MELD score,insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease

作     者：Rebecca Mitchell Jill McDermid Mang M Ma Constance L Chik 

作者机构：Divisions of Endocrinology and MetabolismDepartment of MedicineFaculty of Medicine and DentistryUniversity of AlbertaEdmontonAB T6G 2S2AlbertaCanada Division of GastroenterologyDepartment of MedicineFaculty of Medicine and DentistryUniversity of AlbertaEdmontonAB T6G 2S2AlbertaCanada 

出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)

年 卷 期：2011年第3卷第6期

页      面：157-163页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the Transplant Program of the University of Alberta Hospital 

主　　题：Hepatic osteodystrophy Insulin-like growth factor-1 Cytokines Bone mineral density MELD score 

摘      要：AIM:To determine the contributions of insulin-like growth factor 1 (IGF-1),cytokines and liver disease severity to bone mineral density in patients ***:Serum IGF-1,tumor necrosis factor-α (TNFα) and interleukin 6 (IL-6) were measured and the Model for End-Stage Liver Disease (MELD) score calculated in 121 adult patients referred to a single centre for liver *** mineral density (BMD) of the lumbar spine and femoral neck were assessed via dual energy X-ray ***,liver disease etiology,medication use and relevant biochemistry were ***:A total of 117 subjects were included,with low BMD seen in 68.6%,irrespective of disease *** multivariable analysis,low body mass index (BMI),increased bone turnover and low IGF-1 were independent predictors of low spinal bone *** the hip,BMI,IGF-1 and vitamin D status were *** prevalent elevations of TNFα and IL-6,levels did not correlate with degree of bone *** MELD score failed to predict low BMD in this pre-transplant ***:Osteopenia/osteoporosis is common in advanced liver *** serum IGF-1 is weakly predictive but serum cytokine and MELD score fail to predict the severity of bone disease.