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Oviductal epithelial cells selected boar sperm according to their functional characteristics

Asian Journal of Andrology 2017年第4期19卷 396-403页

作者： rebeca lepez-ubeda Francisco A Garcia-Vazquez Joaquin Gadea Carmen Matas Department of Physiology Veterinary Faculty University of Murcia International Excellence Campus for Higher Education and Research (Campus Mare Nostrum) Murcia 30100 Spain IMIB-Arrixaca (Institute for Biomedical Research of Murcia) Murcia Spain

The interaction of oviductal epithelial cells （OECs） with the spermatozoa has beneficial effects on the sperm functions. The aim of this study is to evaluate the in vitro fertilizing capacity of incubating spermatozoa previously selected by density gradient in OEC and determinate some sperm characteristics that could explain the results obtained. In this study, we assessed in vitro fertilization （IVF）, tyrosine phosphorylation, phosphatidylserine translocation, nuclear DNA fragmentation, and chromatin decondensation. Three experimental sperm groups, previously selected by Percoll gradient, were established according to the origin of the sperm used for IVF：（i） W30 group： spermatozoa were incubated with oocytes in the absence of OEC; （ii） NB group： after sperm incubation in OEC, the unbound spermatozoa were incubated with oocytes, in the absence of OEC; and （iii） B group： after sperm incubation with OEC, the bound spermatozoa were incubated with oocytes in the OEC plates. The results showed that sperm from the NB group led to a lower IVF yield, accompanied by low penetration rates （NB： 19.6%, B： 94.9%, and W30： 62.9%; P 〈 0.001） and problems of nuclear decondensation. Moreover, higher levels of tyrosine phosphorylation were observed in the NB group compared with the W30 and B groups （NB： 58.7%, B： 2.5%, and W30： 4.5%; P 〈 0.01）. A similar trend was observed in phosphatidylserine translocation （NB： 93.7%, B. 5.7%, and W30： 44.2%; P 〈 0.01）. These results demonstrate that the OEC exerts a rigorous degree of sperm selection, even within an already highly selected population of spermatozoa, and can capture the best functional spermatozoa for fertilization.

关键词： DNA status in vitro fertilization oviductal epithelial cells phosphatidylserine translocation sperm selection tyrosinephosphorylation

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Immunometabolic bases of type 2 diabetes in the severity of COVID- 19

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World Journal of Diabetes 2021年第7期12卷 1026-1041页

作者： rebeca Viurcos-Sanabria Galileo Escobedo Research Division Hospital General de MéxicoMexico City 06720Mexico Laboratorio de Proteómica Dirección de InvestigaciónHospital General de Mexico“Dr.Eduardo Liceaga”Mexico City 06720Mexico

The outbreak of coronavirus disease 2019(COVID-19)is caused by the novel severe acute respiratory syndrome coronavirus-2(SARS-CoV-2).COVID-19 and type 2 diabetes(T2D)have now merged into an ongoing global syndemic that is threatening the lives of millions of people around the *** this reason,there is a deep need to understand the immunometabolic bases of the main etiological factors of T2D that affect the severity of ***,we discuss how hyperglycemia contributes to the cytokine storm commonly associated with COVID-19 by stimulating monocytes and macrophages to produce interleukin IL-1β,IL-6,and TNF-αin the airway *** main mechanisms through which hyperglycemia promotes reactive oxygen species release,inhibition of T cell activation,and neutrophil extracellular traps in the lungs of patients with severe SARS-CoV-2 infection are also *** further examine the molecular mechanisms by which proinflammatory cytokines induce insulin resistance,and their deleterious effects on pancreaticβ-cell exhaustion in T2D patients critically ill with *** address the effect of excess glucose on advanced glycation end product(AGE)formation and the role of AGEs in perpetuating pneumonia and acute respiratory distress ***,we discuss the contribution of preexisting endothelial dysfunction secondary to diabetes in the development of neutrophil trafficking,vascular leaking,and thrombotic events in patients with severe SARS-CoV-2 *** we outline here,T2D acts in synergy with SARSCoV-2 infection to increase the progression,severity,and mortality of *** think a better understanding of the T2D-related immunometabolic factors that contribute to exacerbate the severity of COVID-19 will improve our ability to identify patients with high mortality risk and prevent adverse outcomes.

关键词： COVID-19 SARS-CoV-2 Type 2 diabetes Inflammation Hyperglycemia Prothrombotic state

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Efficacy of the vaccination in inflammatory bowel disease

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World Journal of Gastroenterology 2013年第9期19卷 1349-1353页

作者： Elisa Carrera rebeca Manzano Elena Garrido Department of Gastroenterology University Hospital of Guadalajara 19002 Guadalajara Spain Department of Gastroenterology Sureste Hospital Arganda 28500 Madrid Spain Inflammatory Bowel Disease Clinic Department of Gastroenterology University Hospital Ramón y Cajal 28034 Madrid Spain

Inflammatory bowel disease (IBD) is associated with conditions that may predispose to infections, such as the lack of an appropriate innate immune response to infectious agents, malnutrition, surgery, and immunosuppressive and biological drugs. Some of these infections may be preventable by vaccination. Therefore, for this particular patient population, the benefits of implementing a well-established immunization protocol in daily clinical practice are potentially even greater than for the general population. In recent years international consensus guidelines have been published, but in spite of theses recommendations, studies have shown that a significant number of patients with IBD remain inadequately immunized. Another important issue regarding immunization in this population is that vaccine efficacy among patients receiving immunosuppressive therapies has been variable. In a healthy population, a humoral immune response to hepatitis B vaccination (HBV) is expected in > 90%, whereas a much lower rate is achieved in the IBD patients. Immunosuppressive, anti-tumor necrosis factor therapy and disease activity have been implicated in the impaired efficacy of the vaccination. The serological response to HBV should be confirmed and patients with an inadequate response should receive a second full series of vaccine. Modified dosing regimens, including doubling the standard antigen dose, might increase the effectiveness. Response to influenza, pneumococcal and tetanus immunization is still not clear, as there are studies that show a normal response to the vaccination while others demonstrate a lack of efficacy. We pose a series of questions on the efficacy of the different vaccinations recommended for IBD patients and attempt to answer them using scientific evidence.

关键词： Vaccination Efficacy Infections Immunization Inflammatory bowel disease Immunosuppressive medications Hepatitis B vaccines Influenza vaccines Pneumococcal vaccines Tetanus vaccines

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Analyzing the Impact of Eco-innovation on Carbon Emissions: A Comparative Anaysis between Oecd and Brics Countries

Analyzing the Impact of Eco-innovation on Carbon Emissions: ...

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作者： rebeca Nasolwa Mkumbo 江苏大学

学位级别：硕士

考虑到当前与气候变化、能源和其他服务以及生态系统相关的环境和资源问题,国内和国际层面的机构和政策制定者必须提倡当代大多数资源利用领域以及与生态系统联系的领域显著的改变。本研究旨在评估生态创新对经合组织和金砖国家碳排放... 详细信息

考虑到当前与气候变化、能源和其他服务以及生态系统相关的环境和资源问题,国内和国际层面的机构和政策制定者必须提倡当代大多数资源利用领域以及与生态系统联系的领域显著的改变。本研究旨在评估生态创新对经合组织和金砖国家碳排放的影响。因此,本文将34个经合组织和5个金砖国家作为一个小组进行了抽样,用来详细解释这一现象。该研究提供了一个探索各国异同的机会,这也使区域政策制定者能够吸取经验,在环境保护新技术方面采用最佳措施。本研究的数据来自经合组织数据库和世界银行2006年至2019年的世界发展指标。采用多种计量经济学方法得出本研究的结论。计量经济学方法,如单位根检验、相关矩阵、协整检验、格兰杰因果检验、普通最小二乘回归方法和完全修正的普通最小二乘回归方法。研究结果表明,生态创新可以对所使用的代理类型产生积极和消极的碳排放影响。从调查结果可以看出,能源强度和专利对碳排放有积极影响,能源强度增加一个百分点可以导致碳排放量增加0.677%和0.705%,专利增加一个百分点也可以导致碳排放量分别增加经合组织国家碳排放量的0.073%和0.087%。对于金砖国家而言,能源强度每增加一个百分点,在1%的显著性水平上,碳排放量会增加0.202%。此外,在1%的显著性水平上,专利增加一个百分点可能会分别导致0.126%和0.087%的碳排放增加。另一方面,研发支出似乎有助于减少碳排放,研发支出每增加一个百分点,就可以减少0.032%的碳排放。但在金砖国家样本中,研究发现研发支出对碳排放产生积极影响。这意味着实际收入的增加可以鼓励研发并降低能源强度。此外,为确保低碳经济,应鼓励推行降低能源强度、加强环境法规和改进研发的节能政策。

关键词：生态创新研发能源强度专利碳排放

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Rechargeable Na-MnO_(2) battery with modified cell chemistry

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Journal of Energy Chemistry 2023年第9期84卷 414-423页

作者： Sirugaloor Thangavel Senthilkumar rebeca Marcilla Youngsik Kim Jesus Palma Mani Ulaganathan Jeong-Sun Park School of Energy&Chemical Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 689-798Republic of Korea Electrochemical Processes Unit IMDEA Energy InstituteAvda.Ramón de La Sagra 328935MóstolesSpain Center for Advanced Materials Research Research Institute of Science and TechnologyUniversity of SharjahP.O.Box 27272SharjahUnited Arab Emirates Energy Materials and Devices Lab 4TOONE CorporationUNIST-gil 50Ulsan 689-798Republic of Korea Department of Sciences Amrita School of Physical SciencesAmrita Vishwa VidyapeethamCoimbatore 641112India

High voltage,high energy density,nominal cycle life,and low cost are the most critical requirements of rechargeable batteries for their widespread energy storage applications in electric vehicles and renewable energy ***-MnO_(2) battery could be a low-cost contender,but it suffers extensively from its low cell voltage and poor *** this study,we modified the conventional cell structure of Na-MnO_(2) battery and established altered cell chemistry through a hybrid electrochemical process consisting of Na striping/plating at the anode and Zn^(2+) insertion/de-insertion along with MnO_(2) dissolution/deposition at the *** the modification,Na-MnO_(2) battery exhibits a discharge capacity of 267.10 mA h/g and a cell voltage of 3.30 V(***/Na^(+)),resulting in a high specific energy density of 881.43 Wh/*** 300 cycles,the battery retains 98% of its first-cycle discharge capacity with100% coulombic ***,Na metal-free battery assembled using sodium biphenyl as a safer anode also delivers an excellent energy density of 810.0 Wh/*** work could provide a feasible method to develop an advanced Na-MnO_(2) battery for real-time energy storage applications.

关键词： Hybrid battery Sodium metal Sodium biphenyl High cell voltage Manganese dioxide battery Modified cell chemistry

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Impact of ZnSO_(4)^(-)and ZnO Nanoparticles on Seed Germination and Seedling Growth of Lettuce

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Phyton-International Journal of Experimental Botany 2023年第6期92卷 1831-1840页

作者： Adalberto Benavides-Mendoza rebeca Betancourt-Galindo Nazario Francisco-Francisco Departamento de Horticultura Universidad Autónoma Agraria Antonio NarroSaltillo25315México Departamento de Materiales Avanzados Centro de Investigación en Química AplicadaSaltillo25294México Departamento de Agricultura Sustentable y Protegida Universidad Tecnológica de TehuacánTehuacán75859México

Micronutrient nanoparticles(NPs)are currently an option for chemical fertilization and biostimulation in ***,there is little information on the phytotoxic or biostimulatory effects of NPs at low concentrations of some elements,such as *** this study,the effect of low concentrations of Zn oxide(ZnO)NPs on germination,growth variables,and nutritional attributes of lettuce(Lactuca sativa L.)was evaluated in comparison to Zn *** lettuce seeds were treated with ZnSO_(4)^(-)×7H_(2)O and ZnO NPs at Zn molar concentrations of 1×10^(−3),5×10^(−3),1×10^(−4),5×10^(−4),1×10^(−5),5×10^(−5),1×10^(−6),and 5×10^(−6).The seeds treated with ZnSO4−at 5×10^(−6)registered the highest radicle length,73%more than the control *** seeds treated with ZnSO4−at 5×10^(−3)registered the lowest values,with 50%less than the control *** NPs at 5×10^(−6)significantly increased content of chlorophyll A and B and total *** results indicate the possible existence of a mechanism related to the intrinsic nanoparticle properties,especially at low concentrations.

关键词： Micronutrients biostimulation nanotechnology nanofertilizers germination chlorophyll total phenols

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Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease

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World Journal of Gastroenterology 2013年第1期19卷 17-25页

作者： Elena Garrido Elisa Carrera rebeca Manzano Antonio Lopez-Sanroman Inflammatory Bowel Disease Clinic Department of GastroenterologyUniversity Hospital Ramón y Cajal28034 MadridSpain Department of Gastroenterology University Hospital of Guadalajara19002 GuadalajaraSpain Department of Gastroenterology Hospital Sureste28500 MadridSpain

Cytomegalovirus(CMV) infection is common in *** virus then enters a "latency phase" and can reactivate to different stimuli such as *** clinical significance of CMV infection in inflammatory bowel disease is different in Crohn's disease(CD) and ulcerative colitis(UC).CMV does not interfere in the clinical course of ***,CMV reactivation is frequent in severe or steroid-resistant *** is not known whether the virus exacerbates the disease or simply appears as a bystander of a severe *** methods are used to diagnose CMV *** is classically based on histopathological identification of viral-infected cells or CMV antigens in biopsied tissues using haematoxylin-eosin or immunohistochemistry,other tests on blood or tissue samples are currently being *** chain reaction performed in colonic mucosa has a high sensitivity and a positive result could be associated with a worse prognosis disease;further studies are needed to determine the most appropriate strategy with positive CMV-DNA in colonic *** endoscopic features have not been described in active UC and CMV *** colitis is usually treated with ganciclovir for several weeks,there are different opinions about whether or not to stop immunosuppressive *** antiviral drugs may be *** controlled studies would needed to determine which subgroup of UC patients would benefit from early antiviral treatment.

关键词： Cytomegalovirus Inflammatory bowel disease Crohn’s disease Ulcerative colitis Hematoxylin and eosin Immunohistochemical Polymerase chain reaction Ganciclovir Infectious colitis

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Hydrogels for neuroprotection and functional rewiring: a new era for brain engineering

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Neural Regeneration Research 2020年第5期15卷 783-789页

作者： Rocío Fernández-Serra rebeca Gallego Paloma Lozano Daniel González-Nieto Center for Biomedical Technology Universidad Politécnica de Madrid. MadridSpain Departamento de Tecnología Fotónica y Bioingeniería ETSI TelecomunicacionesUniversidad Politécnica de MadridMadridSpain Biomedical Research Networking Center in Bioengineering Biomaterials and Nanomedicine (CIBER-BBN) MadridSpain

The neurological devastation of neurodegenerative and cerebrovascular diseases reinforces our perseverance to find advanced treatments to deal with these fatal ***-performance preclinical results have failed at clinical level,as it has been the case for a wide variety of neuroprotective agents and cell-based therapies employed to treat high prevalent brain pathologies such as stroke,Alzheimer’s and Parkinson’s *** unquestionable reality is the current absence of effective therapies to neuroprotect the brain,to arrest neurodegeneration and rewire the impaired brain *** of the problem might arise from the lack of adequate in vitro and in vivo models and that most of the underlying pathophysiological mechanisms are not yet *** contributing factor is the lack of efficient systems to sustain drug release at therapeutic concentrations and enhance the survival and function of grafted cells in transplantation *** medical applications the use of biomaterials of different compositions and formats has experienced a boom in the last *** the greater complexity of central nervous system has probably conditioned their extensive use with respect to other organs,the number of biomaterials-based applications to treat the injured brain or in the process of being damaged has grown ***-based biomaterials have constituted a turning point in the treatment of cerebral disorders using a new form of advanced *** show mechanical properties in the range of cerebral tissue resulting very suitable for local implantation of drugs and *** is also possible to fabricate three-dimensional hydrogel constructs with adaptable mesh size to facilitate axonal guidance and *** this article,we review the current trends in this area highlighting the positive impact of hydrogel-based biomaterials over the exhaustive control of drug delivery,cell engraftment and axonal reinnervation in brain p

关键词： advanced therapies Alzheimer’s disease biomaterials brain hydrogels neurological diseases Parkinson’s disease polymers stroke

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Susceptibility to gravitational processes due to land cover change in the Río Chiquito-Barranca del Muerto subbasin(Pico De Orizaba Volcano, México)

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Journal of Mountain Science 2017年第12期14卷 2511-2526页

作者： alanis-anaya rocío marisol legorreta-paulin gabriel mas jean francois granados-ramirez guadalupe rebeca college of geography faculty of philosophy and lettersnational autonomus university of mexico(unam)Mexico City 04510Mexico department of physical geography institute of geographynational autonomus university of mexico(unam)Mexico City 04510Mexico center for research in environmental geography national autonomus university of mexico(unam)Mexico City 58190Mexico

instability associated Land cover change can lead to slope by accelerating erosive processes with agriculture, forestry, and infrastructure. The Rio Chiquito-Barranca del Muerto subbasin has experienced an increase in land cover change due to government programs and the establishment of agricultural and urban areas. The aim of this study was to provide a model to map the susceptibility to gravitational processes along sites where anthropogenic land cover change has occurred. The method was based on the stratification of the subbasin according to landforms and cartographic variables. These variables were used in a multi- criteria assessment to assign weights according to their contribution to the onset of new gravitationalprocesses. Those weights were used to create a susceptibility map based on a weighted linear sum. The accuracy of the resulting map was validated in an error matrix with a random stratified design based on susceptibility classes per landform. The results produced a map of areas with susceptibility to gravitational processes due to land cover change; this susceptibility is very high in the undifferentiated pyroclastic slope and limestone mountain, where it derives not only from anthropogenie effects on natural vegetation cover, but also from steep slopes, weathered materials, low apparent density, high erosivity, and previous gravitational processes. The results support other studies that concluded that loss of vegetation is a triggering factor in the formation of gravitational processes, but also show that excessive reforestation can increase gravitational processes.

关键词： Gravitational processes susceptibility Land cover change Multi-criteria assessment Pico de Orizaba volcano

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A Numerical Study on Piezoelectric Energy Harvesting by Combining Transverse Galloping and Parametric Instability Phenomena

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Journal of Marine Science and Application 2017年第4期16卷 465-472页

作者： Guilherme Rosa Franzini rebeca Caramêz Saraiva Santos Celso Pupo Pesce Escola PolitEnica University of SAO Paulo SAO Paulo SP 05508-030 Brazil

This paper aims to numerically investigate the effects of parametric instability on piezoelectric energy harvesting from the transverse galloping of a square prism. A two degrees-of-freedom reduced-order model for this problem is proposed and numerically integrated. A usual quasi-steady galloping model is applied, where the transverse force coefficient is adopted as a cubic polynomial function with respect to the angle of attack. Time-histories of nondimensional prism displacement, electric voltage and power dissipated at both the dashpot and the electrical resistance are obtained as functions of the reduced velocity. Both, oscillation amplitude and electric voltage, increased with the reduced velocity for all parametric excitation conditions tested. For low values of reduced velocity, 2:1 parametric excitation enhances the electric voltage. On the other hand, for higher reduced velocities, a 1:1 parametric excitation(i.e., the same as the natural frequency) enhances both oscillation amplitude and electric voltage. It has been also found that, depending on the parametric excitation frequency, the harvested electrical power can be amplified in 70% when compared to the case under no parametric excitation.

关键词： transverse galloping energy harvesting piezoelectricity parametric instability numerical simulations

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