Renal progenitors: Roles in kidney disease and regeneration
Renal progenitors: Roles in kidney disease and regeneration作者机构：Department of Biological Sciences Center for Zebrafish Research Center for Stem Cells and Regenerative Medicine University of Notre Dame
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2016年第8卷第11期
页 面：367-375页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：Supported by National Institutes of Health,No.DP2 OD008470 the University of Notre Dame College of Science and Graduate School a generous donation to support stem cell research provided by the Gallagher Family
主 题：Kidney Renal progenitor Nephrogenesis Development Nephron Regeneration Zebrafish Parietal epithelial cell Tubular progenitor cell
摘 要：Kidney disease is a devastating condition that affects millions of people worldwide, and its prevalence predicted to significantly increase. The kidney is complex organ encompassing many diverse cell type organized in a elaborate tissue architecture, makin regeneration a challenging feat. In recent years, there ha been a surge in the field of stem cell research to develo regenerative therapies for various organ systems. Here we review some recent progressions in characterizing th role of renal progenitors in development, regeneration and kidney disease in mammals. We also discuss how the zebrafish provides a unique experimental anima model that can provide a greater molecular and genet understanding of renal progenitors, which may contribut to the development of potential regenerative therapies fo human renal afflictions.
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