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No evidence for enzootic plague within black-tailed prairie dog(Cynomys ludovicianus)populations

Integrative Zoology 2021年第6期16卷 834-851页

作者： rebecca e.colman R.Jory BRINKeRHOFF Joseph D.BUSCH Chris RAY Adina DOYLe Jason W.SAHL Paul KeIM Sharon K.COLLINGe David M.WAGNeR Pathogen and Microbiome Institute Northern Arizona UniversityFlagstaffArizonaUSA environmental Studies Program University of Colorado at BoulderBoulderColoradoUSA

Yersinia pestis,causative agent of plague,occurs throughout the western United States in rodent populations and periodically causes epizootics in susceptible species,including black-tailed prairie dogs(Cynomys ludovicianus).How *** persists long-term in the environment between these epizootics is poorly understood but multiple mechanisms have been proposed,including,among others,a separate enzootic transmission cycle that maintains *** without involvement of epizootic hosts and persistence of *** within epizootic host populations without causing high mortality within those *** live-trapped and collected fleas from black-tailed prairie dogs and other mammal species from sites with and without black-tailed prairie dogs in 2004 and 2005 and tested all fleas for presence of *** was not detected in 2126 fleas collected in 2004 but was detected in 294 fleas collected from multiple sites in 2005,before and during a widespread epizootic that drastically reduced black-tailed prairie dog populations in the affected *** and spatial patterns of *** occurrence in fleas and genotyping of *** present in some infected fleas suggest *** was introduced multiple times from sources outside the study area and once introduced,was dispersed between several *** conclude *** likely was not present in these black-tailed prairie dog colonies prior to epizootic activity in these *** we did not identify likely enzootic hosts,we found evidence that deer mice(Peromyscus maniculatus)may serve as bridging hosts for *** between unknown enzootic hosts and black-tailed prairie dogs.

关键词： black-tailed prairie dog Cynomys ludovicianus plague prairie dogs Yersinia pestis

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《晚期癌症患者呼吸困难处理:美国临床肿瘤学会指南》解读

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协和医学杂志 2024年第1期15卷 52-57页

作者：贾之萌 colman rebecca 宁晓红哈佛大学医学院全球健康与社会医学系美国马萨诸塞州波士顿市MA 02138 多伦多西奈山医院Temmy Latner姑息关怀中心加拿大多伦多市M5S 2E8 多伦多大学家庭与社区医学系加拿大多伦多市M5S 2E8 多伦多大学大学健康网络医学系加拿大多伦多市M5S 2E8 中国医学科学院北京协和医院老年医学科北京100730 中国医学科学院北京协和医院缓和医学中心北京100730

呼吸困难是一种自觉症状,其给晚期癌症患者带来了巨大痛苦。有效评估和处理晚期癌症患者的呼吸困难是一线临床医生和专业护理人员应具备的核心能力,中国目前尚缺乏此方面的规范处理流程。基于循证医学证据,美国临床肿瘤学会发布了“晚... 详细信息

呼吸困难是一种自觉症状,其给晚期癌症患者带来了巨大痛苦。有效评估和处理晚期癌症患者的呼吸困难是一线临床医生和专业护理人员应具备的核心能力,中国目前尚缺乏此方面的规范处理流程。基于循证医学证据,美国临床肿瘤学会发布了“晚期癌症呼吸困难处理实践指南”,该指南针对晚期癌症患者给出了呼吸困难评估和分级处理策略。本文结合中国国情,旨在对该指南中的关键内容进行详细解读,以期为中国的临床实践提供指导和借鉴。

关键词：晚期癌症呼吸困难缓和医疗指南解读

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Insights into kidney stem cell development and regeneration using zebrafish

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World Journal of Stem Cells 2016年第2期8卷 22-31页

作者： Bridgette e Drummond rebecca A Wingert Department of Biological Sciences Center for Zebrafish ResearchCenter for Stem Cells and Regenerative MedicineUniversity of Notre Dame

Kidney disease is an escalating global health problem,for which the formulation of therapeutic approaches using stem cells has received increasing research *** complexity of kidney anatomy and function,which includes the diversity of renal cell types,poses formidable challenges in the identification of methods to generate replacement *** work using the zebrafish has revealed their high capacity to regenerate the integral working units of the kidney,known as nephrons,following acute ***,we discuss these findings and explore the ways that zebrafish can be further utilized to gain a deeper molecular appreciation of renal stem cell biology,which may uncover important clues for regenerative medicine.

关键词： Kidney Renal stem cell Renal progenitor Regeneration Nephron Blood filter Renal corpuscle Tubule

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Calcium carbonate-associated milk-alkali syndrome as a cause of altered mental status in the emergency department:a case report

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World Journal of emergency Medicine 2024年第6期15卷 499-501页

作者： rebecca Leff Bo e.Madsen Department of emergency Medicine Mayo ClinicRochester 55905USA

Hypercalcemic crises as a result of milk-alkali syndrome(MAS)are an uncommon cause of altered mental status and acute renal failure in the emergency *** it is uncommonly reported in the emergency medicine literature,emergency physicians should be aware of this syndrome due to significant morbidity and mortality if left undiagnosed.

关键词： mortality acute alkali

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Renal progenitors: Roles in kidney disease and regeneration

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World Journal of Stem Cells 2016年第11期8卷 367-375页

作者： Brooke e Chambers rebecca A Wingert Department of Biological Sciences Center for Zebrafish Research Center for Stem Cells and Regenerative Medicine University of Notre Dame

Kidney disease is a devastating condition that affects millions of people worldwide, and its prevalence predicted to significantly increase. The kidney is complex organ encompassing many diverse cell type organized in a elaborate tissue architecture, makin regeneration a challenging feat. In recent years, there ha been a surge in the field of stem cell research to develo regenerative therapies for various organ systems. Here we review some recent progressions in characterizing th role of renal progenitors in development, regeneration and kidney disease in mammals. We also discuss how the zebrafish provides a unique experimental anima model that can provide a greater molecular and genet understanding of renal progenitors, which may contribut to the development of potential regenerative therapies fo human renal afflictions.

关键词： Kidney Renal progenitor Nephrogenesis Development Nephron Regeneration Zebrafish Parietal epithelial cell Tubular progenitor cell

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Asymmetric reinforcement in Lucania killifish:assessing reproductive isolation when both sexes choose

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Current Zoology 2021年第2期67卷 215-224页

作者： Michelle e.ST.JOHN rebecca C.FULLeR School of Integrative Biology University of liois Urbana-ChampaignChampaignIL 61820USA

Reinforcement can occur when maladaptive hybridization in sympatry favors the evolution of con-specific preferences and target traits that promote behav ioral isolation(BI).In many systems,enhanced BI is due to increased female preference for *** others,BI is driven by male preference,and in other systems both sexes exert *** of these patterns can be atributed to classic sex-specific costs and benefits of ***,sex differences in conspecific preference can emerge due to asymmetric postzygotic isolation(e.g.,hybrid offspring from female A × male B have lower fitness than hybrid offspring from female B × male A),which can lead to asymmetric BI(e.g.,female A and male B are less likely to mate than female B and male A).Understanding reinforcement requires understanding how conspecific preferences evolve in ***,estimating conspecific preferences can be difficult when both sexes are *** this study,we use Lucania killifish to test the hypothesis that patterns of reinforcement are driven by asymmetric postzygotic isolation between *** true,we predicted that sympatric female Lucania goodei and sympatric male *** should have lower levels of BI compared with their sympatric counterparts,as they produce hybrid offspring with the highest *** address the problem of measuring BI when both sexes are choosy,we inferred the contribution to BI of each partner using assays where one sex in the mating pair comes from an allopatric population with potentially low preference,whereas the other comes from a sympatric population with high *** one hybrid cross direction,we found that both female *** and male *** have high contributions to BI in *** the other hybrid cross direction,we found that only female *** contribute to *** male *** readily engaged in hybrid spawnings with allo-patric *** *** results indicate that both asymmetric postzygotic isolation

关键词： reinforcement behavioral isolatin female mate choice male mate choice asymmetric costs to hybridization

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Rice:Reducing arsenic content by controlling water irrigation

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Journal of environmental Sciences 2015年第4期27卷 129-131页

作者： Ashley M.Newbigging rebecca e.Paliwoda X.Chris Le University of Alberta

Arsenic has long been recognized as a *** in water supplies that are used for both drinking and crop irrigation can expose many people chronically to elevated levels of arsenic.

关键词： Arsenic Cadmium Rice Food Water irrigation Metal contamination

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From micro-to macroevolution:brood parasitism as a driver of phenotypic diversity in birds

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Current Zoology 2020年第5期66卷 515-526页

作者： Iliana Medina rebecca M.Kilner Naomi e.Langmore School of BioSciences University of MelbourneVictoria3010Australia Department of Zoology University of CambridgeCambridgeCB23EJUK Division of ecology and evolution Australian National UniversityCanberraACT 2600Australia

A fun dame ntal question in biology is how diversity evolves and why some clades are more diverse than *** diversity has often been shown to result from morphological adaptation to different *** role of behavioral interactions as a driver of broadscale phenotypic diversity has received comparatively less *** interactions,however,are a key agent of natural *** behavioral interactions with predators or with parasites can have significant fitness consequences,and hence act as strong evolutionary forces on the phe no type of species,ultimately gen erating diversity betwee n species of both victims and *** obligate brood parasites lay their eggs in the nests of other species,their hosts,and this behavioral interaction between hosts and parasites is often considered one of the best examples of coevolution in the natural *** this review,we use the coevolution between brood parasites and their hosts to illustrate the potential of behavioral interactions to drive evolution of phenotypic diversity at different taxonomic *** provide a bridge between behavioral ecology and macroevolution by describing how this interaction has increased avian phenotypic diversity not only in the brood parasitic clades but also in their hosts.

关键词： brood parasitism coevolution diversity phenotypic variation macroevolution

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Benefits and risks associated with consumption of Great Lakes fish containing omega-3 fatty acids and polychlorinated biphenyls(PCBs)

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Journal of environmental Sciences 2016年第3期28卷 1-5页

作者： rebecca e.Paliwoda Ashley M.Newbigging Zhixin Wang X.Chris Le Department of Chemistry University of Alberta Division of Analytical and environmental Toxicology Department of Laboratory Medicine and PathologyUniversity of Alberta

Introduction Assessment of environmental health effects arising from exposure to multiple substances is often very *** is particularly true when humans are exposed to a mixture that contains both beneficial and harmfu... 详细信息

关键词： environmental epidemiology Polychlorinated biphenyls(PCBs) Omega-3 fatty acids Thyroid cancer Dietary exposure Food contamination New York fishermen

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Fetal vs adult mesenchymal stem cells achieve greater gene expression, but less osteoinduction

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World Journal of Stem Cells 2015年第1期7卷 223-234页

作者： Juan e Santiago-Torres rebecca Lovasz Alicia L Bertone Comparative Orthopedic Research Laboratory Department of Veterinary Clinical Sciences College of Veterinary Medicine The Ohio State University Columbus OH 43210 United States College of Medicine The Ohio State University Columbus OH 43210 United States

AIM: To investigate adenoviral transduction in mesenchymal stem cells(MSCs) and effects on stemness in vitro and function as a cell therapy in ***: Bone marrow-derived adult and fetal MSC were isolated from an equine source and expanded in monolayer tissue culture. Polyethylenimine(PeI)-mediated transfection of pc DNA3-e GFP or adenoviral transduction of green fluorescent protein(GFP) was evaluated in fetal MSCs. Adenoviral-mediated transduction was chosen for subsequent experiments. All experiments were carried out at least in triplicate unless otherwise noted. Outcome assessment was obtained by flow cytometry or immunohystochemistry and included transduction efficiency, cell viability, stemness(i.e., cell proliferation, osteogenic and chondrogenic cell differentiation), and quantification of GFP expression. Fetal and adult MSCs were then transduced with an adenoviral vector containing the gene for the bone morphogenic protein 2(BMP2). In vitro BMP2 expression was assessed by enzyme linked immunosorbent assay. In addition, MSC-mediated gene delivery of BMP2 was evaluated in vivo in an osteoinduction nude mouse quadriceps model. New bone formation was evaluated by microradiography and ***: PeI provided greater transfection and viability in fetal MSCs than other commercial chemical reagents. Adenoviral transduction efficiency was superior to PeI-mediated transfection of GFP in fetal MSCs(81.3% ± 1.3% vs 35.0% ± 1.6%, P enoviral transduction provided significantly greater expression of GFP in fetal than adult MSCs(7.4 ± 0.1 vs 4.4 ± 0.3 millions of mean fluorescence intensity units, P ell as significantly greater in vitro BMP2 expression(0.16 pg/cell-day vs 0.10 pg/cell-day, P etal MSC GFP positive cells decreased significantly faster than adult MSCs(1.15% ± 0.05% vs 11.4% ± 2.1% GFP positive at 2 wk post-transduction, P ell proliferation and osteo

关键词： Mesenchymal stem cells Biomarkers Next generation sequencing Diagnostic tool Tumor-initiating cells

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