检索结果-南通市图书馆

Metabolic pathways as possible therapeutic targets for progressive multiple sclerosis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第8期12卷 1262-1267页

作者： rebecca M.Heidker mitchell R.Emerson Steven M.Le Vine Department of Molecular and Integrative Physiology University of Kansas Medical Center Department of Pharmaceutical Sciences College of Pharmacy-Glendale Midwestern University

Unlike relapsing remitting multiple sclerosis, there are very few therapeutic options for patients with progressive forms of multiple sclerosis. While immune mechanisms are key participants in the pathogenesis of relapsing remitting multiple sclerosis, the mechanisms underlying the development of progressive multiple sclerosis are less well understood. Putative mechanisms behind progressive multiple sclerosis have been put forth： insufficient energy production via mitochondrial dysfunction, activated microglia, iron accumulation, oxidative stress, activated astrocytes, Wallerian degeneration, apoptosis, etc. Furthermore, repair processes such as remyelination are incomplete. Experimental therapies that strive to improve metabolism within neurons and glia, e.g., oligodendrocytes, could act to counter inadequate energy supplies and/or support remyelination. Most experimental approaches have been examined as standalone interventions; however, it is apparent that the biochemical steps being targeted are part of larger pathways, which are further intertwined with other metabolic pathways. Thus, the potential benefits of a tested intervention, or of an established therapy, e.g., ocrelizumab, could be undermined by constraints on upstream and/or downstream steps. If correct, then this argues for a more comprehensive, multifaceted approach to therapy. Here we review experimental approaches to support neuronal and glial metabolism, and/or promote remyelination, which may have potential to lessen or delay progressive multiple sclerosis.

关键词： acetyl-coenzyme A carboxylase biotin estrogen iron Kynurenine pathway mitochondria thyroidhormone remyelination stem cells vitamin D

Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第4期13卷 1429-1437页

作者： Kamila Butowska Xuexiang Han Ningqiang Gong Rakan El-Mayta rebecca MHaley Lulu Xue Wenqun Zhong Wei Guo Karin Wang Michael J.mitchell Department of Bioengineering University of PennsylvaniaPhiladelphiaPA 19104USA Intercollegiate Faculty of Biotechnology University of Gdańsk&Medical University of GdańskGdańsk 80-307Poland Department of Biology University of PennsylvaniaPhiladelphiaPA 19104USA Department of Bioengineering Temple UniversityPhiladelphiaPA 19122USA Abramson Cancer Center Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Institute for Immunology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Cardiovascular Institute Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Institute for Regenerative Medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

Evasion of apoptosis is a hallmark of cancer,attributed in part to overexpression of the antiapoptotic protein B-cell lymphoma 2(Bcl-2).In a variety of cancer types,including lymphoma,Bcl-2 is *** targeting of Bcl-2 has demonstrated efficacy in the clinic and is the subject of extensive clinical testing in combination with ***,the development of co-delivery systems for Bcl-2 targeting agents,such as small interfering RNA(siRNA),and chemotherapeutics,such as doxorubicin(DOX),holds promise for enabling combination cancer *** nanoparticles(LNPs)are a clinically advanced nucleic acid delivery system with a compact structure suitable for siRNA encapsulation and *** by ongoing clinical trials of albumin-hitchhiking doxorubicin prodrugs,here we developed a DOX-siRNA co-delivery strategy via conjugation of doxorubicin to the surface of siRNAloaded *** optimized LNPs enabled potent knockdown of Bcl-2 and efficient delivery of DOX into the nucleus of Burkitts'lymphoma(Raji)cells,leading to effective inhibition of tumor growth in a mouse model of *** on these results,our LNPs may provide a platform for the co-delivery of various nucleic acids and DOX for the development of new combination cancer therapies.

关键词： Lipid nanoparticles Doxorubicin Bcl-2 siRNA delivery Chemotherapy Lymphoma

Assessing adequacy of emergency provider documentation among interhospital transferred patients with acute aortic dissection

在线全文

学校读者我要写书评

暂无评论

World Journal of Emergency Medicine 2019年第2期10卷 94-100页

作者： Mark Rose Carina Newton Benchaa Boualam Nancy Bogne Adam Ketchum Umang Shah Jordan mitchell Safura Tanveer Tucker Lurie Walesia Robinson rebecca Duncan Stephen Thom Quincy Khoi Tran Department of Emergency Medicine University of Maryland School of Medicine University of Maryland at College Park University of Maryland School of Medicine Program of Trauma The R Adams Cowley Shock Trauma Center University of Maryland School of Medicine

BACKGROUND: Acute aortic dissection(AoD) is a hypertensive emergency often requiring the transfer of patients to higher care hospitals; thus, clinical care documentation and compliance with the Emergency Medical Treatment and Active Labor Act(EMTALA) is crucial. The study assessed emergency providers(EP) documentation of clinical care and EMTALA compliance among interhospital transferred AoD ***: This retrospective study examined adult patients transferred directly from a referring emergency department(ED) to a quaternary academic center between January 1, 2011 and September 30, 2015. The primary outcome was the percentage of records with adequate documentation of clinical care(ADoCC). The secondary outcome was the percentage of records with adequate documentation of EMTALA compliance(ADoEMTALA). RESULTS: There were 563 electronically identified patients with 287 included in the final analysis. One hundred and five(36.6%) patients had ADoCC while 166(57.8%) patients had ADoEMTALA. Patients with inadequate documentation of EMTALA(IDoEMTALA) were associated with a higher likelihood of not meeting the American Heart Association(AHA) ED Departure SBP guideline(OR 1.8, 95% CI 1.03–3.2, P=0.04). Male gender, handwritten type of documentation, and transport by air were associated with an increased risk of inadequate documentation of clinical care(IDoCC), while receiving continuous infusion was associated with higher risk of ***: Documentation of clinical care and EMTALA compliance by Emergency Providers is poor. Inadequate EMTALA documentation was associated with a higher likelihood of patients not meeting the AHA ED Departure SBP guideline. Therefore, Emergency Providers should thoroughly document clinical care and EMTALA compliance among this critically ill group before transfer.

关键词： Acute aortic dissection EMTALA Interhospital transfer Documentation Compliance

The "five senses of success" in nursing students: Assessing first-year support engagement

在线全文

学校读者我要写书评

暂无评论

International Journal of Nursing Sciences 2019年第3期6卷 322-328页

作者： Peta-Anne Zimmerman rebecca Eaton Lynne Brown Valda Frommolt Creina mitchell Elizabeth Elder Frances Lin School of Nursing and Midwifery Griffith UniversitySouthportAustralia Gold Coast Hospital and Health Service Australia Menzies Health Institute Queensland Griffith UniversityAustralia LaTrobe University MelbourneAustralia

Objectives: This study aimed to identify School and University support services available and accessed by nursing students transitioning into a university environment as many struggle to adjust to competing demands of personal commitments and expectations at ***: A mixed methods design was used,based on activity theory and Lizzio's Five Senses of Success frameworks as exploratory *** study was conducted amongst the first year cohort at one campus of the Bachelor of Nursing (BN) program in Queensland,*** initial baseline assessment of what University and School-based support services were on offer for students,and how the students interacted with the support services was *** was followed by a survey to identify awareness and access to support *** groups were then conducted to clarify the previous results and to determine engagement with these support ***: A randomly selected number of students (n =150) in the first-year 2014 cohort of the BN program (n =300) were included in this *** survey was completed by 54 students and three semistructured focus groups were *** analysis indicated that the support services in place were successful in reaching the majority of students and contributed to their sense of success at university,Specifically students identified that a whole cohort approach to support enhanced their transition to ***: Identifying lesser known services early in the first year will ensure that students are supported and encouraged to use all services,contributing to their sense of success at university.

关键词： Engagement First year experience Nursing student Supports Retention University transition