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国际医学放射学杂志 2024年第5期 626页

作者： A.pons-Escoda A.garcia-Ruiz p.Naval-Baudin I.Martinez-Zalacain J.Castell A.Camins 高博聪

目的术前鉴别星形细胞瘤和少突胶质细胞瘤仍是神经肿瘤学尚未解决的难题。研究旨在深入观察2种肿瘤动态磁敏感对比增强-灌注加权成像（DSC-pWI）特点，评估

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一项关于缺血性卒中患者-148C/T纤维蛋白原基因多态性和纤维蛋白原水平的病例对照研究

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世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 21-21页

作者： Van Goor M.-L.p.J. Gómez-garcia E.B. Leebeek F.W.G. 高中宝 M.-L. p.J. Van Goor Erasmus MC Rotterdam Department of Neurology PO Box 2040 3000 CA Rotterdam Netherlands Dr.

Background: To determine whether -148 C/T fibrinogen gene promoter polymorp hism increases stroke risk by modifying the fibrinogen level. Design: A case-c ontrol study of patients with first ever ischaemic stroke, confirmed by computed tomography. Methods: Venous blood samples were collected for fibrinogen and rou tine coagulation tests one week after the stroke, and after three months in abou t half the patients. population controls were age and sex matched. -148 G/T fi brinogen polymorphism was determinedly polymerase chain reaction followed by dig estion with restriction enzymes HindIII/Alul. Results: There were 124 patients a nd 125 controls, mean age 56 years (range 18 to 75); 34 patients (27% ) and 41 controls (33% ) were heterozygous for -148 C/T fibrinogen polymorphism, six p atients (5% ) and five controls (4% ) had the T/T genotype. The odds ratio of ischaemic stroke associated with CC homozygotes v T carriers was 0.8 (95% conf idence interval, 0.5 to 1.4). Relative risk for ischaemic stroke associated with fibrinogen levels in the highest quartile was 3.9 (1.9 to 8;4) at one week, dec reasing to 1.4 (0.6 to 3.3) at three months. Conclusions: -148 C/T fibrinogen gene polymorphism was not a strong risk factor for ischaemic stroke. High fibrin ogen levels early after acute stroke probably represent an acute phase response.

关键词：缺血性卒中基因多态性病例对照研究急性卒中凝血试验急性期静脉血标本基因表型杂合子纯合子

Evidence of a J/ψΛstructure and observation of excited■^(-)states in the■b^(-)→J/ψΛK^(-) decay

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Science Bulletin 2021年第13期66卷 1278-1287,M0003页

作者： R.Aaij C.Abellán Beteta T.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala S.Aiola Z.Ajaltouni S.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov p.Alvarez Cartelle S.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier S.Bachmann M.Bachmayer J.J.Back S.Baker p.Baladron Rodriguez V.Balagura W.Baldini J.Baptista Leite R.J.Barlow S.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter V.Belavin S.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko S.Bhasin J.Bhom L.Bian M.S.Bieker S.Bifani p.Billoir M.Birch F.C.R.Bishop A.Bizzeti M.Bj┆rn M.p.Blago T.Blake F.Blanc S.Blusk D.Bobulska J.A.Boelhauve O.Boente garcia T.Boettcher A.Boldyrev A.Bondar N.Bondar S.Borghi M.Borisyak M.Borsato J.T.Borsuk S.A.Bouchiba T.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley S.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Bursche A.Butkevich J.S.Butter J.Buytaert W.Byczynski S.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz S.Cali R.Calladine M.Calvi M.Calvo Gomez p.Camargo Magalhaes A.Camboni p.Campana A.F.Campoverde Quezada S.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli p.Carniti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero S.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen S.Chen A.Chernov S.-G.Chitic V.Chobanova S.Cholak M.Chrzaszcz A.Chubykin V.Chulikov p.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek p.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu p.Collins T.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa Sobral B.Couturier D.C.Craik J.Crkovská M.Cruz Torres R.Currie C.L.Da Silva E.Dall’ Centro Brasileiro de pesquisas Físicas(CBpF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy physics Tsinghua UniversityBeijingChina School of physics State Key Laboratory of Nuclear physics and Technology Peking UniversityBeijingChina University of Chinese Academy of Sciences BeijingChina Institute Of High Energy physics(IHEp) BeijingChina Institute of particle physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Universitéparis-Saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-ringuet(llr) PalaiseauFrance LpNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät physik Technische Universität DortmundDortmundGermany Max-planck-Institut für Kernphysik(MpIK) HeidelbergGermany physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany School of physics University College DublinDublinIreland INFN Sezione di Bari BariItaly INFN Sezione di Bologna BolognaItaly INFN Sezione di Ferrara FerraraItaly INFN Sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN Sezione di Genova GenovaItaly INFN Sezione di Milano-Bicocca MilanoItaly INFN Sezione di Milano MilanoItaly INFN Sezione di Cagliari MonserratoItaly Universita degli Studi di padova Universita e INFNPadovaPadovaItaly INFN Sezione di pisa PisaItaly INFN Sezione di Roma Tor Vergata RomaItaly INFN Sezione di Roma La Sapienza RomaItaly Nikhef National Institute for Subatomic physics AmsterdamNetherlands Nikhef National Institute for Subatomic physics and VU University Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear physics polish Academy of Sciences KrakówPoland AGH-University of Science and Techno

First evidence of a structure in the J/ψΛinvariant mass distribution is obtained from an amplitude analysis of■b^(-)J/ψΛK^(-)*** observed structure is consistent with being due to a charmonium pentaquark with strangeness with a significance of 3.1r including systematic uncertainties and lookelsewhere *** mass and width are determined to be 4458:8±2:9t4:7-1:1 MeV and 17:3±6:5t8:0-5:7 MeV,respectively,where the quoted uncertainties are statistical and *** structure is also consistent with being due to two *** addition,the narrow excited■^(-)states,N■(1690)and■(1820),are seen for the first time in a■b^(-)decay,and their masses and widths are measured with improved *** analysis is performed using pp collision data corresponding to a total integrated luminosity of 9 fb^(-1),collected with the LHCb experiment at centre-of-mass energies of 7,8 and 13 TeV.

关键词： QCD Exotics pentaquark Spectroscopy Quarkonium particle and resonance production

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医院小丑在儿科症状管理中的效果

英国医学杂志中文版 2021年第10期24卷 606-608页

作者： Lufs Carlos Lopes-Junior Emiliana Bomfim Karin Olson Eliane Tatsch Neves Denise Sayuri Calheiros Silveira Michelle Darezzo Rodrigues Nunes Lucila Castanheira Nascimento Gabriela pereira-da-Silva Regina Aparccida garcia Lima 蔡思雨(译) 彭晓霞(校) Federal University of Espirito Santo Avenida Marechai CampusES.Brazil University of Saskatchewan College of Medicine.SaskatoonSKCanada University of Alberta EdmontonABCanada Federal University of Santa Maria Santa Maria.RSBrazil Federal Institute of Espirito Santo LinharesESBrazil Rio de Janeiro State University Rio de Janeiro.RJ.Brazil University of Sao paulo at Ribeirao prelo College of Nursing SPBrazil 国家儿童医学中心首都医科大学附属北京儿童医院临床流行病学与循证医学中心

目的基于随机对照试验和非随机对照试验产生的证据,在因急慢性疾病住院的儿童和青少年中,评价医院小丑对一系列症状群的干预效果。研究设计基于随机和非随机对照试验的系统综述。数据来源美国国立医学图书馆(MEDLINE).美国科学情报研究... 详细信息

目的基于随机对照试验和非随机对照试验产生的证据,在因急慢性疾病住院的儿童和青少年中,评价医院小丑对一系列症状群的干预效果。研究设计基于随机和非随机对照试验的系统综述。数据来源美国国立医学图书馆(MEDLINE).美国科学情报研究所数据库(ISI of Knowledge).考科蓝对照试验注册中心(Cochrane Cental Registerof Controled Trials)、Science Diret全文数据库、Sopus数据库、美国心理协会数据库(American psychalogical Association peyeINFO)、护理和健康文献累积指数数据库(Curmulative Index to Nursing and Alied Heauth Literature),以及拉丁美洲和加勒比健康科学文献数据库(Lain Ameriean and Caribbean Health Sciences Literature)。研究筛选经間行评议后筛选随机和非随机对照试脸,纳人标准如下:因急性或慢性疾病人院的儿童和青少年,比较医院小丑与标准护理的研究,此外研究将医院小丑对住院儿童和青少年症状管理的影响作为主要结局指标。数据提取与整合由两名研究者独立完成研究筛选,数据摘录,以及偏倚风险评价。方法学评价也由两名研究者独立进行,评价工具有:Jadnd量表、随机对照试验的偏倚风险评估工具(RoB 2)和非随机对照试验的偏倚风险评估工具(ROBINS-I)。结果24项研究(n=1612)符合纳入标准,对其进行数据摘录和分析。大多数研究是随机对照试验(n=13)。最常分析的症状是焦虑(n=13),其次是疼痛(n=9)、心理和情绪反应以及幸福感(n=4)、压力(n=4)、癌症相关疲劳(n-3)和哭泣(n=2)。5项研究使用生物标志物(主要为皮质醇)来评估医院小丑对压力或疲劳的影响。方法学评价显示,大多数随机对照试验(n=11;85%)存在潜在偏倚风险,2项试验具有高度偏倚风险。ROBINS-I评价结果显示,大多数非随机对照试验(n=6;55%)存在中度偏倚风险。研究表明,无论父母是否在场,医院小丑出现时,儿童和青少年在一系列医疗程序中的焦虑显著降低,心理调节也得到改善(ppC0.05)。结论这些研究表明,在医疗程序术前诱导麻醉,以及慢性病常规护理中进行医院小丑干预,可能是症状管理的有效策略。此外,与接受标准护理的患儿相比,医院小丑干预可能有助于改善患有急慢性疾病的儿童和青少年的心理健康状态。

关键词：急慢性疾病方法学评价慢性病患者心理健康状态诱导麻醉症状群情报研究所文献数据库

吡嗪酰胺与利福平联合治疗HIV(-)结核感染的安全性

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结核与肺部疾病杂志 2005年第3期8卷 96-100页

作者： C. Tortajada J. Martinez-Lacasa F. Snchez A. Jimnez-Fuentes M. L. De Souza J. F. garcia J. A. Martinez J. A. Cayl 马玙 Departmento de Epidemiologia Agenda de Salut Publica de Barcelona Barcelona Departmento de Medicina Interna Hospital Mutua de Terrassa Terrassa Barcelona Departmento de Epidemiologia Agenda de Salut Publica de Barcelona Barcelona Departmento de Medicina Interna Hospital del Mar Barcelona Unitat de Control i prevencio de Tuberculosis Barcelona Departmento de Medicina Interna Hospital A. Marcide-Profesor Novoa Santos EI Ferrol La Coruna Departmento de Enfermedades Infecciosas Hospital Clinic Universitari Barcelona Spain

背景:西班牙四个城市9 家公共卫生治疗中心。目的:比较2 个月利福平+吡嗪酰胺(2RZ)与6 个月异烟肼(6H)治疗潜伏结核感染(LTBI),评估其效益及安全性。设计:对传染性肺结核病人的HIV(-)接触者进行多中心的前瞻性随机比较研究。结果:352 ... 详细信息

背景:西班牙四个城市9 家公共卫生治疗中心。目的:比较2 个月利福平+吡嗪酰胺(2RZ)与6 个月异烟肼(6H)治疗潜伏结核感染(LTBI),评估其效益及安全性。设计:对传染性肺结核病人的HIV(-)接触者进行多中心的前瞻性随机比较研究。结果:352 例中接受6H 者199 例,2RZ 者153 例;6H 组及2RZ 组治疗完成率各为73%及71%(p=0.73)。因肝毒性反应(AST 或ALT>5 倍正常上限值(ULN))而中断治疗者,2RZ 组为10%,6H 组为2.5%(p=0.007)。2RZ 组肝毒性反应高于期望发生率,因而未到期即终止了研究。停止治疗后肝功能均恢复正常。结论是RZ 方案只应用于不适用其它治疗方案者,且需有强化观察肝功能的条件。

关键词：潜伏结核感染 HIV血清学阴性肝毒性反应异烟肼利福平吡嗪酰胺潜伏结核感染联合治疗吡嗪酰胺安全性利福平前瞻性随机比较研究毒性反应肺结核病人正常上限值

Approach to paroxysmal Atrial Fibrillation Type Arrhythmia in a Cardiology Service:A Case Report

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Modern Research in Inflammation 2020年第2期9卷 9-17页

作者： Miriam Viviane Baron Luis Manuel Ley Dominguez Carolina paz Mohamad Isa Gabriela Di Lorenzo garcia Scherer Michele paula dos Santos Vitoria pereira Itaquy Talia Guimaraes dos Santos Julia Braga da Silveira paulo Ricardo Martins Amanda Correa dos Santos Marcus Vinicius de Mello pinto Janine Koepp Daiana Klein Weber Carissimi Joice Nedel Ott Carolina Goncalves pinheiro Nathalia Ken pereira Iketani Gabriela Feltez Bartira Ercília pinheiro da Costa postgraduate program in Medicine and Health Sciences of the pontifical Catholic University of Rio Grande do Sul(pUC/RS) Porto AlegreBrazil Improvement of Higher Education personnel Brazil(CAPES)Distrito FederalBrazil School of Medicine of the pontifical Catholic University of Rio Grande do Sul(pUC/RS) Porto AlegreBrazil School of Health and Life Sciences of the pontifical Catholic University of Rio Grande do Sul(pUC/RS) Porto AlegreBrazil Celulare Institute PetrópolisBrazil Undergraduate Nursing Course of the University of Santa Cruz do Sul(UNISC) Santa Cruz do SulBrazil postgraduate program in Health Sciences of the Faculty of Medicine of ABC(FMABC) Sao PauloBrazil Undergraduate physiotherapy Course of the Vale do Salgado Faculty(FVS) CearáBrazil physiotherapy of the Hospital Beneficiente portuguesa of Belém ParáBrazil Rehabilitation Sciences of the Federal University of Health Sciences of porto Alegre Porto AlegreBrazil postgraduate program in Medicine and Health Sciences School of Medicine of the Pontifical Catholic University of Rio Grande do Sul(PUC/RS)Porto AlegreBrazil

Atrial fibrillation is a cardiac arrhythmia of high prevalence in the population, especially in the elderly. Its main electrical characteristics are the interval between two successive irregular R waves, absence of p waves and presence of f waves between QRS complexes. The most common symptoms of atrial fibrillation are irregular palpitations associated with dyspnea, dizziness, feeling tired, fatigue and general malaise, but not all patients have any symptoms. The present report presents the history of an elderly patient who arrived at the hospital’s emergency department with irregular heart rhythm and palpitations. The patient’s symptoms, associated with the electrocardiogram results, indicated paroxysmal atrial fibrillation. Electrical cardioversion was performed, and after, cardiac ablation via the femoral vein at the hospital’s cardiology service. There were no complications during the procedure. As a routine imaging exam after ablation, control esophagogastroduodenoscopy was requested to verify that there was no formation of atrio-esophageal fistula developed by the invasive ablation procedure and electrocardiogram, which showed normal sinus rhythm. The patient remained in the cardiac intensive care unit for observation for 24 hours. After the electrical cardioversion and catheter ablation procedures, the patient improved his clinical picture of atrial fibrillation and was discharged after 24 hours of hospitalization. He received treatment to perform at home, to reduce acid reflux into the esophagus and to prevent thrombosis. He did not present pulmonary thromboembolism after hospital discharge. It is believed, therefore, that this form of treatment and management of paroxysmal atrial fibrillation is effective for the solution of the proposed problem and can also serve as a reference for other professionals within the cardiology service.

关键词： Atrial Fibrillation Electrical Cardioversion Catheter Ablation Hypertension Obstructive Sleep Apnea Syndrome

非增强CT预测阴性结石病人输尿管结石的发生

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国际医学放射学杂志 2012年第6期 604-604页

作者： A.Ciudin M.p.Luque Galvez R.Salvador Izquierdo A.Franco de Castro E.garcia-Cruz J.Alcover García 赵阳 Urology Department Hospital Clínic BarcelonaCalle Villarroel 17008036 BarcelonaSpain

目的确定非增强CT(uCT)能否在肾结石形成前发现肾乳头内的钙沉积。方法回顾性分析413例结石病例,确定其中31例有输尿管结石病史且uCT可显示结石,而在结石形成前的uCT检查无阳性发现的病人(结石正在成形组)。设立对照组(31例),由无结石... 详细信息

目的确定非增强CT(uCT)能否在肾结石形成前发现肾乳头内的钙沉积。方法回顾性分析413例结石病例,确定其中31例有输尿管结石病史且uCT可显示结石,而在结石形成前的uCT检查无阳性发现的病人(结石正在成形组)。设立对照组(31例),由无结石病史且uCT检查无阳性发现的活体肾捐献者组成。所有CT检查中,在肾乳头尖端和相邻区均使用两个大小分别为0.05cm2和0.1cm2的兴趣区进行CT衰减测量。两组间的统计学对照采用t检验及配对t检验。结果结石正在成形组肾乳头顶部的CT衰减较高,与对照组对比的结果为45.2HU:32.1HU,p=0.001,结石正在成形组的肾乳头顶部的CT衰减甚至高于已形成结石的病例,其结果显示为44.2HU:32.1HU,p=0.003。而肾乳头的衰减在结石形成前组和已形成结石组没有显著差别(45.2HU:44.2HU,p=0.82)。结论即使在结石形成前,结石正在成形期的病人肾乳头显示更高的密度。此结果可帮助诊断那些正处于结石形成过程中的高危人群。

关键词：结石病肾结石肾钙斑 CT平扫肾乳头

儿科心脏体外生命支持存活者健康相关生存质量

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中国小儿急救医学 2014年第10期21卷 670-670页

作者： garcia Guerra G Robertson CM Alton GY 方伯梁首都医科大学附属北京儿童医院

目的评估接受心脏体外生命支持(extracorporeal life support,ECLS)患儿的健康相关生存质量(health-related quality of life,HRQL)。我们猜测ECLS存活者HRQL评分低于健康患儿、慢性病患儿及行先天性心脏病手术但未行ECLS的患儿。设计... 详细信息

目的评估接受心脏体外生命支持(extracorporeal life support,ECLS)患儿的健康相关生存质量(health-related quality of life,HRQL)。我们猜测ECLS存活者HRQL评分低于健康患儿、慢性病患儿及行先天性心脏病手术但未行ECLS的患儿。设计前瞻性队列研究。场所斯托勒里儿童医院及复杂儿科治疗方法随访计划门诊。研究对象1999年至2009年于斯托勒里儿童医院接受ECLS的5岁及5岁以下心脏病(先天性或获得性)患儿。干预无。测量方法采用pedsQLTM4.0普适性核心量表评估HRQL,量表由患儿家长在随访时完成。主要结果 47例心脏ECLS幸存者中位HRQL评估年龄为4岁。相比于健康患儿,接受静-动脉ECLS患儿pedsQLTM显著降低(64.9 vs 82.2,ppedsQLTM评分亦显著低于慢性病患儿(64.9 vs 73.1,p=0.007)。与在婴儿早期行先天性心脏病手术且未行ECLS患儿相比,ECLS存活者pedsQLTM评分明显较低(64.9 vs 81.1,ppedsQLTM评分和ECLS后首个24 h内高变力评分及住院时间延长独立相关。结论儿科心脏ECLS存活者HRQL评分低于健康患儿、慢性病患儿及未行ECLS的先天性心脏病患儿。

关键词：体外膜肺儿科重症监护生存质量心脏病预后研究

Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

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Journal of Geriatric Cardiology 2021年第1期18卷 20-29页

作者： Juan Martínez-Milla Marcelino Cortés García Julia Anna palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-pelaéz JoséTuñón Department of Cardiology Hospital Universitario Fundación Jiménez Díaz-Quirónsalud Centro Nacional de Investigaciones Cardiovasculares MadridSpain Department of Cardiology Hospital Central de Asturias Department of Cardiology Hospital Universitario Ruber-Quirónsalud Department of Cardiology Hospital Universitario Infanta Leonor Department of Endocrinology Hospital Clínico San Carlos Universidad Autónoma de Madrid CIBERCV MadridSpain

OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 *** AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^*** analyzed the relationship between treatment with BB and mortality or cardiovascular *** mean age of our population was 82.6±4.1 *** ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,andper 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving *** median follow-up was28.04(IR:19.41-36.67)*** the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;ppatients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,pper 1.73 m^2;HR=0.55,95%CI:0.26-1.06,p=0.007),and stages IV and V(GFRper 1.73 m~2;HR=0.29,95%CI:0.11-0.76;p=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better *** of BB should be encouraged when possible.

关键词： CKD GFR Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher E.Mason Department of physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced pattern Analysis&Human performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative pCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIp)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIp in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight