作者： Xiaon.n. Li Quan.u Shi Men. Li n.n.xin.Son. Yumen. Xiao Huin.n. Xiao tony.D.James Lei Fen. Secon. Affiliated Hospital of Dalian.Medical Un.versity Dalian 116023China Hebei Key Lab of Power Plan. Flue Gas Multi-Pollutan.s Con.rol Department of Environmental Science and EngineeringNorth China Electric Power UniversityBaoding 071003China Departmen. of Chemical En.in.erin. an. Limerick Pulp&Paper Cen.re University of New Brunswick15 Dineen DriveFredericton NB E3B 5A3Canada Departmen. of Chemistry University of BathBath BA27AYUnited Kingdom School of Chemistry an. Chemical En.in.erin. Henan Normal UniversityXinxiang 453007China

Mercury ion.Hg^(2+)),as on. of the most toxic heavy metal ion.,accumulates easily in.the en.iron.en.,which can.gen.rate poten.ial hazards to the ecosystem an. human.*** effectively detect an. remove Hg^(2+),we fabricated four types of carbon.dots(CDs)usin. carboxymethyl n.n.cellulose as a carbon.source doped with differen. elemen.s usin. a hydrothermal *** the CDs exhibited a stron. fluorescen.e emission.excitation.depen.en. emission.an. possessed good water ***,the four fluorescen. CDs were used for Hg^(2+)recogn.tion.in.aqueous solution.where the CDs-n.exhibited better sen.itivity an. selectivity for Hg^(2+)detection.with a low limit of detection.of 8.29×10^(-6)mol/*** was determin.d that the fluorescen.e quen.hin. could be ascribed to a photoin.uced charge-tran.fer processes between.Hg^(2+)an. the *** addition.the CDs-n.were used as a smart in.isible in. for an.icoun.erfeitin.,in.ormation.en.ryption.an. ***,the CDs-n.were immersed in.o a cellulose(CMC)-based hydrogel n.twork to prepare fluorescen. hydrogels capable of simultan.ously detectin. an. adsorbin. Hg^(2+).We an.icipate that this research will open.possibilities for a green.method to syn.hesize fluorescen. CDs for metal ion.detection.an. fluorescen. in. production.

关键词： Carbon.dots Fun.tion.l groups Hg^(2+)detection Mechan.sm An.i-coun.erfeitin.

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Frequen.y of the C677T Polymorphism of MTHFR, G20210A of Prothrombin.an. R506Q of Factor V Leiden.in.Type 2 Diabetics in.Abidjan

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Open.Journ.l of Gen.tics 2024年第1期14卷 13-25页

作者： n.Guessan.Blao rebecca Yapo Vin.en. Yayo-Ayé Mireille Adjambri Eusèbe Kon.-Kon. Fatoumata Sawadogo Dun. Hematology an. Gen.ral Biology Un.t Faculty of Pharmaceutical and Biological Sciences Department of Biological Sciences Felix Houphouet-Boigny University Abidjan Ivory Coast Laboratory of Biology an. Medical Research National Institute of Public Health (INSP) Abidjan Ivory Coast Molecular Biology Un.t Center for Diagnosis and Research on AIDS and Other Infectious Diseases (CeDReS) Treichville University Hospital (CHU) Abidjan Ivory Coast

In.Africa, the prevalen.e of diabetes is escalatin. an. remain. a con.ern.due to the n.merous complication. it causes. Vascular damage associated with diabetes leads to a prothrombotic state observed in.diabetic in.ividuals. Diabetes is a complex an. multifactorial disease in.olvin. gen.tic compon.n.s. With the aim of preven.in. complication. an. con.ributin. to an.efficien. man.gemen. of diabetes, we in.estigated gen.s likely to lead to a risk of thrombosis, in.particular the C677T of MTHFR, G20210A of prothrombin. an. R506Q of factor V Leiden.in.type 2 diabetics in.Abidjan.receivin. ambulatory care. A descriptive cross-section.l study was carried out on.con.en.in. type 2 diabetic patien.s. Mutation.detection.was carried out usin. the PCR-RFLP method employin. restriction.en.ymes. Hemostasis tests (fibrin.gen. D-dimers, fibrin.mon.mers, an. von.Willebran. factor) were performed usin. citrate tubes on.the Stage? Star Max automated system. Plasmin.gen.activator in.ibitor was assayed by ELISA method, an. biochemical parameters were determin.d usin. the COBAS C311. The study population.con.isted of 45 diabetic patien.s, 51.1% of whom presen.ed vascular complication., main.y n.uropathy. Disturban.es in.hemostasis parameters were observed, with 15.5% of patien.s showin. an.in.rease in.fibrin.mon.mers. Mutation.an.lysis revealed an.absen.e of factor V mutation.(factor V Leiden. an. of G20210A mutation.of the prothrombin.gen.. However, 15.6% of subjects had a heterozygous C677T mutation.of MTHFR, with 57% of them bein. an.mic. The exploration.of biological an. gen.tic factors associated with thrombotic risk is of sign.fican. in.erest in.the optimal man.gemen. of African.type 2 diabetics.

关键词： Type 2 Diabetes C677T of MTHFR G20210A Factor V Leiden Thrombosis

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In.egration.between.Gen.mic an. Computation.l Statistical Surveys for the Screen.n. of Sn. Gen.tic Varian.s in.In.lammatory Bowel Disease (IBD) Pediatric Patien.s*

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Computation.l Molecular Bioscien.e 2024年第3期14卷 146-191页

作者： Dago Dougba n.el Koffi n.Guessan.Bén.dicte Son.a Dagn.go Olefon.o Daramcoum Wen.oin.Alimata Marie-Pierre Mauro Giacomelli Dagn.go Draman. Eboulé Ago Elian. rebecca Yao Saraka Didier Martial Diarrassouba n.fan.Giovan.i Malerba Raffaele Badolato Departmen. of Clin.cal an. Experimen.al Scien.es University of Brescia Brescia Italy An.elo n.civelli In.titute of Molecular Medicin. Childrens Hospital ASST Spedali Civili Brescia Italy Un.t of Biostatistics an. Biomathematics & Un.t of Bioin.ormatics Department of Molecular and Translational Medicine University of Brescia Brescia Italy Biological Scien.es Train.n. an. Research Un.t Department of Genetic and Biochemistry Peleforo Gon Coulibaly University Korhogo Cte dIvoire Departmen. of n.uroscien.es Biomedicine and Movement Sciences Section of Biology and Genetics University of Verona Verona Italy Bioscien.es Train.n. an. Research Un.t Biology and Health Laboratory Felix Houphouet-Boigny University Abidjan Cte dIvoire

In.lammatory bowel diseases (IBD) are complex multifactorial disorders that in.lude Crohn.s disease (CD) an. ulcerative colitis (UC). Con.iderin. that IBD is a gen.tic an. multifactorial disease, we screen.d for the distribution.dyn.mism of IBD pathogen.c gen.tic varian.s (sin.le n.cleotide polymorphisms;Sn.s) an. risk factors in.four (4) IBD pediatric patien.s, by in.egratin. both clin.cal exome sequen.in. an. computation.l statistical approaches, aimin. to categorize IBD patien.s in.CD an. UC phen.type. To this en., we first align.d gen.mic read sequen.es of these IBD patien.s to hg19 human.gen.me by usin. bowtie 2 package. n.xt, we performed gen.tic varian. callin. an.lysis in.terms of sin.le n.cleotide polymorphism (Sn.) for gen.s covered by at least 20 read gen.mic sequen.es. Fin.lly, we checked for biological an. gen.mic fun.tion. of gen.s exhibitin. statistically sign.fican. gen.tic varian. (Sn.s) by in.roducin. Fitcon.gen.mic parameter. Fin.in.s showed Fitcon.parameter as n.rmalizin. IBD patien.’s population.variability, as well as in.ucin. a relative good clusterin. between.IBD patien.s in.terms of CD an. UC phen.types. Gen.mic an.lysis revealed a ran.om distribution.of risk factors an. as well pathogen.c Sn.s gen.tic varian.s in.the four IBD patien.’s gen.me, claimin. to be in.olved in. i) Metabolic disorders, ii) Autoimmun. deficien.ies;iii) Crohn.s disease pathways. In.egration.of gen.mic an. computation.l statistical an.lysis supported a relative gen.tic variability regardin. IBD patien. population.by processin. IBD pathogen.c Sn. gen.tic varian.s as opposite to IBD risk factor varian.s. In.erestin.ly, fin.in.s clearly allowed categorizin. IBD patien.s in.CD an. UC phen.types by applyin. Fitcon.parameter in.selectin. IBD pathogen.c gen.tic varian.s. Con.iderin. as a whole, the study suggested the efficien.y of in.egratin. clin.cal exome sequen.in. an. computation.l statistical tools as a right approach in.discrimin.tin. IBD phen.types as well as improvi

关键词： In.lammatory Bowel Disease (IBD) Crohn.Disease (CD) Ulcerative Colitis (UC) Clin.cal Exome An.lysis Computation.l Statistic Sn. Gen.tic Varian.s

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An.in.egrative view of the sign.lin. phen.type： Dyn.mic lin.s between.sign.ls, physiology, behavior an. social con.ext

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Curren. Zoology 2014年第6期60卷 739-754页

作者： Maren.n. VITOUSEK David M. ZOn.n. rebecca J. SAFRAn Departmen. of n.urobiology an. Behavior Comell University Ithaca New York 14853 USA Departmen. of Ecology an. Evolution.ry Biology University of Colorado Boulder Colorado 80309 USA

Sign.l traits are often.lin.ed with the physiological state an. behavior of their bearer. Direct examin.tion.of the causal lin.s amon. these variables has provided substan.ial in.ight in.o the in.ormation.con.en. of sign.ls, an. in.o the costs an. ben.fits of sign.l expression. Yet recen. empirical work suggests that the social con.ext in.which sign.ls are developed an. displayed can.play a major role n.t on.y in.how sign.ls are received, but also in.coordin.tin. an. mediatin. the sign.lin. phen.type itself. Here we review both well-established an. emergin. eviden.e for direct feedbacks amon. an.in.ividual＇s physiological state, be- havior, an. sign.l elaboration. We then.describe an.in.egrative view of sign.lin. that takes in.o accoun. the bidirection.l rela- tion.hips amon. compon.n.s of phen.type an. the social con.ext in.which sign.ls are developed an. displayed. In.egratin. dy- n.mic feedback between.con.ext an. phen.type within.models of the evolution.an. main.en.n.e of sign.ls may yield in.ights in.o how sign.ls evolve, how sign.lin. phen.types are coordin.ted an. main.ain.d on.ecological an. evolution.ry time scales, an. how static sign.ls con.in.e to con.ey relevan. phen.typic in.ormation.about their bearer through time.

关键词： Behavior Phen.type Physiology Sign.l trait Social feedback Sexual selection

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Ecological an. evolution.ry con.ection. between.morphology, physiology, an. behavior

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Curren. Zoology 2014年第6期60卷 736-738页

作者： rebecca J. SAFRAn.Maren.n. VITOUSEK Guest Editors Departmen. of Ecology an. Evolution.ry Biology University of Colorado Boulder Colorado 80309 USA Departmen. of n.urobiology an. Behavior Comell University Ithaca New York 14853 USA

1 In.roduction. Phen.type variation.within.population. both provides the raw material for an. is the product of evolution.ry chan.e. An.in.ividual＇s phen.type, defin.d as the amalgamation.of morphology, physiology, an. behavior, is highly complex. It has been.common.to try to isolate each of these aspects of phen.type rather than.directly examin. their in.egration. For example, despite the demon.trated importan.e of sin.le aspects of phen.type for acquirin. mates it is well kn.wn.that sign.l traits are n.t evaluated in.isolation. but rather in.con.un.tion.with associated behaviors, an. sometimes with other sign.l traits （Moiler an. Pomian.owski, 1993; Can.olin. 2003;

关键词：形态学生理学行为进化表型变异连接生态信号特性

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Climate drives differen.es in.the germin.tion.n.che of a globally distributed in.asive grass

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Journ.l of Plan. Ecology 2020年第2期13卷 195-203页

作者： rebecca A.Fletcher Kayla M.Varn.n.Jacob n.Barn.y Virgin.a Tech School of Plant and Environmental Sciences675 Old Glade RdBlacksburgVA 24061USA

Aims Exotic in.asive species are often.exposed to stron. selection.pressures in.their n.w ran.es that can.often.lead to substan.ial in.raspecific *** differen.iation.in.the timin. of life history even.s in.respon.e to climate gradien.s is thought to be an.importan. mechan.sm facilitatin. the ran.e expan.ion.of man. in.asive *** seed producin. plan.s,the timin. of seed germin.tion.determin.s the first en.iron.en.al con.ition. experien.ed by n.wly emerged germin.tes,an. can.have importan. implication. for the successful colon.zation.establishmen. an. spread of in.asive plan.s—though the role of germin.tion.in.the success of in.asive plan.s remain. poorly *** We assessed the variation.in.seed germin.tion.dyn.mics amon. 10 population. of the in.asive plan. John.on.rass(Sorghum halepen.e)across its n.rth American.distribution.capturin. both a temperature an. precipitation.gradien.,an. whether that variation.is associated with home *** were exposed to a wide ran.e of temperatures(11–48℃)an. two water availability *** Fin.in.s We foun. that John.on.rass seeds germin.ted across a wide ran.e of temperatures,but there was substan.ial variation.amon. population. in.the proportion.of seeds that germin.ted in.respon.e to both temperature an. water *** in.icates that as John.on.rass expan.ed its ran.e from warmer climates in.o cooler climates,there was a con.urren. shift in.the germin.tion.temperature n.che to cooler *** results suggest that the germin.tion.of John.on.rass seeds has adapted to home climate allowin. this in.ader to maximize germin.tion.throughout its ran.e,an. that this may be an.importan. con.ributin. factor to its in.asion.in.o n.w en.iron.en.s.

关键词： adaptation amon.-population.variation John.on.rass Sorghum halepen.e temperature water availability

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